LeishMANIAdb
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Putative UDP-galactose transporter

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Putative UDP-galactose transporter
Gene product:
UDP-galactose transporter
Species:
Leishmania major
UniProt:
Q4QAU5_LEIMA
TriTrypDb:
LmjF.24.0360 , LMJLV39_240008900 * , LMJSD75_240008600 *
Length:
600

Annotations

LeishMANIAdb annotations

Homologous to animal UDP-N-acetylglucosamine, UDP-galactose and CMP-sialic acid transporters. Only expanded in the Leptomonas lineage. Localization: Golgi (by homology)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 2, no: 13
NetGPI no yes: 0, no: 15
Cellular components
Term Name Level Count
GO:0000139 Golgi membrane 5 16
GO:0016020 membrane 2 16
GO:0031090 organelle membrane 3 16
GO:0098588 bounding membrane of organelle 4 16
GO:0110165 cellular anatomical entity 1 16

Expansion

Sequence features

Q4QAU5
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QAU5

Function

Biological processes
Term Name Level Count
GO:0006810 transport 3 2
GO:0006811 monoatomic ion transport 4 2
GO:0006820 monoatomic anion transport 5 2
GO:0009987 cellular process 1 2
GO:0015711 organic anion transport 5 2
GO:0015780 nucleotide-sugar transmembrane transport 3 2
GO:0015931 nucleobase-containing compound transport 5 2
GO:0034220 monoatomic ion transmembrane transport 3 2
GO:0051179 localization 1 2
GO:0051234 establishment of localization 2 2
GO:0055085 transmembrane transport 2 2
GO:0071702 organic substance transport 4 2
GO:0071705 nitrogen compound transport 4 2
GO:0072334 UDP-galactose transmembrane transport 5 2
GO:0090481 pyrimidine nucleotide-sugar transmembrane transport 4 2
GO:0098656 monoatomic anion transmembrane transport 4 2
GO:1901264 carbohydrate derivative transport 5 2
Molecular functions
Term Name Level Count
GO:0005215 transporter activity 1 16
GO:0005338 nucleotide-sugar transmembrane transporter activity 4 16
GO:0005459 UDP-galactose transmembrane transporter activity 6 2
GO:0015136 sialic acid transmembrane transporter activity 4 2
GO:0015165 pyrimidine nucleotide-sugar transmembrane transporter activity 5 16
GO:0015932 nucleobase-containing compound transmembrane transporter activity 3 16
GO:0022857 transmembrane transporter activity 2 16
GO:1901505 carbohydrate derivative transmembrane transporter activity 3 16

