J domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QAX3_LEIMA

TriTrypDb:

LmjF.24.0070 , LMJLV39_240006000 , LMJSD75_240005700

Length:

439

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	10
GO:0110165	cellular anatomical entity	1	10

Expansion

Sequence features

Q4QAX3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QAX3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	104	108	PF00656	0.476
CLV_C14_Caspase3-7	249	253	PF00656	0.575
CLV_C14_Caspase3-7	396	400	PF00656	0.648
CLV_C14_Caspase3-7	76	80	PF00656	0.429
CLV_NRD_NRD_1	227	229	PF00675	0.790
CLV_NRD_NRD_1	31	33	PF00675	0.637
CLV_NRD_NRD_1	384	386	PF00675	0.423
CLV_NRD_NRD_1	392	394	PF00675	0.434
CLV_NRD_NRD_1	74	76	PF00675	0.577
CLV_PCSK_FUR_1	342	346	PF00082	0.480
CLV_PCSK_KEX2_1	227	229	PF00082	0.797
CLV_PCSK_KEX2_1	344	346	PF00082	0.426
CLV_PCSK_KEX2_1	377	379	PF00082	0.396
CLV_PCSK_KEX2_1	392	394	PF00082	0.437
CLV_PCSK_KEX2_1	411	413	PF00082	0.400
CLV_PCSK_KEX2_1	74	76	PF00082	0.590
CLV_PCSK_PC1ET2_1	344	346	PF00082	0.426
CLV_PCSK_PC1ET2_1	377	379	PF00082	0.396
CLV_PCSK_PC1ET2_1	411	413	PF00082	0.470
CLV_PCSK_PC7_1	388	394	PF00082	0.434
CLV_PCSK_SKI1_1	188	192	PF00082	0.712
CLV_PCSK_SKI1_1	214	218	PF00082	0.758
CLV_PCSK_SKI1_1	300	304	PF00082	0.625
CLV_PCSK_SKI1_1	313	317	PF00082	0.589
CLV_PCSK_SKI1_1	377	381	PF00082	0.402
CLV_PCSK_SKI1_1	38	42	PF00082	0.671
CLV_PCSK_SKI1_1	417	421	PF00082	0.453
CLV_PCSK_SKI1_1	68	72	PF00082	0.548
DEG_Nend_UBRbox_1	1	4	PF02207	0.523
DOC_CYCLIN_RxL_1	211	222	PF00134	0.516
DOC_MAPK_gen_1	313	323	PF00069	0.334
DOC_MAPK_gen_1	411	418	PF00069	0.607
DOC_MAPK_MEF2A_6	411	418	PF00069	0.609
DOC_MAPK_MEF2A_6	57	64	PF00069	0.358
DOC_MAPK_NFAT4_5	411	419	PF00069	0.624
DOC_MAPK_RevD_3	60	75	PF00069	0.368
DOC_USP7_MATH_1	129	133	PF00917	0.500
DOC_USP7_MATH_1	246	250	PF00917	0.591
DOC_USP7_MATH_1	262	266	PF00917	0.521
DOC_USP7_MATH_1	272	276	PF00917	0.484
DOC_USP7_MATH_1	387	391	PF00917	0.628
DOC_USP7_MATH_1	402	406	PF00917	0.627
DOC_USP7_UBL2_3	23	27	PF12436	0.459
LIG_14-3-3_CanoR_1	130	139	PF00244	0.475
LIG_14-3-3_CanoR_1	201	208	PF00244	0.548
LIG_14-3-3_CanoR_1	345	354	PF00244	0.677
LIG_14-3-3_CanoR_1	392	398	PF00244	0.655
LIG_14-3-3_CanoR_1	74	78	PF00244	0.376
LIG_14-3-3_CanoR_1	89	93	PF00244	0.344
LIG_Actin_WH2_2	174	190	PF00022	0.440
LIG_APCC_ABBA_1	333	338	PF00400	0.378
LIG_BIR_III_4	79	83	PF00653	0.441
LIG_BRCT_BRCA1_1	319	323	PF00533	0.263
LIG_FHA_1	17	23	PF00498	0.477
LIG_FHA_1	187	193	PF00498	0.455
LIG_FHA_1	236	242	PF00498	0.585
LIG_FHA_1	307	313	PF00498	0.442
LIG_FHA_1	328	334	PF00498	0.246
LIG_FHA_2	139	145	PF00498	0.427
LIG_FHA_2	232	238	PF00498	0.595
LIG_FHA_2	266	272	PF00498	0.565
LIG_FHA_2	285	291	PF00498	0.427
LIG_FHA_2	299	305	PF00498	0.396
LIG_FHA_2	394	400	PF00498	0.644
LIG_FHA_2	408	414	PF00498	0.581
LIG_FHA_2	74	80	PF00498	0.395
LIG_LIR_Gen_1	24	29	PF02991	0.474
LIG_LIR_Gen_1	320	329	PF02991	0.378
LIG_LIR_Gen_1	331	341	PF02991	0.378
LIG_LIR_Gen_1	85	94	PF02991	0.352
LIG_LIR_Nem_3	134	139	PF02991	0.452
LIG_LIR_Nem_3	24	28	PF02991	0.439
LIG_LIR_Nem_3	320	326	PF02991	0.378
LIG_LIR_Nem_3	331	337	PF02991	0.378
LIG_LIR_Nem_3	43	47	PF02991	0.242
LIG_LIR_Nem_3	85	90	PF02991	0.366
LIG_LIR_Nem_3	91	97	PF02991	0.331
