Pre-mRNA-splicing factor SYF1

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QAY3_LEIMA

TriTrypDb:

LmjF.23.1550 , LMJLV39_230027200 , LMJSD75_230027800

Length:

794

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0000974	Prp19 complex	2	2
GO:0005654	nucleoplasm	2	2
GO:0005681	spliceosomal complex	3	2
GO:0005684	U2-type spliceosomal complex	4	2
GO:0032991	protein-containing complex	1	2
GO:0071007	U2-type catalytic step 2 spliceosome	4	2
GO:0071013	catalytic step 2 spliceosome	3	2
GO:0071014	post-mRNA release spliceosomal complex	4	2
GO:0110165	cellular anatomical entity	1	2
GO:0140513	nuclear protein-containing complex	2	2
GO:1902494	catalytic complex	2	2
GO:1990904	ribonucleoprotein complex	2	2

Expansion

Sequence features

Q4QAY3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QAY3

Function

Biological processes
Term	Name	Level	Count
GO:0000349	generation of catalytic spliceosome for first transesterification step	7	2
GO:0000375	RNA splicing, via transesterification reactions	8	11
GO:0000377	RNA splicing, via transesterification reactions with bulged adenosine as nucleophile	9	11
GO:0000398	mRNA splicing, via spliceosome	8	11
GO:0006139	nucleobase-containing compound metabolic process	3	11
GO:0006396	RNA processing	6	11
GO:0006397	mRNA processing	7	11
GO:0006725	cellular aromatic compound metabolic process	3	11
GO:0006807	nitrogen compound metabolic process	2	11
GO:0008152	metabolic process	1	11
GO:0008380	RNA splicing	7	11
GO:0009987	cellular process	1	11
GO:0016043	cellular component organization	3	2
GO:0016070	RNA metabolic process	5	11
GO:0016071	mRNA metabolic process	6	11
GO:0022607	cellular component assembly	4	2
GO:0022618	ribonucleoprotein complex assembly	6	2
GO:0034641	cellular nitrogen compound metabolic process	3	11
GO:0043170	macromolecule metabolic process	3	11
GO:0043933	protein-containing complex organization	4	2
GO:0044237	cellular metabolic process	2	11
GO:0044238	primary metabolic process	2	11
GO:0046483	heterocycle metabolic process	3	11
GO:0065003	protein-containing complex assembly	5	2
GO:0071704	organic substance metabolic process	2	11
GO:0071826	ribonucleoprotein complex subunit organization	5	2
GO:0071840	cellular component organization or biogenesis	2	2
GO:0090304	nucleic acid metabolic process	4	11
GO:1901360	organic cyclic compound metabolic process	3	11

