Putative ATPase domain protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ATPase domain protein, putative

Species:

Leishmania major

UniProt:

Q4QAW3_LEIMA

TriTrypDb:

LmjF.24.0180 , LMJLV39_240007000 , LMJSD75_240006700

Length:

535

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 14
NetGPI	no	yes: 0, no: 14

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	2
GO:0110165	cellular anatomical entity	1	2
GO:0005778	peroxisomal membrane	6	1
GO:0031090	organelle membrane	3	1
GO:0031903	microbody membrane	5	1
GO:0042579	microbody	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0098588	bounding membrane of organelle	4	1

Expansion

Sequence features

Q4QAW3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QAW3

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0019538	protein metabolic process	3	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044238	primary metabolic process	2	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1
GO:0009987	cellular process	1	2
GO:0051301	cell division	2	1
GO:0006605	protein targeting	5	1
GO:0006625	protein targeting to peroxisome	5	1
GO:0006810	transport	3	1
GO:0006886	intracellular protein transport	4	1
GO:0006996	organelle organization	4	1
GO:0007031	peroxisome organization	5	1
GO:0008104	protein localization	4	1
GO:0015031	protein transport	4	1
GO:0016043	cellular component organization	3	1
GO:0033036	macromolecule localization	2	1
GO:0033365	protein localization to organelle	5	1
GO:0043574	peroxisomal transport	4	1
GO:0045184	establishment of protein localization	3	1
GO:0046907	intracellular transport	3	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0051641	cellular localization	2	1
GO:0051649	establishment of localization in cell	3	1
GO:0070727	cellular macromolecule localization	3	1
GO:0071702	organic substance transport	4	1
GO:0071705	nitrogen compound transport	4	1
GO:0071840	cellular component organization or biogenesis	2	1
GO:0072594	establishment of protein localization to organelle	4	1
GO:0072662	protein localization to peroxisome	6	1
GO:0072663	establishment of protein localization to peroxisome	5	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	15
GO:0003824	catalytic activity	1	15
GO:0005488	binding	1	15
GO:0005524	ATP binding	5	15
GO:0016462	pyrophosphatase activity	5	15
GO:0016787	hydrolase activity	2	15
GO:0016817	hydrolase activity, acting on acid anhydrides	3	15
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	15
GO:0016887	ATP hydrolysis activity	7	15
GO:0017076	purine nucleotide binding	4	15
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	15
GO:0030554	adenyl nucleotide binding	5	15
GO:0032553	ribonucleotide binding	3	15
GO:0032555	purine ribonucleotide binding	4	15
GO:0032559	adenyl ribonucleotide binding	5	15
GO:0035639	purine ribonucleoside triphosphate binding	4	15
GO:0036094	small molecule binding	2	15
GO:0043167	ion binding	2	15
GO:0043168	anion binding	3	15
GO:0097159	organic cyclic compound binding	2	15
GO:0097367	carbohydrate derivative binding	2	15
GO:1901265	nucleoside phosphate binding	3	15
GO:1901363	heterocyclic compound binding	2	15
GO:0004175	endopeptidase activity	4	1
GO:0004176	ATP-dependent peptidase activity	2	1
GO:0004222	metalloendopeptidase activity	5	1
GO:0008233	peptidase activity	3	1
