Protein kinase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Protein kinase

Gene product:

CAMK/CAMKL family protein kinase, putative

Species:

Leishmania major

UniProt:

Q4QAV8_LEIMA

TriTrypDb:

LmjF.24.0230 , LMJLV39_240007500 , LMJSD75_240007200

Length:

538

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	2
GO:0005737	cytoplasm	2	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4QAV8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QAV8

Function

Biological processes
Term	Name	Level	Count
GO:0000075	cell cycle checkpoint signaling	4	2
GO:0000077	DNA damage checkpoint signaling	5	2
GO:0006468	protein phosphorylation	5	8
GO:0006793	phosphorus metabolic process	3	8
GO:0006796	phosphate-containing compound metabolic process	4	8
GO:0006807	nitrogen compound metabolic process	2	8
GO:0006950	response to stress	2	2
GO:0006974	DNA damage response	4	2
GO:0007093	mitotic cell cycle checkpoint signaling	4	2
GO:0007165	signal transduction	2	2
GO:0007346	regulation of mitotic cell cycle	5	2
GO:0008152	metabolic process	1	8
GO:0009987	cellular process	1	8
GO:0010564	regulation of cell cycle process	5	2
GO:0010948	negative regulation of cell cycle process	6	2
GO:0016310	phosphorylation	5	8
GO:0019538	protein metabolic process	3	8
GO:0022402	cell cycle process	2	2
GO:0031570	DNA integrity checkpoint signaling	5	2
GO:0033554	cellular response to stress	3	2
GO:0035556	intracellular signal transduction	3	2
GO:0036211	protein modification process	4	8
GO:0042770	signal transduction in response to DNA damage	4	2
GO:0043170	macromolecule metabolic process	3	8
GO:0043412	macromolecule modification	4	8
GO:0044237	cellular metabolic process	2	8
GO:0044238	primary metabolic process	2	8
GO:0044773	mitotic DNA damage checkpoint signaling	6	2
GO:0044774	mitotic DNA integrity checkpoint signaling	5	2
GO:0045786	negative regulation of cell cycle	5	2
GO:0045930	negative regulation of mitotic cell cycle	6	2
GO:0048519	negative regulation of biological process	3	2
GO:0048523	negative regulation of cellular process	4	2
GO:0050789	regulation of biological process	2	2
GO:0050794	regulation of cellular process	3	2
GO:0050896	response to stimulus	1	2
GO:0051716	cellular response to stimulus	2	2
GO:0051726	regulation of cell cycle	4	2
GO:0065007	biological regulation	1	2
GO:0071704	organic substance metabolic process	2	8
GO:1901564	organonitrogen compound metabolic process	3	8
GO:1901987	regulation of cell cycle phase transition	6	2
GO:1901988	negative regulation of cell cycle phase transition	7	2
GO:1903047	mitotic cell cycle process	3	2

