WD repeat protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

WD repeat protein

Gene product:

WD repeat protein

Species:

Leishmania major

UniProt:

Q4QAV7_LEIMA

TriTrypDb:

LmjF.24.0240 , LMJLV39_240007600 , LMJSD75_240007300

Length:

466

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4QAV7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QAV7

Function

Biological processes
Term	Name	Level	Count
GO:0006325	chromatin organization	4	2
GO:0006338	chromatin remodeling	5	2
GO:0006355	regulation of DNA-templated transcription	6	2
GO:0009889	regulation of biosynthetic process	4	2
GO:0009987	cellular process	1	2
GO:0010468	regulation of gene expression	5	2
GO:0010556	regulation of macromolecule biosynthetic process	5	2
GO:0016043	cellular component organization	3	2
GO:0019219	regulation of nucleobase-containing compound metabolic process	5	2
GO:0019222	regulation of metabolic process	3	2
GO:0031323	regulation of cellular metabolic process	4	2
GO:0031326	regulation of cellular biosynthetic process	5	2
GO:0050789	regulation of biological process	2	2
GO:0050794	regulation of cellular process	3	2
GO:0051171	regulation of nitrogen compound metabolic process	4	2
GO:0051252	regulation of RNA metabolic process	5	2
GO:0060255	regulation of macromolecule metabolic process	4	2
GO:0065007	biological regulation	1	2
GO:0071840	cellular component organization or biogenesis	2	2
GO:0080090	regulation of primary metabolic process	4	2
GO:1903506	regulation of nucleic acid-templated transcription	7	2
GO:2001141	regulation of RNA biosynthetic process	6	2

