Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QAV0_LEIMA

TriTrypDb:

LmjF.24.0310 , LMJLV39_240008300 , LMJSD75_240008000

Length:

319

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005815	microtubule organizing center	2	2
GO:0036064	ciliary basal body	3	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4QAV0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QAV0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	129	131	PF00675	0.629
CLV_NRD_NRD_1	18	20	PF00675	0.609
CLV_NRD_NRD_1	236	238	PF00675	0.577
CLV_NRD_NRD_1	84	86	PF00675	0.648
CLV_PCSK_KEX2_1	129	131	PF00082	0.667
CLV_PCSK_KEX2_1	18	20	PF00082	0.609
CLV_PCSK_KEX2_1	196	198	PF00082	0.437
CLV_PCSK_KEX2_1	236	238	PF00082	0.577
CLV_PCSK_KEX2_1	84	86	PF00082	0.648
CLV_PCSK_PC1ET2_1	196	198	PF00082	0.464
CLV_PCSK_SKI1_1	236	240	PF00082	0.542
CLV_PCSK_SKI1_1	60	64	PF00082	0.776
DEG_APCC_DBOX_1	171	179	PF00400	0.625
DEG_APCC_DBOX_1	244	252	PF00400	0.395
DEG_SPOP_SBC_1	216	220	PF00917	0.623
DOC_CYCLIN_yCln2_LP_2	34	40	PF00134	0.611
DOC_MAPK_gen_1	243	251	PF00069	0.408
DOC_PP2B_LxvP_1	163	166	PF13499	0.557
DOC_USP7_MATH_1	137	141	PF00917	0.725
DOC_USP7_MATH_1	50	54	PF00917	0.771
DOC_USP7_MATH_1	89	93	PF00917	0.679
DOC_WW_Pin1_4	217	222	PF00397	0.577
DOC_WW_Pin1_4	33	38	PF00397	0.672
DOC_WW_Pin1_4	91	96	PF00397	0.593
LIG_14-3-3_CanoR_1	155	163	PF00244	0.669
LIG_14-3-3_CanoR_1	18	22	PF00244	0.670
LIG_14-3-3_CanoR_1	236	242	PF00244	0.524
LIG_14-3-3_CanoR_1	84	89	PF00244	0.694
LIG_BIR_III_4	103	107	PF00653	0.535
LIG_CtBP_PxDLS_1	255	259	PF00389	0.501
LIG_FHA_1	196	202	PF00498	0.370
LIG_FHA_1	233	239	PF00498	0.489
LIG_FHA_1	29	35	PF00498	0.559
LIG_FHA_2	6	12	PF00498	0.740
LIG_LIR_Apic_2	117	123	PF02991	0.506
LIG_LIR_Gen_1	203	213	PF02991	0.391
LIG_LIR_Nem_3	203	208	PF02991	0.378
LIG_MYND_1	173	177	PF01753	0.449
LIG_NRBOX	260	266	PF00104	0.419
LIG_Pex14_2	21	25	PF04695	0.700
LIG_Pex14_2	301	305	PF04695	0.345
LIG_SH2_PTP2	205	208	PF00017	0.377
LIG_SH2_PTP2	4	7	PF00017	0.699
LIG_SH2_STAT3	180	183	PF00017	0.415
LIG_SH2_STAT5	205	208	PF00017	0.377
LIG_SH2_STAT5	4	7	PF00017	0.699
LIG_SH3_3	164	170	PF00018	0.659
LIG_SH3_3	34	40	PF00018	0.660
LIG_SH3_3	83	89	PF00018	0.566
LIG_SUMO_SIM_anti_2	259	265	PF11976	0.378
LIG_SUMO_SIM_par_1	246	252	PF11976	0.405
LIG_SUMO_SIM_par_1	254	260	PF11976	0.490
LIG_TRAF2_1	181	184	PF00917	0.394
MOD_CDK_SPK_2	217	222	PF00069	0.611
MOD_CK1_1	171	177	PF00069	0.626
MOD_CK1_1	215	221	PF00069	0.444
MOD_CK1_1	278	284	PF00069	0.484
MOD_CK1_1	72	78	PF00069	0.557
MOD_CK2_1	178	184	PF00069	0.431
MOD_CK2_1	5	11	PF00069	0.657
MOD_Cter_Amidation	16	19	PF01082	0.623
MOD_DYRK1A_RPxSP_1	91	95	PF00069	0.695
MOD_GlcNHglycan	15	18	PF01048	0.671
MOD_GlcNHglycan	158	161	PF01048	0.585
MOD_GlcNHglycan	86	89	PF01048	0.730
MOD_GSK3_1	13	20	PF00069	0.636
MOD_GSK3_1	139	146	PF00069	0.636
MOD_GSK3_1	147	154	PF00069	0.566
MOD_GSK3_1	212	219	PF00069	0.495
MOD_GSK3_1	273	280	PF00069	0.701
MOD_GSK3_1	50	57	PF00069	0.563
MOD_LATS_1	68	74	PF00433	0.703
MOD_N-GLC_1	114	119	PF02516	0.645
MOD_N-GLC_1	307	312	PF02516	0.582
MOD_NEK2_1	151	156	PF00069	0.620
MOD_NEK2_1	54	59	PF00069	0.697
MOD_PIKK_1	39	45	PF00454	0.572
MOD_PKA_1	84	90	PF00069	0.641
MOD_PKA_2	128	134	PF00069	0.640
MOD_PKA_2	17	23	PF00069	0.633
MOD_PKA_2	171	177	PF00069	0.638
MOD_PKA_2	209	215	PF00069	0.594
MOD_PKA_2	84	90	PF00069	0.750
MOD_Plk_1	143	149	PF00069	0.469
MOD_Plk_1	285	291	PF00069	0.593
MOD_Plk_4	171	177	PF00069	0.580
MOD_ProDKin_1	217	223	PF00069	0.576
MOD_ProDKin_1	33	39	PF00069	0.671
MOD_ProDKin_1	91	97	PF00069	0.592
TRG_ENDOCYTIC_2	205	208	PF00928	0.406
TRG_ER_diArg_1	128	130	PF00400	0.654
TRG_ER_diArg_1	236	238	PF00400	0.580
TRG_ER_diArg_1	83	85	PF00400	0.617
TRG_NES_CRM1_1	246	260	PF08389	0.387
TRG_Pf-PMV_PEXEL_1	199	203	PF00026	0.325
TRG_Pf-PMV_PEXEL_1	99	103	PF00026	0.675

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1G9	Leptomonas seymouri	61%	100%
A0A1X0NJB4	Trypanosomatidae	36%	100%
A0A3Q8IB82	Leishmania donovani	91%	100%
A0A3R7RTA5	Trypanosoma rangeli	36%	100%
A4HD87	Leishmania braziliensis	81%	100%
D0A6Z9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	100%
E9AH42	Leishmania infantum	92%	100%
E9AWM0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
V5C0R1	Trypanosoma cruzi	39%	100%