Beta transducin-like protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

WD40/YVTN repeat-like-containing protein

Species:

Leishmania major

UniProt:

Q4QAW8_LEIMA

TriTrypDb:

LmjF.24.0130 , LMJLV39_240006500 , LMJSD75_240006200

Length:

555

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	2
GO:0043226	organelle	2	3
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	3
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	3
GO:0005840	ribosome	5	1
GO:0032991	protein-containing complex	1	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:1990904	ribonucleoprotein complex	2	1

Expansion

Sequence features

Q4QAW8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QAW8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	267	271	PF00656	0.341
CLV_C14_Caspase3-7	71	75	PF00656	0.386
CLV_NRD_NRD_1	130	132	PF00675	0.365
CLV_NRD_NRD_1	151	153	PF00675	0.430
CLV_NRD_NRD_1	239	241	PF00675	0.460
CLV_NRD_NRD_1	328	330	PF00675	0.589
CLV_PCSK_KEX2_1	130	132	PF00082	0.378
CLV_PCSK_KEX2_1	151	153	PF00082	0.389
CLV_PCSK_KEX2_1	239	241	PF00082	0.460
CLV_PCSK_KEX2_1	452	454	PF00082	0.349
CLV_PCSK_PC1ET2_1	452	454	PF00082	0.479
CLV_PCSK_SKI1_1	152	156	PF00082	0.491
CLV_PCSK_SKI1_1	233	237	PF00082	0.493
CLV_PCSK_SKI1_1	351	355	PF00082	0.426
DEG_APCC_DBOX_1	150	158	PF00400	0.405
DEG_Nend_UBRbox_1	1	4	PF02207	0.448
DEG_SPOP_SBC_1	264	268	PF00917	0.329
DEG_SPOP_SBC_1	505	509	PF00917	0.584
DOC_CYCLIN_RxL_1	149	159	PF00134	0.465
DOC_CYCLIN_yCln2_LP_2	66	72	PF00134	0.434
DOC_MAPK_DCC_7	312	322	PF00069	0.448
DOC_MAPK_gen_1	151	157	PF00069	0.488
DOC_MAPK_MEF2A_6	2	9	PF00069	0.425
DOC_PP2B_LxvP_1	543	546	PF13499	0.400
DOC_USP7_MATH_1	506	510	PF00917	0.586
DOC_USP7_UBL2_3	47	51	PF12436	0.415
DOC_WW_Pin1_4	227	232	PF00397	0.522
DOC_WW_Pin1_4	313	318	PF00397	0.496
DOC_WW_Pin1_4	461	466	PF00397	0.601
LIG_14-3-3_CanoR_1	239	248	PF00244	0.510
LIG_14-3-3_CanoR_1	290	298	PF00244	0.312
LIG_14-3-3_CanoR_1	301	306	PF00244	0.336
LIG_14-3-3_CanoR_1	34	42	PF00244	0.488
LIG_14-3-3_CanoR_1	65	69	PF00244	0.453
LIG_APCC_ABBA_1	96	101	PF00400	0.473
LIG_BRCT_BRCA1_1	80	84	PF00533	0.332
LIG_Clathr_ClatBox_1	373	377	PF01394	0.387
LIG_FHA_1	2	8	PF00498	0.562
LIG_FHA_1	302	308	PF00498	0.438
LIG_FHA_1	37	43	PF00498	0.434
LIG_FHA_1	387	393	PF00498	0.511
LIG_FHA_1	430	436	PF00498	0.401
LIG_FHA_1	445	451	PF00498	0.230
LIG_FHA_1	538	544	PF00498	0.378
LIG_FHA_2	148	154	PF00498	0.368
LIG_FHA_2	21	27	PF00498	0.540
LIG_FHA_2	337	343	PF00498	0.450
LIG_FHA_2	437	443	PF00498	0.454
LIG_GBD_Chelix_1	58	66	PF00786	0.466
LIG_LIR_Gen_1	186	197	PF02991	0.445
LIG_LIR_Gen_1	518	528	PF02991	0.368
LIG_LIR_Nem_3	186	192	PF02991	0.431
LIG_LIR_Nem_3	246	250	PF02991	0.391
LIG_LIR_Nem_3	275	279	PF02991	0.414
LIG_LIR_Nem_3	457	462	PF02991	0.578
LIG_LIR_Nem_3	518	523	PF02991	0.369
LIG_PDZ_Class_2	550	555	PF00595	0.502
LIG_REV1ctd_RIR_1	82	91	PF16727	0.356
LIG_SH2_CRK	520	524	PF00017	0.314
LIG_SH2_CRK	55	59	PF00017	0.486
LIG_SH2_GRB2like	313	316	PF00017	0.514
LIG_SH2_STAP1	142	146	PF00017	0.326
LIG_SH2_STAP1	218	222	PF00017	0.352
LIG_SH2_STAP1	292	296	PF00017	0.312
LIG_SH2_STAP1	55	59	PF00017	0.549
LIG_SH2_STAT5	222	225	PF00017	0.364
LIG_SH2_STAT5	254	257	PF00017	0.413
LIG_SH2_STAT5	313	316	PF00017	0.608
LIG_SH2_STAT5	361	364	PF00017	0.319
LIG_SH2_STAT5	385	388	PF00017	0.406
LIG_SH2_STAT5	495	498	PF00017	0.480
LIG_SH3_3	228	234	PF00018	0.574
LIG_SUMO_SIM_anti_2	74	81	PF11976	0.329
LIG_SUMO_SIM_par_1	153	159	PF11976	0.474
LIG_TYR_ITIM	187	192	PF00017	0.397
LIG_WRC_WIRS_1	550	555	PF05994	0.530
MOD_CDC14_SPxK_1	230	233	PF00782	0.517
MOD_CDK_SPxK_1	227	233	PF00069	0.482
MOD_CK1_1	156	162	PF00069	0.464
MOD_CK1_1	266	272	PF00069	0.493
MOD_CK1_1	345	351	PF00069	0.372
MOD_CK1_1	356	362	PF00069	0.398
MOD_CK1_1	426	432	PF00069	0.494
MOD_CK1_1	436	442	PF00069	0.327
MOD_CK1_1	500	506	PF00069	0.502
MOD_CK1_1	508	514	PF00069	0.610
MOD_CK2_1	147	153	PF00069	0.369
MOD_CK2_1	20	26	PF00069	0.465
MOD_CK2_1	396	402	PF00069	0.429
MOD_GlcNHglycan	200	203	PF01048	0.362
MOD_GlcNHglycan	355	359	PF01048	0.456
MOD_GlcNHglycan	425	428	PF01048	0.438
MOD_GlcNHglycan	472	475	PF01048	0.371
MOD_GlcNHglycan	515	518	PF01048	0.596
MOD_GlcNHglycan	91	94	PF01048	0.513
MOD_GSK3_1	156	163	PF00069	0.514
MOD_GSK3_1	172	179	PF00069	0.236
MOD_GSK3_1	234	241	PF00069	0.496
MOD_GSK3_1	265	272	PF00069	0.322
MOD_GSK3_1	342	349	PF00069	0.318
MOD_GSK3_1	365	372	PF00069	0.475
MOD_GSK3_1	386	393	PF00069	0.443
MOD_GSK3_1	406	413	PF00069	0.198
MOD_GSK3_1	429	436	PF00069	0.356
MOD_GSK3_1	470	477	PF00069	0.376
MOD_GSK3_1	497	504	PF00069	0.527
MOD_GSK3_1	64	71	PF00069	0.510
MOD_N-GLC_1	169	174	PF02516	0.377
MOD_N-GLC_1	212	217	PF02516	0.519
MOD_N-GLC_1	497	502	PF02516	0.543
MOD_NEK2_1	1	6	PF00069	0.525
MOD_NEK2_1	132	137	PF00069	0.376
MOD_NEK2_1	20	25	PF00069	0.544
MOD_NEK2_1	238	243	PF00069	0.513
MOD_NEK2_1	296	301	PF00069	0.493
MOD_NEK2_1	346	351	PF00069	0.369
MOD_NEK2_1	353	358	PF00069	0.389
MOD_NEK2_1	404	409	PF00069	0.455
MOD_NEK2_1	476	481	PF00069	0.328
MOD_NEK2_1	499	504	PF00069	0.621
MOD_NEK2_2	234	239	PF00069	0.550
MOD_PIKK_1	379	385	PF00454	0.379
MOD_PKA_1	239	245	PF00069	0.425
MOD_PKA_2	238	244	PF00069	0.389
MOD_PKA_2	311	317	PF00069	0.499
MOD_PKA_2	64	70	PF00069	0.487
MOD_Plk_1	212	218	PF00069	0.434
MOD_Plk_1	342	348	PF00069	0.400
MOD_Plk_1	37	43	PF00069	0.536
MOD_Plk_1	410	416	PF00069	0.357
MOD_Plk_2-3	537	543	PF00069	0.338
MOD_Plk_2-3	549	555	PF00069	0.474
MOD_Plk_4	160	166	PF00069	0.505
MOD_Plk_4	212	218	PF00069	0.419
MOD_Plk_4	301	307	PF00069	0.467
MOD_Plk_4	342	348	PF00069	0.400
MOD_Plk_4	369	375	PF00069	0.363
MOD_Plk_4	37	43	PF00069	0.572
MOD_Plk_4	411	417	PF00069	0.343
MOD_Plk_4	527	533	PF00069	0.519
MOD_Plk_4	54	60	PF00069	0.421
MOD_ProDKin_1	227	233	PF00069	0.534
MOD_ProDKin_1	313	319	PF00069	0.489
MOD_ProDKin_1	461	467	PF00069	0.596
MOD_SUMO_rev_2	108	112	PF00179	0.494
TRG_DiLeu_BaLyEn_6	135	140	PF01217	0.413
TRG_ENDOCYTIC_2	189	192	PF00928	0.409
TRG_ENDOCYTIC_2	520	523	PF00928	0.314
TRG_ENDOCYTIC_2	55	58	PF00928	0.496
TRG_ER_diArg_1	129	131	PF00400	0.379
TRG_ER_diArg_1	238	240	PF00400	0.483

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1S8	Leptomonas seymouri	74%	100%
A0A1X0NIQ5	Trypanosomatidae	47%	99%
A0A3R7NVJ1	Trypanosoma rangeli	47%	99%
A0A3S7WY01	Leishmania donovani	98%	100%
A4HD70	Leishmania braziliensis	90%	100%
C9ZSK5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	22%	87%
D0A6Y3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	48%	99%
E9AH24	Leishmania infantum	98%	100%
E9AWK2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
V5C0S8	Trypanosoma cruzi	47%	99%