Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QAY5_LEIMA

TriTrypDb:

LmjF.23.1530 , LMJLV39_230027000 , LMJSD75_230027600

Length:

651

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QAY5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QAY5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	156	160	PF00656	0.506
CLV_C14_Caspase3-7	353	357	PF00656	0.618
CLV_C14_Caspase3-7	421	425	PF00656	0.520
CLV_NRD_NRD_1	193	195	PF00675	0.558
CLV_NRD_NRD_1	319	321	PF00675	0.457
CLV_PCSK_KEX2_1	193	195	PF00082	0.558
CLV_PCSK_KEX2_1	319	321	PF00082	0.462
CLV_PCSK_KEX2_1	369	371	PF00082	0.529
CLV_PCSK_PC1ET2_1	369	371	PF00082	0.529
CLV_PCSK_SKI1_1	102	106	PF00082	0.658
CLV_PCSK_SKI1_1	131	135	PF00082	0.561
CLV_PCSK_SKI1_1	181	185	PF00082	0.485
CLV_PCSK_SKI1_1	355	359	PF00082	0.567
CLV_PCSK_SKI1_1	496	500	PF00082	0.605
CLV_PCSK_SKI1_1	567	571	PF00082	0.559
DEG_APCC_DBOX_1	180	188	PF00400	0.498
DEG_APCC_DBOX_1	307	315	PF00400	0.417
DEG_APCC_DBOX_1	32	40	PF00400	0.516
DEG_Nend_UBRbox_2	1	3	PF02207	0.637
DOC_CDC14_PxL_1	613	621	PF14671	0.442
DOC_CKS1_1	499	504	PF01111	0.572
DOC_CYCLIN_RxL_1	573	585	PF00134	0.490
DOC_CYCLIN_RxL_1	628	636	PF00134	0.501
DOC_CYCLIN_yCln2_LP_2	489	495	PF00134	0.450
DOC_MAPK_DCC_7	640	649	PF00069	0.414
DOC_MAPK_gen_1	459	467	PF00069	0.346
DOC_MAPK_MEF2A_6	308	315	PF00069	0.473
DOC_MAPK_MEF2A_6	40	47	PF00069	0.570
DOC_MAPK_MEF2A_6	536	544	PF00069	0.440
DOC_MAPK_NFAT4_5	308	316	PF00069	0.516
DOC_PP2B_LxvP_1	302	305	PF13499	0.456
DOC_PP2B_LxvP_1	9	12	PF13499	0.659
DOC_PP4_FxxP_1	286	289	PF00568	0.541
DOC_PP4_FxxP_1	499	502	PF00568	0.645
DOC_USP7_MATH_1	112	116	PF00917	0.671
DOC_USP7_MATH_1	12	16	PF00917	0.692
DOC_USP7_MATH_1	243	247	PF00917	0.521
DOC_USP7_MATH_1	350	354	PF00917	0.654
DOC_USP7_MATH_1	477	481	PF00917	0.523
DOC_USP7_MATH_1	529	533	PF00917	0.530
DOC_WW_Pin1_4	204	209	PF00397	0.403
DOC_WW_Pin1_4	341	346	PF00397	0.590
DOC_WW_Pin1_4	408	413	PF00397	0.528
DOC_WW_Pin1_4	498	503	PF00397	0.565
DOC_WW_Pin1_4	504	509	PF00397	0.507
LIG_14-3-3_CanoR_1	111	117	PF00244	0.676
LIG_14-3-3_CanoR_1	262	268	PF00244	0.269
LIG_14-3-3_CanoR_1	308	314	PF00244	0.530
LIG_14-3-3_CanoR_1	33	43	PF00244	0.578
LIG_14-3-3_CanoR_1	391	396	PF00244	0.464
LIG_14-3-3_CanoR_1	51	56	PF00244	0.622
LIG_14-3-3_CanoR_1	567	572	PF00244	0.521
LIG_14-3-3_CanoR_1	578	583	PF00244	0.455
LIG_Actin_WH2_2	309	327	PF00022	0.426
LIG_Actin_WH2_2	482	498	PF00022	0.535
LIG_APCC_ABBA_1	43	48	PF00400	0.574
LIG_APCC_ABBA_1	580	585	PF00400	0.521
LIG_APCC_ABBA_1	610	615	PF00400	0.500
LIG_BIR_III_2	538	542	PF00653	0.464
LIG_eIF4E_1	359	365	PF01652	0.532
LIG_eIF4E_1	613	619	PF01652	0.470
LIG_FHA_1	156	162	PF00498	0.633
LIG_FHA_1	262	268	PF00498	0.502
LIG_FHA_1	319	325	PF00498	0.489
LIG_FHA_1	449	455	PF00498	0.446
LIG_FHA_1	65	71	PF00498	0.506
LIG_FHA_2	291	297	PF00498	0.439
LIG_FHA_2	405	411	PF00498	0.580
LIG_FHA_2	526	532	PF00498	0.529
LIG_GBD_Chelix_1	225	233	PF00786	0.341
LIG_GBD_Chelix_1	95	103	PF00786	0.569
LIG_LIR_Apic_2	497	502	PF02991	0.512
LIG_LIR_Gen_1	142	148	PF02991	0.486
LIG_LIR_Gen_1	356	366	PF02991	0.540
LIG_LIR_Gen_1	531	542	PF02991	0.453
LIG_LIR_Gen_1	97	104	PF02991	0.505
LIG_LIR_Nem_3	142	147	PF02991	0.447
LIG_LIR_Nem_3	327	332	PF02991	0.526
LIG_LIR_Nem_3	356	362	PF02991	0.525
LIG_LIR_Nem_3	627	633	PF02991	0.393
LIG_LIR_Nem_3	97	103	PF02991	0.497
LIG_NRBOX	451	457	PF00104	0.465
LIG_PCNA_PIPBox_1	53	62	PF02747	0.514
LIG_Pex14_1	512	516	PF04695	0.466
LIG_SH2_CRK	100	104	PF00017	0.620
LIG_SH2_CRK	359	363	PF00017	0.582
LIG_SH2_GRB2like	326	329	PF00017	0.505
LIG_SH2_SRC	422	425	PF00017	0.504
LIG_SH2_SRC	613	616	PF00017	0.483
LIG_SH2_STAP1	256	260	PF00017	0.536
LIG_SH2_STAP1	326	330	PF00017	0.580
LIG_SH2_STAP1	419	423	PF00017	0.538
LIG_SH2_STAP1	516	520	PF00017	0.391
LIG_SH2_STAT5	214	217	PF00017	0.406
LIG_SH2_STAT5	266	269	PF00017	0.382
LIG_SH2_STAT5	326	329	PF00017	0.598
LIG_SH2_STAT5	399	402	PF00017	0.536
LIG_SH2_STAT5	422	425	PF00017	0.381
LIG_SH2_STAT5	607	610	PF00017	0.490
LIG_SH3_1	406	412	PF00018	0.602
LIG_SH3_3	199	205	PF00018	0.405
LIG_SH3_3	406	412	PF00018	0.602
LIG_SH3_3	640	646	PF00018	0.384
LIG_Sin3_3	300	307	PF02671	0.505
LIG_Sin3_3	434	441	PF02671	0.470
LIG_SUMO_SIM_anti_2	451	456	PF11976	0.420
LIG_SUMO_SIM_anti_2	78	84	PF11976	0.537
LIG_SUMO_SIM_par_1	645	651	PF11976	0.438
LIG_TRAF2_1	11	14	PF00917	0.731
LIG_TRAF2_1	137	140	PF00917	0.507
LIG_TRFH_1	171	175	PF08558	0.571
LIG_WRC_WIRS_1	390	395	PF05994	0.519
MOD_CK1_1	115	121	PF00069	0.567
MOD_CK1_1	155	161	PF00069	0.627
MOD_CK1_1	162	168	PF00069	0.477
MOD_CK1_1	176	182	PF00069	0.468
MOD_CK1_1	221	227	PF00069	0.423
MOD_CK1_1	235	241	PF00069	0.407
MOD_CK1_1	411	417	PF00069	0.502
MOD_CK1_1	466	472	PF00069	0.498
MOD_CK2_1	134	140	PF00069	0.488
MOD_CK2_1	142	148	PF00069	0.455
MOD_CK2_1	203	209	PF00069	0.519
MOD_CK2_1	221	227	PF00069	0.293
MOD_CK2_1	290	296	PF00069	0.606
MOD_CK2_1	404	410	PF00069	0.554
MOD_CK2_1	482	488	PF00069	0.571
MOD_CK2_1	525	531	PF00069	0.505
MOD_CK2_1	589	595	PF00069	0.534
MOD_CK2_1	7	13	PF00069	0.739
MOD_GlcNHglycan	114	117	PF01048	0.633
MOD_GlcNHglycan	13	17	PF01048	0.601
MOD_GlcNHglycan	136	139	PF01048	0.554
MOD_GlcNHglycan	144	147	PF01048	0.464
MOD_GlcNHglycan	220	223	PF01048	0.467
MOD_GlcNHglycan	239	242	PF01048	0.269
MOD_GlcNHglycan	352	355	PF01048	0.660
MOD_GlcNHglycan	475	478	PF01048	0.469
MOD_GlcNHglycan	479	482	PF01048	0.505
MOD_GlcNHglycan	531	534	PF01048	0.470
