Protoheme IX farnesyltransferase, mitochondrial

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

protoheme IX farnesyltransferase, putative

Species:

Leishmania major

UniProt:

Q4QAY6_LEIMA

TriTrypDb:

LmjF.23.1520 , LMJLV39_230026900 , LMJSD75_230027500

Length:

433

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	2
GO:0016020	membrane	2	12
GO:0031090	organelle membrane	3	8
GO:0031966	mitochondrial membrane	4	8
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	12

Expansion

Sequence features

Q4QAY6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QAY6

Function

Biological processes
Term	Name	Level	Count
GO:0006725	cellular aromatic compound metabolic process	3	12
GO:0006778	porphyrin-containing compound metabolic process	5	12
GO:0006779	porphyrin-containing compound biosynthetic process	6	12
GO:0006783	heme biosynthetic process	4	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0009058	biosynthetic process	2	12
GO:0009987	cellular process	1	12
GO:0018130	heterocycle biosynthetic process	4	12
GO:0019438	aromatic compound biosynthetic process	4	12
GO:0033013	tetrapyrrole metabolic process	4	12
GO:0033014	tetrapyrrole biosynthetic process	5	12
GO:0034641	cellular nitrogen compound metabolic process	3	12
GO:0042168	heme metabolic process	3	12
GO:0042440	pigment metabolic process	2	12
GO:0044237	cellular metabolic process	2	12
GO:0044249	cellular biosynthetic process	3	12
GO:0044271	cellular nitrogen compound biosynthetic process	4	12
GO:0046148	pigment biosynthetic process	3	12
GO:0046483	heterocycle metabolic process	3	12
GO:0071704	organic substance metabolic process	2	12
GO:1901360	organic cyclic compound metabolic process	3	12
GO:1901362	organic cyclic compound biosynthetic process	4	12
GO:1901564	organonitrogen compound metabolic process	3	12
GO:1901566	organonitrogen compound biosynthetic process	4	12
GO:1901576	organic substance biosynthetic process	3	12

