LeishMANIAdb
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V-type proton ATPase subunit a

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
V-type proton ATPase subunit a
Gene product:
V-type proton ATPase subunit a, putative
Species:
Leishmania major
UniProt:
Q4QAY7_LEIMA
TriTrypDb:
LmjF.23.1510 , LMJLV39_230026800 * , LMJSD75_230027400 *
Length:
775

Annotations

LeishMANIAdb annotations

Homologous to animal V-type proton pumps, vacuolar or lysosomal. For some reason, this family expanded in kinetoplastids. Localization: Endosomal (by homology) / Lysosomal (by homology)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 18
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 21
NetGPI no yes: 0, no: 21
Cellular components
Term Name Level Count
GO:0000220 vacuolar proton-transporting V-type ATPase, V0 domain 5 22
GO:0000323 lytic vacuole 6 2
GO:0005764 lysosome 7 2
GO:0005773 vacuole 5 2
GO:0005794 Golgi apparatus 5 2
GO:0016020 membrane 2 22
GO:0016469 proton-transporting two-sector ATPase complex 3 3
GO:0016471 vacuolar proton-transporting V-type ATPase complex 5 3
GO:0020022 acidocalcisome 5 2
GO:0032991 protein-containing complex 1 22
GO:0033176 proton-transporting V-type ATPase complex 4 3
GO:0033177 proton-transporting two-sector ATPase complex, proton-transporting domain 3 22
GO:0033179 proton-transporting V-type ATPase, V0 domain 4 22
GO:0043226 organelle 2 2
GO:0043227 membrane-bounded organelle 3 2
GO:0043229 intracellular organelle 3 2
GO:0043231 intracellular membrane-bounded organelle 4 2
GO:0098796 membrane protein complex 2 22
GO:0110165 cellular anatomical entity 1 22

Expansion

Sequence features

Q4QAY7
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QAY7

Function

Biological processes
Term Name Level Count
GO:0006873 intracellular monoatomic ion homeostasis 4 3
GO:0006885 regulation of pH 8 3
GO:0007035 vacuolar acidification 10 3
GO:0009987 cellular process 1 3
GO:0019725 cellular homeostasis 2 3
GO:0030003 intracellular monoatomic cation homeostasis 5 3
GO:0030004 obsolete cellular monovalent inorganic cation homeostasis 6 3
GO:0030641 regulation of cellular pH 7 3
GO:0042592 homeostatic process 3 3
GO:0048878 chemical homeostasis 4 3
GO:0050801 monoatomic ion homeostasis 5 3
GO:0051452 intracellular pH reduction 9 3
GO:0051453 regulation of intracellular pH 8 3
GO:0055067 obsolete monovalent inorganic cation homeostasis 7 3
GO:0055080 monoatomic cation homeostasis 6 3
GO:0055082 intracellular chemical homeostasis 3 3
GO:0065007 biological regulation 1 3
GO:0065008 regulation of biological quality 2 3
GO:0098771 inorganic ion homeostasis 6 3
Molecular functions
Term Name Level Count
GO:0005215 transporter activity 1 22
GO:0005488 binding 1 3
GO:0005515 protein binding 2 3
GO:0008324 monoatomic cation transmembrane transporter activity 4 22
GO:0009678 pyrophosphate hydrolysis-driven proton transmembrane transporter activity 5 22
GO:0015075 monoatomic ion transmembrane transporter activity 3 22
GO:0015078 proton transmembrane transporter activity 5 22
GO:0015318 inorganic molecular entity transmembrane transporter activity 3 22
GO:0015399 primary active transmembrane transporter activity 4 22
GO:0019829 ATPase-coupled monoatomic cation transmembrane transporter activity 3 22
GO:0019899 enzyme binding 3 3
GO:0022804 active transmembrane transporter activity 3 22
GO:0022853 active monoatomic ion transmembrane transporter activity 4 22
GO:0022857 transmembrane transporter activity 2 22
GO:0022890 inorganic cation transmembrane transporter activity 4 22
GO:0042625 ATPase-coupled ion transmembrane transporter activity 3 22
GO:0042626 ATPase-coupled transmembrane transporter activity 2 22
GO:0044769 ATPase activity, coupled to transmembrane movement of ions, rotational mechanism 4 22
GO:0046961 proton-transporting ATPase activity, rotational mechanism 4 22
GO:0051117 ATPase binding 4 3
GO:0140657 ATP-dependent activity 1 22
GO:0003824 catalytic activity 1 2
GO:0016787 hydrolase activity 2 2

