HEAT repeat-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QAW2_LEIMA

TriTrypDb:

LmjF.24.0190 , LMJLV39_240007100 , LMJSD75_240006800

Length:

813

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0005929	cilium	4	2
GO:0042995	cell projection	2	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0110165	cellular anatomical entity	1	2
GO:0120025	plasma membrane bounded cell projection	3	2

Expansion

Sequence features

Q4QAW2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QAW2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	149	153	PF00656	0.442
CLV_C14_Caspase3-7	711	715	PF00656	0.447
CLV_MEL_PAP_1	436	442	PF00089	0.348
CLV_NRD_NRD_1	337	339	PF00675	0.330
CLV_NRD_NRD_1	400	402	PF00675	0.451
CLV_NRD_NRD_1	657	659	PF00675	0.469
CLV_NRD_NRD_1	716	718	PF00675	0.372
CLV_NRD_NRD_1	736	738	PF00675	0.321
CLV_NRD_NRD_1	761	763	PF00675	0.611
CLV_NRD_NRD_1	777	779	PF00675	0.561
CLV_NRD_NRD_1	809	811	PF00675	0.740
CLV_PCSK_KEX2_1	337	339	PF00082	0.330
CLV_PCSK_KEX2_1	400	402	PF00082	0.451
CLV_PCSK_KEX2_1	696	698	PF00082	0.488
CLV_PCSK_KEX2_1	716	718	PF00082	0.493
CLV_PCSK_KEX2_1	736	738	PF00082	0.293
CLV_PCSK_KEX2_1	777	779	PF00082	0.705
CLV_PCSK_KEX2_1	811	813	PF00082	0.738
CLV_PCSK_PC1ET2_1	696	698	PF00082	0.455
CLV_PCSK_PC1ET2_1	811	813	PF00082	0.723
CLV_PCSK_SKI1_1	189	193	PF00082	0.399
CLV_PCSK_SKI1_1	319	323	PF00082	0.327
CLV_PCSK_SKI1_1	416	420	PF00082	0.464
CLV_PCSK_SKI1_1	425	429	PF00082	0.445
CLV_PCSK_SKI1_1	463	467	PF00082	0.351
CLV_PCSK_SKI1_1	477	481	PF00082	0.272
CLV_PCSK_SKI1_1	542	546	PF00082	0.423
CLV_PCSK_SKI1_1	643	647	PF00082	0.367
CLV_PCSK_SKI1_1	736	740	PF00082	0.457
CLV_PCSK_SKI1_1	741	745	PF00082	0.419
CLV_PCSK_SKI1_1	796	800	PF00082	0.643
DEG_APCC_DBOX_1	131	139	PF00400	0.498
DEG_APCC_DBOX_1	337	345	PF00400	0.321
DEG_APCC_DBOX_1	462	470	PF00400	0.411
DEG_APCC_DBOX_1	718	726	PF00400	0.509
DEG_APCC_DBOX_1	736	744	PF00400	0.413
DEG_Nend_UBRbox_2	1	3	PF02207	0.555
DOC_CKS1_1	194	199	PF01111	0.384
DOC_CYCLIN_RxL_1	263	274	PF00134	0.325
DOC_CYCLIN_RxL_1	422	432	PF00134	0.405
DOC_CYCLIN_RxL_1	643	656	PF00134	0.423
DOC_MAPK_FxFP_2	405	408	PF00069	0.443
DOC_MAPK_gen_1	745	755	PF00069	0.576
DOC_PP1_RVXF_1	122	128	PF00149	0.453
DOC_PP1_RVXF_1	198	204	PF00149	0.310
DOC_PP1_RVXF_1	498	504	PF00149	0.437
DOC_PP2B_LxvP_1	262	265	PF13499	0.435
DOC_PP2B_PxIxI_1	196	202	PF00149	0.425
DOC_PP4_FxxP_1	331	334	PF00568	0.289
DOC_PP4_FxxP_1	405	408	PF00568	0.443