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	2
GO:0005515	protein binding	2	2
GO:0042393	histone binding	3	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	142	144	PF00675	0.394
CLV_NRD_NRD_1	232	234	PF00675	0.567
CLV_NRD_NRD_1	44	46	PF00675	0.267
CLV_PCSK_KEX2_1	142	144	PF00082	0.394
CLV_PCSK_KEX2_1	215	217	PF00082	0.453
CLV_PCSK_KEX2_1	232	234	PF00082	0.457
CLV_PCSK_PC1ET2_1	215	217	PF00082	0.481
CLV_PCSK_SKI1_1	142	146	PF00082	0.382
CLV_PCSK_SKI1_1	398	402	PF00082	0.380
CLV_PCSK_SKI1_1	419	423	PF00082	0.370
CLV_PCSK_SKI1_1	460	464	PF00082	0.393
CLV_Separin_Metazoa	188	192	PF03568	0.475
DEG_Nend_UBRbox_2	1	3	PF02207	0.662
DEG_SPOP_SBC_1	163	167	PF00917	0.471
DEG_SPOP_SBC_1	317	321	PF00917	0.483
DOC_ANK_TNKS_1	231	238	PF00023	0.588
DOC_CYCLIN_RxL_1	395	403	PF00134	0.382
DOC_CYCLIN_yClb5_NLxxxL_5	49	55	PF00134	0.533
DOC_MAPK_DCC_7	154	163	PF00069	0.420
DOC_MAPK_gen_1	215	224	PF00069	0.562
DOC_MAPK_MEF2A_6	215	224	PF00069	0.511
DOC_USP7_MATH_1	164	168	PF00917	0.394
DOC_USP7_MATH_1	264	268	PF00917	0.378
DOC_USP7_MATH_1	317	321	PF00917	0.477
DOC_USP7_MATH_1	343	347	PF00917	0.443
DOC_USP7_MATH_1	362	366	PF00917	0.436
DOC_USP7_MATH_2	198	204	PF00917	0.598
DOC_USP7_UBL2_3	419	423	PF12436	0.495
DOC_WW_Pin1_4	308	313	PF00397	0.556
DOC_WW_Pin1_4	347	352	PF00397	0.359
DOC_WW_Pin1_4	61	66	PF00397	0.456
LIG_14-3-3_CanoR_1	301	309	PF00244	0.395
LIG_14-3-3_CanoR_1	330	340	PF00244	0.531
LIG_14-3-3_CanoR_1	372	380	PF00244	0.438
LIG_14-3-3_CanoR_1	40	45	PF00244	0.443
LIG_Actin_WH2_2	356	374	PF00022	0.487
LIG_BIR_III_4	361	365	PF00653	0.459
LIG_BRCT_BRCA1_1	364	368	PF00533	0.407
LIG_Clathr_ClatBox_1	55	59	PF01394	0.481
LIG_deltaCOP1_diTrp_1	433	438	PF00928	0.348
LIG_deltaCOP1_diTrp_1	59	69	PF00928	0.505
LIG_FHA_1	107	113	PF00498	0.545
LIG_FHA_1	121	127	PF00498	0.426
LIG_FHA_1	266	272	PF00498	0.424
LIG_FHA_1	319	325	PF00498	0.406
LIG_FHA_1	332	338	PF00498	0.399
LIG_FHA_1	426	432	PF00498	0.357
LIG_FHA_1	79	85	PF00498	0.451
LIG_FHA_1	8	14	PF00498	0.702
LIG_FHA_2	204	210	PF00498	0.503
LIG_FHA_2	223	229	PF00498	0.461
LIG_FHA_2	255	261	PF00498	0.478
LIG_FHA_2	308	314	PF00498	0.520
LIG_LIR_Apic_2	308	312	PF02991	0.416
LIG_LIR_Apic_2	59	65	PF02991	0.456
LIG_LIR_Gen_1	176	185	PF02991	0.452
LIG_LIR_Gen_1	94	105	PF02991	0.456
LIG_LIR_Nem_3	176	180	PF02991	0.397
LIG_LIR_Nem_3	288	293	PF02991	0.483
LIG_LIR_Nem_3	365	371	PF02991	0.362
LIG_LIR_Nem_3	94	100	PF02991	0.480
LIG_PDZ_Class_2	461	466	PF00595	0.492
LIG_REV1ctd_RIR_1	366	376	PF16727	0.537
LIG_SH2_CRK	155	159	PF00017	0.425
LIG_SH2_GRB2like	325	328	PF00017	0.518
LIG_SH2_NCK_1	119	123	PF00017	0.577
LIG_SH2_NCK_1	155	159	PF00017	0.464
LIG_SH2_PTP2	97	100	PF00017	0.517
LIG_SH2_SRC	155	158	PF00017	0.461
LIG_SH2_STAT5	173	176	PF00017	0.353
LIG_SH2_STAT5	325	328	PF00017	0.518
LIG_SH2_STAT5	72	75	PF00017	0.514
LIG_SH2_STAT5	97	100	PF00017	0.456
LIG_SH3_1	154	160	PF00018	0.512
LIG_SH3_2	186	191	PF14604	0.519
LIG_SH3_3	10	16	PF00018	0.729
LIG_SH3_3	154	160	PF00018	0.495
LIG_SH3_3	183	189	PF00018	0.514
LIG_SH3_3	192	198	PF00018	0.515
LIG_SUMO_SIM_par_1	159	168	PF11976	0.376
LIG_TRAF2_1	205	208	PF00917	0.504
LIG_TRAF2_1	28	31	PF00917	0.623
LIG_TRAF2_1	34	37	PF00917	0.418
LIG_TRAF2_1	437	440	PF00917	0.487
LIG_WW_3	188	192	PF00397	0.506
MOD_CK1_1	120	126	PF00069	0.591
MOD_CK1_1	165	171	PF00069	0.399
MOD_CK1_1	203	209	PF00069	0.581
MOD_CK1_1	21	27	PF00069	0.634
MOD_CK1_1	265	271	PF00069	0.408
MOD_CK1_1	308	314	PF00069	0.462
MOD_CK1_1	448	454	PF00069	0.400
MOD_CK1_1	77	83	PF00069	0.551
MOD_CK2_1	203	209	PF00069	0.512
MOD_CK2_1	254	260	PF00069	0.544
MOD_CK2_1	31	37	PF00069	0.562
MOD_CK2_1	434	440	PF00069	0.483
MOD_GlcNHglycan	101	104	PF01048	0.310
MOD_GlcNHglycan	2	5	PF01048	0.714
MOD_GlcNHglycan	264	267	PF01048	0.361
MOD_GlcNHglycan	402	405	PF01048	0.320
MOD_GlcNHglycan	76	79	PF01048	0.330
MOD_GlcNHglycan	85	88	PF01048	0.276
MOD_GSK3_1	18	25	PF00069	0.659
MOD_GSK3_1	199	206	PF00069	0.522
MOD_GSK3_1	277	284	PF00069	0.520
MOD_GSK3_1	307	314	PF00069	0.475
MOD_GSK3_1	31	38	PF00069	0.510
MOD_GSK3_1	332	339	PF00069	0.502
MOD_GSK3_1	343	350	PF00069	0.273
MOD_GSK3_1	74	81	PF00069	0.546
MOD_GSK3_1	83	90	PF00069	0.471
MOD_N-GLC_1	277	282	PF02516	0.486
MOD_N-GLC_1	305	310	PF02516	0.521
MOD_N-GLC_1	413	418	PF02516	0.387
MOD_NEK2_1	101	106	PF00069	0.394
MOD_NEK2_1	162	167	PF00069	0.394
MOD_NEK2_1	175	180	PF00069	0.330
MOD_NEK2_1	253	258	PF00069	0.473
MOD_NEK2_1	307	312	PF00069	0.492
MOD_NEK2_1	371	376	PF00069	0.508
MOD_NEK2_1	400	405	PF00069	0.331
MOD_NEK2_1	434	439	PF00069	0.435
MOD_NEK2_1	85	90	PF00069	0.477
MOD_NEK2_2	35	40	PF00069	0.490
MOD_NEK2_2	362	367	PF00069	0.264
MOD_PIKK_1	106	112	PF00454	0.578
MOD_PIKK_1	18	24	PF00454	0.667
MOD_PIKK_1	300	306	PF00454	0.441
MOD_PKA_2	231	237	PF00069	0.582
MOD_PKA_2	300	306	PF00069	0.384
MOD_PKA_2	371	377	PF00069	0.439
MOD_Plk_1	175	181	PF00069	0.408
MOD_Plk_1	30	36	PF00069	0.630
MOD_Plk_1	305	311	PF00069	0.407
MOD_Plk_1	386	392	PF00069	0.438
MOD_Plk_1	93	99	PF00069	0.507
MOD_Plk_2-3	31	37	PF00069	0.616
MOD_Plk_2-3	336	342	PF00069	0.474
MOD_Plk_4	311	317	PF00069	0.399
MOD_Plk_4	80	86	PF00069	0.457
MOD_Plk_4	93	99	PF00069	0.435
MOD_ProDKin_1	308	314	PF00069	0.549
MOD_ProDKin_1	347	353	PF00069	0.365
MOD_ProDKin_1	61	67	PF00069	0.456
TRG_DiLeu_BaLyEn_6	157	162	PF01217	0.432
TRG_ENDOCYTIC_2	155	158	PF00928	0.505
TRG_ENDOCYTIC_2	52	55	PF00928	0.456
TRG_ENDOCYTIC_2	97	100	PF00928	0.456
TRG_ER_diArg_1	142	144	PF00400	0.394
TRG_ER_diArg_1	190	193	PF00400	0.505
TRG_ER_diArg_1	457	460	PF00400	0.343
TRG_NES_CRM1_1	361	373	PF08389	0.511
TRG_Pf-PMV_PEXEL_1	143	147	PF00026	0.402
TRG_Pf-PMV_PEXEL_1	49	53	PF00026	0.267

