Transcription elongation factor-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

transcription elongation factor-like protein

Species:

Leishmania major

UniProt:

Q4QAW1_LEIMA

TriTrypDb:

LmjF.24.0200 , LMJLV39_240007200 , LMJSD75_240006900

Length:

305

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

Q4QAW1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QAW1

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	7
GO:0006351	DNA-templated transcription	7	7
GO:0006725	cellular aromatic compound metabolic process	3	7
GO:0006807	nitrogen compound metabolic process	2	7
GO:0008152	metabolic process	1	7
GO:0009058	biosynthetic process	2	7
GO:0009059	macromolecule biosynthetic process	4	7
GO:0009987	cellular process	1	7
GO:0016070	RNA metabolic process	5	7
GO:0018130	heterocycle biosynthetic process	4	7
GO:0019438	aromatic compound biosynthetic process	4	7
GO:0032774	RNA biosynthetic process	5	7
GO:0034641	cellular nitrogen compound metabolic process	3	7
GO:0034654	nucleobase-containing compound biosynthetic process	4	7
GO:0043170	macromolecule metabolic process	3	7
GO:0044237	cellular metabolic process	2	7
GO:0044238	primary metabolic process	2	7
GO:0044249	cellular biosynthetic process	3	7
GO:0044271	cellular nitrogen compound biosynthetic process	4	7
GO:0046483	heterocycle metabolic process	3	7
GO:0071704	organic substance metabolic process	2	7
GO:0090304	nucleic acid metabolic process	4	7
GO:0097659	nucleic acid-templated transcription	6	7
GO:1901360	organic cyclic compound metabolic process	3	7
GO:1901362	organic cyclic compound biosynthetic process	4	7
GO:1901576	organic substance biosynthetic process	3	7