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 351 355 PF00656 0.286
CLV_C14_Caspase3-7 461 465 PF00656 0.339
CLV_C14_Caspase3-7 84 88 PF00656 0.231
CLV_NRD_NRD_1 271 273 PF00675 0.471
CLV_NRD_NRD_1 61 63 PF00675 0.459
CLV_NRD_NRD_1 67 69 PF00675 0.456
CLV_PCSK_KEX2_1 271 273 PF00082 0.474
CLV_PCSK_KEX2_1 61 63 PF00082 0.459
CLV_PCSK_SKI1_1 194 198 PF00082 0.434
CLV_PCSK_SKI1_1 209 213 PF00082 0.389
CLV_PCSK_SKI1_1 257 261 PF00082 0.468
CLV_PCSK_SKI1_1 278 282 PF00082 0.473
CLV_PCSK_SKI1_1 421 425 PF00082 0.304
CLV_PCSK_SKI1_1 563 567 PF00082 0.536
DEG_APCC_DBOX_1 256 264 PF00400 0.260
DEG_APCC_DBOX_1 420 428 PF00400 0.310
DOC_CDC14_PxL_1 200 208 PF14671 0.290
DOC_CYCLIN_RxL_1 62 76 PF00134 0.329
DOC_CYCLIN_yClb1_LxF_4 496 501 PF00134 0.273
DOC_MAPK_gen_1 123 132 PF00069 0.249
DOC_MAPK_gen_1 255 263 PF00069 0.283
DOC_MAPK_gen_1 506 515 PF00069 0.254
DOC_MAPK_MEF2A_6 11 20 PF00069 0.342
DOC_MAPK_MEF2A_6 255 263 PF00069 0.339
DOC_MAPK_MEF2A_6 506 515 PF00069 0.260
DOC_MAPK_MEF2A_6 541 548 PF00069 0.288
DOC_PP1_RVXF_1 496 502 PF00149 0.283
DOC_PP1_RVXF_1 535 541 PF00149 0.516
DOC_PP1_RVXF_1 66 73 PF00149 0.324
DOC_PP1_RVXF_1 742 748 PF00149 0.454
DOC_PP4_FxxP_1 201 204 PF00568 0.248
DOC_PP4_FxxP_1 585 588 PF00568 0.254
DOC_USP7_MATH_1 301 305 PF00917 0.282
DOC_USP7_MATH_1 480 484 PF00917 0.200
DOC_USP7_MATH_2 2 8 PF00917 0.410
DOC_WW_Pin1_4 332 337 PF00397 0.320
LIG_14-3-3_CanoR_1 233 239 PF00244 0.303
LIG_14-3-3_CanoR_1 272 281 PF00244 0.306
LIG_Actin_WH2_2 19 35 PF00022 0.360
LIG_APCC_ABBA_1 397 402 PF00400 0.313
LIG_APCC_ABBA_1 620 625 PF00400 0.310
LIG_BIR_III_4 89 93 PF00653 0.161
LIG_BRCT_BRCA1_1 133 137 PF00533 0.387
LIG_BRCT_BRCA1_1 482 486 PF00533 0.200
LIG_BRCT_BRCA1_1 549 553 PF00533 0.313
LIG_BRCT_BRCA1_1 692 696 PF00533 0.313
LIG_BRCT_BRCA1_1 697 701 PF00533 0.313
LIG_Clathr_ClatBox_1 702 706 PF01394 0.424
LIG_Clathr_ClatBox_1 730 734 PF01394 0.304
LIG_deltaCOP1_diTrp_1 694 701 PF00928 0.297
LIG_EVH1_2 336 340 PF00568 0.273
LIG_FHA_1 147 153 PF00498 0.237
LIG_FHA_1 174 180 PF00498 0.224
LIG_FHA_1 244 250 PF00498 0.272
LIG_FHA_1 340 346 PF00498 0.257
LIG_FHA_1 525 531 PF00498 0.336
LIG_FHA_1 588 594 PF00498 0.221
LIG_FHA_1 722 728 PF00498 0.363
LIG_FHA_2 323 329 PF00498 0.251
LIG_FHA_2 564 570 PF00498 0.217
LIG_FHA_2 82 88 PF00498 0.307
LIG_LIR_Apic_2 451 456 PF02991 0.218
LIG_LIR_Apic_2 582 588 PF02991 0.258
LIG_LIR_Gen_1 103 112 PF02991 0.294
LIG_LIR_Gen_1 114 120 PF02991 0.218
LIG_LIR_Gen_1 346 356 PF02991 0.263
LIG_LIR_Gen_1 392 400 PF02991 0.294
LIG_LIR_Gen_1 412 422 PF02991 0.327
LIG_LIR_Gen_1 500 507 PF02991 0.254
LIG_LIR_Gen_1 527 536 PF02991 0.487
LIG_LIR_Gen_1 552 562 PF02991 0.306
LIG_LIR_Gen_1 676 687 PF02991 0.454
