RING-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Ring finger domain containing protein, putative

Species:

Leishmania major

UniProt:

Q4QAX2_LEIMA

TriTrypDb:

LmjF.24.0080 , LMJLV39_240006100 , LMJSD75_240005800

Length:

409

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	2
GO:0005737	cytoplasm	2	2
GO:0005886	plasma membrane	3	2
GO:0016020	membrane	2	2
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0097014	ciliary plasm	5	2
GO:0099568	cytoplasmic region	3	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4QAX2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QAX2

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	2
GO:0004842	ubiquitin-protein transferase activity	4	2
GO:0016740	transferase activity	2	2
GO:0019787	ubiquitin-like protein transferase activity	3	2
GO:0061630	ubiquitin protein ligase activity	5	2
GO:0061659	ubiquitin-like protein ligase activity	4	2
GO:0140096	catalytic activity, acting on a protein	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_SKI1_1	74	78	PF00082	0.438
DOC_USP7_MATH_1	127	131	PF00917	0.360
DOC_USP7_MATH_1	165	169	PF00917	0.607
DOC_USP7_MATH_1	34	38	PF00917	0.351
DOC_USP7_MATH_1	388	392	PF00917	0.464
DOC_WW_Pin1_4	150	155	PF00397	0.566
DOC_WW_Pin1_4	295	300	PF00397	0.508
LIG_14-3-3_CanoR_1	313	319	PF00244	0.325
LIG_14-3-3_CanoR_1	7	14	PF00244	0.481
LIG_BRCT_BRCA1_1	363	367	PF00533	0.359
LIG_BRCT_BRCA1_1	390	394	PF00533	0.475
LIG_deltaCOP1_diTrp_1	199	208	PF00928	0.467
LIG_FHA_1	171	177	PF00498	0.473
LIG_FHA_1	216	222	PF00498	0.327
LIG_FHA_1	37	43	PF00498	0.341
LIG_FHA_1	84	90	PF00498	0.518
LIG_FHA_2	127	133	PF00498	0.531
LIG_FHA_2	164	170	PF00498	0.531
LIG_FHA_2	381	387	PF00498	0.495
LIG_LIR_Gen_1	242	253	PF02991	0.424
LIG_LIR_Gen_1	391	401	PF02991	0.428
LIG_LIR_Nem_3	242	248	PF02991	0.407
LIG_LIR_Nem_3	267	271	PF02991	0.374
LIG_LIR_Nem_3	391	397	PF02991	0.457
LIG_LIR_Nem_3	43	49	PF02991	0.407
LIG_MYND_1	354	358	PF01753	0.483
LIG_PCNA_yPIPBox_3	66	80	PF02747	0.391
LIG_Pex14_2	336	340	PF04695	0.522
LIG_Pex14_2	68	72	PF04695	0.376
LIG_REV1ctd_RIR_1	11	20	PF16727	0.458
LIG_SH2_CRK	32	36	PF00017	0.459
LIG_SH2_CRK	46	50	PF00017	0.477
LIG_SH2_NCK_1	245	249	PF00017	0.421
LIG_SH2_STAP1	95	99	PF00017	0.374
LIG_SH2_STAT5	137	140	PF00017	0.331
LIG_SH2_STAT5	192	195	PF00017	0.337
LIG_SH2_STAT5	245	248	PF00017	0.575
LIG_SH2_STAT5	271	274	PF00017	0.304
LIG_SH2_STAT5	326	329	PF00017	0.310
LIG_SH3_3	121	127	PF00018	0.492
LIG_SH3_3	227	233	PF00018	0.476
LIG_SH3_3	28	34	PF00018	0.367
LIG_SUMO_SIM_par_1	115	120	PF11976	0.501
LIG_TRAF2_1	298	301	PF00917	0.388
LIG_TYR_ITIM	44	49	PF00017	0.372
MOD_CK1_1	150	156	PF00069	0.643
MOD_CK1_1	163	169	PF00069	0.442
MOD_CK1_1	23	29	PF00069	0.364
MOD_CK1_1	335	341	PF00069	0.438
MOD_CK2_1	112	118	PF00069	0.539
MOD_CK2_1	136	142	PF00069	0.488
MOD_CK2_1	163	169	PF00069	0.544
MOD_CK2_1	295	301	PF00069	0.394
MOD_CK2_1	34	40	PF00069	0.460
MOD_GlcNHglycan	149	152	PF01048	0.609
MOD_GlcNHglycan	22	25	PF01048	0.531
MOD_GSK3_1	108	115	PF00069	0.491
MOD_GSK3_1	159	166	PF00069	0.544
MOD_GSK3_1	20	27	PF00069	0.543
MOD_GSK3_1	235	242	PF00069	0.548
MOD_GSK3_1	36	43	PF00069	0.242
MOD_N-GLC_2	81	83	PF02516	0.500
MOD_NEK2_1	1	6	PF00069	0.475
MOD_NEK2_1	160	165	PF00069	0.603
MOD_NEK2_1	20	25	PF00069	0.297
MOD_NEK2_1	235	240	PF00069	0.366
MOD_NEK2_1	259	264	PF00069	0.512
MOD_OFUCOSY	359	365	PF10250	0.384
MOD_PIKK_1	160	166	PF00454	0.616
MOD_PIKK_1	329	335	PF00454	0.453
MOD_PIKK_1	7	13	PF00454	0.399
MOD_Plk_2-3	112	118	PF00069	0.547
MOD_Plk_2-3	183	189	PF00069	0.404
MOD_Plk_4	112	118	PF00069	0.415
MOD_Plk_4	314	320	PF00069	0.314
MOD_ProDKin_1	150	156	PF00069	0.568
MOD_ProDKin_1	295	301	PF00069	0.510
MOD_SUMO_for_1	210	213	PF00179	0.431
TRG_DiLeu_BaLyEn_6	230	235	PF01217	0.391
TRG_ENDOCYTIC_2	245	248	PF00928	0.445
TRG_ENDOCYTIC_2	32	35	PF00928	0.462
TRG_ENDOCYTIC_2	46	49	PF00928	0.477
TRG_Pf-PMV_PEXEL_1	74	78	PF00026	0.358

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1P9Y9	Leptomonas seymouri	57%	87%
A0A1X0NKC7	Trypanosomatidae	34%	88%
A0A3Q8ICQ4	Leishmania donovani	93%	76%
A0A3R7LDY0	Trypanosoma rangeli	36%	88%
A4HD66	Leishmania braziliensis	77%	86%
A4I0N1	Leishmania infantum	93%	75%
D0A6X9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	88%
E9AWJ8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	80%
V5DSQ1	Trypanosoma cruzi	36%	88%