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ILV6	Leptomonas seymouri	78%	100%
A0A0S4J9M2	Bodo saltans	49%	93%
A0A1X0NIM0	Trypanosomatidae	57%	100%
A0A3Q8IMH5	Leishmania donovani	98%	79%
A0A3R7LDW9	Trypanosoma rangeli	59%	100%
A4HD80	Leishmania braziliensis	89%	100%
D0A6Z2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	55%	100%
E9AH35	Leishmania infantum	98%	100%
E9AWL3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
O22466	Solanum lycopersicum	23%	100%
O22467	Arabidopsis thaliana	23%	100%
O22468	Arabidopsis thaliana	23%	100%
O22469	Arabidopsis thaliana	22%	100%
O22607	Arabidopsis thaliana	22%	92%
O93377	Xenopus laevis	25%	100%
P0CS36	Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565)	24%	100%
P0CS37	Cryptococcus neoformans var. neoformans serotype D (strain B-3501A)	24%	100%
P13712	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	23%	100%
P90916	Caenorhabditis elegans	24%	100%
P90917	Caenorhabditis elegans	24%	100%
Q09028	Homo sapiens	25%	100%
Q10G81	Oryza sativa subsp. japonica	24%	100%
Q16576	Homo sapiens	24%	100%
Q24572	Drosophila melanogaster	25%	100%
Q2UA71	Aspergillus oryzae (strain ATCC 42149 / RIB 40)	23%	100%
Q3MHL3	Bos taurus	25%	100%
Q3SWX8	Bos taurus	24%	100%
Q4I7L0	Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)	24%	100%
Q4P553	Ustilago maydis (strain 521 / FGSC 9021)	26%	100%
Q4R304	Macaca fascicularis	24%	100%
Q4WEI5	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	24%	100%
Q54SD4	Dictyostelium discoideum	22%	100%
Q5M7K4	Xenopus tropicalis	25%	100%
Q5R654	Pongo abelii	24%	100%
Q5RF92	Pongo abelii	25%	100%
Q60972	Mus musculus	25%	100%
Q60973	Mus musculus	24%	100%
Q61Y48	Caenorhabditis briggsae	25%	100%
Q6C7Q4	Yarrowia lipolytica (strain CLIB 122 / E 150)	22%	100%
Q6INH0	Xenopus laevis	25%	100%
Q6P315	Xenopus tropicalis	24%	100%
Q6P3H7	Danio rerio	24%	100%
Q71UF4	Rattus norvegicus	24%	100%
Q75C99	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	20%	100%
Q7S7N3	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	23%	100%
Q7ZTY4	Danio rerio	24%	100%
Q8AVH1	Xenopus laevis	24%	100%
Q8SRK1	Encephalitozoon cuniculi (strain GB-M1)	24%	100%
Q9I8G9	Gallus gallus	24%	100%
Q9W7I5	Gallus gallus	25%	100%
Q9Y825	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	24%	100%
V5BAV4	Trypanosoma cruzi	59%	89%