DOC_USP7_MATH_1	117	121	PF00917	0.401
DOC_USP7_MATH_1	17	21	PF00917	0.638
DOC_USP7_MATH_1	438	442	PF00917	0.460
DOC_USP7_MATH_1	704	708	PF00917	0.582
DOC_USP7_UBL2_3	141	145	PF12436	0.477
DOC_USP7_UBL2_3	28	32	PF12436	0.725
DOC_USP7_UBL2_3	729	733	PF12436	0.414
DOC_WW_Pin1_4	193	198	PF00397	0.399
DOC_WW_Pin1_4	2	7	PF00397	0.570
DOC_WW_Pin1_4	452	457	PF00397	0.469
DOC_WW_Pin1_4	754	759	PF00397	0.674
DOC_WW_Pin1_4	800	805	PF00397	0.798
LIG_14-3-3_CanoR_1	124	128	PF00244	0.464
LIG_14-3-3_CanoR_1	18	26	PF00244	0.721
LIG_14-3-3_CanoR_1	319	329	PF00244	0.299
LIG_14-3-3_CanoR_1	439	446	PF00244	0.431
LIG_14-3-3_CanoR_1	50	55	PF00244	0.759
LIG_14-3-3_CanoR_1	500	504	PF00244	0.428
LIG_14-3-3_CanoR_1	542	550	PF00244	0.423
LIG_14-3-3_CanoR_1	604	608	PF00244	0.410
LIG_14-3-3_CanoR_1	616	621	PF00244	0.370
LIG_14-3-3_CanoR_1	796	804	PF00244	0.646
LIG_Actin_WH2_2	480	498	PF00022	0.421
LIG_AP_GAE_1	666	672	PF02883	0.283
LIG_AP2alpha_1	384	388	PF02296	0.336
LIG_APCC_ABBA_1	381	386	PF00400	0.418
LIG_BRCT_BRCA1_1	611	615	PF00533	0.347
LIG_eIF4E_1	336	342	PF01652	0.445
LIG_EVH1_1	755	759	PF00568	0.599
LIG_FHA_1	194	200	PF00498	0.350
LIG_FHA_1	371	377	PF00498	0.312
LIG_FHA_1	455	461	PF00498	0.390
LIG_FHA_1	543	549	PF00498	0.413
LIG_FHA_1	70	76	PF00498	0.567
LIG_FHA_1	768	774	PF00498	0.677
LIG_FHA_1	789	795	PF00498	0.693
LIG_FHA_2	147	153	PF00498	0.439
LIG_FHA_2	391	397	PF00498	0.427
LIG_FHA_2	541	547	PF00498	0.376
LIG_GBD_Chelix_1	206	214	PF00786	0.231
LIG_GBD_Chelix_1	480	488	PF00786	0.439
LIG_LIR_Apic_2	2	6	PF02991	0.595
LIG_LIR_Apic_2	330	334	PF02991	0.299
LIG_LIR_Gen_1	305	314	PF02991	0.333
LIG_LIR_Gen_1	462	472	PF02991	0.446
LIG_LIR_Gen_1	502	512	PF02991	0.379
LIG_LIR_Gen_1	606	615	PF02991	0.369
LIG_LIR_Gen_1	666	676	PF02991	0.351
LIG_LIR_Nem_3	126	131	PF02991	0.349
LIG_LIR_Nem_3	212	216	PF02991	0.366
LIG_LIR_Nem_3	305	310	PF02991	0.321
LIG_LIR_Nem_3	330	335	PF02991	0.377
LIG_LIR_Nem_3	339	345	PF02991	0.276
LIG_LIR_Nem_3	363	367	PF02991	0.301
LIG_LIR_Nem_3	462	468	PF02991	0.445
LIG_LIR_Nem_3	502	507	PF02991	0.383
LIG_LIR_Nem_3	606	610	PF02991	0.367
LIG_LIR_Nem_3	612	618	PF02991	0.360
LIG_NRBOX	146	152	PF00104	0.464
LIG_NRBOX	171	177	PF00104	0.439
LIG_NRBOX	305	311	PF00104	0.330
LIG_NRBOX	507	513	PF00104	0.393
LIG_NRBOX	739	745	PF00104	0.440
LIG_Pex14_2	384	388	PF04695	0.424
LIG_REV1ctd_RIR_1	615	625	PF16727	0.430
LIG_SH2_CRK	3	7	PF00017	0.551
LIG_SH2_SRC	213	216	PF00017	0.402