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 293 297 PF00656 0.637
CLV_NRD_NRD_1 160 162 PF00675 0.524
CLV_NRD_NRD_1 24 26 PF00675 0.362
CLV_NRD_NRD_1 314 316 PF00675 0.338
CLV_NRD_NRD_1 40 42 PF00675 0.386
CLV_NRD_NRD_1 63 65 PF00675 0.418
CLV_NRD_NRD_1 94 96 PF00675 0.426
CLV_NRD_NRD_1 97 99 PF00675 0.426
CLV_PCSK_FUR_1 75 79 PF00082 0.455
CLV_PCSK_FUR_1 95 99 PF00082 0.376
CLV_PCSK_KEX2_1 160 162 PF00082 0.500
CLV_PCSK_KEX2_1 24 26 PF00082 0.362
CLV_PCSK_KEX2_1 316 318 PF00082 0.309
CLV_PCSK_KEX2_1 40 42 PF00082 0.386
CLV_PCSK_KEX2_1 474 476 PF00082 0.376
CLV_PCSK_KEX2_1 63 65 PF00082 0.429
CLV_PCSK_KEX2_1 77 79 PF00082 0.439
CLV_PCSK_KEX2_1 96 98 PF00082 0.380
CLV_PCSK_PC1ET2_1 316 318 PF00082 0.325
CLV_PCSK_PC1ET2_1 474 476 PF00082 0.376
CLV_PCSK_PC1ET2_1 77 79 PF00082 0.453
CLV_PCSK_PC1ET2_1 96 98 PF00082 0.380
CLV_PCSK_SKI1_1 161 165 PF00082 0.444
CLV_PCSK_SKI1_1 210 214 PF00082 0.694
CLV_PCSK_SKI1_1 227 231 PF00082 0.275
CLV_PCSK_SKI1_1 25 29 PF00082 0.368
CLV_PCSK_SKI1_1 310 314 PF00082 0.436
CLV_PCSK_SKI1_1 327 331 PF00082 0.305
CLV_PCSK_SKI1_1 337 341 PF00082 0.301
CLV_PCSK_SKI1_1 375 379 PF00082 0.409
CLV_PCSK_SKI1_1 384 388 PF00082 0.361
DEG_APCC_DBOX_1 23 31 PF00400 0.571
DEG_SCF_TRCP1_1 264 269 PF00400 0.781
DOC_CKS1_1 253 258 PF01111 0.630
DOC_CKS1_1 574 579 PF01111 0.330
DOC_CYCLIN_RxL_1 305 314 PF00134 0.515
DOC_MAPK_gen_1 160 166 PF00069 0.651
DOC_MAPK_gen_1 24 32 PF00069 0.575
DOC_MAPK_gen_1 315 323 PF00069 0.582
DOC_MAPK_gen_1 325 332 PF00069 0.576
DOC_MAPK_gen_1 335 344 PF00069 0.551
DOC_MAPK_MEF2A_6 24 32 PF00069 0.575
DOC_MAPK_MEF2A_6 375 383 PF00069 0.356
DOC_MAPK_MEF2A_6 395 404 PF00069 0.379
DOC_MAPK_NFAT4_5 25 33 PF00069 0.578
DOC_PP1_RVXF_1 208 215 PF00149 0.432
DOC_PP1_RVXF_1 373 379 PF00149 0.427
DOC_PP1_RVXF_1 525 532 PF00149 0.290
DOC_PP2B_LxvP_1 28 31 PF13499 0.579
DOC_PP4_FxxP_1 153 156 PF00568 0.685
DOC_USP7_MATH_1 120 124 PF00917 0.628
DOC_USP7_MATH_1 281 285 PF00917 0.783
DOC_USP7_MATH_1 428 432 PF00917 0.388
DOC_WW_Pin1_4 109 114 PF00397 0.596
DOC_WW_Pin1_4 152 157 PF00397 0.688
DOC_WW_Pin1_4 252 257 PF00397 0.747
DOC_WW_Pin1_4 273 278 PF00397 0.774
DOC_WW_Pin1_4 33 38 PF00397 0.592
DOC_WW_Pin1_4 389 394 PF00397 0.576
DOC_WW_Pin1_4 573 578 PF00397 0.451
DOC_WW_Pin1_4 67 72 PF00397 0.610
DOC_WW_Pin1_4 87 92 PF00397 0.611
DOC_WW_Pin1_4 97 102 PF00397 0.599
LIG_14-3-3_CanoR_1 210 215 PF00244 0.504
LIG_14-3-3_CanoR_1 247 253 PF00244 0.591
LIG_14-3-3_CanoR_1 63 71 PF00244 0.649
LIG_AP2alpha_1 521 525 PF02296 0.376
LIG_APCC_ABBA_1 270 275 PF00400 0.596
LIG_BIR_II_1 1 5 PF00653 0.581
LIG_BIR_III_4 85 89 PF00653 0.636
LIG_BRCT_BRCA1_1 463 467 PF00533 0.462
LIG_BRCT_BRCA1_1 518 522 PF00533 0.376
LIG_BRCT_BRCA1_1 557 561 PF00533 0.462
LIG_EH1_1 348 356 PF00400 0.462
LIG_eIF4E_1 336 342 PF01652 0.576
LIG_eIF4E_1 349 355 PF01652 0.462
LIG_eIF4E_1 372 378 PF01652 0.449
LIG_FHA_1 102 108 PF00498 0.592
LIG_FHA_1 12 18 PF00498 0.639