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0004311	farnesyltranstransferase activity	5	12
GO:0004659	prenyltransferase activity	4	12
GO:0008495	protoheme IX farnesyltransferase activity	6	12
GO:0016740	transferase activity	2	12
GO:0016765	transferase activity, transferring alkyl or aryl (other than methyl) groups	3	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	117	119	PF00675	0.348
CLV_NRD_NRD_1	19	21	PF00675	0.333
CLV_NRD_NRD_1	191	193	PF00675	0.215
CLV_NRD_NRD_1	301	303	PF00675	0.204
CLV_NRD_NRD_1	66	68	PF00675	0.415
CLV_PCSK_KEX2_1	117	119	PF00082	0.348
CLV_PCSK_KEX2_1	187	189	PF00082	0.226
CLV_PCSK_KEX2_1	19	21	PF00082	0.333
CLV_PCSK_KEX2_1	191	193	PF00082	0.238
CLV_PCSK_KEX2_1	245	247	PF00082	0.204
CLV_PCSK_KEX2_1	301	303	PF00082	0.204
CLV_PCSK_KEX2_1	66	68	PF00082	0.415
CLV_PCSK_PC1ET2_1	187	189	PF00082	0.226
CLV_PCSK_PC1ET2_1	245	247	PF00082	0.204
CLV_PCSK_PC7_1	113	119	PF00082	0.308
CLV_PCSK_PC7_1	62	68	PF00082	0.369
CLV_PCSK_SKI1_1	184	188	PF00082	0.219
CLV_PCSK_SKI1_1	19	23	PF00082	0.333
CLV_PCSK_SKI1_1	365	369	PF00082	0.332
CLV_PCSK_SKI1_1	40	44	PF00082	0.440
CLV_PCSK_SKI1_1	47	51	PF00082	0.419
CLV_Separin_Metazoa	372	376	PF03568	0.498
DEG_APCC_DBOX_1	18	26	PF00400	0.537
DEG_Nend_Nbox_1	1	3	PF02207	0.577
DOC_CKS1_1	240	245	PF01111	0.428
DOC_CKS1_1	273	278	PF01111	0.217
DOC_CYCLIN_RxL_1	362	372	PF00134	0.332
DOC_MAPK_gen_1	117	124	PF00069	0.466
DOC_MAPK_gen_1	187	198	PF00069	0.491
DOC_MAPK_HePTP_8	114	126	PF00069	0.498
DOC_MAPK_MEF2A_6	117	126	PF00069	0.484
DOC_PP1_RVXF_1	308	315	PF00149	0.404
DOC_PP1_RVXF_1	363	370	PF00149	0.297
DOC_PP4_FxxP_1	198	201	PF00568	0.433
DOC_PP4_FxxP_1	314	317	PF00568	0.404
DOC_PP4_FxxP_1	33	36	PF00568	0.608
DOC_USP7_MATH_1	120	124	PF00917	0.518
DOC_USP7_MATH_1	206	210	PF00917	0.423
DOC_USP7_MATH_1	21	25	PF00917	0.580
DOC_USP7_MATH_1	426	430	PF00917	0.400
DOC_USP7_UBL2_3	43	47	PF12436	0.527
DOC_WW_Pin1_4	100	105	PF00397	0.600
DOC_WW_Pin1_4	197	202	PF00397	0.471
DOC_WW_Pin1_4	220	225	PF00397	0.204
DOC_WW_Pin1_4	239	244	PF00397	0.383
DOC_WW_Pin1_4	272	277	PF00397	0.310
DOC_WW_Pin1_4	419	424	PF00397	0.284
DOC_WW_Pin1_4	82	87	PF00397	0.639
LIG_14-3-3_CanoR_1	20	26	PF00244	0.570
LIG_14-3-3_CanoR_1	246	254	PF00244	0.404
LIG_14-3-3_CanoR_1	319	323	PF00244	0.404
LIG_14-3-3_CanoR_1	62	68	PF00244	0.670
LIG_Actin_WH2_2	229	247	PF00022	0.239
LIG_Actin_WH2_2	3	21	PF00022	0.495
LIG_BRCT_BRCA1_1	365	369	PF00533	0.332
LIG_BRCT_BRCA1_1	69	73	PF00533	0.670
LIG_FHA_1	119	125	PF00498	0.496
LIG_FHA_1	13	19	PF00498	0.556
LIG_FHA_1	150	156	PF00498	0.323
LIG_FHA_1	214	220	PF00498	0.345
LIG_FHA_1	273	279	PF00498	0.215
LIG_LIR_Gen_1	179	186	PF02991	0.471
LIG_LIR_Gen_1	283	291	PF02991	0.299
LIG_LIR_Gen_1	384	395	PF02991	0.238
LIG_LIR_Nem_3	179	185	PF02991	0.508
LIG_LIR_Nem_3	252	257	PF02991	0.332
LIG_LIR_Nem_3	283	287	PF02991	0.299
LIG_LIR_Nem_3	321	325	PF02991	0.421
LIG_LIR_Nem_3	384	390	PF02991	0.238
LIG_LIR_Nem_3	4	10	PF02991	0.649
LIG_Pex14_1	318	322	PF04695	0.404
LIG_Pex14_1	8	12	PF04695	0.482
LIG_Pex14_2	284	288	PF04695	0.332
LIG_Pex14_2	314	318	PF04695	0.404
LIG_SH2_CRK	182	186	PF00017	0.508
LIG_SH2_CRK	241	245	PF00017	0.434