MOD_GlcNHglycan	562	565	PF01048	0.460
MOD_GlcNHglycan	567	570	PF01048	0.510
MOD_GlcNHglycan	595	599	PF01048	0.497
MOD_GlcNHglycan	9	12	PF01048	0.754
MOD_GSK3_1	102	109	PF00069	0.558
MOD_GSK3_1	115	122	PF00069	0.605
MOD_GSK3_1	153	160	PF00069	0.611
MOD_GSK3_1	228	235	PF00069	0.454
MOD_GSK3_1	385	392	PF00069	0.435
MOD_GSK3_1	404	411	PF00069	0.319
MOD_GSK3_1	446	453	PF00069	0.417
MOD_GSK3_1	473	480	PF00069	0.381
MOD_GSK3_1	498	505	PF00069	0.607
MOD_GSK3_1	525	532	PF00069	0.500
MOD_GSK3_1	590	597	PF00069	0.302
MOD_GSK3_1	90	97	PF00069	0.530
MOD_N-GLC_1	309	314	PF02516	0.424
MOD_N-GLC_2	577	579	PF02516	0.404
MOD_NEK2_1	318	323	PF00069	0.474
MOD_NEK2_1	324	329	PF00069	0.489
MOD_NEK2_1	364	369	PF00069	0.475
MOD_NEK2_1	385	390	PF00069	0.449
MOD_NEK2_1	46	51	PF00069	0.545
MOD_NEK2_1	572	577	PF00069	0.507
MOD_NEK2_1	589	594	PF00069	0.292
MOD_NEK2_1	94	99	PF00069	0.580
MOD_NEK2_2	232	237	PF00069	0.439
MOD_PIKK_1	411	417	PF00454	0.561
MOD_PK_1	51	57	PF00069	0.626
MOD_PKA_2	142	148	PF00069	0.461
MOD_PKA_2	2	8	PF00069	0.784
MOD_PKA_2	261	267	PF00069	0.270
MOD_PKA_2	318	324	PF00069	0.495
MOD_Plk_1	309	315	PF00069	0.415
MOD_Plk_1	404	410	PF00069	0.598
MOD_Plk_1	624	630	PF00069	0.497
MOD_Plk_4	243	249	PF00069	0.481
MOD_Plk_4	309	315	PF00069	0.428
MOD_Plk_4	450	456	PF00069	0.511
MOD_Plk_4	51	57	PF00069	0.578
MOD_Plk_4	567	573	PF00069	0.491
MOD_Plk_4	578	584	PF00069	0.472
MOD_Plk_4	90	96	PF00069	0.543
MOD_ProDKin_1	204	210	PF00069	0.399
MOD_ProDKin_1	341	347	PF00069	0.601
MOD_ProDKin_1	408	414	PF00069	0.521
MOD_ProDKin_1	498	504	PF00069	0.564
TRG_DiLeu_BaEn_1	615	620	PF01217	0.495
TRG_DiLeu_BaLyEn_6	286	291	PF01217	0.509
TRG_DiLeu_BaLyEn_6	614	619	PF01217	0.548
TRG_DiLeu_BaLyEn_6	643	648	PF01217	0.490
TRG_DiLeu_BaLyEn_6	99	104	PF01217	0.622
TRG_ENDOCYTIC_2	100	103	PF00928	0.385
TRG_ENDOCYTIC_2	326	329	PF00928	0.583
TRG_ENDOCYTIC_2	359	362	PF00928	0.548
TRG_ENDOCYTIC_2	607	610	PF00928	0.405
TRG_ENDOCYTIC_2	613	616	PF00928	0.398
TRG_ER_diArg_1	193	195	PF00400	0.558
TRG_ER_diArg_1	318	320	PF00400	0.462
TRG_ER_diArg_1	456	459	PF00400	0.547
TRG_NES_CRM1_1	35	48	PF08389	0.573
TRG_Pf-PMV_PEXEL_1	102	106	PF00026	0.581
TRG_Pf-PMV_PEXEL_1	194	199	PF00026	0.553
TRG_Pf-PMV_PEXEL_1	237	242	PF00026	0.470
TRG_Pf-PMV_PEXEL_1	631	636	PF00026	0.492

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IKS3	Leptomonas seymouri	54%	78%
A0A1X0NXC2	Trypanosomatidae	26%	83%
A0A3Q8IBR0	Leishmania donovani	94%	100%
A0A3R7RJS0	Trypanosoma rangeli	28%	82%
A4HD37	Leishmania braziliensis	85%	77%
C9ZNR6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	80%
E9AH15	Leishmania infantum	94%	100%
E9AWI5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
V5BFS5	Trypanosoma cruzi	26%	82%