Neutral sphingomyelinase activation associated factor-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

neutral sphingomyelinase activation associated factor-like protein

Species:

Leishmania major

UniProt:

Q4QAY1_LEIMA

TriTrypDb:

LmjF.23.1570 , LMJLV39_230027400 , LMJSD75_230028000

Length:

925

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QAY1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QAY1

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	5
GO:0004620	phospholipase activity	5	5
GO:0004767	sphingomyelin phosphodiesterase activity	6	5
GO:0008081	phosphoric diester hydrolase activity	5	5
GO:0016298	lipase activity	4	5
GO:0016787	hydrolase activity	2	5
GO:0016788	hydrolase activity, acting on ester bonds	3	5
GO:0042578	phosphoric ester hydrolase activity	4	5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	587	591	PF00656	0.640
CLV_C14_Caspase3-7	766	770	PF00656	0.419
CLV_NRD_NRD_1	147	149	PF00675	0.565
CLV_NRD_NRD_1	164	166	PF00675	0.364
CLV_NRD_NRD_1	201	203	PF00675	0.425
CLV_NRD_NRD_1	4	6	PF00675	0.578
CLV_NRD_NRD_1	835	837	PF00675	0.396
CLV_PCSK_FUR_1	2	6	PF00082	0.551
CLV_PCSK_KEX2_1	147	149	PF00082	0.565
CLV_PCSK_KEX2_1	164	166	PF00082	0.364
CLV_PCSK_KEX2_1	2	4	PF00082	0.603
CLV_PCSK_KEX2_1	201	203	PF00082	0.425
CLV_PCSK_KEX2_1	661	663	PF00082	0.471
CLV_PCSK_KEX2_1	835	837	PF00082	0.396
CLV_PCSK_PC1ET2_1	661	663	PF00082	0.471
CLV_PCSK_SKI1_1	133	137	PF00082	0.568
CLV_PCSK_SKI1_1	173	177	PF00082	0.362
CLV_PCSK_SKI1_1	33	37	PF00082	0.545
CLV_PCSK_SKI1_1	335	339	PF00082	0.314
CLV_PCSK_SKI1_1	463	467	PF00082	0.304
CLV_PCSK_SKI1_1	623	627	PF00082	0.393
CLV_PCSK_SKI1_1	650	654	PF00082	0.407
DEG_APCC_DBOX_1	32	40	PF00400	0.510
DEG_APCC_DBOX_1	6	14	PF00400	0.499
DEG_Nend_UBRbox_1	1	4	PF02207	0.613
DEG_SCF_FBW7_1	227	234	PF00400	0.419
DEG_SCF_FBW7_1	94	100	PF00400	0.545
DEG_SPOP_SBC_1	611	615	PF00917	0.404
DOC_AGCK_PIF_1	499	504	PF00069	0.304
DOC_CDC14_PxL_1	393	401	PF14671	0.304
DOC_CKS1_1	94	99	PF01111	0.563
DOC_CYCLIN_RxL_1	27	40	PF00134	0.466
DOC_CYCLIN_RxL_1	884	893	PF00134	0.457
DOC_CYCLIN_yCln2_LP_2	324	330	PF00134	0.304
DOC_CYCLIN_yCln2_LP_2	498	504	PF00134	0.304
DOC_MAPK_DCC_7	509	518	PF00069	0.308
DOC_MAPK_FxFP_2	119	122	PF00069	0.419
DOC_MAPK_FxFP_2	296	299	PF00069	0.304
DOC_MAPK_FxFP_2	502	505	PF00069	0.369
DOC_MAPK_gen_1	170	178	PF00069	0.371
DOC_MAPK_gen_1	2	10	PF00069	0.576
DOC_MAPK_gen_1	812	820	PF00069	0.445