LIG_SH2_CRK	309	313	PF00017	0.404
LIG_SH2_CRK	364	368	PF00017	0.297
LIG_SH2_NCK_1	304	308	PF00017	0.415
LIG_SH2_PTP2	237	240	PF00017	0.332
LIG_SH2_PTP2	385	388	PF00017	0.271
LIG_SH2_SRC	146	149	PF00017	0.401
LIG_SH2_STAP1	182	186	PF00017	0.471
LIG_SH2_STAP1	323	327	PF00017	0.238
LIG_SH2_STAP1	352	356	PF00017	0.429
LIG_SH2_STAT5	137	140	PF00017	0.282
LIG_SH2_STAT5	146	149	PF00017	0.234
LIG_SH2_STAT5	220	223	PF00017	0.237
LIG_SH2_STAT5	237	240	PF00017	0.161
LIG_SH2_STAT5	241	244	PF00017	0.404
LIG_SH2_STAT5	385	388	PF00017	0.241
LIG_SH2_STAT5	412	415	PF00017	0.297
LIG_SH3_3	219	225	PF00018	0.253
LIG_WRC_WIRS_1	281	286	PF05994	0.299
MOD_CDK_SPxK_1	239	245	PF00069	0.256
MOD_CDK_SPxxK_3	239	246	PF00069	0.238
MOD_CK1_1	11	17	PF00069	0.438
MOD_CK1_1	132	138	PF00069	0.397
MOD_CK1_1	170	176	PF00069	0.247
MOD_CK1_1	23	29	PF00069	0.420
MOD_CK1_1	38	44	PF00069	0.489
MOD_CK1_1	421	427	PF00069	0.504
MOD_CK2_1	205	211	PF00069	0.297
MOD_CK2_1	426	432	PF00069	0.616
MOD_GlcNHglycan	134	137	PF01048	0.271
MOD_GlcNHglycan	169	172	PF01048	0.286
MOD_GlcNHglycan	247	250	PF01048	0.238
MOD_GlcNHglycan	25	28	PF01048	0.445
MOD_GlcNHglycan	424	427	PF01048	0.494
MOD_GlcNHglycan	69	72	PF01048	0.547
MOD_GSK3_1	120	127	PF00069	0.387
MOD_GSK3_1	161	168	PF00069	0.271
MOD_GSK3_1	202	209	PF00069	0.274
MOD_GSK3_1	245	252	PF00069	0.242
MOD_GSK3_1	415	422	PF00069	0.456
MOD_GSK3_1	426	433	PF00069	0.510
MOD_GSK3_1	78	85	PF00069	0.598
MOD_GSK3_1	8	15	PF00069	0.581
MOD_NEK2_1	129	134	PF00069	0.358
MOD_NEK2_1	165	170	PF00069	0.262
MOD_NEK2_1	186	191	PF00069	0.238
MOD_NEK2_1	210	215	PF00069	0.297
MOD_NEK2_1	280	285	PF00069	0.324
MOD_NEK2_1	381	386	PF00069	0.238
MOD_NEK2_1	50	55	PF00069	0.598
MOD_NEK2_1	6	11	PF00069	0.544
MOD_NEK2_1	61	66	PF00069	0.516
MOD_NEK2_2	318	323	PF00069	0.238
MOD_PIKK_1	124	130	PF00454	0.395
MOD_PIKK_1	61	67	PF00454	0.597
MOD_PKA_1	245	251	PF00069	0.238
MOD_PKA_2	245	251	PF00069	0.238
MOD_PKA_2	318	324	PF00069	0.238
MOD_PKA_2	61	67	PF00069	0.513
MOD_Plk_1	12	18	PF00069	0.444
MOD_Plk_1	210	216	PF00069	0.236
MOD_Plk_4	120	126	PF00069	0.420
MOD_Plk_4	13	19	PF00069	0.592
MOD_Plk_4	161	167	PF00069	0.246
MOD_Plk_4	249	255	PF00069	0.238
MOD_Plk_4	280	286	PF00069	0.335
MOD_Plk_4	318	324	PF00069	0.238
MOD_Plk_4	325	331	PF00069	0.238
MOD_Plk_4	332	338	PF00069	0.238
MOD_Plk_4	363	369	PF00069	0.357
MOD_Plk_4	386	392	PF00069	0.253
MOD_Plk_4	45	51	PF00069	0.621
MOD_Plk_4	84	90	PF00069	0.615
MOD_ProDKin_1	100	106	PF00069	0.498
MOD_ProDKin_1	197	203	PF00069	0.332
MOD_ProDKin_1	220	226	PF00069	0.238
MOD_ProDKin_1	239	245	PF00069	0.383
MOD_ProDKin_1	272	278	PF00069	0.386
MOD_ProDKin_1	419	425	PF00069	0.358
MOD_ProDKin_1	82	88	PF00069	0.569
TRG_ENDOCYTIC_2	182	185	PF00928	0.332
TRG_ENDOCYTIC_2	237	240	PF00928	0.295
TRG_ENDOCYTIC_2	241	244	PF00928	0.282
TRG_ENDOCYTIC_2	309	312	PF00928	0.238
TRG_ENDOCYTIC_2	351	354	PF00928	0.262
TRG_ENDOCYTIC_2	364	367	PF00928	0.248
TRG_ENDOCYTIC_2	385	388	PF00928	0.238
TRG_ER_diArg_1	117	119	PF00400	0.440
TRG_ER_diArg_1	18	20	PF00400	0.424
TRG_ER_diArg_1	191	193	PF00400	0.253
TRG_ER_diArg_1	66	68	PF00400	0.590
TRG_Pf-PMV_PEXEL_1	40	44	PF00026	0.416

