Putative transcription elongation factor

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

transcription elongation factor, putative

Species:

Leishmania major

UniProt:

Q4QAW0_LEIMA

TriTrypDb:

LmjF.24.0210 , LMJLV39_240007300 , LMJSD75_240007000

Length:

333

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4QAW0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QAW0

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	10
GO:0006351	DNA-templated transcription	7	10
GO:0006725	cellular aromatic compound metabolic process	3	10
GO:0006807	nitrogen compound metabolic process	2	10
GO:0008152	metabolic process	1	10
GO:0009058	biosynthetic process	2	10
GO:0009059	macromolecule biosynthetic process	4	10
GO:0009987	cellular process	1	10
GO:0016070	RNA metabolic process	5	10
GO:0018130	heterocycle biosynthetic process	4	10
GO:0019438	aromatic compound biosynthetic process	4	10
GO:0032774	RNA biosynthetic process	5	10
GO:0034641	cellular nitrogen compound metabolic process	3	10
GO:0034654	nucleobase-containing compound biosynthetic process	4	10
GO:0043170	macromolecule metabolic process	3	10
GO:0044237	cellular metabolic process	2	10
GO:0044238	primary metabolic process	2	10
GO:0044249	cellular biosynthetic process	3	10
GO:0044271	cellular nitrogen compound biosynthetic process	4	10
GO:0046483	heterocycle metabolic process	3	10
GO:0071704	organic substance metabolic process	2	10
GO:0090304	nucleic acid metabolic process	4	10
GO:0097659	nucleic acid-templated transcription	6	10
GO:1901360	organic cyclic compound metabolic process	3	10
GO:1901362	organic cyclic compound biosynthetic process	4	10
GO:1901576	organic substance biosynthetic process	3	10