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	8
GO:0003824	catalytic activity	1	8
GO:0004672	protein kinase activity	3	8
GO:0004674	protein serine/threonine kinase activity	4	2
GO:0005488	binding	1	8
GO:0005524	ATP binding	5	8
GO:0016301	kinase activity	4	8
GO:0016740	transferase activity	2	8
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	8
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	8
GO:0017076	purine nucleotide binding	4	8
GO:0030554	adenyl nucleotide binding	5	8
GO:0032553	ribonucleotide binding	3	8
GO:0032555	purine ribonucleotide binding	4	8
GO:0032559	adenyl ribonucleotide binding	5	8
GO:0035639	purine ribonucleoside triphosphate binding	4	8
GO:0036094	small molecule binding	2	8
GO:0043167	ion binding	2	8
GO:0043168	anion binding	3	8
GO:0097159	organic cyclic compound binding	2	8
GO:0097367	carbohydrate derivative binding	2	8
GO:0140096	catalytic activity, acting on a protein	2	8
GO:1901265	nucleoside phosphate binding	3	8
GO:1901363	heterocyclic compound binding	2	8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	356	360	PF00656	0.477
CLV_NRD_NRD_1	143	145	PF00675	0.477
CLV_NRD_NRD_1	38	40	PF00675	0.742
CLV_NRD_NRD_1	65	67	PF00675	0.676
CLV_PCSK_KEX2_1	143	145	PF00082	0.405
CLV_PCSK_KEX2_1	18	20	PF00082	0.647
CLV_PCSK_KEX2_1	333	335	PF00082	0.438
CLV_PCSK_KEX2_1	38	40	PF00082	0.489
CLV_PCSK_KEX2_1	65	67	PF00082	0.676
CLV_PCSK_PC1ET2_1	18	20	PF00082	0.647
CLV_PCSK_PC1ET2_1	333	335	PF00082	0.244
CLV_PCSK_SKI1_1	299	303	PF00082	0.352
CLV_PCSK_SKI1_1	41	45	PF00082	0.568
CLV_PCSK_SKI1_1	465	469	PF00082	0.392
CLV_PCSK_SKI1_1	480	484	PF00082	0.436
CLV_PCSK_SKI1_1	512	516	PF00082	0.607
CLV_PCSK_SKI1_1	518	522	PF00082	0.648
CLV_Separin_Metazoa	246	250	PF03568	0.329
DEG_APCC_DBOX_1	155	163	PF00400	0.477
DEG_APCC_DBOX_1	194	202	PF00400	0.405
DEG_APCC_DBOX_1	488	496	PF00400	0.352
DEG_Nend_UBRbox_2	1	3	PF02207	0.736
DEG_SPOP_SBC_1	340	344	PF00917	0.399
DEG_SPOP_SBC_1	42	46	PF00917	0.772
DOC_ANK_TNKS_1	89	96	PF00023	0.596
DOC_CYCLIN_yClb5_NLxxxL_5	108	117	PF00134	0.244
DOC_CYCLIN_yCln2_LP_2	9	15	PF00134	0.638
DOC_MAPK_gen_1	453	463	PF00069	0.399
DOC_MAPK_MEF2A_6	323	331	PF00069	0.405
DOC_PP2B_LxvP_1	107	110	PF13499	0.477
DOC_PP4_FxxP_1	161	164	PF00568	0.487
DOC_SPAK_OSR1_1	90	94	PF12202	0.611
DOC_USP7_MATH_1	180	184	PF00917	0.544
DOC_USP7_MATH_1	237	241	PF00917	0.405
DOC_USP7_MATH_1	514	518	PF00917	0.698
DOC_WW_Pin1_4	31	36	PF00397	0.662
DOC_WW_Pin1_4	373	378	PF00397	0.405
DOC_WW_Pin1_4	406	411	PF00397	0.324
DOC_WW_Pin1_4	525	530	PF00397	0.586
DOC_WW_Pin1_4	73	78	PF00397	0.555
LIG_14-3-3_CanoR_1	147	155	PF00244	0.352
LIG_14-3-3_CanoR_1	21	26	PF00244	0.726
LIG_14-3-3_CanoR_1	465	473	PF00244	0.463
LIG_14-3-3_CanoR_1	480	485	PF00244	0.338
LIG_APCC_ABBAyCdc20_2	315	321	PF00400	0.341
LIG_BRCT_BRCA1_1	183	187	PF00533	0.621
LIG_BRCT_BRCA1_1	527	531	PF00533	0.743
LIG_EH_1	290	294	PF12763	0.352
LIG_FHA_1	522	528	PF00498	0.653
LIG_FHA_1	79	85	PF00498	0.455
LIG_FHA_2	163	169	PF00498	0.539
LIG_FHA_2	186	192	PF00498	0.660
LIG_FHA_2	241	247	PF00498	0.386
LIG_FHA_2	292	298	PF00498	0.396
LIG_FHA_2	334	340	PF00498	0.247
LIG_FHA_2	354	360	PF00498	0.394
LIG_GBD_Chelix_1	113	121	PF00786	0.244
LIG_Integrin_isoDGR_2	141	143	PF01839	0.477
LIG_LIR_Apic_2	158	164	PF02991	0.387
LIG_LIR_Apic_2	409	415	PF02991	0.352
LIG_LIR_Gen_1	175	180	PF02991	0.404
LIG_LIR_Gen_1	184	193	PF02991	0.578
LIG_LIR_Gen_1	280	286	PF02991	0.322
LIG_LIR_Nem_3	175	179	PF02991	0.418
LIG_LIR_Nem_3	184	190	PF02991	0.497
LIG_LIR_Nem_3	280	285	PF02991	0.322
