LeishMANIAdb
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G_PROTEIN_RECEP_F2_4 domain-containing protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
G_PROTEIN_RECEP_F2_4 domain-containing protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania major
UniProt:
Q4QAU6_LEIMA
TriTrypDb:
LmjF.24.0350 , LMJLV39_240008700 * , LMJSD75_240008400
Length:
263

Annotations

LeishMANIAdb annotations

A small and unique family of kinetoplastid proteins. No relationship to amastins.

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 9
NetGPI no yes: 0, no: 9
Cellular components
Term Name Level Count
GO:0016020 membrane 2 9
GO:0110165 cellular anatomical entity 1 9

Expansion

Sequence features

Q4QAU6
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QAU6

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 251 255 PF00656 0.685
CLV_NRD_NRD_1 171 173 PF00675 0.405
CLV_NRD_NRD_1 176 178 PF00675 0.309
CLV_NRD_NRD_1 247 249 PF00675 0.506
CLV_NRD_NRD_1 259 261 PF00675 0.443
CLV_NRD_NRD_1 87 89 PF00675 0.377
CLV_PCSK_FUR_1 169 173 PF00082 0.426
CLV_PCSK_FUR_1 174 178 PF00082 0.328
CLV_PCSK_KEX2_1 171 173 PF00082 0.372
CLV_PCSK_KEX2_1 176 178 PF00082 0.314
CLV_PCSK_KEX2_1 247 249 PF00082 0.506
CLV_PCSK_KEX2_1 259 261 PF00082 0.443
CLV_PCSK_KEX2_1 87 89 PF00082 0.376
CLV_PCSK_PC7_1 172 178 PF00082 0.349
DEG_Nend_UBRbox_2 1 3 PF02207 0.584
DOC_PP2B_PxIxI_1 107 113 PF00149 0.323
DOC_PP4_FxxP_1 105 108 PF00568 0.527
DOC_PP4_MxPP_1 218 221 PF00568 0.611
DOC_USP7_MATH_1 15 19 PF00917 0.646
DOC_USP7_MATH_1 23 27 PF00917 0.574
DOC_WW_Pin1_4 216 221 PF00397 0.701
LIG_14-3-3_CanoR_1 133 143 PF00244 0.395
LIG_14-3-3_CanoR_1 190 196 PF00244 0.669
LIG_14-3-3_CanoR_1 226 231 PF00244 0.696
LIG_BIR_III_4 254 258 PF00653 0.668
LIG_deltaCOP1_diTrp_1 120 130 PF00928 0.309
LIG_deltaCOP1_diTrp_1 168 175 PF00928 0.624
LIG_FHA_1 225 231 PF00498 0.701
LIG_FHA_1 35 41 PF00498 0.498
LIG_FHA_1 5 11 PF00498 0.552
LIG_FHA_2 226 232 PF00498 0.716
LIG_LIR_Apic_2 167 173 PF02991 0.593
LIG_LIR_Gen_1 229 238 PF02991 0.686
LIG_LIR_Gen_1 34 44 PF02991 0.359
LIG_LIR_Gen_1 48 56 PF02991 0.357
LIG_LIR_Nem_3 229 235 PF02991 0.726
LIG_LIR_Nem_3 30 36 PF02991 0.497
LIG_LIR_Nem_3 48 52 PF02991 0.214
LIG_Pex14_1 101 105 PF04695 0.593
LIG_Pex14_1 20 24 PF04695 0.621
LIG_Pex14_2 161 165 PF04695 0.387
LIG_PTB_Apo_2 72 79 PF02174 0.285
LIG_SH2_CRK 183 187 PF00017 0.650