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDJ6	Leptomonas seymouri	79%	100%
A0A0S4JPE1	Bodo saltans	54%	100%
A0A1X0NWM0	Trypanosomatidae	60%	100%
A0A3Q8IFZ4	Leishmania donovani	94%	100%
A0A3R7KFR3	Trypanosoma rangeli	59%	100%
A0KAR0	Burkholderia cenocepacia (strain HI2424)	29%	100%
A0QWY2	Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155)	31%	100%
A1KIP0	Mycobacterium bovis (strain BCG / Pasteur 1173P2)	29%	100%
A1QRH1	Mycobacterium tuberculosis (strain F11)	29%	100%
A1SY55	Psychromonas ingrahamii (strain 37)	30%	100%
A1UZV8	Burkholderia mallei (strain SAVP1)	30%	100%
A1VKM6	Polaromonas naphthalenivorans (strain CJ2)	29%	100%
A2S646	Burkholderia mallei (strain NCTC 10229)	30%	100%
A3MQ44	Burkholderia mallei (strain NCTC 10247)	30%	100%
A3N5D1	Burkholderia pseudomallei (strain 668)	30%	100%
A3NR29	Burkholderia pseudomallei (strain 1106a)	30%	100%
A3PGX5	Cereibacter sphaeroides (strain ATCC 17029 / ATH 2.4.9)	29%	100%
A4FBP2	Saccharopolyspora erythraea (strain ATCC 11635 / DSM 40517 / JCM 4748 / NBRC 13426 / NCIMB 8594 / NRRL 2338)	30%	100%
A4HD36	Leishmania braziliensis	88%	100%
A4I0M3	Leishmania infantum	94%	100%
A4JI25	Burkholderia vietnamiensis (strain G4 / LMG 22486)	28%	100%
A5U2F4	Mycobacterium tuberculosis (strain ATCC 25177 / H37Ra)	29%	100%
A5UPV7	Roseiflexus sp. (strain RS-1)	27%	81%
A5VP40	Brucella ovis (strain ATCC 25840 / 63/290 / NCTC 10512)	31%	100%
A9M8Z3	Brucella canis (strain ATCC 23365 / NCTC 10854)	31%	100%
B0CKF4	Brucella suis (strain ATCC 23445 / NCTC 10510)	30%	100%
B0R3W4	Halobacterium salinarum (strain ATCC 29341 / DSM 671 / R1)	27%	94%
B0T0X6	Caulobacter sp. (strain K31)	26%	100%
B1JZ41	Burkholderia cenocepacia (strain MC0-3)	29%	100%
B1YIW5	Exiguobacterium sibiricum (strain DSM 17290 / CIP 109462 / JCM 13490 / 255-15)	29%	100%
B1YN86	Burkholderia ambifaria (strain MC40-6)	29%	100%
B2IGJ6	Beijerinckia indica subsp. indica (strain ATCC 9039 / DSM 1715 / NCIMB 8712)	30%	100%
B4EA84	Burkholderia cenocepacia (strain ATCC BAA-245 / DSM 16553 / LMG 16656 / NCTC 13227 / J2315 / CF5610)	29%	100%
B4SHI1	Stenotrophomonas maltophilia (strain R551-3)	30%	100%
B5ZSV2	Rhizobium leguminosarum bv. trifolii (strain WSM2304)	29%	100%
B9JAP1	Agrobacterium radiobacter (strain K84 / ATCC BAA-868)	28%	100%
B9KLZ5	Cereibacter sphaeroides (strain KD131 / KCTC 12085)	29%	100%
C0RHH6	Brucella melitensis biotype 2 (strain ATCC 23457)	31%	100%
C1AN96	Mycobacterium bovis (strain BCG / Tokyo 172 / ATCC 35737 / TMC 1019)	29%	100%
C9ZNR4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	63%	96%
E9AWI4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
O64886	Arabidopsis thaliana	34%	100%
P67053	Brucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094)	31%	100%
P67054	Brucella suis biovar 1 (strain 1330)	31%	100%
