Putative aspartate aminotransferase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

aspartate aminotransferase, putative

Species:

Leishmania major

UniProt:

Q4QAU4_LEIMA

TriTrypDb:

LmjF.24.0370 , LMJLV39_240009000 , LMJSD75_240008700

Length:

431

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 25

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 16

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0005739	mitochondrion	5	2
GO:0031974	membrane-enclosed lumen	2	2
GO:0031981	nuclear lumen	5	2
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0043233	organelle lumen	3	2
GO:0070013	intracellular organelle lumen	4	2
GO:0097014	ciliary plasm	5	2
GO:0099568	cytoplasmic region	3	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4QAU4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QAU4

Function

Biological processes
Term	Name	Level	Count
GO:0006082	organic acid metabolic process	3	13
GO:0006520	amino acid metabolic process	3	13
GO:0006807	nitrogen compound metabolic process	2	13
GO:0008152	metabolic process	1	13
GO:0009058	biosynthetic process	2	13
GO:0009987	cellular process	1	13
GO:0019752	carboxylic acid metabolic process	5	13
GO:0043436	oxoacid metabolic process	4	13
GO:0044237	cellular metabolic process	2	13
GO:0044238	primary metabolic process	2	13
GO:0044281	small molecule metabolic process	2	13
GO:0071704	organic substance metabolic process	2	13
GO:1901564	organonitrogen compound metabolic process	3	13

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	13
GO:0004069	L-aspartate:2-oxoglutarate aminotransferase activity	5	13
GO:0005488	binding	1	13
GO:0008483	transaminase activity	4	13
GO:0016740	transferase activity	2	13
GO:0016769	transferase activity, transferring nitrogenous groups	3	13
GO:0019842	vitamin binding	3	13
GO:0030170	pyridoxal phosphate binding	4	13
GO:0036094	small molecule binding	2	13
GO:0043167	ion binding	2	13
GO:0043168	anion binding	3	13
GO:0070279	vitamin B6 binding	3	13
GO:0097159	organic cyclic compound binding	2	13
GO:1901363	heterocyclic compound binding	2	13

