Ankyrin/TPR repeat protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ankyrin/TPR repeat protein

Species:

Leishmania major

UniProt:

Q4QAW7_LEIMA

TriTrypDb:

LmjF.24.0140 , LMJLV39_240006600 , LMJSD75_240006300

Length:

394

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 8

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 7

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QAW7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QAW7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	73	77	PF00656	0.457
CLV_NRD_NRD_1	349	351	PF00675	0.368
CLV_PCSK_KEX2_1	272	274	PF00082	0.433
CLV_PCSK_PC1ET2_1	272	274	PF00082	0.452
CLV_PCSK_SKI1_1	28	32	PF00082	0.485
CLV_PCSK_SKI1_1	295	299	PF00082	0.377
CLV_PCSK_SKI1_1	351	355	PF00082	0.340
CLV_PCSK_SKI1_1	390	394	PF00082	0.471
CLV_PCSK_SKI1_1	61	65	PF00082	0.333
DEG_Nend_UBRbox_2	1	3	PF02207	0.571
DOC_CYCLIN_RxL_1	58	65	PF00134	0.333
DOC_CYCLIN_yCln2_LP_2	166	172	PF00134	0.403
DOC_MAPK_gen_1	188	195	PF00069	0.352
DOC_MAPK_gen_1	295	304	PF00069	0.370
DOC_MAPK_gen_1	350	358	PF00069	0.476
DOC_MAPK_MEF2A_6	298	306	PF00069	0.368
DOC_PP2B_LxvP_1	166	169	PF13499	0.404
DOC_USP7_MATH_1	150	154	PF00917	0.354
DOC_USP7_MATH_1	17	21	PF00917	0.510
DOC_USP7_MATH_1	235	239	PF00917	0.443
DOC_USP7_MATH_1	24	28	PF00917	0.523
DOC_USP7_MATH_1	254	258	PF00917	0.506
DOC_USP7_UBL2_3	261	265	PF12436	0.451
DOC_USP7_UBL2_3	390	394	PF12436	0.511
DOC_WW_Pin1_4	210	215	PF00397	0.313
DOC_WW_Pin1_4	243	248	PF00397	0.313
DOC_WW_Pin1_4	76	81	PF00397	0.313
LIG_14-3-3_CanoR_1	350	358	PF00244	0.431
LIG_APCC_ABBA_1	302	307	PF00400	0.379
LIG_CtBP_PxDLS_1	247	251	PF00389	0.424
LIG_FHA_1	299	305	PF00498	0.362
LIG_FHA_1	307	313	PF00498	0.416
LIG_FHA_1	57	63	PF00498	0.396
LIG_FHA_1	77	83	PF00498	0.291
LIG_FHA_2	244	250	PF00498	0.433
LIG_FHA_2	375	381	PF00498	0.479
LIG_LIR_Gen_1	179	190	PF02991	0.359
LIG_LIR_Nem_3	179	185	PF02991	0.344
LIG_LIR_Nem_3	386	392	PF02991	0.516
LIG_Pex14_1	344	348	PF04695	0.367
LIG_Pex14_2	182	186	PF04695	0.360
LIG_Pex14_2	322	326	PF04695	0.480
LIG_PTB_Apo_2	320	327	PF02174	0.388
LIG_SH2_CRK	45	49	PF00017	0.445
LIG_SH2_GRB2like	314	317	PF00017	0.365
LIG_SH2_GRB2like	321	324	PF00017	0.336
LIG_SH2_STAP1	116	120	PF00017	0.424
LIG_SH2_STAP1	164	168	PF00017	0.401
LIG_SH2_STAP1	300	304	PF00017	0.360
LIG_SH2_STAP1	314	318	PF00017	0.447
LIG_SH2_STAP1	361	365	PF00017	0.484
LIG_SH2_STAT3	321	324	PF00017	0.367
LIG_SH2_STAT5	122	125	PF00017	0.318
LIG_SH2_STAT5	300	303	PF00017	0.358
LIG_SH2_STAT5	321	324	PF00017	0.365
LIG_SH2_STAT5	327	330	PF00017	0.331
LIG_SH2_STAT5	348	351	PF00017	0.328
LIG_SH3_3	339	345	PF00018	0.429
LIG_UBA3_1	128	136	PF00899	0.424
LIG_UBA3_1	181	189	PF00899	0.383
MOD_CK1_1	109	115	PF00069	0.418
MOD_CK1_1	20	26	PF00069	0.502
MOD_GlcNHglycan	108	111	PF01048	0.420
MOD_GlcNHglycan	152	155	PF01048	0.370
MOD_GlcNHglycan	236	240	PF01048	0.424
MOD_GSK3_1	104	111	PF00069	0.424
MOD_GSK3_1	138	145	PF00069	0.482
MOD_GSK3_1	176	183	PF00069	0.361
MOD_GSK3_1	20	27	PF00069	0.444
MOD_GSK3_1	359	366	PF00069	0.507
MOD_N-GLC_1	254	259	PF02516	0.491
MOD_NEK2_1	229	234	PF00069	0.352
MOD_NEK2_1	81	86	PF00069	0.224
MOD_NEK2_2	300	305	PF00069	0.426
MOD_OFUCOSY	226	233	PF10250	0.411
MOD_PIKK_1	366	372	PF00454	0.495
MOD_PKA_1	359	365	PF00069	0.505
MOD_PKA_2	20	26	PF00069	0.440
MOD_Plk_1	24	30	PF00069	0.511
MOD_Plk_4	142	148	PF00069	0.341
MOD_ProDKin_1	210	216	PF00069	0.313
MOD_ProDKin_1	243	249	PF00069	0.313
MOD_ProDKin_1	76	82	PF00069	0.313
MOD_SUMO_for_1	384	387	PF00179	0.515
MOD_SUMO_rev_2	238	247	PF00179	0.457
TRG_DiLeu_BaEn_1	142	147	PF01217	0.413
TRG_DiLeu_BaEn_1	225	230	PF01217	0.313
TRG_DiLeu_BaEn_1	32	37	PF01217	0.418
TRG_DiLeu_BaEn_1	58	63	PF01217	0.380
TRG_DiLeu_BaEn_2	190	196	PF01217	0.326
TRG_DiLeu_BaLyEn_6	124	129	PF01217	0.366
TRG_DiLeu_LyEn_5	225	230	PF01217	0.424
TRG_DiLeu_LyEn_5	58	63	PF01217	0.380
TRG_ENDOCYTIC_2	45	48	PF00928	0.437
TRG_Pf-PMV_PEXEL_1	127	131	PF00026	0.309
TRG_Pf-PMV_PEXEL_1	28	32	PF00026	0.520
TRG_Pf-PMV_PEXEL_1	61	65	PF00026	0.333

