Ubiquitin-like domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania major

UniProt:

Q4QAV9_LEIMA

TriTrypDb:

LmjF.24.0220 , LMJLV39_240007400 , LMJSD75_240007100

Length:

340

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QAV9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QAV9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	17	21	PF00656	0.643
CLV_MEL_PAP_1	36	42	PF00089	0.497
CLV_NRD_NRD_1	146	148	PF00675	0.748
CLV_NRD_NRD_1	195	197	PF00675	0.464
CLV_PCSK_KEX2_1	146	148	PF00082	0.690
CLV_PCSK_KEX2_1	321	323	PF00082	0.574
CLV_PCSK_PC1ET2_1	321	323	PF00082	0.574
CLV_PCSK_SKI1_1	139	143	PF00082	0.623
CLV_PCSK_SKI1_1	318	322	PF00082	0.766
CLV_PCSK_SKI1_1	6	10	PF00082	0.553
DEG_Nend_UBRbox_1	1	4	PF02207	0.414
DOC_CKS1_1	220	225	PF01111	0.561
DOC_CKS1_1	273	278	PF01111	0.534
DOC_CYCLIN_yCln2_LP_2	273	279	PF00134	0.527
DOC_MAPK_gen_1	272	279	PF00069	0.535
DOC_MAPK_MEF2A_6	33	40	PF00069	0.517
DOC_MAPK_RevD_3	131	147	PF00069	0.666
DOC_PP2B_LxvP_1	133	136	PF13499	0.624
DOC_USP7_UBL2_3	115	119	PF12436	0.646
DOC_WW_Pin1_4	21	26	PF00397	0.560
DOC_WW_Pin1_4	219	224	PF00397	0.502
DOC_WW_Pin1_4	272	277	PF00397	0.540
LIG_14-3-3_CanoR_1	12	16	PF00244	0.419
LIG_14-3-3_CanoR_1	2	6	PF00244	0.544
LIG_14-3-3_CanoR_1	262	266	PF00244	0.431
LIG_14-3-3_CanoR_1	322	329	PF00244	0.699
LIG_AP2alpha_2	224	226	PF02296	0.694
LIG_BIR_III_4	152	156	PF00653	0.799
LIG_Clathr_ClatBox_1	48	52	PF01394	0.538
LIG_FHA_1	56	62	PF00498	0.589
LIG_FHA_1	74	80	PF00498	0.310
LIG_FHA_2	26	32	PF00498	0.492
LIG_FHA_2	94	100	PF00498	0.692
LIG_FXI_DFP_1	245	249	PF00024	0.568
LIG_G3BP_FGDF_1	243	248	PF02136	0.450
LIG_LIR_Gen_1	10	21	PF02991	0.618
LIG_LIR_Gen_1	182	193	PF02991	0.557
LIG_LIR_Gen_1	224	234	PF02991	0.608
LIG_LIR_Gen_1	247	253	PF02991	0.473
LIG_LIR_Gen_1	255	265	PF02991	0.453
LIG_LIR_Gen_1	305	314	PF02991	0.489
LIG_LIR_LC3C_4	256	261	PF02991	0.344
LIG_LIR_Nem_3	10	16	PF02991	0.598
LIG_LIR_Nem_3	182	188	PF02991	0.497
LIG_LIR_Nem_3	224	229	PF02991	0.651
LIG_LIR_Nem_3	247	251	PF02991	0.467
LIG_LIR_Nem_3	255	260	PF02991	0.460
LIG_LIR_Nem_3	305	311	PF02991	0.432
LIG_LYPXL_S_1	285	289	PF13949	0.451
LIG_LYPXL_yS_3	208	211	PF13949	0.446
LIG_LYPXL_yS_3	286	289	PF13949	0.437
LIG_NRBOX	50	56	PF00104	0.578