DOC_MAPK_MEF2A_6	509	518	PF00069	0.304
DOC_MAPK_MEF2A_6	525	534	PF00069	0.304
DOC_PP1_RVXF_1	208	215	PF00149	0.348
DOC_PP2B_LxvP_1	386	389	PF13499	0.369
DOC_PP2B_LxvP_1	511	514	PF13499	0.369
DOC_PP4_FxxP_1	119	122	PF00568	0.377
DOC_PP4_FxxP_1	237	240	PF00568	0.389
DOC_PP4_FxxP_1	296	299	PF00568	0.304
DOC_PP4_FxxP_1	502	505	PF00568	0.369
DOC_PP4_FxxP_1	747	750	PF00568	0.500
DOC_PP4_MxPP_1	538	541	PF00568	0.237
DOC_SPAK_OSR1_1	815	819	PF12202	0.412
DOC_USP7_MATH_1	122	126	PF00917	0.439
DOC_USP7_MATH_1	151	155	PF00917	0.400
DOC_USP7_MATH_1	452	456	PF00917	0.369
DOC_USP7_MATH_1	465	469	PF00917	0.237
DOC_USP7_MATH_1	799	803	PF00917	0.505
DOC_WW_Pin1_4	223	228	PF00397	0.451
DOC_WW_Pin1_4	329	334	PF00397	0.369
DOC_WW_Pin1_4	437	442	PF00397	0.369
DOC_WW_Pin1_4	634	639	PF00397	0.531
DOC_WW_Pin1_4	707	712	PF00397	0.443
DOC_WW_Pin1_4	740	745	PF00397	0.489
DOC_WW_Pin1_4	746	751	PF00397	0.403
DOC_WW_Pin1_4	93	98	PF00397	0.567
LIG_14-3-3_CanoR_1	205	209	PF00244	0.411
LIG_14-3-3_CanoR_1	31	36	PF00244	0.455
LIG_14-3-3_CanoR_1	5	11	PF00244	0.499
LIG_14-3-3_CanoR_1	509	514	PF00244	0.369
LIG_14-3-3_CanoR_1	544	550	PF00244	0.569
LIG_14-3-3_CanoR_1	570	575	PF00244	0.482
LIG_14-3-3_CanoR_1	623	628	PF00244	0.391
LIG_14-3-3_CanoR_1	650	655	PF00244	0.423
LIG_14-3-3_CanoR_1	662	667	PF00244	0.390
LIG_14-3-3_CanoR_1	835	845	PF00244	0.474
LIG_14-3-3_CanoR_1	885	890	PF00244	0.419
LIG_Actin_WH2_2	332	349	PF00022	0.369
LIG_Actin_WH2_2	822	837	PF00022	0.442
LIG_APCC_ABBA_1	191	196	PF00400	0.362
LIG_APCC_ABBA_1	371	376	PF00400	0.294
LIG_APCC_ABBA_1	433	438	PF00400	0.344
LIG_APCC_ABBA_1	532	537	PF00400	0.304
LIG_APCC_ABBA_1	683	688	PF00400	0.343
LIG_APCC_ABBA_1	857	862	PF00400	0.384
LIG_BIR_III_4	598	602	PF00653	0.481
LIG_BRCT_BRCA1_1	233	237	PF00533	0.360
LIG_BRCT_BRCA1_1	406	410	PF00533	0.421
LIG_BRCT_BRCA1_1	454	458	PF00533	0.369
LIG_BRCT_BRCA1_1	620	624	PF00533	0.484
LIG_BRCT_BRCA1_1	80	84	PF00533	0.389
LIG_deltaCOP1_diTrp_1	115	121	PF00928	0.392
LIG_deltaCOP1_diTrp_1	268	274	PF00928	0.237
LIG_DLG_GKlike_1	570	578	PF00625	0.488
LIG_EH1_1	138	146	PF00400	0.479
LIG_FHA_1	228	234	PF00498	0.442
LIG_FHA_1	290	296	PF00498	0.237
LIG_FHA_1	350	356	PF00498	0.347
LIG_FHA_1	38	44	PF00498	0.457
LIG_FHA_1	383	389	PF00498	0.304
LIG_FHA_1	583	589	PF00498	0.648
LIG_FHA_1	612	618	PF00498	0.398
LIG_FHA_1	637	643	PF00498	0.509
LIG_FHA_1	649	655	PF00498	0.339
LIG_FHA_1	704	710	PF00498	0.416