LIG_SH2_CRK 232 236 PF00017 0.696
LIG_SH2_NCK_1 232 236 PF00017 0.613
LIG_SH2_STAP1 113 117 PF00017 0.323
LIG_SH2_STAP1 193 197 PF00017 0.640
LIG_SH2_STAP1 36 40 PF00017 0.372
LIG_SH2_STAT5 116 119 PF00017 0.311
LIG_SH2_STAT5 153 156 PF00017 0.408
LIG_SH2_STAT5 185 188 PF00017 0.614
LIG_SH2_STAT5 193 196 PF00017 0.672
LIG_SH2_STAT5 36 39 PF00017 0.491
LIG_SUMO_SIM_par_1 108 114 PF11976 0.368
LIG_SUMO_SIM_par_1 209 214 PF11976 0.686
LIG_SUMO_SIM_par_1 80 86 PF11976 0.323
LIG_TYR_ITIM 151 156 PF00017 0.385
LIG_TYR_ITIM 230 235 PF00017 0.637
LIG_ULM_U2AF65_1 171 176 PF00076 0.452
LIG_WRC_WIRS_1 46 51 PF05994 0.333
MOD_CK1_1 18 24 PF00069 0.468
MOD_CK1_1 34 40 PF00069 0.224
MOD_Cter_Amidation 245 248 PF01082 0.601
MOD_GlcNHglycan 29 32 PF01048 0.499
MOD_GlcNHglycan 41 44 PF01048 0.367
MOD_GSK3_1 134 141 PF00069 0.476
MOD_GSK3_1 160 167 PF00069 0.444
MOD_GSK3_1 221 228 PF00069 0.623
MOD_GSK3_1 23 30 PF00069 0.434
MOD_GSK3_1 233 240 PF00069 0.717
MOD_NEK2_1 160 165 PF00069 0.348
MOD_NEK2_1 186 191 PF00069 0.495
MOD_NEK2_1 39 44 PF00069 0.320
MOD_NEK2_1 45 50 PF00069 0.301
MOD_NEK2_2 111 116 PF00069 0.323
MOD_NEK2_2 31 36 PF00069 0.401
MOD_NEK2_2 4 9 PF00069 0.434
MOD_PIKK_1 96 102 PF00454 0.512
MOD_PKA_2 191 197 PF00069 0.588
MOD_PKA_2 225 231 PF00069 0.650
MOD_PKA_2 249 255 PF00069 0.669
MOD_PKA_2 27 33 PF00069 0.470
MOD_Plk_1 199 205 PF00069 0.661
MOD_Plk_1 96 102 PF00069 0.455
MOD_Plk_2-3 231 237 PF00069 0.673
MOD_Plk_4 111 117 PF00069 0.420
MOD_Plk_4 161 167 PF00069 0.319
MOD_Plk_4 31 37 PF00069 0.361
MOD_ProDKin_1 216 222 PF00069 0.641
TRG_DiLeu_BaLyEn_6 105 110 PF01217 0.323
TRG_ENDOCYTIC_2 153 156 PF00928 0.349
TRG_ENDOCYTIC_2 183 186 PF00928 0.556
TRG_ENDOCYTIC_2 232 235 PF00928 0.673
TRG_ENDOCYTIC_2 36 39 PF00928 0.392
TRG_ENDOCYTIC_2 66 69 PF00928 0.398
TRG_ER_diArg_1 170 172 PF00400 0.519
TRG_ER_diArg_1 175 177 PF00400 0.328
TRG_ER_diArg_1 190 193 PF00400 0.397
TRG_ER_diArg_1 8 11 PF00400 0.405

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1HZY6 Leptomonas seymouri 57% 100%
A0A1X0NJ34 Trypanosomatidae 33% 72%
A0A3S5ISN9 Trypanosoma rangeli 28% 91%
A0A3S7WY31 Leishmania donovani 93% 100%
A4HD91 Leishmania braziliensis 73% 91%
D0A705 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 27% 100%
E9AH46 Leishmania infantum 93% 100%
E9AWM4 Leishmania mexicana (strain MHOM/GT/2001/U1103) 87% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS