FCP1 homology domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

NLI interacting factor-like phosphatase, putative

Species:

Leishmania major

UniProt:

Q4QAV2_LEIMA

TriTrypDb:

LmjF.24.0290 , LMJLV39_240008100 , LMJSD75_240007800

Length:

238

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4QAV2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QAV2

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	2
GO:0004721	phosphoprotein phosphatase activity	3	2
GO:0016787	hydrolase activity	2	2
GO:0016788	hydrolase activity, acting on ester bonds	3	2
GO:0016791	phosphatase activity	5	2
GO:0042578	phosphoric ester hydrolase activity	4	2
GO:0140096	catalytic activity, acting on a protein	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	36	40	PF00656	0.469
CLV_NRD_NRD_1	149	151	PF00675	0.280
CLV_NRD_NRD_1	21	23	PF00675	0.468
CLV_PCSK_KEX2_1	148	150	PF00082	0.280
CLV_PCSK_KEX2_1	21	23	PF00082	0.468
CLV_PCSK_KEX2_1	213	215	PF00082	0.389
CLV_PCSK_PC1ET2_1	148	150	PF00082	0.168
CLV_PCSK_PC1ET2_1	213	215	PF00082	0.389
CLV_PCSK_SKI1_1	136	140	PF00082	0.280
CLV_PCSK_SKI1_1	21	25	PF00082	0.453
CLV_PCSK_SKI1_1	59	63	PF00082	0.240
CLV_PCSK_SKI1_1	6	10	PF00082	0.473
DEG_APCC_DBOX_1	20	28	PF00400	0.280
DOC_CDC14_PxL_1	206	214	PF14671	0.393
DOC_CYCLIN_RxL_1	3	12	PF00134	0.466
DOC_CYCLIN_yCln2_LP_2	189	195	PF00134	0.350
DOC_CYCLIN_yCln2_LP_2	4	10	PF00134	0.487
DOC_MAPK_gen_1	167	176	PF00069	0.369
DOC_MAPK_gen_1	21	28	PF00069	0.296
DOC_MAPK_gen_1	59	68	PF00069	0.268
DOC_MAPK_JIP1_4	48	54	PF00069	0.240
DOC_MAPK_MEF2A_6	21	30	PF00069	0.280
DOC_MAPK_MEF2A_6	59	68	PF00069	0.240
DOC_MAPK_NFAT4_5	21	29	PF00069	0.280
DOC_PP4_FxxP_1	102	105	PF00568	0.240
DOC_USP7_MATH_1	228	232	PF00917	0.455
LIG_14-3-3_CanoR_1	21	27	PF00244	0.325
LIG_14-3-3_CanoR_1	222	227	PF00244	0.405
LIG_14-3-3_CanoR_1	41	49	PF00244	0.276
LIG_BRCT_BRCA1_1	98	102	PF00533	0.280
LIG_EH1_1	159	167	PF00400	0.240
LIG_eIF4E_1	160	166	PF01652	0.240
LIG_FHA_1	101	107	PF00498	0.166
LIG_FHA_1	171	177	PF00498	0.246
LIG_FHA_1	23	29	PF00498	0.345
LIG_FHA_1	85	91	PF00498	0.373
LIG_GBD_Chelix_1	161	169	PF00786	0.280
LIG_GBD_Chelix_1	26	34	PF00786	0.240
LIG_LIR_Apic_2	194	198	PF02991	0.359
LIG_LIR_Apic_2	99	105	PF02991	0.240
LIG_LIR_Nem_3	142	147	PF02991	0.280
LIG_PTB_Apo_2	154	161	PF02174	0.240
LIG_PTB_Phospho_1	154	160	PF10480	0.240
LIG_REV1ctd_RIR_1	198	204	PF16727	0.380
LIG_SH2_CRK	195	199	PF00017	0.251
LIG_SH2_NCK_1	195	199	PF00017	0.363
LIG_SH2_STAT5	160	163	PF00017	0.240
LIG_SH2_STAT5	50	53	PF00017	0.295
LIG_SH3_3	4	10	PF00018	0.497
LIG_SH3_3	43	49	PF00018	0.280
LIG_SUMO_SIM_anti_2	63	68	PF11976	0.320
LIG_SUMO_SIM_par_1	120	125	PF11976	0.300
LIG_SUMO_SIM_par_1	24	29	PF11976	0.324
MOD_CK1_1	40	46	PF00069	0.280
MOD_CK2_1	69	75	PF00069	0.286
MOD_GlcNHglycan	42	45	PF01048	0.295
MOD_GSK3_1	170	177	PF00069	0.387
MOD_GSK3_1	33	40	PF00069	0.280
MOD_GSK3_1	69	76	PF00069	0.263
MOD_GSK3_1	96	103	PF00069	0.311
MOD_N-GLC_1	228	233	PF02516	0.447
MOD_NEK2_1	30	35	PF00069	0.240
MOD_NEK2_1	84	89	PF00069	0.280
MOD_NEK2_1	96	101	PF00069	0.195
MOD_PIKK_1	100	106	PF00454	0.280
MOD_PKA_2	37	43	PF00069	0.280
MOD_PKA_2	96	102	PF00069	0.280
MOD_Plk_1	124	130	PF00069	0.280
MOD_Plk_1	170	176	PF00069	0.557
MOD_Plk_1	228	234	PF00069	0.449
MOD_Plk_1	30	36	PF00069	0.240
MOD_Plk_4	22	28	PF00069	0.174
MOD_Plk_4	228	234	PF00069	0.449
MOD_Plk_4	30	36	PF00069	0.240
MOD_Plk_4	9	15	PF00069	0.420
MOD_Plk_4	96	102	PF00069	0.300
MOD_SUMO_rev_2	208	215	PF00179	0.390
TRG_DiLeu_BaEn_1	151	156	PF01217	0.295
TRG_DiLeu_BaLyEn_6	109	114	PF01217	0.240
TRG_DiLeu_BaLyEn_6	19	24	PF01217	0.358
TRG_ENDOCYTIC_2	159	162	PF00928	0.240
TRG_ER_diArg_1	21	23	PF00400	0.478
TRG_Pf-PMV_PEXEL_1	112	117	PF00026	0.240
TRG_Pf-PMV_PEXEL_1	120	125	PF00026	0.240

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HTD7	Leptomonas seymouri	30%	83%
A0A0S4ILH7	Bodo saltans	57%	66%
A0A3S7WY63	Leishmania donovani	97%	100%
A4HEM1	Leishmania braziliensis	28%	82%
C9ZJI3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	71%
E9AH40	Leishmania infantum	97%	100%
E9AWL8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
M9PFN0	Drosophila melanogaster	34%	68%
O95476	Homo sapiens	27%	98%
Q1RMV9	Bos taurus	26%	98%
Q28HW9	Xenopus tropicalis	27%	98%
Q3B7T6	Rattus norvegicus	27%	98%
Q3TP92	Mus musculus	27%	98%
Q8BX07	Mus musculus	37%	88%
Q8JIL9	Xenopus laevis	27%	98%
V5BAV0	Trypanosoma cruzi	65%	81%