LIG_SH2_STAT3	602	605	PF00017	0.444
LIG_SH2_STAT5	100	103	PF00017	0.423
LIG_SH2_STAT5	114	117	PF00017	0.359
LIG_SH2_STAT5	213	216	PF00017	0.343
LIG_SH2_STAT5	490	493	PF00017	0.451
LIG_SH2_STAT5	535	538	PF00017	0.353
LIG_SH2_STAT5	607	610	PF00017	0.289
LIG_SH2_STAT5	691	694	PF00017	0.409
LIG_SH3_3	133	139	PF00018	0.473
LIG_SH3_3	191	197	PF00018	0.440
LIG_SH3_3	512	518	PF00018	0.475
LIG_SH3_3	65	71	PF00018	0.639
LIG_SH3_3	753	759	PF00018	0.749
LIG_SH3_3	761	767	PF00018	0.656
LIG_SH3_3	789	795	PF00018	0.734
LIG_SUMO_SIM_anti_2	221	227	PF11976	0.440
LIG_SUMO_SIM_par_1	133	140	PF11976	0.494
LIG_SUMO_SIM_par_1	190	196	PF11976	0.388
LIG_SUMO_SIM_par_1	323	330	PF11976	0.307
LIG_SUMO_SIM_par_1	426	434	PF11976	0.435
LIG_TRAF2_1	107	110	PF00917	0.415
LIG_TRAF2_1	311	314	PF00917	0.481
LIG_TRAF2_1	538	541	PF00917	0.369
LIG_TRAF2_1	664	667	PF00917	0.485
LIG_TYR_ITIM	211	216	PF00017	0.402
LIG_UBA3_1	223	230	PF00899	0.448
LIG_UBA3_1	341	346	PF00899	0.444
LIG_UBA3_1	752	760	PF00899	0.591
LIG_WRC_WIRS_1	536	541	PF05994	0.368
MOD_CDC14_SPxK_1	757	760	PF00782	0.701
MOD_CDK_SPxK_1	754	760	PF00069	0.679
MOD_CDK_SPxK_1	800	806	PF00069	0.702
MOD_CDK_SPxxK_3	193	200	PF00069	0.382
MOD_CK1_1	20	26	PF00069	0.602
MOD_CK1_1	429	435	PF00069	0.479
MOD_CK1_1	499	505	PF00069	0.489
MOD_CK1_1	513	519	PF00069	0.302
MOD_CK1_1	781	787	PF00069	0.670
MOD_CK2_1	104	110	PF00069	0.433
MOD_CK2_1	2	8	PF00069	0.513
MOD_CK2_1	308	314	PF00069	0.469
MOD_CK2_1	390	396	PF00069	0.467
MOD_CK2_1	535	541	PF00069	0.386
MOD_CK2_1	573	579	PF00069	0.329
MOD_CK2_1	743	749	PF00069	0.458
MOD_Cter_Amidation	714	717	PF01082	0.374
MOD_Cter_Amidation	760	763	PF01082	0.625
MOD_GlcNHglycan	109	113	PF01048	0.492
MOD_GlcNHglycan	36	39	PF01048	0.648
MOD_GlcNHglycan	440	443	PF01048	0.412
MOD_GlcNHglycan	504	507	PF01048	0.394
MOD_GlcNHglycan	57	61	PF01048	0.662
MOD_GlcNHglycan	611	614	PF01048	0.329
MOD_GSK3_1	104	111	PF00069	0.426
MOD_GSK3_1	137	144	PF00069	0.487
MOD_GSK3_1	146	153	PF00069	0.384
MOD_GSK3_1	214	221	PF00069	0.449
MOD_GSK3_1	30	37	PF00069	0.671
MOD_GSK3_1	347	354	PF00069	0.467
MOD_GSK3_1	370	377	PF00069	0.384
MOD_GSK3_1	410	417	PF00069	0.337
MOD_GSK3_1	490	497	PF00069	0.498
MOD_GSK3_1	586	593	PF00069	0.448
MOD_GSK3_1	653	660	PF00069	0.474
MOD_GSK3_1	796	803	PF00069	0.714
MOD_N-GLC_1	117	122	PF02516	0.426
MOD_N-GLC_1	228	233	PF02516	0.449
MOD_N-GLC_2	599	601	PF02516	0.306
MOD_NEK2_1	150	155	PF00069	0.465
