Transmembrane protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QAX4_LEIMA

TriTrypDb:

LmjF.24.0060 , LMJLV39_240005900 , LMJSD75_240005600

Length:

414

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 8, no: 0
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	7
GO:0110165	cellular anatomical entity	1	7

Expansion

Sequence features

Q4QAX4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QAX4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	203	207	PF00656	0.421
CLV_PCSK_KEX2_1	306	308	PF00082	0.509
CLV_PCSK_PC1ET2_1	306	308	PF00082	0.538
CLV_PCSK_PC7_1	302	308	PF00082	0.482
CLV_PCSK_SKI1_1	223	227	PF00082	0.615
CLV_PCSK_SKI1_1	307	311	PF00082	0.484
DOC_CYCLIN_RxL_1	154	165	PF00134	0.473
DOC_CYCLIN_yCln2_LP_2	146	149	PF00134	0.489
DOC_MAPK_gen_1	275	283	PF00069	0.339
DOC_MAPK_gen_1	314	322	PF00069	0.697
DOC_MAPK_MEF2A_6	276	285	PF00069	0.300
DOC_PP2B_LxvP_1	146	149	PF13499	0.489
DOC_USP7_MATH_1	166	170	PF00917	0.425
DOC_USP7_MATH_1	173	177	PF00917	0.341
DOC_USP7_MATH_1	403	407	PF00917	0.750
DOC_USP7_MATH_1	56	60	PF00917	0.400
DOC_USP7_UBL2_3	306	310	PF12436	0.689
DOC_WW_Pin1_4	358	363	PF00397	0.773
DOC_WW_Pin1_4	62	67	PF00397	0.491
LIG_14-3-3_CanoR_1	157	162	PF00244	0.462
LIG_14-3-3_CanoR_1	174	178	PF00244	0.321
LIG_14-3-3_CanoR_1	321	327	PF00244	0.666
LIG_14-3-3_CanoR_1	368	374	PF00244	0.714
LIG_BIR_II_1	1	5	PF00653	0.487
LIG_BRCT_BRCA1_1	15	19	PF00533	0.510
LIG_BRCT_BRCA1_1	159	163	PF00533	0.389
LIG_BRCT_BRCA1_1	24	28	PF00533	0.447
LIG_BRCT_BRCA1_1	294	298	PF00533	0.521
LIG_FHA_1	110	116	PF00498	0.487
LIG_FHA_1	208	214	PF00498	0.402
LIG_FHA_1	48	54	PF00498	0.439
LIG_FHA_2	191	197	PF00498	0.428
LIG_FHA_2	201	207	PF00498	0.484
LIG_LIR_Gen_1	141	149	PF02991	0.554
LIG_LIR_Gen_1	2	11	PF02991	0.567
LIG_LIR_Gen_1	46	57	PF02991	0.459
LIG_LIR_Nem_3	132	136	PF02991	0.528
LIG_LIR_Nem_3	141	146	PF02991	0.552
LIG_LIR_Nem_3	154	159	PF02991	0.351
LIG_LIR_Nem_3	162	167	PF02991	0.351
LIG_LIR_Nem_3	193	197	PF02991	0.436
LIG_LIR_Nem_3	2	6	PF02991	0.583
LIG_LIR_Nem_3	232	236	PF02991	0.434
LIG_LIR_Nem_3	46	52	PF02991	0.466
LIG_PCNA_PIPBox_1	178	187	PF02747	0.372
LIG_PCNA_yPIPBox_3	174	185	PF02747	0.369
LIG_PDZ_Class_1	409	414	PF00595	0.653
LIG_Pex14_1	278	282	PF04695	0.391
LIG_SH2_CRK	164	168	PF00017	0.407
LIG_SH2_CRK	236	240	PF00017	0.488
LIG_SH2_CRK	3	7	PF00017	0.589
LIG_SH2_CRK	336	340	PF00017	0.730
LIG_SH2_CRK	346	350	PF00017	0.740
LIG_SH2_CRK	359	363	PF00017	0.619
LIG_SH2_GRB2like	136	139	PF00017	0.519
LIG_SH2_GRB2like	407	410	PF00017	0.659
LIG_SH2_NCK_1	164	168	PF00017	0.407
LIG_SH2_NCK_1	359	363	PF00017	0.719
LIG_SH2_SRC	334	337	PF00017	0.735
LIG_SH2_STAP1	104	108	PF00017	0.431
LIG_SH2_STAP1	233	237	PF00017	0.409
LIG_SH2_STAP1	3	7	PF00017	0.472
LIG_SH2_STAP1	386	390	PF00017	0.740
LIG_SH2_STAT3	386	389	PF00017	0.790
LIG_SH2_STAT3	396	399	PF00017	0.660
LIG_SH2_STAT5	104	107	PF00017	0.296
LIG_SH2_STAT5	136	139	PF00017	0.476
LIG_SH2_STAT5	164	167	PF00017	0.418
LIG_SH2_STAT5	247	250	PF00017	0.401
LIG_SH2_STAT5	279	282	PF00017	0.337
LIG_SH2_STAT5	390	393	PF00017	0.817