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I340	Leptomonas seymouri	83%	100%
A0A0S4J2H9	Bodo saltans	27%	69%
A0A0S4J4D0	Bodo saltans	27%	74%
A0A0S4JCJ8	Bodo saltans	26%	87%
A0A1X0NIN0	Trypanosomatidae	65%	100%
A0A3Q8ICQ2	Leishmania donovani	96%	100%
A0A3R7N419	Trypanosoma rangeli	62%	100%
A2AS55	Mus musculus	26%	100%
A4HD71	Leishmania braziliensis	86%	100%
A6NHY2	Homo sapiens	24%	75%
C7B178	Petunia hybrida	32%	74%
C9ZRD5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	95%
D0A6Y4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	60%	100%
E5RJM6	Homo sapiens	29%	99%
E9AH25	Leishmania infantum	96%	100%
E9AWK3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
Q14DN9	Mus musculus	23%	76%
Q15653	Homo sapiens	25%	100%
Q337A0	Oryza sativa subsp. japonica	32%	76%
Q4FE45	Arabidopsis thaliana	27%	77%
Q5UPG5	Acanthamoeba polyphaga mimivirus	29%	94%
Q60778	Mus musculus	25%	100%
Q63746	Rattus norvegicus	25%	100%
Q6KAE5	Oryza sativa subsp. japonica	29%	79%
Q6NLQ8	Arabidopsis thaliana	28%	78%
Q6P6B7	Homo sapiens	26%	100%
Q7EZ44	Oryza sativa subsp. japonica	31%	80%
Q8N9B4	Homo sapiens	26%	100%
Q8Q0U0	Methanosarcina mazei (strain ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM 11833 / OCM 88)	29%	100%
Q9GKW8	Macaca fascicularis	25%	84%
Q9J516	Fowlpox virus (strain NVSL)	23%	91%
Q9J5H7	Fowlpox virus (strain NVSL)	26%	66%
Q9J5I7	Fowlpox virus (strain NVSL)	25%	90%
Q9JIA3	Rattus norvegicus	26%	100%
Q9SAR5	Arabidopsis thaliana	28%	100%
Q9WV72	Mus musculus	28%	75%
V5BW01	Trypanosoma cruzi	64%	100%