Phosducin domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QAW4_LEIMA

TriTrypDb:

LmjF.24.0170 , LMJLV39_240006900 , LMJSD75_240006600

Length:

242

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

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Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	2
GO:0097014	ciliary plasm	5	2
GO:0099568	cytoplasmic region	3	2
GO:0110165	cellular anatomical entity	1	2

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Expansion

Sequence features

Q4QAW4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QAW4

Function

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Biological processes
Term	Name	Level	Count
GO:0006457	protein folding	2	2
GO:0009987	cellular process	1	2

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Could not find GO molecular_function term for this entry.

Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	162	164	PF00675	0.517
CLV_NRD_NRD_1	98	100	PF00675	0.483
CLV_PCSK_FUR_1	96	100	PF00082	0.478
CLV_PCSK_KEX2_1	161	163	PF00082	0.524
CLV_PCSK_KEX2_1	209	211	PF00082	0.473
CLV_PCSK_KEX2_1	96	98	PF00082	0.474
CLV_PCSK_PC1ET2_1	209	211	PF00082	0.473
CLV_PCSK_SKI1_1	163	167	PF00082	0.383
CLV_PCSK_SKI1_1	193	197	PF00082	0.535
DEG_APCC_DBOX_1	96	104	PF00400	0.544

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1II20	Leptomonas seymouri	75%	100%
A0A0S4J2X1	Bodo saltans	51%	96%
A0A1X0NJ53	Trypanosomatidae	59%	99%
A0A3R7KUG1	Trypanosoma rangeli	30%	98%
A0A3R7KZ12	Trypanosoma rangeli	60%	92%
A0A3S7WY28	Leishmania donovani	93%	100%
A4HD74	Leishmania braziliensis	82%	100%
D0A6Y6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	63%	99%
E9AH28	Leishmania infantum	93%	100%
E9AWK6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%

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