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	410	414	PF00656	0.543
CLV_C14_Caspase3-7	475	479	PF00656	0.541
CLV_NRD_NRD_1	692	694	PF00675	0.557
CLV_NRD_NRD_1	776	778	PF00675	0.440
CLV_PCSK_KEX2_1	149	151	PF00082	0.403
CLV_PCSK_KEX2_1	179	181	PF00082	0.493
CLV_PCSK_KEX2_1	375	377	PF00082	0.376
CLV_PCSK_KEX2_1	494	496	PF00082	0.652
CLV_PCSK_KEX2_1	692	694	PF00082	0.483
CLV_PCSK_KEX2_1	727	729	PF00082	0.428
CLV_PCSK_KEX2_1	775	777	PF00082	0.423
CLV_PCSK_KEX2_1	786	788	PF00082	0.497
CLV_PCSK_PC1ET2_1	149	151	PF00082	0.423
CLV_PCSK_PC1ET2_1	179	181	PF00082	0.480
CLV_PCSK_PC1ET2_1	375	377	PF00082	0.376
CLV_PCSK_PC1ET2_1	494	496	PF00082	0.652
CLV_PCSK_PC1ET2_1	727	729	PF00082	0.471
CLV_PCSK_PC1ET2_1	786	788	PF00082	0.594
CLV_PCSK_SKI1_1	126	130	PF00082	0.470
CLV_PCSK_SKI1_1	146	150	PF00082	0.194
CLV_PCSK_SKI1_1	216	220	PF00082	0.508
CLV_PCSK_SKI1_1	286	290	PF00082	0.448
CLV_PCSK_SKI1_1	477	481	PF00082	0.443
CLV_PCSK_SKI1_1	612	616	PF00082	0.426
CLV_PCSK_SKI1_1	717	721	PF00082	0.372
CLV_PCSK_SKI1_1	95	99	PF00082	0.509
CLV_Separin_Metazoa	118	122	PF03568	0.557
DEG_APCC_DBOX_1	281	289	PF00400	0.421
DEG_Nend_UBRbox_2	1	3	PF02207	0.673
DOC_CKS1_1	620	625	PF01111	0.497
DOC_MAPK_gen_1	146	156	PF00069	0.504
DOC_MAPK_gen_1	179	187	PF00069	0.487
DOC_MAPK_gen_1	246	253	PF00069	0.455
DOC_MAPK_gen_1	255	264	PF00069	0.512
DOC_MAPK_gen_1	349	358	PF00069	0.494
DOC_MAPK_gen_1	429	439	PF00069	0.460
DOC_MAPK_gen_1	669	677	PF00069	0.580
DOC_MAPK_gen_1	775	784	PF00069	0.456
DOC_MAPK_MEF2A_6	163	172	PF00069	0.433
DOC_MAPK_MEF2A_6	257	266	PF00069	0.479
DOC_MAPK_MEF2A_6	564	572	PF00069	0.494
DOC_PP1_RVXF_1	161	168	PF00149	0.280
DOC_PP2B_LxvP_1	202	205	PF13499	0.530
DOC_PP4_FxxP_1	470	473	PF00568	0.352
DOC_USP7_MATH_1	205	209	PF00917	0.649
DOC_USP7_MATH_1	386	390	PF00917	0.491
DOC_USP7_MATH_1	407	411	PF00917	0.623
DOC_USP7_MATH_1	448	452	PF00917	0.496
DOC_USP7_MATH_1	5	9	PF00917	0.525
DOC_USP7_MATH_1	526	530	PF00917	0.475
DOC_USP7_MATH_1	541	545	PF00917	0.518
DOC_USP7_MATH_1	57	61	PF00917	0.505
DOC_WW_Pin1_4	18	23	PF00397	0.631
DOC_WW_Pin1_4	257	262	PF00397	0.402
DOC_WW_Pin1_4	363	368	PF00397	0.521
DOC_WW_Pin1_4	469	474	PF00397	0.542
DOC_WW_Pin1_4	542	547	PF00397	0.534
DOC_WW_Pin1_4	619	624	PF00397	0.477
LIG_14-3-3_CanoR_1	121	125	PF00244	0.392
LIG_14-3-3_CanoR_1	388	392	PF00244	0.469
LIG_14-3-3_CanoR_1	56	66	PF00244	0.532
LIG_14-3-3_CanoR_1	6	14	PF00244	0.604
LIG_14-3-3_CanoR_1	693	699	PF00244	0.441
LIG_14-3-3_CanoR_1	728	738	PF00244	0.491
LIG_14-3-3_CanoR_1	95	104	PF00244	0.468