LIG_NRBOX	438	444	PF00104	0.405
LIG_Pex14_2	135	139	PF04695	0.405
LIG_SH2_NCK_1	412	416	PF00017	0.405
LIG_SH2_SRC	311	314	PF00017	0.386
LIG_SH2_STAP1	378	382	PF00017	0.405
LIG_SH2_STAT5	25	28	PF00017	0.697
LIG_SH2_STAT5	275	278	PF00017	0.361
LIG_SH2_STAT5	284	287	PF00017	0.322
LIG_SH2_STAT5	311	314	PF00017	0.378
LIG_SH2_STAT5	444	447	PF00017	0.405
LIG_SH3_1	29	35	PF00018	0.686
LIG_SH3_1	526	532	PF00018	0.667
LIG_SH3_3	29	35	PF00018	0.746
LIG_SH3_3	448	454	PF00018	0.353
LIG_SH3_3	526	532	PF00018	0.638
LIG_SUMO_SIM_anti_2	468	474	PF11976	0.399
LIG_SUMO_SIM_par_1	519	524	PF11976	0.645
LIG_TRAF2_1	165	168	PF00917	0.626
LIG_TRAF2_1	233	236	PF00917	0.373
LIG_TRAF2_1	426	429	PF00917	0.282
LIG_TRFH_1	196	200	PF08558	0.405
LIG_TRFH_1	73	77	PF08558	0.507
LIG_WW_3	453	457	PF00397	0.399
MOD_CDK_SPxxK_3	31	38	PF00069	0.728
MOD_CK1_1	185	191	PF00069	0.597
MOD_CK1_1	23	29	PF00069	0.726
MOD_CK1_1	240	246	PF00069	0.358
MOD_CK2_1	162	168	PF00069	0.609
MOD_CK2_1	185	191	PF00069	0.607
MOD_CK2_1	230	236	PF00069	0.431
MOD_CK2_1	240	246	PF00069	0.221
MOD_CK2_1	291	297	PF00069	0.405
MOD_CK2_1	333	339	PF00069	0.390
MOD_CK2_1	43	49	PF00069	0.722
MOD_CK2_1	527	533	PF00069	0.616
MOD_Cter_Amidation	141	144	PF01082	0.405
MOD_DYRK1A_RPxSP_1	31	35	PF00069	0.569
MOD_GlcNHglycan	150	153	PF01048	0.244
MOD_GlcNHglycan	184	187	PF01048	0.574
MOD_GlcNHglycan	264	268	PF01048	0.386
MOD_GlcNHglycan	343	346	PF01048	0.466
MOD_GlcNHglycan	388	391	PF01048	0.477
MOD_GlcNHglycan	429	433	PF01048	0.310
MOD_GlcNHglycan	447	450	PF01048	0.352
MOD_GlcNHglycan	506	509	PF01048	0.589
MOD_GSK3_1	108	115	PF00069	0.359
MOD_GSK3_1	131	138	PF00069	0.327
MOD_GSK3_1	181	188	PF00069	0.659
MOD_GSK3_1	19	26	PF00069	0.657
MOD_GSK3_1	339	346	PF00069	0.448
MOD_GSK3_1	349	356	PF00069	0.347
MOD_GSK3_1	402	409	PF00069	0.399
MOD_GSK3_1	41	48	PF00069	0.615
MOD_GSK3_1	480	487	PF00069	0.477
MOD_GSK3_1	521	528	PF00069	0.583
MOD_N-GLC_1	135	140	PF02516	0.316
MOD_N-GLC_1	463	468	PF02516	0.419
MOD_NEK2_1	13	18	PF00069	0.516
MOD_NEK2_1	135	140	PF00069	0.405
MOD_NEK2_1	263	268	PF00069	0.386
MOD_NEK2_1	401	406	PF00069	0.411
MOD_NEK2_1	43	48	PF00069	0.564
MOD_NEK2_1	463	468	PF00069	0.431
MOD_NEK2_1	521	526	PF00069	0.643
MOD_NEK2_1	78	83	PF00069	0.560
MOD_NEK2_2	237	242	PF00069	0.405
MOD_PIKK_1	484	490	PF00454	0.361
MOD_PKA_1	333	339	PF00069	0.361
MOD_PKA_2	148	154	PF00069	0.356
MOD_PKA_2	155	161	PF00069	0.358
MOD_PKA_2	20	26	PF00069	0.730
MOD_PKA_2	230	236	PF00069	0.466
MOD_PKA_2	30	36	PF00069	0.677
MOD_PKA_2	333	339	PF00069	0.390
MOD_PKA_2	488	494	PF00069	0.405
MOD_PKA_2	86	92	PF00069	0.527
MOD_PKB_1	19	27	PF00069	0.694
MOD_PKB_1	39	47	PF00069	0.640
MOD_Plk_1	131	137	PF00069	0.405
MOD_Plk_1	463	469	PF00069	0.477
MOD_Plk_4	119	125	PF00069	0.392
MOD_Plk_4	135	141	PF00069	0.259
MOD_Plk_4	157	163	PF00069	0.341
MOD_Plk_4	360	366	PF00069	0.373
MOD_Plk_4	456	462	PF00069	0.403
MOD_Plk_4	468	474	PF00069	0.393
MOD_ProDKin_1	31	37	PF00069	0.663
MOD_ProDKin_1	373	379	PF00069	0.405
MOD_ProDKin_1	406	412	PF00069	0.324
MOD_ProDKin_1	525	531	PF00069	0.585
MOD_ProDKin_1	73	79	PF00069	0.572
MOD_SUMO_for_1	17	20	PF00179	0.623
MOD_SUMO_for_1	322	325	PF00179	0.352
MOD_SUMO_for_1	390	393	PF00179	0.399
MOD_SUMO_rev_2	316	324	PF00179	0.405
MOD_SUMO_rev_2	366	375	PF00179	0.405
MOD_SUMO_rev_2	46	53	PF00179	0.730
TRG_ER_diArg_1	143	145	PF00400	0.477
TRG_ER_diArg_1	229	232	PF00400	0.399
TRG_ER_diArg_1	29	32	PF00400	0.696
TRG_ER_diArg_1	37	39	PF00400	0.759
TRG_Pf-PMV_PEXEL_1	299	304	PF00026	0.405
TRG_Pf-PMV_PEXEL_1	7	11	PF00026	0.684

