Phosducin domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QAW4_LEIMA

TriTrypDb:

LmjF.24.0170 , LMJLV39_240006900 , LMJSD75_240006600

Length:

242

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	2
GO:0097014	ciliary plasm	5	2
GO:0099568	cytoplasmic region	3	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4QAW4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QAW4

Function

Biological processes
Term	Name	Level	Count
GO:0006457	protein folding	2	2
GO:0009987	cellular process	1	2

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	162	164	PF00675	0.517
CLV_NRD_NRD_1	98	100	PF00675	0.483
CLV_PCSK_FUR_1	96	100	PF00082	0.478
CLV_PCSK_KEX2_1	161	163	PF00082	0.524
CLV_PCSK_KEX2_1	209	211	PF00082	0.473
CLV_PCSK_KEX2_1	96	98	PF00082	0.474
CLV_PCSK_PC1ET2_1	209	211	PF00082	0.473
CLV_PCSK_SKI1_1	163	167	PF00082	0.383
CLV_PCSK_SKI1_1	193	197	PF00082	0.535
DEG_APCC_DBOX_1	96	104	PF00400	0.544
DEG_Nend_UBRbox_2	1	3	PF02207	0.609
DOC_MAPK_gen_1	161	167	PF00069	0.512
DOC_MAPK_gen_1	96	103	PF00069	0.595
DOC_MAPK_MEF2A_6	182	189	PF00069	0.324
DOC_USP7_MATH_1	130	134	PF00917	0.504
DOC_USP7_MATH_1	143	147	PF00917	0.496
DOC_USP7_UBL2_3	193	197	PF12436	0.532
DOC_USP7_UBL2_3	58	62	PF12436	0.592
LIG_14-3-3_CanoR_1	161	166	PF00244	0.500
LIG_14-3-3_CanoR_1	210	214	PF00244	0.439
LIG_14-3-3_CanoR_1	43	52	PF00244	0.581
LIG_14-3-3_CanoR_1	8	17	PF00244	0.479
LIG_APCC_ABBA_1	187	192	PF00400	0.484
LIG_FHA_1	171	177	PF00498	0.432
LIG_FHA_1	213	219	PF00498	0.300
LIG_FHA_1	28	34	PF00498	0.513
LIG_FHA_1	45	51	PF00498	0.576
LIG_FHA_1	77	83	PF00498	0.713
LIG_FHA_2	10	16	PF00498	0.489
LIG_LIR_Gen_1	11	21	PF02991	0.489
LIG_LIR_Nem_3	11	17	PF02991	0.489
LIG_LIR_Nem_3	110	115	PF02991	0.444
LIG_SH2_STAP1	172	176	PF00017	0.535
LIG_SH2_STAT3	52	55	PF00017	0.598
LIG_SH2_STAT5	123	126	PF00017	0.479
LIG_SH2_STAT5	172	175	PF00017	0.524
LIG_SH3_2	177	182	PF14604	0.412
LIG_SH3_3	174	180	PF00018	0.558
LIG_SH3_3	222	228	PF00018	0.497
LIG_SH3_5	119	123	PF00018	0.534
LIG_SUMO_SIM_anti_2	215	221	PF11976	0.495
LIG_SUMO_SIM_anti_2	32	37	PF11976	0.519
LIG_UBA3_1	100	107	PF00899	0.556
MOD_CK1_1	212	218	PF00069	0.423
MOD_CK2_1	143	149	PF00069	0.499
MOD_CK2_1	82	88	PF00069	0.703
MOD_CK2_1	9	15	PF00069	0.481
MOD_GSK3_1	125	132	PF00069	0.424
MOD_GSK3_1	150	157	PF00069	0.480
MOD_GSK3_1	166	173	PF00069	0.322
MOD_N-GLC_2	46	48	PF02516	0.594
MOD_NEK2_1	218	223	PF00069	0.546
MOD_PK_1	161	167	PF00069	0.487
MOD_PK_1	209	215	PF00069	0.478
MOD_PKA_1	161	167	PF00069	0.499
MOD_PKA_1	209	215	PF00069	0.482
MOD_PKA_2	161	167	PF00069	0.529
MOD_PKA_2	209	215	PF00069	0.520
MOD_PKA_2	9	15	PF00069	0.489
MOD_Plk_4	150	156	PF00069	0.382
MOD_Plk_4	166	172	PF00069	0.383
MOD_SUMO_for_1	61	64	PF00179	0.642
TRG_DiLeu_BaEn_3	76	82	PF01217	0.621
TRG_DiLeu_BaLyEn_6	179	184	PF01217	0.454
TRG_ER_diArg_1	161	163	PF00400	0.524
TRG_ER_diArg_1	95	98	PF00400	0.482
TRG_Pf-PMV_PEXEL_1	98	102	PF00026	0.497

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1II20	Leptomonas seymouri	75%	100%
A0A0S4J2X1	Bodo saltans	51%	96%
A0A1X0NJ53	Trypanosomatidae	59%	99%
A0A3R7KUG1	Trypanosoma rangeli	30%	98%
A0A3R7KZ12	Trypanosoma rangeli	60%	92%
A0A3S7WY28	Leishmania donovani	93%	100%
A4HD74	Leishmania braziliensis	82%	100%
D0A6Y6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	63%	99%
E9AH28	Leishmania infantum	93%	100%
E9AWK6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
V5BAV9	Trypanosoma cruzi	58%	100%