LIG_Actin_WH2_2	243	259	PF00022	0.508
LIG_Actin_WH2_2	351	366	PF00022	0.506
LIG_BIR_III_4	740	744	PF00653	0.580
LIG_BRCT_BRCA1_1	264	268	PF00533	0.457
LIG_BRCT_BRCA1_1	544	548	PF00533	0.505
LIG_BRCT_BRCA1_1	684	688	PF00533	0.437
LIG_BRCT_BRCA1_1	780	784	PF00533	0.460
LIG_BRCT_BRCA1_2	780	786	PF00533	0.438
LIG_Clathr_ClatBox_1	588	592	PF01394	0.470
LIG_CtBP_PxDLS_1	261	265	PF00389	0.486
LIG_deltaCOP1_diTrp_1	442	449	PF00928	0.361
LIG_deltaCOP1_diTrp_1	754	760	PF00928	0.512
LIG_FHA_1	123	129	PF00498	0.486
LIG_FHA_1	239	245	PF00498	0.470
LIG_FHA_1	442	448	PF00498	0.441
LIG_FHA_1	583	589	PF00498	0.497
LIG_FHA_1	663	669	PF00498	0.463
LIG_FHA_2	22	28	PF00498	0.572
LIG_FHA_2	34	40	PF00498	0.550
LIG_FHA_2	388	394	PF00498	0.514
LIG_FHA_2	685	691	PF00498	0.451
LIG_FHA_2	763	769	PF00498	0.503
LIG_GBD_Chelix_1	705	713	PF00786	0.543
LIG_LIR_Apic_2	442	448	PF02991	0.474
LIG_LIR_Apic_2	469	473	PF02991	0.338
LIG_LIR_Gen_1	109	116	PF02991	0.325
LIG_LIR_Gen_1	181	187	PF02991	0.387
LIG_LIR_Gen_1	224	233	PF02991	0.394
LIG_LIR_Gen_1	24	33	PF02991	0.472
LIG_LIR_Gen_1	265	273	PF02991	0.399
LIG_LIR_Gen_1	389	398	PF02991	0.527
LIG_LIR_Gen_1	592	600	PF02991	0.485
LIG_LIR_Gen_1	613	623	PF02991	0.451
LIG_LIR_Gen_1	768	774	PF02991	0.485
LIG_LIR_Gen_1	84	93	PF02991	0.472
LIG_LIR_Nem_3	109	113	PF02991	0.316
LIG_LIR_Nem_3	181	186	PF02991	0.382
LIG_LIR_Nem_3	191	195	PF02991	0.379
LIG_LIR_Nem_3	224	229	PF02991	0.389
LIG_LIR_Nem_3	24	28	PF02991	0.465
LIG_LIR_Nem_3	265	271	PF02991	0.399
LIG_LIR_Nem_3	327	333	PF02991	0.451
LIG_LIR_Nem_3	353	357	PF02991	0.494
LIG_LIR_Nem_3	389	394	PF02991	0.540
LIG_LIR_Nem_3	592	597	PF02991	0.481
LIG_LIR_Nem_3	613	618	PF02991	0.444
LIG_LIR_Nem_3	754	759	PF02991	0.433
LIG_LIR_Nem_3	768	773	PF02991	0.374
LIG_LIR_Nem_3	84	89	PF02991	0.346
LIG_LYPXL_SIV_4	329	337	PF13949	0.472
LIG_LYPXL_SIV_4	641	649	PF13949	0.530
LIG_NRBOX	284	290	PF00104	0.458
LIG_NRBOX	457	463	PF00104	0.510
LIG_PCNA_yPIPBox_3	331	345	PF02747	0.431
LIG_Pex14_1	445	449	PF04695	0.363
LIG_Pex14_2	611	615	PF04695	0.523
LIG_SH2_CRK	330	334	PF00017	0.430
LIG_SH2_CRK	695	699	PF00017	0.510
LIG_SH2_NCK_1	527	531	PF00017	0.470
LIG_SH2_STAP1	51	55	PF00017	0.367
LIG_SH2_STAP1	93	97	PF00017	0.359
LIG_SH2_STAT5	169	172	PF00017	0.439
LIG_SH2_STAT5	182	185	PF00017	0.342
LIG_SH2_STAT5	555	558	PF00017	0.377
LIG_SH2_STAT5	561	564	PF00017	0.419
LIG_SH2_STAT5	594	597	PF00017	0.370
LIG_SH2_STAT5	637	640	PF00017	0.339
LIG_SH2_STAT5	68	71	PF00017	0.354
LIG_SH2_STAT5	701	704	PF00017	0.369
LIG_SH3_3	152	158	PF00018	0.395
LIG_SH3_3	98	104	PF00018	0.414