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	23	25	PF00675	0.609
CLV_NRD_NRD_1	78	80	PF00675	0.370
CLV_PCSK_KEX2_1	23	25	PF00082	0.609
CLV_PCSK_SKI1_1	114	118	PF00082	0.466
CLV_PCSK_SKI1_1	408	412	PF00082	0.419
CLV_Separin_Metazoa	330	334	PF03568	0.419
DEG_Nend_Nbox_1	1	3	PF02207	0.597
DOC_CKS1_1	332	337	PF01111	0.419
DOC_MAPK_DCC_7	235	244	PF00069	0.295
DOC_MAPK_HePTP_8	232	244	PF00069	0.276
DOC_MAPK_MEF2A_6	235	244	PF00069	0.264
DOC_MAPK_MEF2A_6	57	64	PF00069	0.276
DOC_PP1_RVXF_1	107	113	PF00149	0.291
DOC_PP1_RVXF_1	406	412	PF00149	0.419
DOC_PP2B_LxvP_1	155	158	PF13499	0.299
DOC_PP4_FxxP_1	112	115	PF00568	0.322
DOC_USP7_MATH_1	158	162	PF00917	0.370
DOC_USP7_MATH_1	202	206	PF00917	0.354
DOC_USP7_MATH_1	365	369	PF00917	0.336
DOC_WW_Pin1_4	156	161	PF00397	0.374
DOC_WW_Pin1_4	219	224	PF00397	0.428
DOC_WW_Pin1_4	331	336	PF00397	0.311
LIG_14-3-3_CanoR_1	123	130	PF00244	0.264
LIG_14-3-3_CanoR_1	3	13	PF00244	0.578
LIG_14-3-3_CanoR_1	314	318	PF00244	0.362
LIG_APCC_ABBA_1	238	243	PF00400	0.311
LIG_APCC_ABBA_1	62	67	PF00400	0.276
LIG_FHA_1	131	137	PF00498	0.319
LIG_FHA_1	150	156	PF00498	0.455
LIG_FHA_1	184	190	PF00498	0.265
LIG_FHA_1	249	255	PF00498	0.348
LIG_FHA_1	269	275	PF00498	0.147
LIG_FHA_1	287	293	PF00498	0.300
LIG_FHA_1	332	338	PF00498	0.445
LIG_FHA_2	215	221	PF00498	0.264
LIG_FHA_2	296	302	PF00498	0.419
LIG_FHA_2	88	94	PF00498	0.312
LIG_Integrin_isoDGR_2	406	408	PF01839	0.276
LIG_LIR_Apic_2	316	320	PF02991	0.314
LIG_LIR_Gen_1	224	233	PF02991	0.301
LIG_LIR_Gen_1	28	39	PF02991	0.409
LIG_LIR_Gen_1	369	379	PF02991	0.283
LIG_LIR_Nem_3	175	181	PF02991	0.303
LIG_LIR_Nem_3	224	229	PF02991	0.289
LIG_LIR_Nem_3	243	249	PF02991	0.320
LIG_LIR_Nem_3	28	34	PF02991	0.398
LIG_LIR_Nem_3	281	285	PF02991	0.318
LIG_LIR_Nem_3	369	375	PF02991	0.268
LIG_LIR_Nem_3	93	97	PF02991	0.287
LIG_PAM2_1	170	182	PF00658	0.229
LIG_RPA_C_Fungi	283	295	PF08784	0.419
LIG_SH2_CRK	317	321	PF00017	0.276
LIG_SH2_CRK	94	98	PF00017	0.264
LIG_SH2_GRB2like	181	184	PF00017	0.407
LIG_SH2_GRB2like	317	320	PF00017	0.264
LIG_SH2_NCK_1	317	321	PF00017	0.264
LIG_SH2_NCK_1	94	98	PF00017	0.264
LIG_SH2_SRC	94	97	PF00017	0.276
LIG_SH2_STAP1	399	403	PF00017	0.322
LIG_SH2_STAT3	197	200	PF00017	0.413
LIG_SH2_STAT3	421	424	PF00017	0.370
LIG_SH2_STAT5	197	200	PF00017	0.403
LIG_SH2_STAT5	259	262	PF00017	0.419
LIG_SH2_STAT5	272	275	PF00017	0.419
LIG_SH2_STAT5	30	33	PF00017	0.554
LIG_SH2_STAT5	374	377	PF00017	0.352
LIG_SH2_STAT5	402	405	PF00017	0.390
LIG_SH2_STAT5	421	424	PF00017	0.157
LIG_SH3_3	157	163	PF00018	0.345
LIG_SH3_3	32	38	PF00018	0.502
LIG_SUMO_SIM_anti_2	205	210	PF11976	0.276
LIG_TRAF2_1	222	225	PF00917	0.339
LIG_WRC_WIRS_1	100	105	PF05994	0.336
MOD_CDK_SPxxK_3	331	338	PF00069	0.419
MOD_CK1_1	126	132	PF00069	0.265
MOD_CK1_1	147	153	PF00069	0.322
MOD_CK1_1	29	35	PF00069	0.503
MOD_CK1_1	412	418	PF00069	0.322
MOD_CK2_1	219	225	PF00069	0.344
MOD_CK2_1	295	301	PF00069	0.336
MOD_GlcNHglycan	125	128	PF01048	0.336
MOD_GlcNHglycan	13	16	PF01048	0.474
MOD_GlcNHglycan	130	133	PF01048	0.304
MOD_GlcNHglycan	146	149	PF01048	0.488
MOD_GlcNHglycan	31	34	PF01048	0.552
MOD_GlcNHglycan	411	414	PF01048	0.264
MOD_GlcNHglycan	7	10	PF01048	0.531
MOD_GSK3_1	126	133	PF00069	0.266
MOD_GSK3_1	143	150	PF00069	0.346
MOD_GSK3_1	25	32	PF00069	0.454
MOD_GSK3_1	274	281	PF00069	0.403
MOD_GSK3_1	304	311	PF00069	0.390
MOD_GSK3_1	397	404	PF00069	0.355
MOD_GSK3_1	409	416	PF00069	0.214
MOD_GSK3_1	99	106	PF00069	0.378
MOD_LATS_1	293	299	PF00433	0.419
MOD_N-GLC_2	59	61	PF02516	0.419
MOD_NEK2_1	103	108	PF00069	0.419
MOD_NEK2_1	130	135	PF00069	0.306
MOD_NEK2_1	143	148	PF00069	0.404
MOD_NEK2_1	278	283	PF00069	0.374
MOD_NEK2_1	309	314	PF00069	0.308
MOD_NEK2_1	382	387	PF00069	0.276
MOD_NEK2_2	151	156	PF00069	0.299
MOD_PIKK_1	295	301	PF00454	0.304
MOD_PIKK_1	304	310	PF00454	0.227
MOD_PIKK_1	87	93	PF00454	0.411
MOD_PKA_2	144	150	PF00069	0.299
MOD_PKA_2	294	300	PF00069	0.419
MOD_PKA_2	313	319	PF00069	0.165
MOD_PKA_2	87	93	PF00069	0.299
MOD_Plk_1	174	180	PF00069	0.299
MOD_Plk_4	174	180	PF00069	0.338
MOD_Plk_4	202	208	PF00069	0.336
MOD_Plk_4	26	32	PF00069	0.426
MOD_Plk_4	268	274	PF00069	0.419
MOD_Plk_4	397	403	PF00069	0.303
MOD_Plk_4	99	105	PF00069	0.413
MOD_ProDKin_1	156	162	PF00069	0.374
MOD_ProDKin_1	219	225	PF00069	0.428
MOD_ProDKin_1	331	337	PF00069	0.311
TRG_DiLeu_BaEn_3	224	230	PF01217	0.322
TRG_ENDOCYTIC_2	181	184	PF00928	0.409
TRG_ENDOCYTIC_2	246	249	PF00928	0.285
TRG_ENDOCYTIC_2	94	97	PF00928	0.267
TRG_ER_diArg_1	355	358	PF00400	0.318
TRG_Pf-PMV_PEXEL_1	262	266	PF00026	0.336