LIG_FHA_1 221 227 PF00498 0.375
LIG_FHA_1 255 261 PF00498 0.746
LIG_FHA_1 524 530 PF00498 0.335
LIG_FHA_1 566 572 PF00498 0.402
LIG_FHA_1 579 585 PF00498 0.278
LIG_FHA_2 414 420 PF00498 0.350
LIG_FHA_2 518 524 PF00498 0.376
LIG_GBD_Chelix_1 347 355 PF00786 0.398
LIG_HCF-1_HBM_1 333 336 PF13415 0.590
LIG_LIR_Apic_2 152 156 PF02991 0.609
LIG_LIR_Apic_2 194 198 PF02991 0.555
LIG_LIR_Gen_1 231 242 PF02991 0.450
LIG_LIR_Gen_1 366 376 PF02991 0.428
LIG_LIR_Gen_1 46 54 PF02991 0.589
LIG_LIR_Gen_1 464 472 PF02991 0.482
LIG_LIR_Gen_1 523 533 PF02991 0.357
LIG_LIR_Gen_1 558 569 PF02991 0.419
LIG_LIR_Gen_1 586 595 PF02991 0.381
LIG_LIR_Nem_3 231 237 PF02991 0.383
LIG_LIR_Nem_3 366 371 PF02991 0.417
LIG_LIR_Nem_3 46 52 PF02991 0.597
LIG_LIR_Nem_3 461 466 PF02991 0.422
LIG_LIR_Nem_3 492 498 PF02991 0.385
LIG_LIR_Nem_3 519 525 PF02991 0.312
LIG_LIR_Nem_3 558 564 PF02991 0.430
LIG_MLH1_MIPbox_1 518 522 PF16413 0.376
LIG_Pex14_1 158 162 PF04695 0.736
LIG_Pex14_2 318 322 PF04695 0.527
LIG_Pex14_2 459 463 PF04695 0.449
LIG_Pex14_2 496 500 PF04695 0.462
LIG_Pex14_2 517 521 PF04695 0.351
LIG_Pex14_2 557 561 PF04695 0.462
LIG_PTB_Apo_2 175 182 PF02174 0.462
LIG_PTB_Phospho_1 175 181 PF10480 0.449
LIG_SH2_CRK 195 199 PF00017 0.423
LIG_SH2_STAP1 358 362 PF00017 0.391
LIG_SH2_STAT3 187 190 PF00017 0.414
LIG_SH2_STAT3 349 352 PF00017 0.356
LIG_SH2_STAT5 162 165 PF00017 0.636
LIG_SH2_STAT5 181 184 PF00017 0.283
LIG_SH2_STAT5 302 305 PF00017 0.702
LIG_SH2_STAT5 495 498 PF00017 0.399
LIG_SH2_STAT5 549 552 PF00017 0.576
LIG_SH2_STAT5 596 599 PF00017 0.472
LIG_SH3_2 35 40 PF14604 0.592
LIG_SH3_2 91 96 PF14604 0.626
LIG_SH3_3 110 116 PF00018 0.602
LIG_SH3_3 250 256 PF00018 0.665
LIG_SH3_3 32 38 PF00018 0.666
LIG_SH3_3 501 507 PF00018 0.229
LIG_SH3_3 88 94 PF00018 0.627
LIG_SH3_CIN85_PxpxPR_1 35 40 PF14604 0.592
LIG_Sin3_3 168 175 PF02671 0.482
LIG_SUMO_SIM_par_1 181 186 PF11976 0.425
LIG_SUMO_SIM_par_1 353 359 PF11976 0.398
LIG_TRAF2_1 204 207 PF00917 0.493
LIG_TRFH_1 389 393 PF08558 0.590
LIG_TYR_ITIM 493 498 PF00017 0.482
LIG_UBA3_1 354 361 PF00899 0.398
LIG_WRC_WIRS_1 150 155 PF05994 0.581
LIG_WRC_WIRS_1 229 234 PF05994 0.370
LIG_WRC_WIRS_1 554 559 PF05994 0.528
LIG_WRC_WIRS_1 584 589 PF05994 0.372
LIG_WW_3 37 41 PF00397 0.594
MOD_CDC14_SPxK_1 392 395 PF00782 0.590
MOD_CDK_SPK_2 273 278 PF00069 0.613
MOD_CDK_SPK_2 67 72 PF00069 0.610
MOD_CDK_SPxK_1 389 395 PF00069 0.590
MOD_CDK_SPxxK_3 33 40 PF00069 0.594
MOD_CK1_1 109 115 PF00069 0.631
MOD_CK1_1 123 129 PF00069 0.579
MOD_CK1_1 135 141 PF00069 0.587
MOD_CK1_1 152 158 PF00069 0.660
MOD_CK1_1 33 39 PF00069 0.711
MOD_CK1_1 444 450 PF00069 0.376
MOD_CK1_1 461 467 PF00069 0.219
MOD_CK1_1 556 562 PF00069 0.431
MOD_CK1_1 67 73 PF00069 0.651
MOD_CK2_1 428 434 PF00069 0.404
MOD_GlcNHglycan 137 140 PF01048 0.491
MOD_GlcNHglycan 248 251 PF01048 0.466
MOD_GlcNHglycan 263 267 PF01048 0.589
MOD_GlcNHglycan 460 463 PF01048 0.376