LIG_NRBOX	66	72	PF00104	0.350
LIG_Pex14_2	380	384	PF04695	0.606
LIG_SH2_PTP2	136	139	PF00017	0.488
LIG_SH2_PTP2	334	337	PF00017	0.363
LIG_SH2_SRC	126	129	PF00017	0.429
LIG_SH2_SRC	136	139	PF00017	0.436
LIG_SH2_SRC	334	337	PF00017	0.314
LIG_SH2_SRC	94	97	PF00017	0.344
LIG_SH2_STAP1	372	376	PF00017	0.583
LIG_SH2_STAT3	372	375	PF00017	0.585
LIG_SH2_STAT5	126	129	PF00017	0.418
LIG_SH2_STAT5	136	139	PF00017	0.425
LIG_SH2_STAT5	334	337	PF00017	0.327
LIG_SH2_STAT5	69	72	PF00017	0.338
LIG_SH3_3	251	257	PF00018	0.507
LIG_SH3_3	55	61	PF00018	0.366
LIG_SUMO_SIM_anti_2	277	284	PF11976	0.466
LIG_SUMO_SIM_par_1	325	331	PF11976	0.285
LIG_SUMO_SIM_par_1	60	65	PF11976	0.380
LIG_TRAF2_1	264	267	PF00917	0.550
LIG_TYR_ITIM	332	337	PF00017	0.363
LIG_TYR_ITIM	49	54	PF00017	0.348
LIG_TYR_ITIM	92	97	PF00017	0.347
MOD_CK1_1	132	138	PF00069	0.485
MOD_CK1_1	265	271	PF00069	0.559
MOD_CK1_1	328	334	PF00069	0.402
MOD_CK2_1	137	143	PF00069	0.458
MOD_CK2_1	231	237	PF00069	0.595
MOD_CK2_1	261	267	PF00069	0.578
MOD_CK2_1	298	304	PF00069	0.439
MOD_CK2_1	346	352	PF00069	0.683
MOD_CK2_1	402	408	PF00069	0.624
MOD_GlcNHglycan	231	234	PF01048	0.741
MOD_GlcNHglycan	242	245	PF01048	0.783
MOD_GSK3_1	182	189	PF00069	0.491
MOD_GSK3_1	231	238	PF00069	0.553
MOD_GSK3_1	261	268	PF00069	0.519
MOD_GSK3_1	346	353	PF00069	0.695
MOD_N-GLC_1	246	251	PF02516	0.709
MOD_N-GLC_1	306	311	PF02516	0.644
MOD_NEK2_1	1	6	PF00069	0.470
MOD_NEK2_1	182	187	PF00069	0.507
MOD_NEK2_1	317	322	PF00069	0.397
MOD_NEK2_1	325	330	PF00069	0.378
MOD_NEK2_1	62	67	PF00069	0.364
MOD_NEK2_1	88	93	PF00069	0.363
MOD_NEK2_2	186	191	PF00069	0.453
MOD_PIKK_1	27	33	PF00454	0.430
MOD_PIKK_1	371	377	PF00454	0.600
MOD_PKA_2	1	7	PF00069	0.544
MOD_PKA_2	129	135	PF00069	0.481
MOD_PKA_2	200	206	PF00069	0.540
MOD_PKA_2	387	393	PF00069	0.630
MOD_PKA_2	402	408	PF00069	0.622
MOD_PKA_2	73	79	PF00069	0.387
MOD_PKA_2	88	94	PF00069	0.345
MOD_Plk_1	265	271	PF00069	0.590
MOD_Plk_1	317	323	PF00069	0.296
MOD_Plk_2-3	284	290	PF00069	0.491
MOD_Plk_4	132	138	PF00069	0.434
MOD_Plk_4	317	323	PF00069	0.296
MOD_Plk_4	328	334	PF00069	0.355
MOD_Plk_4	358	364	PF00069	0.641
MOD_Plk_4	83	89	PF00069	0.433
MOD_SUMO_for_1	315	318	PF00179	0.461
MOD_SUMO_for_1	40	43	PF00179	0.492
MOD_SUMO_rev_2	104	111	PF00179	0.426
MOD_SUMO_rev_2	196	200	PF00179	0.501
MOD_SUMO_rev_2	310	315	PF00179	0.456
MOD_SUMO_rev_2	409	419	PF00179	0.658
TRG_DiLeu_BaEn_1	170	175	PF01217	0.428
TRG_DiLeu_BaEn_2	212	218	PF01217	0.569
TRG_ENDOCYTIC_2	136	139	PF00928	0.488
TRG_ENDOCYTIC_2	25	28	PF00928	0.426
TRG_ENDOCYTIC_2	334	337	PF00928	0.340
TRG_ENDOCYTIC_2	51	54	PF00928	0.348
TRG_ENDOCYTIC_2	94	97	PF00928	0.344
TRG_ER_diArg_1	227	229	PF00400	0.554
TRG_Pf-PMV_PEXEL_1	147	151	PF00026	0.674
TRG_Pf-PMV_PEXEL_1	193	197	PF00026	0.652

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3N9	Leptomonas seymouri	77%	99%
A0A0S4IV95	Bodo saltans	54%	100%
A0A1X0NKJ2	Trypanosomatidae	64%	99%
A0A3Q8ICV4	Leishmania donovani	93%	100%
A4HD65	Leishmania braziliensis	82%	100%
A4I0N0	Leishmania infantum	94%	100%
D0A6X8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	61%	99%
E9AWJ7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
V5BW05	Trypanosoma cruzi	64%	94%