LIG_LIR_Gen_1 698 707 PF02991 0.286
LIG_LIR_Nem_3 103 109 PF02991 0.294
LIG_LIR_Nem_3 114 119 PF02991 0.234
LIG_LIR_Nem_3 180 186 PF02991 0.261
LIG_LIR_Nem_3 190 196 PF02991 0.293
LIG_LIR_Nem_3 346 352 PF02991 0.252
LIG_LIR_Nem_3 373 377 PF02991 0.261
LIG_LIR_Nem_3 392 397 PF02991 0.277
LIG_LIR_Nem_3 412 417 PF02991 0.389
LIG_LIR_Nem_3 500 505 PF02991 0.248
LIG_LIR_Nem_3 527 532 PF02991 0.496
LIG_LIR_Nem_3 552 558 PF02991 0.284
LIG_LIR_Nem_3 676 682 PF02991 0.454
LIG_LIR_Nem_3 693 699 PF02991 0.304
LIG_LYPXL_S_1 467 471 PF13949 0.539
LIG_MYND_1 456 460 PF01753 0.260
LIG_NRP_CendR_1 773 775 PF00754 0.350
LIG_PCNA_PIPBox_1 733 742 PF02747 0.454
LIG_Pex14_1 697 701 PF04695 0.297
LIG_Pex14_2 197 201 PF04695 0.248
LIG_Pex14_2 374 378 PF04695 0.254
LIG_Pex14_2 414 418 PF04695 0.428
LIG_Pex14_2 52 56 PF04695 0.290
LIG_Pex14_2 750 754 PF04695 0.454
LIG_PTB_Apo_2 436 443 PF02174 0.304
LIG_PTB_Apo_2 525 532 PF02174 0.313
LIG_PTB_Apo_2 749 756 PF02174 0.458
LIG_PTB_Phospho_1 525 531 PF10480 0.313
LIG_PTB_Phospho_1 749 755 PF10480 0.458
LIG_SH2_CRK 116 120 PF00017 0.260
LIG_SH2_CRK 193 197 PF00017 0.264
LIG_SH2_CRK 433 437 PF00017 0.448
LIG_SH2_CRK 502 506 PF00017 0.248
LIG_SH2_CRK 555 559 PF00017 0.306
LIG_SH2_GRB2like 531 534 PF00017 0.512
LIG_SH2_SRC 224 227 PF00017 0.257
LIG_SH2_STAP1 106 110 PF00017 0.339
LIG_SH2_STAT5 200 203 PF00017 0.241
LIG_SH2_STAT5 317 320 PF00017 0.273
LIG_SH2_STAT5 339 342 PF00017 0.255
LIG_SH2_STAT5 376 379 PF00017 0.304
LIG_SH2_STAT5 422 425 PF00017 0.300
LIG_SH2_STAT5 529 532 PF00017 0.428
LIG_SH2_STAT5 623 626 PF00017 0.552
LIG_SH2_STAT5 668 671 PF00017 0.453
LIG_SH2_STAT5 679 682 PF00017 0.452
LIG_SH3_1 453 459 PF00018 0.260
LIG_SH3_3 453 459 PF00018 0.240
LIG_SH3_3 466 472 PF00018 0.285
LIG_SUMO_SIM_anti_2 128 134 PF11976 0.223
LIG_SUMO_SIM_par_1 107 114 PF11976 0.333
LIG_SUMO_SIM_par_1 12 19 PF11976 0.381
LIG_SUMO_SIM_par_1 143 149 PF11976 0.336
LIG_SUMO_SIM_par_1 522 527 PF11976 0.311
LIG_SUMO_SIM_par_1 604 610 PF11976 0.311
LIG_SUMO_SIM_par_1 701 706 PF11976 0.421
LIG_TRFH_1 584 588 PF08558 0.304
LIG_TYR_ITIM 380 385 PF00017 0.322
LIG_UBA3_1 326 333 PF00899 0.319
LIG_UBA3_1 617 626 PF00899 0.299
LIG_WRC_WIRS_1 696 701 PF05994 0.360
LIG_WW_1 336 339 PF00397 0.332
MOD_CK1_1 290 296 PF00069 0.318
MOD_CK1_1 348 354 PF00069 0.381
MOD_CK1_1 470 476 PF00069 0.368
MOD_CK1_1 490 496 PF00069 0.127
MOD_CK1_1 690 696 PF00069 0.313
MOD_CK2_1 322 328 PF00069 0.298
MOD_CK2_1 490 496 PF00069 0.332
MOD_CK2_1 563 569 PF00069 0.290
MOD_CK2_1 573 579 PF00069 0.321
MOD_CK2_1 93 99 PF00069 0.418
MOD_GlcNHglycan 201 204 PF01048 0.351
MOD_GlcNHglycan 251 254 PF01048 0.322
MOD_GlcNHglycan 289 292 PF01048 0.322
MOD_GlcNHglycan 318 321 PF01048 0.329
MOD_GlcNHglycan 450 453 PF01048 0.312