LIG_Sin3_3	354	361	PF02671	0.487
LIG_SUMO_SIM_anti_2	434	442	PF11976	0.438
LIG_SUMO_SIM_anti_2	566	572	PF11976	0.478
LIG_SUMO_SIM_anti_2	659	665	PF11976	0.487
LIG_SUMO_SIM_par_1	260	265	PF11976	0.489
LIG_SUMO_SIM_par_1	472	478	PF11976	0.546
LIG_SUMO_SIM_par_1	622	628	PF11976	0.461
LIG_TRAF2_1	212	215	PF00917	0.570
LIG_Vh1_VBS_1	447	465	PF01044	0.512
LIG_Vh1_VBS_1	649	667	PF01044	0.489
LIG_WRC_WIRS_1	169	174	PF05994	0.507
LIG_WRC_WIRS_1	313	318	PF05994	0.530
LIG_WRC_WIRS_1	467	472	PF05994	0.337
LIG_WRC_WIRS_1	594	599	PF05994	0.474
MOD_CDK_SPK_2	18	23	PF00069	0.631
MOD_CK1_1	21	27	PF00069	0.495
MOD_CK1_1	221	227	PF00069	0.445
MOD_CK1_1	441	447	PF00069	0.395
MOD_CK1_1	469	475	PF00069	0.582
MOD_CK1_1	490	496	PF00069	0.693
MOD_CK1_1	729	735	PF00069	0.536
MOD_CK1_1	762	768	PF00069	0.439
MOD_CK2_1	106	112	PF00069	0.289
MOD_CK2_1	21	27	PF00069	0.578
MOD_CK2_1	221	227	PF00069	0.429
MOD_CK2_1	257	263	PF00069	0.415
MOD_CK2_1	684	690	PF00069	0.478
MOD_CK2_1	762	768	PF00069	0.464
MOD_CMANNOS	517	520	PF00535	0.423
MOD_CMANNOS	757	760	PF00535	0.394
MOD_GlcNHglycan	158	161	PF01048	0.503
MOD_GlcNHglycan	434	437	PF01048	0.535
MOD_GlcNHglycan	450	453	PF01048	0.538
MOD_GlcNHglycan	485	488	PF01048	0.522
MOD_GlcNHglycan	489	492	PF01048	0.567
MOD_GlcNHglycan	503	506	PF01048	0.582
MOD_GlcNHglycan	528	531	PF01048	0.519
MOD_GlcNHglycan	548	551	PF01048	0.425
MOD_GlcNHglycan	630	633	PF01048	0.479
MOD_GlcNHglycan	7	10	PF01048	0.590
MOD_GlcNHglycan	728	731	PF01048	0.541
MOD_GlcNHglycan	788	791	PF01048	0.456
MOD_GSK3_1	168	175	PF00069	0.510
MOD_GSK3_1	17	24	PF00069	0.536
MOD_GSK3_1	221	228	PF00069	0.396
MOD_GSK3_1	29	36	PF00069	0.354
MOD_GSK3_1	403	410	PF00069	0.473
MOD_GSK3_1	419	426	PF00069	0.454
MOD_GSK3_1	483	490	PF00069	0.615
MOD_GSK3_1	542	549	PF00069	0.372
MOD_GSK3_1	658	665	PF00069	0.487
MOD_GSK3_1	682	689	PF00069	0.457
MOD_GSK3_1	742	749	PF00069	0.494
MOD_NEK2_1	106	111	PF00069	0.282
MOD_NEK2_1	168	173	PF00069	0.445
MOD_NEK2_1	225	230	PF00069	0.383
MOD_NEK2_1	28	33	PF00069	0.481
MOD_NEK2_1	312	317	PF00069	0.442
MOD_NEK2_1	419	424	PF00069	0.344
MOD_NEK2_1	500	505	PF00069	0.547
MOD_NEK2_1	58	63	PF00069	0.487
MOD_NEK2_1	636	641	PF00069	0.406
MOD_NEK2_1	649	654	PF00069	0.303
MOD_NEK2_1	662	667	PF00069	0.408
MOD_NEK2_1	682	687	PF00069	0.262
MOD_NEK2_1	759	764	PF00069	0.387
MOD_NEK2_2	158	163	PF00069	0.475
MOD_NEK2_2	694	699	PF00069	0.496
MOD_PIKK_1	136	142	PF00454	0.393
MOD_PIKK_1	742	748	PF00454	0.429
MOD_PK_1	564	570	PF00069	0.487
MOD_PKA_1	786	792	PF00069	0.499
MOD_PKA_2	120	126	PF00069	0.388