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	7
GO:0003746	translation elongation factor activity	4	7
GO:0005488	binding	1	7
GO:0008135	translation factor activity, RNA binding	3	7
GO:0045182	translation regulator activity	1	7
GO:0090079	translation regulator activity, nucleic acid binding	2	7
GO:0097159	organic cyclic compound binding	2	7
GO:1901363	heterocyclic compound binding	2	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	169	171	PF00675	0.461
CLV_NRD_NRD_1	279	281	PF00675	0.547
CLV_NRD_NRD_1	42	44	PF00675	0.629
CLV_NRD_NRD_1	70	72	PF00675	0.647
CLV_PCSK_FUR_1	237	241	PF00082	0.449
CLV_PCSK_KEX2_1	169	171	PF00082	0.406
CLV_PCSK_KEX2_1	239	241	PF00082	0.454
CLV_PCSK_KEX2_1	279	281	PF00082	0.547
CLV_PCSK_KEX2_1	42	44	PF00082	0.601
CLV_PCSK_PC1ET2_1	239	241	PF00082	0.454
CLV_PCSK_PC7_1	38	44	PF00082	0.574
CLV_PCSK_SKI1_1	120	124	PF00082	0.434
CLV_PCSK_SKI1_1	162	166	PF00082	0.574
CLV_PCSK_SKI1_1	83	87	PF00082	0.515
DEG_SCF_FBW7_1	59	66	PF00400	0.539
DOC_MAPK_gen_1	225	233	PF00069	0.421
DOC_MAPK_gen_1	71	78	PF00069	0.541
DOC_USP7_MATH_1	160	164	PF00917	0.466
DOC_USP7_MATH_1	19	23	PF00917	0.436
DOC_USP7_MATH_1	63	67	PF00917	0.525
DOC_WW_Pin1_4	217	222	PF00397	0.488
DOC_WW_Pin1_4	59	64	PF00397	0.687
LIG_14-3-3_CanoR_1	183	189	PF00244	0.604
LIG_14-3-3_CanoR_1	207	214	PF00244	0.475
LIG_14-3-3_CanoR_1	228	234	PF00244	0.430
LIG_14-3-3_CanoR_1	240	245	PF00244	0.454
LIG_14-3-3_CanoR_1	38	46	PF00244	0.745
LIG_Actin_WH2_2	119	137	PF00022	0.388
LIG_BIR_II_1	1	5	PF00653	0.627
LIG_BRCT_BRCA1_1	229	233	PF00533	0.363
LIG_Clathr_ClatBox_1	148	152	PF01394	0.473
LIG_CtBP_PxDLS_1	145	149	PF00389	0.418
LIG_FHA_1	121	127	PF00498	0.439
LIG_FHA_1	187	193	PF00498	0.389
LIG_FHA_1	207	213	PF00498	0.514
LIG_FHA_1	218	224	PF00498	0.536
LIG_FHA_1	284	290	PF00498	0.506
LIG_FHA_1	60	66	PF00498	0.545
LIG_FHA_2	191	197	PF00498	0.442
LIG_LIR_Gen_1	201	211	PF02991	0.462
LIG_LIR_Nem_3	201	206	PF02991	0.419
LIG_NRBOX	138	144	PF00104	0.341
LIG_NRP_CendR_1	304	305	PF00754	0.462
LIG_PCNA_yPIPBox_3	183	192	PF02747	0.439
LIG_PTB_Apo_2	202	209	PF02174	0.457
LIG_Rb_LxCxE_1	187	209	PF01857	0.335
LIG_SH2_GRB2like	203	206	PF00017	0.430
LIG_SH2_STAT5	180	183	PF00017	0.456
LIG_SUMO_SIM_anti_2	152	158	PF11976	0.436
LIG_SUMO_SIM_par_1	146	153	PF11976	0.439
MOD_CDK_SPK_2	59	64	PF00069	0.534
MOD_CK1_1	137	143	PF00069	0.470
MOD_CK1_1	259	265	PF00069	0.474
MOD_CK1_1	290	296	PF00069	0.486
MOD_CK1_1	37	43	PF00069	0.631
MOD_CK1_1	4	10	PF00069	0.588
MOD_CK1_1	49	55	PF00069	0.547
MOD_CK1_1	87	93	PF00069	0.454
MOD_CK2_1	10	16	PF00069	0.615
MOD_CK2_1	190	196	PF00069	0.525
MOD_CK2_1	279	285	PF00069	0.531
MOD_Cter_Amidation	237	240	PF01082	0.452
MOD_GlcNHglycan	139	142	PF01048	0.467
MOD_GlcNHglycan	242	245	PF01048	0.446
MOD_GlcNHglycan	258	261	PF01048	0.396
MOD_GlcNHglycan	55	58	PF01048	0.658
MOD_GlcNHglycan	65	68	PF01048	0.606
MOD_GlcNHglycan	89	92	PF01048	0.481
MOD_GlcNHglycan	9	12	PF01048	0.597
MOD_GlcNHglycan	94	97	PF01048	0.457
MOD_GSK3_1	1	8	PF00069	0.672
MOD_GSK3_1	186	193	PF00069	0.451
MOD_GSK3_1	279	286	PF00069	0.528
MOD_GSK3_1	287	294	PF00069	0.466
MOD_GSK3_1	45	52	PF00069	0.752
MOD_GSK3_1	53	60	PF00069	0.616
MOD_GSK3_1	87	94	PF00069	0.429
MOD_N-GLC_1	184	189	PF02516	0.512
MOD_NEK2_1	134	139	PF00069	0.445
MOD_NEK2_1	184	189	PF00069	0.453
MOD_NEK2_1	258	263	PF00069	0.459
MOD_NEK2_1	76	81	PF00069	0.511
MOD_NEK2_1	86	91	PF00069	0.457
MOD_PIKK_1	84	90	PF00454	0.466
MOD_PKA_1	279	285	PF00069	0.531
MOD_PKA_2	134	140	PF00069	0.436
MOD_PKA_2	206	212	PF00069	0.504
MOD_PKA_2	227	233	PF00069	0.429
MOD_PKA_2	279	285	PF00069	0.531
MOD_PKA_2	290	296	PF00069	0.448
MOD_PKA_2	37	43	PF00069	0.569
MOD_PKA_2	63	69	PF00069	0.599
MOD_Plk_1	152	158	PF00069	0.436
MOD_Plk_1	160	166	PF00069	0.459
MOD_Plk_1	184	190	PF00069	0.554
MOD_Plk_1	76	82	PF00069	0.478
MOD_Plk_4	134	140	PF00069	0.577
MOD_Plk_4	152	158	PF00069	0.291
MOD_Plk_4	77	83	PF00069	0.381
MOD_ProDKin_1	217	223	PF00069	0.482
MOD_ProDKin_1	59	65	PF00069	0.687
TRG_DiLeu_BaEn_4	146	152	PF01217	0.435
TRG_ENDOCYTIC_2	203	206	PF00928	0.430
TRG_ER_diArg_1	42	44	PF00400	0.649
TRG_NES_CRM1_1	146	159	PF08389	0.578
TRG_Pf-PMV_PEXEL_1	124	128	PF00026	0.365
TRG_Pf-PMV_PEXEL_1	25	29	PF00026	0.433

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7Y9	Leptomonas seymouri	51%	100%
A0A3S7WY11	Leishmania donovani	88%	100%
E9AH31	Leishmania infantum	88%	100%
E9AWK9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
V5BVZ7	Trypanosoma cruzi	30%	100%