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0F7CUE9	Hapsidospora irregularis	28%	100%
A0A0N0P7Z5	Leptomonas seymouri	73%	98%
A0A0N1PAS7	Leptomonas seymouri	31%	100%
A0A0S4IPP7	Bodo saltans	48%	100%
A0A0S4JFW4	Bodo saltans	36%	100%
A0A1X0NIT8	Trypanosomatidae	36%	100%
A0A1X0NJG0	Trypanosomatidae	52%	100%
A0A1X0NJN9	Trypanosomatidae	37%	100%
A0A1X0NKG0	Trypanosomatidae	51%	100%
A0A3Q8IG20	Leishmania donovani	34%	100%
A0A3R7MWM6	Trypanosoma rangeli	51%	100%
A0A3S7WY33	Leishmania donovani	97%	100%
A0A422NI78	Trypanosoma rangeli	37%	100%
A4HD93	Leishmania braziliensis	92%	100%
A4HMB3	Leishmania braziliensis	36%	100%
A5A6K8	Pan troglodytes	38%	100%
D0A277	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	100%
D0A706	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	51%	100%
E9AH48	Leishmania infantum	97%	100%
E9AWM7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
E9B5W2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	35%	100%
O42652	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	41%	100%
O85746	Klebsiella pneumoniae	36%	100%
O94320	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	42%	99%
P00503	Sus scrofa	38%	100%
P00504	Gallus gallus	38%	100%
P00505	Homo sapiens	41%	100%
P00506	Sus scrofa	41%	100%
P00507	Rattus norvegicus	41%	100%
P00508	Gallus gallus	41%	100%
P00509	Escherichia coli (strain K12)	39%	100%
P04693	Escherichia coli (strain K12)	36%	100%
P05201	Mus musculus	39%	100%
P05202	Mus musculus	41%	100%
P08906	Equus caballus	38%	100%
P08907	Equus caballus	40%	100%
P12344	Bos taurus	42%	100%
P12345	Oryctolagus cuniculus	42%	100%
P13221	Rattus norvegicus	38%	100%
P17174	Homo sapiens	38%	100%
P23542	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	40%	100%
P26563	Lupinus angustifolius	40%	95%
P28011	Medicago sativa	41%	100%
P28734	Daucus carota	42%	100%
P33097	Bos taurus	38%	100%
P37833	Oryza sativa subsp. japonica	39%	100%
P43336	Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)	37%	100%
P44425	Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)	35%	100%
P46248	Arabidopsis thaliana	40%	95%
P46643	Arabidopsis thaliana	40%	100%
P46644	Arabidopsis thaliana	39%	96%
P46645	Arabidopsis thaliana	38%	100%
P46646	Arabidopsis thaliana	37%	100%
P58661	Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)	39%	100%
P72173	Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)	37%	100%
P74861	Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)	37%	100%
P95468	Paracoccus denitrificans	30%	100%
Q01802	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	34%	96%
Q02636	Rhizobium meliloti (strain 1021)	33%	100%
Q22067	Caenorhabditis elegans	37%	100%
Q28F67	Xenopus tropicalis	40%	100%
Q2PD92	Leishmania infantum	34%	100%
Q2T9S8	Bos taurus	28%	100%
Q4FX34	Leishmania major	35%	100%
Q4R559	Macaca fascicularis	41%	100%
Q4R5L1	Macaca fascicularis	38%	100%
Q54SF7	Dictyostelium discoideum	41%	98%
Q55F21	Dictyostelium discoideum	41%	100%
Q56114	Salmonella typhi	39%	100%
Q5R691	Pongo abelii	38%	100%
Q5REB0	Pongo abelii	41%	100%
Q7SYK7	Danio rerio	41%	100%
Q7TSV6	Mus musculus	29%	100%
Q8NHS2	Homo sapiens	27%	100%
V5BSS0	Trypanosoma cruzi	36%	100%
V5BVY2	Trypanosoma cruzi	48%	100%