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	10
GO:0003746	translation elongation factor activity	4	10
GO:0005488	binding	1	10
GO:0008135	translation factor activity, RNA binding	3	10
GO:0008270	zinc ion binding	6	10
GO:0043167	ion binding	2	10
GO:0043169	cation binding	3	10
GO:0045182	translation regulator activity	1	10
GO:0046872	metal ion binding	4	10
GO:0046914	transition metal ion binding	5	10
GO:0090079	translation regulator activity, nucleic acid binding	2	10
GO:0097159	organic cyclic compound binding	2	10
GO:1901363	heterocyclic compound binding	2	10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	124	126	PF00675	0.670
CLV_NRD_NRD_1	128	130	PF00675	0.649
CLV_NRD_NRD_1	235	237	PF00675	0.361
CLV_NRD_NRD_1	261	263	PF00675	0.311
CLV_NRD_NRD_1	281	283	PF00675	0.371
CLV_NRD_NRD_1	330	332	PF00675	0.373
CLV_PCSK_KEX2_1	169	171	PF00082	0.634
CLV_PCSK_KEX2_1	235	237	PF00082	0.361
CLV_PCSK_KEX2_1	52	54	PF00082	0.654
CLV_PCSK_PC1ET2_1	169	171	PF00082	0.634
CLV_PCSK_PC1ET2_1	52	54	PF00082	0.654
CLV_PCSK_SKI1_1	112	116	PF00082	0.743
CLV_PCSK_SKI1_1	169	173	PF00082	0.547
CLV_PCSK_SKI1_1	247	251	PF00082	0.391
DEG_SCF_FBW7_1	128	135	PF00400	0.733
DOC_ANK_TNKS_1	235	242	PF00023	0.534
DOC_CKS1_1	145	150	PF01111	0.671
DOC_CKS1_1	63	68	PF01111	0.785
DOC_MAPK_MEF2A_6	196	204	PF00069	0.516
DOC_PP2B_LxvP_1	32	35	PF13499	0.724
DOC_PP4_FxxP_1	63	66	PF00568	0.780
DOC_USP7_MATH_1	136	140	PF00917	0.686
DOC_USP7_MATH_1	152	156	PF00917	0.625
DOC_USP7_MATH_1	157	161	PF00917	0.671
DOC_USP7_MATH_1	25	29	PF00917	0.798
DOC_USP7_MATH_1	300	304	PF00917	0.429
DOC_USP7_MATH_1	33	37	PF00917	0.669
DOC_USP7_MATH_1	8	12	PF00917	0.789
DOC_USP7_UBL2_3	126	130	PF12436	0.761
DOC_WW_Pin1_4	100	105	PF00397	0.716
DOC_WW_Pin1_4	11	16	PF00397	0.742
DOC_WW_Pin1_4	112	117	PF00397	0.553
DOC_WW_Pin1_4	128	133	PF00397	0.580
DOC_WW_Pin1_4	144	149	PF00397	0.564
DOC_WW_Pin1_4	27	32	PF00397	0.802
DOC_WW_Pin1_4	46	51	PF00397	0.549
DOC_WW_Pin1_4	62	67	PF00397	0.790
DOC_WW_Pin1_4	77	82	PF00397	0.481
LIG_14-3-3_CanoR_1	170	174	PF00244	0.562
LIG_14-3-3_CanoR_1	189	198	PF00244	0.582
LIG_14-3-3_CanoR_1	247	252	PF00244	0.567
LIG_14-3-3_CanoR_1	73	81	PF00244	0.562
LIG_Actin_WH2_2	57	75	PF00022	0.553
LIG_BIR_II_1	1	5	PF00653	0.741
LIG_BRCT_BRCA1_1	289	293	PF00533	0.473
LIG_Clathr_ClatBox_1	248	252	PF01394	0.561
LIG_FHA_1	135	141	PF00498	0.699
LIG_FHA_1	24	30	PF00498	0.749
LIG_FHA_1	316	322	PF00498	0.444
LIG_FHA_1	59	65	PF00498	0.707
LIG_FHA_1	97	103	PF00498	0.666
LIG_FHA_2	248	254	PF00498	0.591
LIG_LIR_Apic_2	61	66	PF02991	0.777
LIG_LIR_Gen_1	118	128	PF02991	0.737
LIG_LIR_Gen_1	217	226	PF02991	0.542
LIG_LIR_Nem_3	118	123	PF02991	0.723
LIG_LIR_Nem_3	217	222	PF02991	0.482
LIG_LIR_Nem_3	328	333	PF02991	0.347
LIG_SH2_CRK	120	124	PF00017	0.732
LIG_SH2_GRB2like	120	123	PF00017	0.726
LIG_SH3_3	113	119	PF00018	0.660
LIG_SH3_3	12	18	PF00018	0.656
LIG_SH3_3	130	136	PF00018	0.601
LIG_SH3_3	143	149	PF00018	0.557
LIG_SH3_3	19	25	PF00018	0.550
LIG_SH3_3	2	8	PF00018	0.719