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P787	Leptomonas seymouri	24%	100%
A0A0N1HTF0	Leptomonas seymouri	26%	85%
A0A0N1HZY0	Leptomonas seymouri	58%	90%
A0A0N1I1M7	Leptomonas seymouri	27%	83%
A0A0S4IZ14	Bodo saltans	40%	90%
A0A0S4J1U0	Bodo saltans	25%	73%
A0A0S4J757	Bodo saltans	25%	99%
A0A0S4JI27	Bodo saltans	25%	75%
A0A3Q8IAQ1	Leishmania donovani	28%	100%
A0A3Q8INQ4	Leishmania donovani	26%	100%
A0A3S5H5G0	Leishmania donovani	23%	100%
A0A3S5H5U5	Leishmania donovani	22%	100%
A0A3S7WTN9	Leishmania donovani	23%	100%
A0A3S7WV74	Leishmania donovani	26%	85%
A0A3S7WVR6	Leishmania donovani	24%	87%
A0A3S7WY10	Leishmania donovani	93%	99%
A0A3S7X8Z8	Leishmania donovani	27%	100%
A4H459	Leishmania braziliensis	24%	100%
A4H9X1	Leishmania braziliensis	27%	85%
A4HD79	Leishmania braziliensis	80%	99%
A4HHE4	Leishmania braziliensis	27%	91%
A4HSE2	Leishmania infantum	23%	100%
A4HWP5	Leishmania infantum	23%	100%
A4HYH7	Leishmania infantum	24%	87%
A4HZW8	Leishmania infantum	28%	100%
A4I1T4	Leishmania infantum	26%	100%
A4IB02	Leishmania infantum	27%	100%
A5A7I7	Solanum tuberosum	27%	97%
C9ZMG9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	83%
C9ZWL6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	84%
E9ADZ1	Leishmania major	27%	91%
E9AET0	Leishmania major	28%	100%
E9AG71	Leishmania infantum	22%	100%
E9AGR6	Leishmania infantum	26%	85%
E9AH34	Leishmania infantum	93%	99%
E9AKB7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	23%	100%
E9ALU0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	92%
E9AQF3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	24%	100%
E9ARW5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	86%
E9AWL2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	99%
E9AXW8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	100%
E9B5Y5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	100%
O43293	Homo sapiens	28%	100%
O61267	Drosophila melanogaster	29%	100%
O94547	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	27%	93%
O96017	Homo sapiens	30%	99%
P00518	Oryctolagus cuniculus	27%	100%
P07934	Mus musculus	27%	100%
P13286	Rattus norvegicus	27%	100%
P34101	Dictyostelium discoideum	27%	90%
P39009	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	26%	100%
P93759	Arabidopsis thaliana	27%	100%
Q09170	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	28%	100%
Q10292	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	26%	100%
Q12701	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	24%	91%
Q16816	Homo sapiens	26%	100%
Q2QMI0	Oryza sativa subsp. japonica	29%	100%
Q42438	Arabidopsis thaliana	30%	100%
Q4Q9K2	Leishmania major	26%	100%
Q4QD63	Leishmania major	24%	87%
Q4QDK7	Leishmania major	26%	85%
Q4QF23	Leishmania major	24%	100%
Q4QJJ0	Leishmania major	23%	100%
Q54BF0	Dictyostelium discoideum	25%	91%
Q54MH0	Dictyostelium discoideum	30%	72%
Q54VI1	Dictyostelium discoideum	27%	76%
Q5XHI9	Xenopus laevis	27%	78%
Q6C3J2	Yarrowia lipolytica (strain CLIB 122 / E 150)	26%	100%
Q8BW96	Mus musculus	30%	100%
Q8IU85	Homo sapiens	29%	100%
Q9U1Y5	Caenorhabditis elegans	28%	100%
Q9Z265	Mus musculus	31%	99%
Q9ZV15	Arabidopsis thaliana	27%	92%
V5B7L8	Trypanosoma cruzi	27%	84%
V5BP88	Trypanosoma cruzi	25%	100%