GO:0008237	metallopeptidase activity	4	1
GO:0140096	catalytic activity, acting on a protein	2	1
GO:0140657	ATP-dependent activity	1	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	177	179	PF00675	0.478
CLV_NRD_NRD_1	390	392	PF00675	0.373
CLV_NRD_NRD_1	463	465	PF00675	0.544
CLV_NRD_NRD_1	486	488	PF00675	0.508
CLV_NRD_NRD_1	527	529	PF00675	0.593
CLV_PCSK_KEX2_1	177	179	PF00082	0.478
CLV_PCSK_KEX2_1	390	392	PF00082	0.290
CLV_PCSK_KEX2_1	463	465	PF00082	0.547
CLV_PCSK_KEX2_1	527	529	PF00082	0.556
CLV_PCSK_SKI1_1	169	173	PF00082	0.622
CLV_PCSK_SKI1_1	177	181	PF00082	0.539
CLV_PCSK_SKI1_1	205	209	PF00082	0.468
CLV_PCSK_SKI1_1	390	394	PF00082	0.290
CLV_PCSK_SKI1_1	487	491	PF00082	0.379
DEG_APCC_DBOX_1	176	184	PF00400	0.573
DEG_APCC_DBOX_1	389	397	PF00400	0.382
DEG_SPOP_SBC_1	135	139	PF00917	0.395
DEG_SPOP_SBC_1	85	89	PF00917	0.551
DOC_CDC14_PxL_1	434	442	PF14671	0.326
DOC_CYCLIN_yCln2_LP_2	100	106	PF00134	0.368
DOC_CYCLIN_yCln2_LP_2	62	68	PF00134	0.550
DOC_MAPK_DCC_7	348	356	PF00069	0.209
DOC_MAPK_gen_1	262	271	PF00069	0.491
DOC_MAPK_gen_1	348	357	PF00069	0.306
DOC_MAPK_gen_1	427	437	PF00069	0.277
DOC_MAPK_gen_1	463	470	PF00069	0.407
DOC_MAPK_MEF2A_6	348	356	PF00069	0.266
DOC_PP2B_LxvP_1	507	510	PF13499	0.377
DOC_PP2B_LxvP_1	62	65	PF13499	0.548
DOC_USP7_MATH_1	135	139	PF00917	0.465
DOC_USP7_MATH_1	201	205	PF00917	0.600
DOC_USP7_MATH_1	273	277	PF00917	0.548
DOC_USP7_MATH_1	32	36	PF00917	0.454
DOC_USP7_MATH_1	37	41	PF00917	0.450
DOC_USP7_MATH_1	478	482	PF00917	0.387
DOC_USP7_MATH_1	66	70	PF00917	0.411
DOC_USP7_MATH_1	85	89	PF00917	0.506
DOC_USP7_UBL2_3	30	34	PF12436	0.443
DOC_WW_Pin1_4	241	246	PF00397	0.693
DOC_WW_Pin1_4	274	279	PF00397	0.607
LIG_14-3-3_CanoR_1	178	184	PF00244	0.559
LIG_14-3-3_CanoR_1	264	269	PF00244	0.469
LIG_14-3-3_CanoR_1	309	315	PF00244	0.349
LIG_Actin_WH2_2	326	343	PF00022	0.306
LIG_Actin_WH2_2	482	498	PF00022	0.513
LIG_Actin_WH2_2	512	529	PF00022	0.512
LIG_BIR_II_1	1	5	PF00653	0.455
LIG_BRCT_BRCA1_1	316	320	PF00533	0.385
LIG_deltaCOP1_diTrp_1	446	453	PF00928	0.359
LIG_EH1_1	262	270	PF00400	0.507
LIG_FHA_1	290	296	PF00498	0.389
LIG_FHA_1	40	46	PF00498	0.460
LIG_FHA_1	409	415	PF00498	0.367
LIG_FHA_2	309	315	PF00498	0.255
LIG_FHA_2	509	515	PF00498	0.528
LIG_Integrin_RGD_1	372	374	PF01839	0.190
LIG_LIR_Apic_2	433	439	PF02991	0.350
LIG_LIR_Gen_1	21	27	PF02991	0.362
LIG_LIR_Gen_1	314	323	PF02991	0.225
LIG_LIR_Gen_1	450	460	PF02991	0.461
LIG_LIR_Gen_1	78	85	PF02991	0.489
LIG_LIR_Nem_3	21	26	PF02991	0.422
LIG_LIR_Nem_3	314	318	PF02991	0.390
LIG_LIR_Nem_3	326	332	PF02991	0.308
LIG_LIR_Nem_3	450	456	PF02991	0.372
LIG_LIR_Nem_3	78	84	PF02991	0.506
LIG_MYND_1	163	167	PF01753	0.407
LIG_MYND_1	99	103	PF01753	0.377
LIG_NRBOX	113	119	PF00104	0.395
LIG_NRBOX	127	133	PF00104	0.467
LIG_NRBOX	392	398	PF00104	0.277
LIG_PCNA_yPIPBox_3	427	435	PF02747	0.425
LIG_PCNA_yPIPBox_3	483	496	PF02747	0.499
LIG_Pex14_1	448	452	PF04695	0.359
LIG_Pex14_1	77	81	PF04695	0.406
LIG_Pex14_2	452	456	PF04695	0.398
LIG_REV1ctd_RIR_1	450	459	PF16727	0.449
LIG_SH2_CRK	81	85	PF00017	0.481
LIG_SH2_NCK_1	81	85	PF00017	0.413
LIG_SH2_PTP2	436	439	PF00017	0.326
LIG_SH2_SRC	436	439	PF00017	0.350
LIG_SH2_STAP1	81	85	PF00017	0.413
LIG_SH2_STAT5	332	335	PF00017	0.340
LIG_SH2_STAT5	436	439	PF00017	0.305
LIG_SH2_STAT5	484	487	PF00017	0.395
LIG_SH3_3	180	186	PF00018	0.629