LIG_FHA_1	740	746	PF00498	0.517
LIG_FHA_1	775	781	PF00498	0.428
LIG_FHA_1	901	907	PF00498	0.401
LIG_FHA_1	918	924	PF00498	0.437
LIG_FHA_2	12	18	PF00498	0.571
LIG_FHA_2	318	324	PF00498	0.299
LIG_FHA_2	36	42	PF00498	0.527
LIG_FHA_2	585	591	PF00498	0.636
LIG_FHA_2	651	657	PF00498	0.403
LIG_FHA_2	764	770	PF00498	0.297
LIG_FHA_2	787	793	PF00498	0.443
LIG_FHA_2	823	829	PF00498	0.289
LIG_FXI_DFP_1	666	670	PF00024	0.409
LIG_LIR_Apic_2	116	122	PF02991	0.417
LIG_LIR_Apic_2	234	240	PF02991	0.367
LIG_LIR_Apic_2	294	299	PF02991	0.304
LIG_LIR_Gen_1	276	284	PF02991	0.294
LIG_LIR_Gen_1	419	430	PF02991	0.292
LIG_LIR_Gen_1	621	632	PF02991	0.489
LIG_LIR_Gen_1	814	824	PF02991	0.432
LIG_LIR_Gen_1	867	876	PF02991	0.444
LIG_LIR_LC3C_4	721	725	PF02991	0.433
LIG_LIR_Nem_3	182	188	PF02991	0.350
LIG_LIR_Nem_3	276	281	PF02991	0.294
LIG_LIR_Nem_3	30	35	PF02991	0.454
LIG_LIR_Nem_3	319	324	PF02991	0.304
LIG_LIR_Nem_3	407	413	PF02991	0.304
LIG_LIR_Nem_3	419	425	PF02991	0.304
LIG_LIR_Nem_3	496	502	PF02991	0.304
LIG_LIR_Nem_3	526	530	PF02991	0.304
LIG_LIR_Nem_3	621	627	PF02991	0.460
LIG_LIR_Nem_3	665	669	PF02991	0.489
LIG_LIR_Nem_3	814	820	PF02991	0.423
LIG_LIR_Nem_3	867	872	PF02991	0.457
LIG_MYND_1	428	432	PF01753	0.369
LIG_PCNA_yPIPBox_3	564	575	PF02747	0.502
LIG_Pex14_1	117	121	PF04695	0.449
LIG_Pex14_1	270	274	PF04695	0.237
LIG_Pex14_2	185	189	PF04695	0.360
LIG_Pex14_2	418	422	PF04695	0.304
LIG_Pex14_2	816	820	PF04695	0.337
LIG_SH2_NCK_1	360	364	PF00017	0.304
LIG_SH2_PTP2	445	448	PF00017	0.303
LIG_SH2_SRC	354	357	PF00017	0.304
LIG_SH2_STAP1	278	282	PF00017	0.502
LIG_SH2_STAP1	308	312	PF00017	0.281
LIG_SH2_STAP1	356	360	PF00017	0.304
LIG_SH2_STAP1	523	527	PF00017	0.304
LIG_SH2_STAT5	177	180	PF00017	0.439
LIG_SH2_STAT5	222	225	PF00017	0.375
LIG_SH2_STAT5	280	283	PF00017	0.304
LIG_SH2_STAT5	308	311	PF00017	0.304
LIG_SH2_STAT5	354	357	PF00017	0.304
LIG_SH2_STAT5	369	372	PF00017	0.304
LIG_SH2_STAT5	445	448	PF00017	0.303
LIG_SH2_STAT5	693	696	PF00017	0.352
LIG_SH3_3	181	187	PF00018	0.407
LIG_SH3_3	296	302	PF00018	0.304
LIG_SH3_3	426	432	PF00018	0.382
LIG_SH3_3	443	449	PF00018	0.216
LIG_SH3_3	58	64	PF00018	0.520
LIG_SH3_3	629	635	PF00018	0.504
LIG_SH3_3	795	801	PF00018	0.416
LIG_SH3_3	876	882	PF00018	0.403
LIG_SH3_3	91	97	PF00018	0.556
LIG_SUMO_SIM_anti_2	334	341	PF11976	0.304
LIG_SUMO_SIM_anti_2	639	645	PF11976	0.421
LIG_SUMO_SIM_anti_2	721	729	PF11976	0.419
LIG_SUMO_SIM_par_1	384	390	PF11976	0.304