P9WFR6	Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)	29%	100%
P9WFR7	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)	29%	100%
Q0BBM3	Burkholderia ambifaria (strain ATCC BAA-244 / AMMD)	29%	100%
Q0C3D1	Hyphomonas neptunium (strain ATCC 15444)	27%	100%
Q12E37	Polaromonas sp. (strain JS666 / ATCC BAA-500)	29%	100%
Q1BTD0	Burkholderia cenocepacia (strain AU 1054)	29%	100%
Q1D1K4	Myxococcus xanthus (strain DK1622)	30%	100%
Q1IGZ4	Pseudomonas entomophila (strain L48)	27%	100%
Q1IPI1	Koribacter versatilis (strain Ellin345)	27%	100%
Q1J1C3	Deinococcus geothermalis (strain DSM 11300 / AG-3a)	28%	100%
Q1MKI5	Rhizobium leguminosarum bv. viciae (strain 3841)	30%	100%
Q28MJ1	Jannaschia sp. (strain CCS1)	28%	100%
Q2IPE5	Anaeromyxobacter dehalogenans (strain 2CP-C)	31%	100%
Q2NYG1	Xanthomonas oryzae pv. oryzae (strain MAFF 311018)	29%	100%
Q2T1F6	Burkholderia thailandensis (strain ATCC 700388 / DSM 13276 / CIP 106301 / E264)	30%	100%
Q39CQ5	Burkholderia lata (strain ATCC 17760 / DSM 23089 / LMG 22485 / NCIMB 9086 / R18194 / 383)	29%	100%
Q3BND5	Xanthomonas campestris pv. vesicatoria (strain 85-10)	30%	100%
Q3IRC9	Natronomonas pharaonis (strain ATCC 35678 / DSM 2160 / CIP 103997 / JCM 8858 / NBRC 14720 / NCIMB 2260 / Gabara)	27%	95%
Q3J5F9	Cereibacter sphaeroides (strain ATCC 17023 / DSM 158 / JCM 6121 / CCUG 31486 / LMG 2827 / NBRC 12203 / NCIMB 8253 / ATH 2.4.1.)	29%	100%
Q3JWF7	Burkholderia pseudomallei (strain 1710b)	30%	100%
Q4I5G1	Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)	34%	85%
Q5GV87	Xanthomonas oryzae pv. oryzae (strain KACC10331 / KXO85)	29%	100%
Q62F61	Burkholderia mallei (strain ATCC 23344)	30%	100%
Q63XS7	Burkholderia pseudomallei (strain K96243)	30%	100%
Q6AF34	Leifsonia xyli subsp. xyli (strain CTCB07)	28%	100%
Q72VU2	Leptospira interrogans serogroup Icterohaemorrhagiae serovar copenhageni (strain Fiocruz L1-130)	27%	100%
Q75F43	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	33%	100%
Q7NIL7	Gloeobacter violaceus (strain ATCC 29082 / PCC 7421)	31%	100%
Q7U021	Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)	29%	100%
Q8F9F8	Leptospira interrogans serogroup Icterohaemorrhagiae serovar Lai (strain 56601)	27%	100%
Q985X0	Mesorhizobium japonicum (strain LMG 29417 / CECT 9101 / MAFF 303099)	29%	100%
Q98LF1	Mesorhizobium japonicum (strain LMG 29417 / CECT 9101 / MAFF 303099)	30%	100%
Q9A301	Caulobacter vibrioides (strain ATCC 19089 / CB15)	26%	100%
Q9CCN4	Mycobacterium leprae (strain TN)	28%	100%
Q9HRJ8	Halobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1)	27%	98%
Q9PDL9	Xylella fastidiosa (strain 9a5c)	30%	100%
Q9RM98	Bradyrhizobium diazoefficiens (strain JCM 10833 / BCRC 13528 / IAM 13628 / NBRC 14792 / USDA 110)	28%	100%
V5BB79	Trypanosoma cruzi	54%	100%