LIG_SH3_3	432	438	PF00018	0.326
LIG_SH3_3	526	532	PF00018	0.461
LIG_SUMO_SIM_anti_2	110	116	PF11976	0.394
LIG_SUMO_SIM_anti_2	358	364	PF11976	0.315
LIG_SUMO_SIM_par_1	353	359	PF11976	0.306
LIG_SUMO_SIM_par_1	465	472	PF11976	0.487
LIG_TYR_ITIM	79	84	PF00017	0.479
LIG_UBA3_1	22	30	PF00899	0.392
LIG_WRC_WIRS_1	38	43	PF05994	0.433
MOD_CK1_1	146	152	PF00069	0.410
MOD_CK1_1	287	293	PF00069	0.536
MOD_CK1_1	40	46	PF00069	0.494
MOD_CK1_1	503	509	PF00069	0.474
MOD_CK1_1	87	93	PF00069	0.559
MOD_CK2_1	187	193	PF00069	0.636
MOD_CK2_1	508	514	PF00069	0.529
MOD_GlcNHglycan	145	148	PF01048	0.439
MOD_GlcNHglycan	196	199	PF01048	0.629
MOD_GlcNHglycan	299	302	PF01048	0.279
MOD_GlcNHglycan	378	381	PF01048	0.383
MOD_GlcNHglycan	405	409	PF01048	0.348
MOD_GlcNHglycan	42	45	PF01048	0.473
MOD_GlcNHglycan	491	495	PF01048	0.474
MOD_GlcNHglycan	502	505	PF01048	0.508
MOD_GSK3_1	217	224	PF00069	0.522
MOD_GSK3_1	284	291	PF00069	0.541
MOD_GSK3_1	323	330	PF00069	0.434
MOD_GSK3_1	33	40	PF00069	0.496
MOD_GSK3_1	404	411	PF00069	0.406
MOD_GSK3_1	80	87	PF00069	0.473
MOD_LATS_1	241	247	PF00433	0.668
MOD_N-GLC_2	211	213	PF02516	0.534
MOD_NEK2_1	117	122	PF00069	0.414
MOD_NEK2_1	136	141	PF00069	0.415
MOD_NEK2_1	179	184	PF00069	0.561
MOD_NEK2_1	187	192	PF00069	0.573
MOD_NEK2_1	194	199	PF00069	0.611
MOD_NEK2_1	284	289	PF00069	0.587
MOD_NEK2_1	327	332	PF00069	0.277
MOD_NEK2_1	386	391	PF00069	0.340
MOD_NEK2_1	469	474	PF00069	0.463
MOD_NEK2_1	490	495	PF00069	0.447
MOD_NEK2_1	519	524	PF00069	0.404
MOD_NEK2_2	18	23	PF00069	0.413
MOD_PIKK_1	146	152	PF00454	0.410
MOD_PIKK_1	381	387	PF00454	0.255
MOD_PIKK_1	438	444	PF00454	0.504
MOD_PK_1	102	108	PF00069	0.382
MOD_PKA_2	308	314	PF00069	0.408
MOD_PKB_1	262	270	PF00069	0.507
MOD_Plk_1	18	24	PF00069	0.504
MOD_Plk_1	234	240	PF00069	0.459
MOD_Plk_1	323	329	PF00069	0.326
MOD_Plk_1	490	496	PF00069	0.468
MOD_Plk_1	72	78	PF00069	0.464
MOD_Plk_4	18	24	PF00069	0.404
MOD_Plk_4	234	240	PF00069	0.540
MOD_Plk_4	267	273	PF00069	0.398
MOD_Plk_4	323	329	PF00069	0.370
MOD_Plk_4	430	436	PF00069	0.306
MOD_Plk_4	508	514	PF00069	0.394
MOD_Plk_4	521	527	PF00069	0.430
MOD_ProDKin_1	241	247	PF00069	0.693
MOD_ProDKin_1	274	280	PF00069	0.614
TRG_DiLeu_BaEn_2	18	24	PF01217	0.338
TRG_DiLeu_BaEn_2	233	239	PF01217	0.641
TRG_DiLeu_BaLyEn_6	123	128	PF01217	0.405
TRG_DiLeu_BaLyEn_6	175	180	PF01217	0.558
TRG_DiLeu_BaLyEn_6	96	101	PF01217	0.419
TRG_ENDOCYTIC_2	81	84	PF00928	0.481
TRG_ER_diArg_1	177	179	PF00400	0.477
TRG_ER_diArg_1	261	264	PF00400	0.506
TRG_ER_diArg_1	348	351	PF00400	0.369
TRG_ER_diArg_1	390	392	PF00400	0.382
TRG_ER_diArg_1	526	528	PF00400	0.591
TRG_Pf-PMV_PEXEL_1	15	19	PF00026	0.499
TRG_Pf-PMV_PEXEL_1	169	173	PF00026	0.633
TRG_Pf-PMV_PEXEL_1	229	233	PF00026	0.521
TRG_Pf-PMV_PEXEL_1	331	335	PF00026	0.320

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HTJ8	Leptomonas seymouri	63%	100%
A0A0S4IKL1	Bodo saltans	28%	80%
A0A0S4J3P5	Bodo saltans	32%	100%
A0A1X0NKH8	Trypanosomatidae	36%	100%
A0A1X0NXH5	Trypanosomatidae	25%	75%
A0A3Q8IG04	Leishmania donovani	93%	100%
A0A3R7MBQ6	Trypanosoma rangeli	38%	100%
A4HD75	Leishmania braziliensis	83%	95%
D0A6Y7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	99%
E9AH29	Leishmania infantum	93%	100%
E9AWK7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
V5B4C8	Trypanosoma cruzi	26%	93%
V5BRB9	Trypanosoma cruzi	40%	100%