LIG_SUMO_SIM_par_1	40	49	PF11976	0.434
LIG_SUMO_SIM_par_1	607	616	PF11976	0.381
LIG_SUMO_SIM_par_1	641	648	PF11976	0.401
LIG_SUMO_SIM_par_1	693	699	PF11976	0.371
LIG_SUMO_SIM_par_1	721	729	PF11976	0.419
LIG_TRFH_1	852	856	PF08558	0.418
LIG_TYR_ITIM	366	371	PF00017	0.304
LIG_UBA3_1	281	286	PF00899	0.369
LIG_WRC_WIRS_1	158	163	PF05994	0.411
LIG_WW_3	539	543	PF00397	0.369
MOD_CDC14_SPxK_1	332	335	PF00782	0.369
MOD_CDK_SPxK_1	329	335	PF00069	0.369
MOD_CK1_1	100	106	PF00069	0.559
MOD_CK1_1	131	137	PF00069	0.485
MOD_CK1_1	154	160	PF00069	0.441
MOD_CK1_1	289	295	PF00069	0.265
MOD_CK1_1	316	322	PF00069	0.304
MOD_CK1_1	402	408	PF00069	0.304
MOD_CK1_1	45	51	PF00069	0.484
MOD_CK1_1	6	12	PF00069	0.492
MOD_CK1_1	613	619	PF00069	0.481
MOD_CK1_1	696	702	PF00069	0.390
MOD_CK1_1	749	755	PF00069	0.475
MOD_CK1_1	843	849	PF00069	0.451
MOD_CK2_1	11	17	PF00069	0.564
MOD_CK2_1	143	149	PF00069	0.459
MOD_CK2_1	273	279	PF00069	0.323
MOD_CK2_1	35	41	PF00069	0.543
MOD_CK2_1	516	522	PF00069	0.304
MOD_CK2_1	570	576	PF00069	0.496
MOD_CK2_1	786	792	PF00069	0.472
MOD_Cter_Amidation	659	662	PF01082	0.471
MOD_GlcNHglycan	153	156	PF01048	0.427
MOD_GlcNHglycan	310	313	PF01048	0.263
MOD_GlcNHglycan	361	364	PF01048	0.304
MOD_GlcNHglycan	471	474	PF01048	0.430
MOD_GlcNHglycan	564	567	PF01048	0.570
MOD_GlcNHglycan	590	593	PF01048	0.629
MOD_GlcNHglycan	620	623	PF01048	0.424
MOD_GlcNHglycan	733	736	PF01048	0.416
MOD_GlcNHglycan	766	769	PF01048	0.416
MOD_GlcNHglycan	801	804	PF01048	0.411
MOD_GlcNHglycan	873	876	PF01048	0.488
MOD_GlcNHglycan	892	895	PF01048	0.327
MOD_GSK3_1	153	160	PF00069	0.482
MOD_GSK3_1	223	230	PF00069	0.452
MOD_GSK3_1	27	34	PF00069	0.474
MOD_GSK3_1	313	320	PF00069	0.302
MOD_GSK3_1	354	361	PF00069	0.304
MOD_GSK3_1	401	408	PF00069	0.344
MOD_GSK3_1	465	472	PF00069	0.300
MOD_GSK3_1	545	552	PF00069	0.513
MOD_GSK3_1	584	591	PF00069	0.741
MOD_GSK3_1	607	614	PF00069	0.453
MOD_GSK3_1	623	630	PF00069	0.344
MOD_GSK3_1	644	651	PF00069	0.431
MOD_GSK3_1	684	691	PF00069	0.432
MOD_GSK3_1	703	710	PF00069	0.293
MOD_GSK3_1	78	85	PF00069	0.419
MOD_GSK3_1	836	843	PF00069	0.481
MOD_GSK3_1	881	888	PF00069	0.519
MOD_GSK3_1	908	915	PF00069	0.424
MOD_GSK3_1	917	924	PF00069	0.392
MOD_GSK3_1	93	100	PF00069	0.493
MOD_N-GLC_1	405	410	PF02516	0.304
MOD_NEK2_1	313	318	PF00069	0.304
MOD_NEK2_1	35	40	PF00069	0.550
MOD_NEK2_1	355	360	PF00069	0.304
MOD_NEK2_1	377	382	PF00069	0.369
MOD_NEK2_1	399	404	PF00069	0.304