MOD_PKA_2	238	244	PF00069	0.476
MOD_PKA_2	29	35	PF00069	0.558
MOD_PKA_2	387	393	PF00069	0.505
MOD_PKA_2	482	488	PF00069	0.585
MOD_PKA_2	5	11	PF00069	0.632
MOD_PKA_2	73	79	PF00069	0.336
MOD_PKA_2	786	792	PF00069	0.649
MOD_PKB_1	72	80	PF00069	0.332
MOD_Plk_1	221	227	PF00069	0.411
MOD_Plk_1	262	268	PF00069	0.472
MOD_Plk_1	658	664	PF00069	0.523
MOD_Plk_1	682	688	PF00069	0.386
MOD_Plk_1	74	80	PF00069	0.467
MOD_Plk_4	106	112	PF00069	0.289
MOD_Plk_4	221	227	PF00069	0.398
MOD_Plk_4	294	300	PF00069	0.484
MOD_Plk_4	423	429	PF00069	0.502
MOD_Plk_4	45	51	PF00069	0.554
MOD_Plk_4	593	599	PF00069	0.477
MOD_ProDKin_1	18	24	PF00069	0.624
MOD_ProDKin_1	257	263	PF00069	0.402
MOD_ProDKin_1	363	369	PF00069	0.521
MOD_ProDKin_1	469	475	PF00069	0.540
MOD_ProDKin_1	542	548	PF00069	0.531
MOD_ProDKin_1	619	625	PF00069	0.471
MOD_SUMO_for_1	178	181	PF00179	0.463
TRG_DiLeu_BaEn_1	214	219	PF01217	0.537
TRG_DiLeu_BaEn_1	284	289	PF01217	0.516
TRG_DiLeu_BaEn_1	294	299	PF01217	0.507
TRG_DiLeu_BaEn_1	353	358	PF01217	0.481
TRG_DiLeu_BaEn_1	613	618	PF01217	0.483
TRG_DiLeu_BaLyEn_6	352	357	PF01217	0.463
TRG_ENDOCYTIC_2	110	113	PF00928	0.464
TRG_ENDOCYTIC_2	169	172	PF00928	0.443
TRG_ENDOCYTIC_2	182	185	PF00928	0.290
TRG_ENDOCYTIC_2	330	333	PF00928	0.422
TRG_ENDOCYTIC_2	594	597	PF00928	0.472
TRG_ENDOCYTIC_2	695	698	PF00928	0.511
TRG_ENDOCYTIC_2	756	759	PF00928	0.507
TRG_ER_diArg_1	668	671	PF00400	0.574
TRG_ER_diArg_1	71	74	PF00400	0.368
TRG_ER_diArg_1	775	777	PF00400	0.535
TRG_NES_CRM1_1	296	310	PF08389	0.525
TRG_Pf-PMV_PEXEL_1	286	290	PF00026	0.510
TRG_Pf-PMV_PEXEL_1	323	327	PF00026	0.550
TRG_Pf-PMV_PEXEL_1	95	99	PF00026	0.434

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCJ1	Leptomonas seymouri	71%	100%
A0A1X0NWW2	Trypanosomatidae	41%	100%
A0A3Q8IBX9	Leishmania donovani	94%	100%
A0A422NJT0	Trypanosoma rangeli	39%	100%
A4HD39	Leishmania braziliensis	88%	100%
C9ZNR8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	87%
E9AH17	Leishmania infantum	95%	100%
E9AWI7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
Q4WVF4	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	23%	95%
Q52DF3	Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958)	23%	95%
Q54Z08	Dictyostelium discoideum	22%	93%
Q5BH69	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	24%	93%
Q7SAK5	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	23%	96%
Q99PK0	Rattus norvegicus	23%	93%
Q9DCD2	Mus musculus	23%	93%
Q9HCS7	Homo sapiens	23%	93%
Q9P7R9	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	21%	100%
V5ARA5	Trypanosoma cruzi	40%	100%