MOD_GlcNHglycan 48 52 PF01048 0.332
MOD_GlcNHglycan 489 492 PF01048 0.314
MOD_GlcNHglycan 596 599 PF01048 0.439
MOD_GlcNHglycan 6 9 PF01048 0.491
MOD_GlcNHglycan 708 711 PF01048 0.324
MOD_GlcNHglycan 736 739 PF01048 0.309
MOD_GSK3_1 165 172 PF00069 0.297
MOD_GSK3_1 241 248 PF00069 0.319
MOD_GSK3_1 335 342 PF00069 0.273
MOD_GSK3_1 348 355 PF00069 0.127
MOD_GSK3_1 470 477 PF00069 0.351
MOD_GSK3_1 564 571 PF00069 0.339
MOD_GSK3_1 573 580 PF00069 0.274
MOD_GSK3_1 671 678 PF00069 0.309
MOD_GSK3_1 683 690 PF00069 0.294
MOD_N-GLC_1 123 128 PF02516 0.288
MOD_N-GLC_1 249 254 PF02516 0.253
MOD_N-GLC_1 532 537 PF02516 0.301
MOD_NEK2_1 146 151 PF00069 0.440
MOD_NEK2_1 234 239 PF00069 0.335
MOD_NEK2_1 249 254 PF00069 0.300
MOD_NEK2_1 287 292 PF00069 0.292
MOD_NEK2_1 501 506 PF00069 0.322
MOD_NEK2_1 507 512 PF00069 0.322
MOD_NEK2_1 532 537 PF00069 0.392
MOD_NEK2_1 549 554 PF00069 0.265
MOD_NEK2_1 577 582 PF00069 0.283
MOD_NEK2_1 607 612 PF00069 0.305
MOD_NEK2_1 687 692 PF00069 0.333
MOD_NEK2_1 721 726 PF00069 0.395
MOD_NEK2_1 767 772 PF00069 0.535
MOD_PIKK_1 243 249 PF00454 0.367
MOD_PIKK_1 687 693 PF00454 0.327
MOD_PK_1 169 175 PF00069 0.313
MOD_PKA_2 165 171 PF00069 0.308
MOD_PKA_2 474 480 PF00069 0.357
MOD_Plk_1 249 255 PF00069 0.448
MOD_Plk_1 401 407 PF00069 0.286
MOD_Plk_1 47 53 PF00069 0.309
MOD_Plk_1 480 486 PF00069 0.175
MOD_Plk_1 532 538 PF00069 0.301
MOD_Plk_2-3 573 579 PF00069 0.246
MOD_Plk_4 169 175 PF00069 0.297
MOD_Plk_4 192 198 PF00069 0.375
MOD_Plk_4 217 223 PF00069 0.286
MOD_Plk_4 322 328 PF00069 0.314
MOD_Plk_4 335 341 PF00069 0.264
MOD_Plk_4 348 354 PF00069 0.127
MOD_Plk_4 389 395 PF00069 0.281
MOD_Plk_4 480 486 PF00069 0.245
MOD_Plk_4 507 513 PF00069 0.302
MOD_Plk_4 573 579 PF00069 0.267
MOD_Plk_4 675 681 PF00069 0.304
MOD_Plk_4 81 87 PF00069 0.385
MOD_ProDKin_1 332 338 PF00069 0.398
MOD_SUMO_for_1 478 481 PF00179 0.253
MOD_SUMO_rev_2 490 499 PF00179 0.303
MOD_SUMO_rev_2 625 633 PF00179 0.313
MOD_SUMO_rev_2 64 70 PF00179 0.283
MOD_SUMO_rev_2 93 102 PF00179 0.313
TRG_DiLeu_BaLyEn_6 206 211 PF01217 0.431
TRG_ENDOCYTIC_2 106 109 PF00928 0.355
TRG_ENDOCYTIC_2 116 119 PF00928 0.262
TRG_ENDOCYTIC_2 193 196 PF00928 0.302
TRG_ENDOCYTIC_2 382 385 PF00928 0.304
TRG_ENDOCYTIC_2 422 425 PF00928 0.301
TRG_ENDOCYTIC_2 433 436 PF00928 0.304
TRG_ENDOCYTIC_2 438 441 PF00928 0.304
TRG_ENDOCYTIC_2 468 471 PF00928 0.429
TRG_ENDOCYTIC_2 502 505 PF00928 0.301
TRG_ENDOCYTIC_2 529 532 PF00928 0.360
TRG_ENDOCYTIC_2 555 558 PF00928 0.322
TRG_ENDOCYTIC_2 679 682 PF00928 0.304
TRG_ER_diArg_1 254 257 PF00400 0.360
TRG_ER_diArg_1 270 272 PF00400 0.316
TRG_ER_diArg_1 60 62 PF00400 0.311
TRG_NES_CRM1_1 734 749 PF08389 0.304
TRG_Pf-PMV_PEXEL_1 71 75 PF00026 0.283

