DUF4005 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QAW5_LEIMA

TriTrypDb:

LmjF.24.0160 , LMJLV39_240006800 , LMJSD75_240006500

Length:

289

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QAW5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QAW5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	168	170	PF00675	0.470
CLV_NRD_NRD_1	33	35	PF00675	0.664
CLV_NRD_NRD_1	80	82	PF00675	0.474
CLV_PCSK_KEX2_1	256	258	PF00082	0.720
CLV_PCSK_KEX2_1	33	35	PF00082	0.586
CLV_PCSK_KEX2_1	60	62	PF00082	0.689
CLV_PCSK_KEX2_1	82	84	PF00082	0.418
CLV_PCSK_PC1ET2_1	256	258	PF00082	0.720
CLV_PCSK_PC1ET2_1	60	62	PF00082	0.689
CLV_PCSK_PC1ET2_1	82	84	PF00082	0.418
CLV_PCSK_SKI1_1	128	132	PF00082	0.609
CLV_PCSK_SKI1_1	169	173	PF00082	0.466
CLV_PCSK_SKI1_1	275	279	PF00082	0.685
CLV_PCSK_SKI1_1	38	42	PF00082	0.547
CLV_PCSK_SKI1_1	64	68	PF00082	0.699
DOC_MAPK_gen_1	33	42	PF00069	0.731
DOC_PP1_RVXF_1	273	280	PF00149	0.445
DOC_PP4_FxxP_1	245	248	PF00568	0.538
DOC_USP7_MATH_1	121	125	PF00917	0.626
DOC_USP7_MATH_1	146	150	PF00917	0.481
DOC_USP7_MATH_1	240	244	PF00917	0.603
LIG_14-3-3_CanoR_1	116	121	PF00244	0.530
LIG_14-3-3_CanoR_1	239	249	PF00244	0.732
LIG_14-3-3_CanoR_1	257	262	PF00244	0.743
LIG_14-3-3_CanoR_1	64	72	PF00244	0.570
LIG_14-3-3_CanoR_1	92	99	PF00244	0.604
LIG_AP2alpha_2	120	122	PF02296	0.631
LIG_BRCT_BRCA1_1	107	111	PF00533	0.570
LIG_BRCT_BRCA1_1	118	122	PF00533	0.475
LIG_FHA_2	179	185	PF00498	0.456
LIG_FHA_2	39	45	PF00498	0.602
LIG_LIR_Apic_2	117	121	PF02991	0.557
LIG_LIR_Apic_2	243	248	PF02991	0.535
LIG_LIR_Gen_1	276	286	PF02991	0.434
LIG_LIR_Nem_3	276	282	PF02991	0.565
LIG_Pex14_1	118	122	PF04695	0.555
LIG_SH2_NCK_1	142	146	PF00017	0.419
LIG_SH2_SRC	142	145	PF00017	0.411
LIG_SH2_STAP1	142	146	PF00017	0.437
LIG_SH2_STAT5	103	106	PF00017	0.545
LIG_SH2_STAT5	231	234	PF00017	0.678
LIG_SH2_STAT5	78	81	PF00017	0.484
LIG_SH3_3	227	233	PF00018	0.510
LIG_SH3_3	42	48	PF00018	0.595
LIG_SUMO_SIM_par_1	38	44	PF11976	0.518
MOD_CK1_1	11	17	PF00069	0.571
MOD_CK1_1	124	130	PF00069	0.484
MOD_CK1_1	49	55	PF00069	0.703
MOD_CK1_1	91	97	PF00069	0.490
MOD_CK2_1	146	152	PF00069	0.526
MOD_CK2_1	178	184	PF00069	0.453
MOD_GlcNHglycan	131	134	PF01048	0.594
MOD_GlcNHglycan	148	151	PF01048	0.635
MOD_GlcNHglycan	216	219	PF01048	0.548
MOD_GlcNHglycan	48	51	PF01048	0.662
MOD_GlcNHglycan	64	67	PF01048	0.510
MOD_GlcNHglycan	99	102	PF01048	0.556
MOD_GSK3_1	122	129	PF00069	0.585
MOD_GSK3_1	158	165	PF00069	0.481
MOD_GSK3_1	214	221	PF00069	0.579
MOD_GSK3_1	248	255	PF00069	0.640
MOD_GSK3_1	256	263	PF00069	0.591
MOD_GSK3_1	281	288	PF00069	0.583
MOD_GSK3_1	60	67	PF00069	0.584
MOD_GSK3_1	7	14	PF00069	0.550
MOD_GSK3_1	72	79	PF00069	0.482
MOD_GSK3_1	88	95	PF00069	0.451
MOD_N-GLC_1	197	202	PF02516	0.417
MOD_N-GLC_1	263	268	PF02516	0.621
MOD_N-GLC_1	97	102	PF02516	0.522
MOD_NEK2_1	122	127	PF00069	0.595
MOD_NEK2_1	72	77	PF00069	0.665
MOD_NEK2_1	8	13	PF00069	0.563
MOD_NEK2_1	88	93	PF00069	0.459
MOD_NEK2_1	99	104	PF00069	0.490
MOD_PKA_1	256	262	PF00069	0.701
MOD_PKA_1	60	66	PF00069	0.500
MOD_PKA_2	122	128	PF00069	0.570
MOD_PKA_2	256	262	PF00069	0.738
MOD_PKA_2	60	66	PF00069	0.626
MOD_PKA_2	91	97	PF00069	0.566
MOD_Plk_1	158	164	PF00069	0.538
MOD_Plk_1	197	203	PF00069	0.392
MOD_Plk_1	55	61	PF00069	0.611
MOD_Plk_4	281	287	PF00069	0.631
MOD_Plk_4	99	105	PF00069	0.521
MOD_SUMO_for_1	277	280	PF00179	0.532
TRG_DiLeu_BaEn_1	187	192	PF01217	0.498
TRG_ER_diArg_1	33	35	PF00400	0.643

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PA94	Leptomonas seymouri	59%	100%
A0A0S4J4T0	Bodo saltans	33%	97%
A0A1X0NIP3	Trypanosomatidae	42%	100%
A0A3S7WY29	Leishmania donovani	93%	100%
A0A422P481	Trypanosoma rangeli	44%	100%
A4HD73	Leishmania braziliensis	81%	100%
D0A6Y5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	43%	100%
E9AH27	Leishmania infantum	93%	100%
E9AWK5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
V5DSP6	Trypanosoma cruzi	42%	100%