MOD_NEK2_1	187	192	PF00069	0.379
MOD_NEK2_1	495	500	PF00069	0.486
MOD_NEK2_1	646	651	PF00069	0.396
MOD_NEK2_1	653	658	PF00069	0.433
MOD_PIKK_1	17	23	PF00454	0.565
MOD_PIKK_1	651	657	PF00454	0.444
MOD_PKA_2	123	129	PF00069	0.469
MOD_PKA_2	17	23	PF00069	0.702
MOD_PKA_2	438	444	PF00069	0.320
MOD_PKA_2	499	505	PF00069	0.430
MOD_PKA_2	603	609	PF00069	0.447
MOD_PKA_2	635	641	PF00069	0.478
MOD_PKA_2	657	663	PF00069	0.521
MOD_Plk_1	540	546	PF00069	0.352
MOD_Plk_1	578	584	PF00069	0.286
MOD_Plk_2-3	104	110	PF00069	0.517
MOD_Plk_2-3	308	314	PF00069	0.469
MOD_Plk_2-3	374	380	PF00069	0.461
MOD_Plk_2-3	540	546	PF00069	0.429
MOD_Plk_4	146	152	PF00069	0.410
MOD_Plk_4	187	193	PF00069	0.351
MOD_Plk_4	214	220	PF00069	0.470
MOD_Plk_4	471	477	PF00069	0.246
MOD_Plk_4	499	505	PF00069	0.436
MOD_Plk_4	510	516	PF00069	0.436
MOD_Plk_4	558	564	PF00069	0.446
MOD_Plk_4	566	572	PF00069	0.419
MOD_Plk_4	578	584	PF00069	0.192
MOD_Plk_4	603	609	PF00069	0.424
MOD_ProDKin_1	193	199	PF00069	0.388
MOD_ProDKin_1	2	8	PF00069	0.566
MOD_ProDKin_1	452	458	PF00069	0.458
MOD_ProDKin_1	754	760	PF00069	0.679
MOD_ProDKin_1	800	806	PF00069	0.799
MOD_SUMO_for_1	744	747	PF00179	0.431
MOD_SUMO_rev_2	374	384	PF00179	0.363
MOD_SUMO_rev_2	489	498	PF00179	0.541
TRG_DiLeu_BaEn_1	355	360	PF01217	0.313
TRG_DiLeu_BaEn_2	362	368	PF01217	0.307
TRG_DiLeu_BaEn_3	667	673	PF01217	0.407
TRG_DiLeu_BaLyEn_6	464	469	PF01217	0.419
TRG_DiLeu_BaLyEn_6	648	653	PF01217	0.408
TRG_DiLeu_LyEn_5	448	453	PF01217	0.462
TRG_ENDOCYTIC_2	213	216	PF00928	0.402
TRG_ENDOCYTIC_2	607	610	PF00928	0.335
TRG_ER_diArg_1	278	281	PF00400	0.360
TRG_ER_diArg_1	336	338	PF00400	0.311
TRG_ER_diArg_1	810	813	PF00400	0.714
TRG_ER_FFAT_2	497	509	PF00635	0.388
TRG_NES_CRM1_1	205	220	PF08389	0.410
TRG_NES_CRM1_1	284	296	PF08389	0.332
TRG_NLS_MonoExtN_4	25	31	PF00514	0.716
TRG_Pf-PMV_PEXEL_1	467	471	PF00026	0.435
TRG_Pf-PMV_PEXEL_1	542	546	PF00026	0.416
TRG_Pf-PMV_PEXEL_1	750	754	PF00026	0.602

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P426	Leptomonas seymouri	70%	99%
A0A1X0NKB5	Trypanosomatidae	49%	100%
A0A3Q8IBR9	Leishmania donovani	96%	100%
A0A3S5ISP0	Trypanosoma rangeli	45%	100%
A4HD76	Leishmania braziliensis	86%	100%
D0A6Y8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	47%	100%
E9AH30	Leishmania infantum	96%	100%
E9AWK8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
Q6NUP7	Homo sapiens	23%	93%
Q8C0Y0	Mus musculus	23%	93%
V5C0S3	Trypanosoma cruzi	48%	100%