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P622 Leptomonas seymouri 88% 100%
A0A0N1PFQ1 Leptomonas seymouri 42% 84%
A0A0S4JG87 Bodo saltans 46% 86%
A0A0S4JMR5 Bodo saltans 62% 100%
A0A1X0NV83 Trypanosomatidae 42% 92%
A0A1X0NWN0 Trypanosomatidae 73% 100%
A0A3Q8IB62 Leishmania donovani 97% 100%
A0A3Q8IGN1 Leishmania donovani 43% 87%
A0A3R7KUW1 Trypanosoma rangeli 43% 91%
A0A422NJD7 Trypanosoma rangeli 71% 100%
A1A5G6 Xenopus tropicalis 39% 93%
A4HD35 Leishmania braziliensis 91% 100%
A4HK73 Leishmania braziliensis 44% 86%
A4I0M2 Leishmania infantum 97% 100%
A4I7Q8 Leishmania infantum 43% 87%
C9ZNR3 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 65% 99%
E9AWI3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 96% 100%
E9B2L6 Leishmania mexicana (strain MHOM/GT/2001/U1103) 42% 87%
G5EEK9 Caenorhabditis elegans 33% 89%
G5EGP4 Caenorhabditis elegans 33% 90%
O13742 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 34% 93%
O29106 Archaeoglobus fulgidus (strain ATCC 49558 / DSM 4304 / JCM 9628 / NBRC 100126 / VC-16) 20% 100%
O97681 Bos taurus 35% 91%
P15920 Mus musculus 35% 91%
P25286 Rattus norvegicus 38% 92%
P30628 Caenorhabditis elegans 35% 86%
P32563 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 35% 92%
P37296 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 33% 87%
Q01290 Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) 34% 91%
Q13488 Homo sapiens 34% 93%
Q29466 Bos taurus 39% 92%
Q4Q5J0 Leishmania major 42% 100%
Q54E04 Dictyostelium discoideum 38% 95%
Q5R422 Pongo abelii 39% 93%
Q8AVM5 Xenopus laevis 39% 93%
Q8RWZ7 Arabidopsis thaliana 37% 95%
Q8W4S4 Arabidopsis thaliana 39% 94%
Q920R6 Mus musculus 37% 93%
Q93050 Homo sapiens 39% 93%
Q9HBG4 Homo sapiens 36% 92%
Q9I8D0 Gallus gallus 38% 92%
Q9SJT7 Arabidopsis thaliana 38% 94%
Q9Y487 Homo sapiens 34% 91%
Q9Z1G4 Mus musculus 38% 92%
V5BQN9 Trypanosoma cruzi 43% 100%
V5D763 Trypanosoma cruzi 72% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS