Enkurin domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Calmodulin-binding, putative

Species:

Leishmania major

UniProt:

Q4QAX0_LEIMA

TriTrypDb:

LmjF.24.0100 , LMJLV39_240006300 , LMJSD75_240006000

Length:

279

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0005930	axoneme	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4QAX0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QAX0

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	2
GO:0005515	protein binding	2	2
GO:0005516	calmodulin binding	3	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	11	15	PF00656	0.513
CLV_C14_Caspase3-7	60	64	PF00656	0.648
CLV_NRD_NRD_1	188	190	PF00675	0.369
CLV_NRD_NRD_1	224	226	PF00675	0.287
CLV_NRD_NRD_1	35	37	PF00675	0.646
CLV_NRD_NRD_1	69	71	PF00675	0.551
CLV_NRD_NRD_1	90	92	PF00675	0.630
CLV_PCSK_KEX2_1	224	226	PF00082	0.285
CLV_PCSK_KEX2_1	35	37	PF00082	0.600
CLV_PCSK_SKI1_1	190	194	PF00082	0.308
DOC_CKS1_1	241	246	PF01111	0.269
DOC_MAPK_gen_1	118	127	PF00069	0.611
DOC_MAPK_gen_1	128	136	PF00069	0.472
DOC_MAPK_gen_1	266	274	PF00069	0.298
DOC_MAPK_MEF2A_6	118	127	PF00069	0.611
DOC_MAPK_MEF2A_6	255	262	PF00069	0.414
DOC_USP7_MATH_1	12	16	PF00917	0.632
DOC_USP7_MATH_1	31	35	PF00917	0.659
DOC_USP7_MATH_1	40	44	PF00917	0.396
DOC_USP7_UBL2_3	236	240	PF12436	0.307
DOC_WW_Pin1_4	156	161	PF00397	0.635
DOC_WW_Pin1_4	240	245	PF00397	0.269
DOC_WW_Pin1_4	82	87	PF00397	0.577
LIG_14-3-3_CanoR_1	165	172	PF00244	0.605
LIG_APCC_ABBA_1	272	277	PF00400	0.414
LIG_BIR_II_1	1	5	PF00653	0.482
LIG_Clathr_ClatBox_1	257	261	PF01394	0.395
LIG_FHA_1	149	155	PF00498	0.486
LIG_FHA_1	42	48	PF00498	0.512
LIG_FHA_2	119	125	PF00498	0.497
LIG_FHA_2	165	171	PF00498	0.586
LIG_LIR_Gen_1	205	215	PF02991	0.269
LIG_LIR_Gen_1	235	244	PF02991	0.256
LIG_LIR_Gen_1	4	12	PF02991	0.466
LIG_LIR_Nem_3	170	175	PF02991	0.424
LIG_LIR_Nem_3	205	210	PF02991	0.269
LIG_LIR_Nem_3	235	241	PF02991	0.288
LIG_LIR_Nem_3	4	10	PF02991	0.509
LIG_NRBOX	214	220	PF00104	0.294
LIG_PTB_Apo_2	105	112	PF02174	0.646
LIG_SH2_CRK	7	11	PF00017	0.567
LIG_SH2_NCK_1	61	65	PF00017	0.612
LIG_SH2_NCK_1	7	11	PF00017	0.567
LIG_SH2_STAT5	178	181	PF00017	0.253
LIG_SH2_STAT5	61	64	PF00017	0.612
LIG_SH3_1	120	126	PF00018	0.603
LIG_SH3_2	123	128	PF14604	0.602
LIG_SH3_3	120	126	PF00018	0.603
LIG_SH3_CIN85_PxpxPR_1	160	165	PF14604	0.524
LIG_SUMO_SIM_par_1	256	261	PF11976	0.351
LIG_TRAF2_1	202	205	PF00917	0.400
LIG_TRAF2_1	248	251	PF00917	0.395
LIG_WRC_WIRS_1	73	78	PF05994	0.630
MOD_CDK_SPxxK_3	240	247	PF00069	0.269
MOD_CK1_1	208	214	PF00069	0.270
MOD_CK1_1	82	88	PF00069	0.602
MOD_CK2_1	164	170	PF00069	0.615
MOD_CK2_1	208	214	PF00069	0.279
MOD_GlcNHglycan	1	4	PF01048	0.508
MOD_GlcNHglycan	10	13	PF01048	0.518
MOD_GlcNHglycan	107	111	PF01048	0.641
MOD_GlcNHglycan	209	213	PF01048	0.198
MOD_GlcNHglycan	50	53	PF01048	0.480
MOD_GSK3_1	102	109	PF00069	0.570
MOD_GSK3_1	27	34	PF00069	0.602
MOD_GSK3_1	62	69	PF00069	0.649
MOD_GSK3_1	8	15	PF00069	0.638
MOD_NEK2_1	97	102	PF00069	0.545
MOD_PIKK_1	242	248	PF00454	0.269
MOD_PKA_2	164	170	PF00069	0.615
MOD_PKA_2	205	211	PF00069	0.253
MOD_Plk_1	106	112	PF00069	0.645
MOD_Plk_1	148	154	PF00069	0.545
MOD_Plk_1	62	68	PF00069	0.632
MOD_ProDKin_1	156	162	PF00069	0.635
MOD_ProDKin_1	240	246	PF00069	0.269
MOD_ProDKin_1	82	88	PF00069	0.577
MOD_SUMO_rev_2	194	199	PF00179	0.414
TRG_DiLeu_BaEn_1	214	219	PF01217	0.458
TRG_ENDOCYTIC_2	7	10	PF00928	0.566
TRG_ER_diArg_1	224	226	PF00400	0.283
TRG_NLS_MonoExtC_3	31	36	PF00514	0.667

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3N8	Leptomonas seymouri	75%	100%
A0A0S4IY56	Bodo saltans	44%	100%
A0A1X0NJ07	Trypanosomatidae	59%	100%
A0A3R7RTB5	Trypanosoma rangeli	57%	100%
A0A3S7WY66	Leishmania donovani	95%	100%
A0A4X1TZW7	Sus scrofa	26%	100%
D0A6Y1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	58%	100%
E1B836	Bos taurus	26%	100%
E9AH22	Leishmania infantum	95%	100%
E9AUG8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	76%
E9AWK0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
V5BAW3	Trypanosoma cruzi	57%	100%