MOD_NEK2_1	516	521	PF00069	0.506
MOD_NEK2_1	627	632	PF00069	0.485
MOD_NEK2_1	686	691	PF00069	0.349
MOD_NEK2_1	695	700	PF00069	0.363
MOD_NEK2_1	726	731	PF00069	0.417
MOD_NEK2_1	889	894	PF00069	0.365
MOD_NEK2_1	900	905	PF00069	0.346
MOD_NEK2_1	912	917	PF00069	0.294
MOD_OFUCOSY	785	790	PF10250	0.458
MOD_PIKK_1	313	319	PF00454	0.369
MOD_PIKK_1	718	724	PF00454	0.432
MOD_PK_1	509	515	PF00069	0.369
MOD_PKA_1	3	9	PF00069	0.547
MOD_PKA_1	835	841	PF00069	0.393
MOD_PKA_2	122	128	PF00069	0.436
MOD_PKA_2	204	210	PF00069	0.405
MOD_PKA_2	289	295	PF00069	0.237
MOD_PKA_2	3	9	PF00069	0.504
MOD_PKA_2	739	745	PF00069	0.519
MOD_PKA_2	811	817	PF00069	0.423
MOD_PKA_2	835	841	PF00069	0.393
MOD_PKA_2	889	895	PF00069	0.339
MOD_Plk_1	349	355	PF00069	0.347
MOD_Plk_1	822	828	PF00069	0.291
MOD_Plk_2-3	822	828	PF00069	0.291
MOD_Plk_4	113	119	PF00069	0.481
MOD_Plk_4	154	160	PF00069	0.469
MOD_Plk_4	231	237	PF00069	0.363
MOD_Plk_4	570	576	PF00069	0.503
MOD_Plk_4	6	12	PF00069	0.543
MOD_Plk_4	607	613	PF00069	0.431
MOD_Plk_4	650	656	PF00069	0.369
MOD_Plk_4	769	775	PF00069	0.395
MOD_Plk_4	822	828	PF00069	0.514
MOD_Plk_4	840	846	PF00069	0.385
MOD_Plk_4	908	914	PF00069	0.439
MOD_ProDKin_1	223	229	PF00069	0.448
MOD_ProDKin_1	329	335	PF00069	0.369
MOD_ProDKin_1	437	443	PF00069	0.369
MOD_ProDKin_1	634	640	PF00069	0.514
MOD_ProDKin_1	707	713	PF00069	0.437
MOD_ProDKin_1	740	746	PF00069	0.481
MOD_ProDKin_1	93	99	PF00069	0.571
TRG_DiLeu_BaEn_1	245	250	PF01217	0.396
TRG_DiLeu_BaEn_1	867	872	PF01217	0.457
TRG_DiLeu_BaEn_2	340	346	PF01217	0.304
TRG_DiLeu_BaEn_2	575	581	PF01217	0.586
TRG_DiLeu_BaEn_4	350	356	PF01217	0.369
TRG_DiLeu_BaLyEn_6	426	431	PF01217	0.369
TRG_DiLeu_BaLyEn_6	567	572	PF01217	0.539
TRG_DiLeu_BaLyEn_6	741	746	PF01217	0.467
TRG_ENDOCYTIC_2	278	281	PF00928	0.304
TRG_ENDOCYTIC_2	298	301	PF00928	0.183
TRG_ENDOCYTIC_2	368	371	PF00928	0.304
TRG_ENDOCYTIC_2	445	448	PF00928	0.303
TRG_ER_diArg_1	1	4	PF00400	0.613
TRG_ER_diArg_1	138	141	PF00400	0.469
TRG_ER_diArg_1	5	8	PF00400	0.516
TRG_ER_diArg_1	541	544	PF00400	0.426
TRG_ER_diArg_1	834	836	PF00400	0.408
TRG_NES_CRM1_1	811	823	PF08389	0.451
TRG_Pf-PMV_PEXEL_1	411	416	PF00026	0.304

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P621	Leptomonas seymouri	54%	99%
A0A3Q8IMF5	Leishmania donovani	93%	100%
A4HD41	Leishmania braziliensis	80%	100%
E9AH19	Leishmania infantum	94%	100%
E9AWI9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%