DUF3592 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QAX1_LEIMA

TriTrypDb:

LmjF.24.0090 , LMJLV39_240006200 , LMJSD75_240005900

Length:

228

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	2
GO:0016020	membrane	2	10
GO:0020023	kinetoplast	2	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	10

Expansion

Sequence features

Q4QAX1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QAX1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	17	19	PF00675	0.455
CLV_NRD_NRD_1	188	190	PF00675	0.406
CLV_NRD_NRD_1	195	197	PF00675	0.454
CLV_NRD_NRD_1	73	75	PF00675	0.492
CLV_PCSK_SKI1_1	14	18	PF00082	0.346
DEG_Nend_Nbox_1	1	3	PF02207	0.583
DOC_CDC14_PxL_1	128	136	PF14671	0.235
DOC_CYCLIN_RxL_1	11	20	PF00134	0.561
DOC_MAPK_gen_1	196	202	PF00069	0.670
DOC_PP1_RVXF_1	197	203	PF00149	0.636
DOC_USP7_UBL2_3	146	150	PF12436	0.230
DOC_WW_Pin1_4	105	110	PF00397	0.235
DOC_WW_Pin1_4	210	215	PF00397	0.595
LIG_14-3-3_CanoR_1	139	143	PF00244	0.283
LIG_14-3-3_CanoR_1	62	71	PF00244	0.304
LIG_Actin_WH2_2	174	191	PF00022	0.475
LIG_APCC_ABBAyCdc20_2	139	145	PF00400	0.248
LIG_FHA_2	119	125	PF00498	0.237
LIG_LIR_Nem_3	163	169	PF02991	0.371
LIG_Pex14_2	162	166	PF04695	0.310
LIG_Pex14_2	169	173	PF04695	0.221
LIG_SH2_CRK	119	123	PF00017	0.258
LIG_SH2_CRK	13	17	PF00017	0.591
LIG_SH2_CRK	78	82	PF00017	0.233
LIG_SH2_GRB2like	44	47	PF00017	0.269
LIG_SH2_NCK_1	119	123	PF00017	0.254
LIG_SH2_PTP2	80	83	PF00017	0.223
LIG_SH2_SRC	205	208	PF00017	0.699
LIG_SH2_SRC	80	83	PF00017	0.254
LIG_SH2_STAP1	86	90	PF00017	0.235
LIG_SH2_STAT5	127	130	PF00017	0.270
LIG_SH2_STAT5	44	47	PF00017	0.280
LIG_SH2_STAT5	50	53	PF00017	0.360
LIG_SH2_STAT5	80	83	PF00017	0.224
LIG_SH2_STAT5	99	102	PF00017	0.373
LIG_SH3_1	205	211	PF00018	0.666
LIG_SH3_2	211	216	PF14604	0.711
LIG_SH3_3	205	211	PF00018	0.608
LIG_SH3_3	212	218	PF00018	0.624
LIG_SH3_3	29	35	PF00018	0.428
LIG_TYR_ITIM	76	81	PF00017	0.235
LIG_UBA3_1	70	75	PF00899	0.248
LIG_WW_3	224	228	PF00397	0.746
MOD_CDC14_SPxK_1	108	111	PF00782	0.235
MOD_CDC14_SPxK_1	213	216	PF00782	0.579
MOD_CDK_SPxK_1	105	111	PF00069	0.235
MOD_CDK_SPxK_1	210	216	PF00069	0.570
MOD_CK2_1	118	124	PF00069	0.242
MOD_GlcNHglycan	152	155	PF01048	0.446
MOD_GlcNHglycan	8	11	PF01048	0.347
MOD_GSK3_1	158	165	PF00069	0.248
MOD_GSK3_1	98	105	PF00069	0.238
MOD_NEK2_1	162	167	PF00069	0.235
MOD_PIKK_1	219	225	PF00454	0.657
MOD_PIKK_1	63	69	PF00454	0.347
MOD_PKA_1	5	11	PF00069	0.658
MOD_PKA_2	102	108	PF00069	0.235
MOD_PKA_2	138	144	PF00069	0.248
MOD_Plk_1	162	168	PF00069	0.254
MOD_Plk_2-3	120	126	PF00069	0.265
MOD_Plk_2-3	158	164	PF00069	0.235
MOD_Plk_4	138	144	PF00069	0.270
MOD_ProDKin_1	105	111	PF00069	0.235
MOD_ProDKin_1	210	216	PF00069	0.600
MOD_SUMO_for_1	88	91	PF00179	0.290
MOD_SUMO_rev_2	141	149	PF00179	0.329
TRG_DiLeu_BaLyEn_6	171	176	PF01217	0.311
TRG_ENDOCYTIC_2	119	122	PF00928	0.258
TRG_ENDOCYTIC_2	13	16	PF00928	0.535
TRG_ENDOCYTIC_2	78	81	PF00928	0.235
TRG_ER_diArg_1	198	201	PF00400	0.609
TRG_NLS_MonoExtN_4	194	200	PF00514	0.648

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P429	Leptomonas seymouri	84%	100%
A0A0S4J094	Bodo saltans	68%	100%
A0A1X0NJD4	Trypanosomatidae	75%	100%
A0A3R7KS59	Trypanosoma rangeli	70%	100%
A0A3S7WXZ8	Leishmania donovani	96%	100%
A4HD67	Leishmania braziliensis	91%	100%
D0A6Y0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	72%	100%
E9AH21	Leishmania infantum	94%	100%
E9AWJ9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	92%