Mitochondrial small ribosomal subunit Rsm22-domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Mitochondrial small ribosomal subunit Rsm22, putative

Species:

Leishmania major

UniProt:

Q4QAU8_LEIMA

TriTrypDb:

LmjF.24.0330 , LMJLV39_240008500 , LMJSD75_240008200

Length:

1040

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

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Cellular components
Term	Name	Level	Count
GO:0000314	organellar small ribosomal subunit	5	2
GO:0005739	mitochondrion	5	7
GO:0005763	mitochondrial small ribosomal subunit	3	2
GO:0015935	small ribosomal subunit	4	2
GO:0032991	protein-containing complex	1	2
GO:0043226	organelle	2	7
GO:0043227	membrane-bounded organelle	3	7
GO:0043229	intracellular organelle	3	7
GO:0043231	intracellular membrane-bounded organelle	4	7
GO:0044391	ribosomal subunit	3	2

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Expansion

Sequence features

Q4QAU8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QAU8

Function

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Biological processes
Term	Name	Level	Count
GO:0006412	translation	4	10
GO:0006518	peptide metabolic process	4	10
GO:0006807	nitrogen compound metabolic process	2	10
GO:0008152	metabolic process	1	10
GO:0009058	biosynthetic process	2	10
GO:0009059	macromolecule biosynthetic process	4	10
GO:0009987	cellular process	1	10
GO:0019538	protein metabolic process	3	10
GO:0032259	methylation	2	9
GO:0034641	cellular nitrogen compound metabolic process	3	10

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Molecular functions
Term	Name	Level	Count
GO:0003735	structural constituent of ribosome	2	2
GO:0003824	catalytic activity	1	10
GO:0005198	structural molecule activity	1	2
GO:0008168	methyltransferase activity	4	10
GO:0016740	transferase activity	2	10
GO:0016741	transferase activity, transferring one-carbon groups	3	10

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	412	416	PF00656	0.499
CLV_C14_Caspase3-7	443	447	PF00656	0.646
CLV_C14_Caspase3-7	535	539	PF00656	0.437
CLV_NRD_NRD_1	114	116	PF00675	0.451
CLV_NRD_NRD_1	205	207	PF00675	0.545
CLV_NRD_NRD_1	3	5	PF00675	0.708
CLV_NRD_NRD_1	348	350	PF00675	0.656
CLV_NRD_NRD_1	357	359	PF00675	0.558
CLV_NRD_NRD_1	384	386	PF00675	0.550
CLV_NRD_NRD_1	400	402	PF00675	0.624

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I6P8	Leptomonas seymouri	82%	100%
A0A1X0NIP1	Trypanosomatidae	73%	100%
A0A3Q8IG11	Leishmania donovani	97%	100%
A4HD89	Leishmania braziliensis	92%	100%
D0A703	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	72%	100%
E9AH44	Leishmania infantum	96%	100%
E9AWM2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
V5BAU4	Trypanosoma cruzi	74%	100%

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