LIG_Pex14_2	307	311	PF04695	0.509
LIG_SH2_CRK	185	189	PF00017	0.544
LIG_SH2_NCK_1	13	17	PF00017	0.580
LIG_SH2_SRC	185	188	PF00017	0.571
LIG_SH2_STAT5	244	247	PF00017	0.454
LIG_SH3_3	118	124	PF00018	0.694
LIG_SH3_3	156	162	PF00018	0.726
LIG_SH3_3	208	214	PF00018	0.486
LIG_SH3_3	67	73	PF00018	0.556
LIG_SUMO_SIM_anti_2	255	262	PF11976	0.439
LIG_SUMO_SIM_anti_2	46	52	PF11976	0.454
LIG_SUMO_SIM_anti_2	63	68	PF11976	0.481
LIG_SUMO_SIM_par_1	291	297	PF11976	0.433
LIG_SUMO_SIM_par_1	46	52	PF11976	0.506
LIG_SUMO_SIM_par_1	56	63	PF11976	0.556
LIG_TYR_ITIM	206	211	PF00017	0.431
LIG_UBA3_1	111	119	PF00899	0.559
MOD_CK1_1	24	30	PF00069	0.538
MOD_CK1_1	264	270	PF00069	0.501
MOD_CK2_1	11	17	PF00069	0.522
MOD_CK2_1	25	31	PF00069	0.392
MOD_CK2_1	80	86	PF00069	0.665
MOD_GlcNHglycan	315	318	PF01048	0.681
MOD_GlcNHglycan	331	334	PF01048	0.683
MOD_GSK3_1	21	28	PF00069	0.481
MOD_GSK3_1	7	14	PF00069	0.480
MOD_NEK2_1	1	6	PF00069	0.545
MOD_NEK2_1	55	60	PF00069	0.522
MOD_NEK2_1	85	90	PF00069	0.697
MOD_PK_1	62	68	PF00069	0.549
MOD_PKA_1	321	327	PF00069	0.569
MOD_PKA_2	1	7	PF00069	0.545
MOD_PKA_2	11	17	PF00069	0.431
MOD_PKA_2	261	267	PF00069	0.433
MOD_PKA_2	321	327	PF00069	0.703
MOD_PKA_2	80	86	PF00069	0.595
MOD_Plk_1	25	31	PF00069	0.594
MOD_Plk_1	252	258	PF00069	0.473
MOD_Plk_1	55	61	PF00069	0.503
MOD_Plk_4	11	17	PF00069	0.453
MOD_Plk_4	253	259	PF00069	0.389
MOD_Plk_4	62	68	PF00069	0.554
MOD_Plk_4	80	86	PF00069	0.467
MOD_ProDKin_1	21	27	PF00069	0.553
MOD_ProDKin_1	219	225	PF00069	0.520
MOD_ProDKin_1	272	278	PF00069	0.543
MOD_SUMO_rev_2	173	182	PF00179	0.519
MOD_SUMO_rev_2	26	35	PF00179	0.544
TRG_DiLeu_BaEn_1	31	36	PF01217	0.486
TRG_DiLeu_BaLyEn_6	284	289	PF01217	0.549
TRG_ENDOCYTIC_2	13	16	PF00928	0.577
TRG_ENDOCYTIC_2	185	188	PF00928	0.497
TRG_ENDOCYTIC_2	208	211	PF00928	0.431
TRG_ENDOCYTIC_2	286	289	PF00928	0.437
TRG_ER_diArg_1	136	139	PF00400	0.541
TRG_ER_diArg_1	190	193	PF00400	0.478
TRG_ER_diArg_1	271	274	PF00400	0.533

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7K8	Leptomonas seymouri	68%	100%
A0A0S4JUQ7	Bodo saltans	39%	100%
A0A1X0NIQ0	Trypanosomatidae	46%	100%
A0A3Q8IBY8	Leishmania donovani	94%	100%
E9AH33	Leishmania infantum	94%	100%
E9AWL1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%