Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QAX5_LEIMA

TriTrypDb:

LmjF.24.0050 , LMJLV39_240005800 , LMJSD75_240005500

Length:

466

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QAX5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QAX5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	171	175	PF00656	0.518
CLV_NRD_NRD_1	224	226	PF00675	0.356
CLV_PCSK_KEX2_1	216	218	PF00082	0.369
CLV_PCSK_KEX2_1	224	226	PF00082	0.318
CLV_PCSK_KEX2_1	32	34	PF00082	0.587
CLV_PCSK_KEX2_1	398	400	PF00082	0.349
CLV_PCSK_PC1ET2_1	216	218	PF00082	0.438
CLV_PCSK_PC1ET2_1	32	34	PF00082	0.587
CLV_PCSK_PC1ET2_1	398	400	PF00082	0.349
CLV_PCSK_PC7_1	220	226	PF00082	0.378
CLV_PCSK_SKI1_1	155	159	PF00082	0.594
CLV_PCSK_SKI1_1	170	174	PF00082	0.446
CLV_PCSK_SKI1_1	19	23	PF00082	0.672
CLV_PCSK_SKI1_1	216	220	PF00082	0.387
CLV_PCSK_SKI1_1	263	267	PF00082	0.429
CLV_PCSK_SKI1_1	283	287	PF00082	0.397
CLV_PCSK_SKI1_1	398	402	PF00082	0.322
CLV_PCSK_SKI1_1	423	427	PF00082	0.419
CLV_PCSK_SKI1_1	457	461	PF00082	0.530
DEG_APCC_DBOX_1	139	147	PF00400	0.265
DEG_APCC_DBOX_1	23	31	PF00400	0.578
DEG_MDM2_SWIB_1	189	196	PF02201	0.361
DEG_Nend_Nbox_1	1	3	PF02207	0.545
DEG_SCF_FBW7_1	71	76	PF00400	0.512
DOC_CKS1_1	37	42	PF01111	0.554
DOC_CYCLIN_RxL_1	134	144	PF00134	0.456
DOC_CYCLIN_RxL_1	165	175	PF00134	0.381
DOC_CYCLIN_RxL_1	260	270	PF00134	0.429
DOC_CYCLIN_yCln2_LP_2	139	145	PF00134	0.267
DOC_MAPK_DCC_7	225	235	PF00069	0.468
DOC_MAPK_gen_1	216	223	PF00069	0.474
DOC_MAPK_MEF2A_6	292	300	PF00069	0.462
DOC_MAPK_MEF2A_6	42	51	PF00069	0.517
DOC_PP1_RVXF_1	135	142	PF00149	0.368
DOC_PP1_RVXF_1	156	162	PF00149	0.449
DOC_USP7_MATH_1	267	271	PF00917	0.376
DOC_USP7_MATH_1	67	71	PF00917	0.458
DOC_USP7_UBL2_3	62	66	PF12436	0.608
DOC_WW_Pin1_4	36	41	PF00397	0.540
DOC_WW_Pin1_4	69	74	PF00397	0.620
DOC_WW_Pin1_4	91	96	PF00397	0.563
LIG_14-3-3_CanoR_1	140	149	PF00244	0.513
LIG_14-3-3_CanoR_1	190	194	PF00244	0.462
LIG_14-3-3_CanoR_1	283	288	PF00244	0.484
LIG_14-3-3_CanoR_1	399	407	PF00244	0.382
LIG_14-3-3_CanoR_1	434	438	PF00244	0.470
LIG_14-3-3_CanoR_1	457	462	PF00244	0.405
LIG_BRCT_BRCA1_1	185	189	PF00533	0.555
LIG_Clathr_ClatBox_1	146	150	PF01394	0.323
LIG_FHA_1	124	130	PF00498	0.503
LIG_FHA_1	190	196	PF00498	0.469
LIG_FHA_1	276	282	PF00498	0.384
LIG_FHA_1	415	421	PF00498	0.341
LIG_FHA_1	63	69	PF00498	0.672
LIG_FHA_2	266	272	PF00498	0.578
LIG_FHA_2	312	318	PF00498	0.518
LIG_FHA_2	363	369	PF00498	0.394
LIG_FHA_2	74	80	PF00498	0.490
LIG_GBD_Chelix_1	424	432	PF00786	0.449
LIG_GBD_Chelix_1	82	90	PF00786	0.584
LIG_LIR_Apic_2	249	254	PF02991	0.370
LIG_LIR_Gen_1	252	261	PF02991	0.487
LIG_LIR_Gen_1	345	354	PF02991	0.358
LIG_LIR_Nem_3	192	196	PF02991	0.457
LIG_LIR_Nem_3	252	258	PF02991	0.466
LIG_LIR_Nem_3	270	276	PF02991	0.285
LIG_LIR_Nem_3	345	349	PF02991	0.367
LIG_LIR_Nem_3	351	357	PF02991	0.309
LIG_LIR_Nem_3	368	373	PF02991	0.313
LIG_NRBOX	194	200	PF00104	0.459
LIG_OCRL_FandH_1	288	300	PF00620	0.464
LIG_Pex14_2	189	193	PF04695	0.368
LIG_Pex14_2	354	358	PF04695	0.413
LIG_SH2_CRK	273	277	PF00017	0.474
LIG_SH2_CRK	435	439	PF00017	0.472
LIG_SH2_NCK_1	251	255	PF00017	0.359
LIG_SH2_PTP2	242	245	PF00017	0.335
LIG_SH2_STAT5	228	231	PF00017	0.544
LIG_SH2_STAT5	242	245	PF00017	0.406
LIG_SH2_STAT5	273	276	PF00017	0.402
LIG_SH2_STAT5	435	438	PF00017	0.463
LIG_SH3_1	228	234	PF00018	0.378
LIG_SH3_3	228	234	PF00018	0.419
LIG_SH3_3	458	464	PF00018	0.379
LIG_Sin3_3	418	425	PF02671	0.387
LIG_SUMO_SIM_anti_2	126	132	PF11976	0.553
LIG_SUMO_SIM_anti_2	144	150	PF11976	0.234
LIG_SUMO_SIM_anti_2	450	456	PF11976	0.413
LIG_SUMO_SIM_par_1	147	154	PF11976	0.455
LIG_SUMO_SIM_par_1	207	213	PF11976	0.545
LIG_SUMO_SIM_par_1	450	456	PF11976	0.367
LIG_TRAF2_1	105	108	PF00917	0.347
LIG_TRAF2_1	314	317	PF00917	0.425
LIG_TYR_ITIM	240	245	PF00017	0.440
LIG_UBA3_1	392	398	PF00899	0.341
LIG_UBA3_1	56	62	PF00899	0.623
MOD_CDK_SPxK_1	36	42	PF00069	0.584
MOD_CK1_1	305	311	PF00069	0.451
MOD_CK1_1	402	408	PF00069	0.304
MOD_CK1_1	94	100	PF00069	0.659
MOD_CK2_1	266	272	PF00069	0.424
MOD_CK2_1	311	317	PF00069	0.458
MOD_CK2_1	73	79	PF00069	0.499
MOD_Cter_Amidation	214	217	PF01082	0.469
MOD_GlcNHglycan	116	119	PF01048	0.552
MOD_GlcNHglycan	143	146	PF01048	0.526
MOD_GlcNHglycan	212	215	PF01048	0.425
MOD_GlcNHglycan	304	307	PF01048	0.383
MOD_GlcNHglycan	335	338	PF01048	0.446
MOD_GlcNHglycan	381	384	PF01048	0.475
MOD_GlcNHglycan	440	443	PF01048	0.327
MOD_GlcNHglycan	52	55	PF01048	0.497
MOD_GSK3_1	119	126	PF00069	0.456
MOD_GSK3_1	267	274	PF00069	0.465
MOD_GSK3_1	433	440	PF00069	0.560
MOD_GSK3_1	67	74	PF00069	0.570
MOD_N-GLC_1	379	384	PF02516	0.487
MOD_NEK2_1	151	156	PF00069	0.391
MOD_NEK2_1	172	177	PF00069	0.425
MOD_NEK2_1	189	194	PF00069	0.495
MOD_NEK2_1	265	270	PF00069	0.555
MOD_NEK2_1	50	55	PF00069	0.466
MOD_NEK2_1	60	65	PF00069	0.620
MOD_PIKK_1	200	206	PF00454	0.523
MOD_PIKK_1	311	317	PF00454	0.537
MOD_PKA_2	189	195	PF00069	0.505
MOD_PKA_2	308	314	PF00069	0.378
MOD_PKA_2	433	439	PF00069	0.476
MOD_PKA_2	99	105	PF00069	0.545
MOD_Plk_1	183	189	PF00069	0.543
MOD_Plk_1	402	408	PF00069	0.402
MOD_Plk_1	78	84	PF00069	0.496
MOD_Plk_4	189	195	PF00069	0.442
MOD_Plk_4	433	439	PF00069	0.522
MOD_ProDKin_1	36	42	PF00069	0.538
MOD_ProDKin_1	69	75	PF00069	0.608
MOD_ProDKin_1	91	97	PF00069	0.568
TRG_DiLeu_BaEn_1	260	265	PF01217	0.333
TRG_DiLeu_BaEn_1	416	421	PF01217	0.536
TRG_DiLeu_BaEn_1	450	455	PF01217	0.411
TRG_DiLeu_LyEn_5	260	265	PF01217	0.309
TRG_ENDOCYTIC_2	242	245	PF00928	0.449
TRG_ENDOCYTIC_2	273	276	PF00928	0.474
TRG_ENDOCYTIC_2	435	438	PF00928	0.463
TRG_ER_diArg_1	223	225	PF00400	0.336
TRG_NLS_MonoExtN_4	395	401	PF00514	0.326
TRG_Pf-PMV_PEXEL_1	371	375	PF00026	0.376
TRG_Pf-PMV_PEXEL_1	399	403	PF00026	0.423
TRG_Pf-PMV_PEXEL_1	80	84	PF00026	0.528

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBX3	Leptomonas seymouri	52%	100%
A0A1X0NIQ1	Trypanosomatidae	27%	100%
A0A3R7MWR0	Trypanosoma rangeli	29%	98%
A0A3S7WY18	Leishmania donovani	93%	100%
A4HD63	Leishmania braziliensis	80%	100%
A4I0M8	Leishmania infantum	93%	100%
D0A6X6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	99%
E9AWJ5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
V5BRC9	Trypanosoma cruzi	28%	99%