LIG_SH2_STAT5	86	89	PF00017	0.497
LIG_SH3_3	282	288	PF00018	0.259
LIG_SH3_3	57	63	PF00018	0.499
LIG_SUMO_SIM_par_1	111	116	PF11976	0.458
LIG_SUMO_SIM_par_1	77	83	PF11976	0.426
LIG_TYR_ITIM	192	197	PF00017	0.456
LIG_TYR_ITSM	160	167	PF00017	0.397
LIG_WRC_WIRS_1	181	186	PF05994	0.455
MOD_CK1_1	109	115	PF00069	0.416
MOD_CK1_1	139	145	PF00069	0.513
MOD_CK1_1	151	157	PF00069	0.499
MOD_CK1_1	176	182	PF00069	0.440
MOD_CK1_1	2	8	PF00069	0.469
MOD_CK1_1	207	213	PF00069	0.446
MOD_CK1_1	47	53	PF00069	0.390
MOD_CK1_1	65	71	PF00069	0.384
MOD_CK2_1	309	315	PF00069	0.637
MOD_Cter_Amidation	304	307	PF01082	0.431
MOD_GlcNHglycan	108	111	PF01048	0.721
MOD_GlcNHglycan	115	118	PF01048	0.678
MOD_GlcNHglycan	303	306	PF01048	0.410
MOD_GlcNHglycan	322	325	PF01048	0.506
MOD_GSK3_1	102	109	PF00069	0.477
MOD_GSK3_1	113	120	PF00069	0.467
MOD_GSK3_1	134	141	PF00069	0.544
MOD_GSK3_1	147	154	PF00069	0.425
MOD_GSK3_1	162	169	PF00069	0.304
MOD_GSK3_1	173	180	PF00069	0.365
MOD_GSK3_1	200	207	PF00069	0.439
MOD_GSK3_1	262	269	PF00069	0.504
MOD_GSK3_1	43	50	PF00069	0.410
MOD_GSK3_1	52	59	PF00069	0.406
MOD_GSK3_1	62	69	PF00069	0.513
MOD_GSK3_1	80	87	PF00069	0.462
MOD_N-GLC_1	100	105	PF02516	0.645
MOD_N-GLC_1	134	139	PF02516	0.707
MOD_N-GLC_1	151	156	PF02516	0.597
MOD_N-GLC_1	157	162	PF02516	0.595
MOD_N-GLC_1	266	271	PF02516	0.680
MOD_N-GLC_1	35	40	PF02516	0.661
MOD_N-GLC_2	138	140	PF02516	0.695
MOD_NEK2_1	1	6	PF00069	0.670
MOD_NEK2_1	113	118	PF00069	0.469
MOD_NEK2_1	119	124	PF00069	0.449
MOD_NEK2_1	13	18	PF00069	0.584
MOD_NEK2_1	159	164	PF00069	0.362
MOD_NEK2_1	177	182	PF00069	0.334
MOD_NEK2_1	197	202	PF00069	0.463
MOD_NEK2_1	291	296	PF00069	0.381
MOD_NEK2_1	52	57	PF00069	0.437
MOD_PIKK_1	166	172	PF00454	0.409
MOD_PIKK_1	197	203	PF00454	0.439
MOD_PIKK_1	390	396	PF00454	0.728
MOD_PKA_2	173	179	PF00069	0.433
MOD_PKA_2	301	307	PF00069	0.631
MOD_PKA_2	320	326	PF00069	0.662
MOD_PKA_2	367	373	PF00069	0.754
MOD_Plk_1	151	157	PF00069	0.460
MOD_Plk_1	22	28	PF00069	0.581
MOD_Plk_1	223	229	PF00069	0.449
MOD_Plk_1	35	41	PF00069	0.425
MOD_Plk_4	129	135	PF00069	0.509
MOD_Plk_4	159	165	PF00069	0.369
MOD_Plk_4	180	186	PF00069	0.407
MOD_Plk_4	2	8	PF00069	0.605
MOD_Plk_4	204	210	PF00069	0.479
MOD_Plk_4	226	232	PF00069	0.432
MOD_Plk_4	235	241	PF00069	0.393
MOD_Plk_4	66	72	PF00069	0.441
MOD_Plk_4	80	86	PF00069	0.411
MOD_ProDKin_1	358	364	PF00069	0.774
MOD_ProDKin_1	62	68	PF00069	0.492
MOD_SUMO_rev_2	238	246	PF00179	0.308
TRG_ENDOCYTIC_2	164	167	PF00928	0.403
TRG_ENDOCYTIC_2	194	197	PF00928	0.463
TRG_ENDOCYTIC_2	236	239	PF00928	0.429
TRG_ENDOCYTIC_2	279	282	PF00928	0.360
TRG_ENDOCYTIC_2	3	6	PF00928	0.594
TRG_ENDOCYTIC_2	346	349	PF00928	0.737
TRG_Pf-PMV_PEXEL_1	307	311	PF00026	0.441

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I0L6	Leptomonas seymouri	45%	98%
A0A3S7WY17	Leishmania donovani	90%	100%
A4HD64	Leishmania braziliensis	61%	100%
A4I0M9	Leishmania infantum	91%	100%
D0A6X7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	100%
E9AWJ6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	100%
V5C0T3	Trypanosoma cruzi	28%	100%