LIG_SH3_3	53	59	PF00018	0.717
LIG_SUMO_SIM_par_1	317	322	PF11976	0.444
LIG_UBA3_1	222	230	PF00899	0.490
MOD_CDC14_SPxK_1	49	52	PF00782	0.719
MOD_CDK_SPK_2	100	105	PF00069	0.763
MOD_CDK_SPK_2	112	117	PF00069	0.538
MOD_CDK_SPxK_1	46	52	PF00069	0.757
MOD_CDK_SPxxK_3	46	53	PF00069	0.725
MOD_CK1_1	11	17	PF00069	0.535
MOD_CK1_1	118	124	PF00069	0.659
MOD_CK1_1	134	140	PF00069	0.565
MOD_CK1_1	160	166	PF00069	0.674
MOD_CK1_1	191	197	PF00069	0.620
MOD_CK1_1	273	279	PF00069	0.637
MOD_CK1_1	288	294	PF00069	0.428
MOD_CK1_1	46	52	PF00069	0.797
MOD_CK1_1	75	81	PF00069	0.739
MOD_CK1_1	82	88	PF00069	0.742
MOD_CK2_1	189	195	PF00069	0.401
MOD_CK2_1	300	306	PF00069	0.394
MOD_CK2_1	309	315	PF00069	0.293
MOD_DYRK1A_RPxSP_1	112	116	PF00069	0.676
MOD_GlcNHglycan	159	162	PF01048	0.681
MOD_GlcNHglycan	311	314	PF01048	0.344
MOD_GlcNHglycan	45	48	PF01048	0.804
MOD_GSK3_1	108	115	PF00069	0.646
MOD_GSK3_1	128	135	PF00069	0.653
MOD_GSK3_1	136	143	PF00069	0.613
MOD_GSK3_1	152	159	PF00069	0.584
MOD_GSK3_1	23	30	PF00069	0.748
MOD_GSK3_1	284	291	PF00069	0.534
MOD_GSK3_1	315	322	PF00069	0.394
MOD_GSK3_1	42	49	PF00069	0.726
MOD_GSK3_1	58	65	PF00069	0.598
MOD_GSK3_1	7	14	PF00069	0.571
MOD_GSK3_1	73	80	PF00069	0.658
MOD_GSK3_1	96	103	PF00069	0.738
MOD_N-GLC_1	141	146	PF02516	0.650
MOD_N-GLC_1	276	281	PF02516	0.645
MOD_N-GLC_1	288	293	PF02516	0.577
MOD_N-GLC_2	324	326	PF02516	0.325
MOD_NEK2_1	1	6	PF00069	0.790
MOD_NEK2_1	140	145	PF00069	0.730
MOD_NEK2_1	285	290	PF00069	0.563
MOD_NEK2_1	72	77	PF00069	0.761
MOD_PIKK_1	325	331	PF00454	0.444
MOD_PKA_1	169	175	PF00069	0.570
MOD_PKA_2	169	175	PF00069	0.569
MOD_PKA_2	188	194	PF00069	0.653
MOD_PKA_2	285	291	PF00069	0.565
MOD_PKA_2	300	306	PF00069	0.354
MOD_PKA_2	307	313	PF00069	0.383
MOD_PKA_2	72	78	PF00069	0.566
MOD_Plk_1	141	147	PF00069	0.701
MOD_Plk_1	288	294	PF00069	0.532
MOD_Plk_1	301	307	PF00069	0.271
MOD_Plk_4	141	147	PF00069	0.721
MOD_Plk_4	218	224	PF00069	0.531
MOD_Plk_4	288	294	PF00069	0.461
MOD_Plk_4	315	321	PF00069	0.361
MOD_ProDKin_1	100	106	PF00069	0.719
MOD_ProDKin_1	11	17	PF00069	0.738
MOD_ProDKin_1	112	118	PF00069	0.549
MOD_ProDKin_1	128	134	PF00069	0.580
MOD_ProDKin_1	144	150	PF00069	0.565
MOD_ProDKin_1	27	33	PF00069	0.803
MOD_ProDKin_1	46	52	PF00069	0.550
MOD_ProDKin_1	62	68	PF00069	0.793
MOD_ProDKin_1	77	83	PF00069	0.475
MOD_SUMO_rev_2	260	269	PF00179	0.591
TRG_DiLeu_BaEn_1	240	245	PF01217	0.561
TRG_ENDOCYTIC_2	120	123	PF00928	0.726
TRG_ER_diArg_1	234	236	PF00400	0.561
TRG_ER_diArg_1	53	56	PF00400	0.704
TRG_NES_CRM1_1	246	260	PF08389	0.536
TRG_NLS_MonoCore_2	51	56	PF00514	0.678
TRG_NLS_MonoExtN_4	50	56	PF00514	0.737

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PFJ1	Leptomonas seymouri	63%	96%
A0A1X0NIZ8	Trypanosomatidae	46%	100%
A0A3Q8IER0	Leishmania donovani	93%	100%
A0A422P430	Trypanosoma rangeli	41%	100%
A4HD78	Leishmania braziliensis	74%	100%
E9AH32	Leishmania infantum	93%	100%
E9AWL0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	99%
V5DSP1	Trypanosoma cruzi	45%	100%