MOD_GlcNHglycan 481 484 PF01048 0.355
MOD_GlcNHglycan 565 568 PF01048 0.309
MOD_GSK3_1 108 115 PF00069 0.612
MOD_GSK3_1 133 140 PF00069 0.776
MOD_GSK3_1 210 217 PF00069 0.439
MOD_GSK3_1 262 269 PF00069 0.737
MOD_GSK3_1 281 288 PF00069 0.725
MOD_GSK3_1 436 443 PF00069 0.341
MOD_GSK3_1 444 451 PF00069 0.290
MOD_GSK3_1 563 570 PF00069 0.338
MOD_GSK3_1 67 74 PF00069 0.651
MOD_GSK3_1 97 104 PF00069 0.614
MOD_N-GLC_1 578 583 PF02516 0.590
MOD_NEK2_1 107 112 PF00069 0.637
MOD_NEK2_1 214 219 PF00069 0.392
MOD_NEK2_1 228 233 PF00069 0.336
MOD_NEK2_1 311 316 PF00069 0.580
MOD_NEK2_1 356 361 PF00069 0.506
MOD_NEK2_1 404 409 PF00069 0.407
MOD_NEK2_1 420 425 PF00069 0.350
MOD_NEK2_1 448 453 PF00069 0.341
MOD_NEK2_1 479 484 PF00069 0.531
MOD_NEK2_1 517 522 PF00069 0.373
MOD_NEK2_1 565 570 PF00069 0.361
MOD_NEK2_1 578 583 PF00069 0.287
MOD_NEK2_1 588 593 PF00069 0.366
MOD_NEK2_2 103 108 PF00069 0.593
MOD_NEK2_2 281 286 PF00069 0.674
MOD_NEK2_2 567 572 PF00069 0.458
MOD_PIKK_1 185 191 PF00454 0.347
MOD_PKA_2 133 139 PF00069 0.772
MOD_PKA_2 246 252 PF00069 0.631
MOD_PKA_2 266 272 PF00069 0.673
MOD_Plk_1 123 129 PF00069 0.621
MOD_Plk_4 103 109 PF00069 0.594
MOD_Plk_4 228 234 PF00069 0.394
MOD_Plk_4 363 369 PF00069 0.312
MOD_Plk_4 517 523 PF00069 0.338
MOD_Plk_4 567 573 PF00069 0.359
MOD_Plk_4 578 584 PF00069 0.300
MOD_ProDKin_1 109 115 PF00069 0.595
MOD_ProDKin_1 152 158 PF00069 0.687
MOD_ProDKin_1 252 258 PF00069 0.750
MOD_ProDKin_1 273 279 PF00069 0.773
MOD_ProDKin_1 33 39 PF00069 0.592
MOD_ProDKin_1 389 395 PF00069 0.576
MOD_ProDKin_1 573 579 PF00069 0.451
MOD_ProDKin_1 67 73 PF00069 0.611
MOD_ProDKin_1 87 93 PF00069 0.612
MOD_ProDKin_1 97 103 PF00069 0.596
TRG_ENDOCYTIC_2 181 184 PF00928 0.444
TRG_ENDOCYTIC_2 495 498 PF00928 0.388
TRG_ER_diArg_1 159 161 PF00400 0.714
TRG_ER_diArg_1 23 25 PF00400 0.563
TRG_ER_diArg_1 315 318 PF00400 0.538
TRG_ER_diArg_1 39 41 PF00400 0.586
TRG_ER_diArg_1 62 64 PF00400 0.614
TRG_ER_diArg_1 80 83 PF00400 0.596
TRG_ER_diArg_1 94 97 PF00400 0.616
TRG_NES_CRM1_1 352 364 PF08389 0.398
TRG_NES_CRM1_1 536 551 PF08389 0.374
TRG_NLS_Bipartite_1 77 99 PF00514 0.637
TRG_NLS_MonoCore_2 94 99 PF00514 0.590
TRG_NLS_MonoExtN_4 94 100 PF00514 0.629

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P7L9 Leptomonas seymouri 52% 100%
A0A0N1HVQ8 Leptomonas seymouri 28% 100%
A0A1X0NTD6 Trypanosomatidae 30% 100%
A0A3Q8IES0 Leishmania donovani 90% 100%
A0A3S7WY47 Leishmania donovani 75% 100%
A0A422P321 Trypanosoma rangeli 30% 100%
A4HD92 Leishmania braziliensis 70% 100%
A4HDA0 Leishmania braziliensis 70% 100%
A4I0N2 Leishmania infantum 75% 100%
D0AAP4 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 27% 100%
E9AH47 Leishmania infantum 90% 100%
E9AWM5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 70% 100%
E9AWM6 Leishmania mexicana (strain MHOM/GT/2001/U1103) 88% 100%
V5BLB8 Trypanosoma cruzi 30% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS