Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QAU2_LEIMA

TriTrypDb:

LmjF.24.0390 , LMJLV39_240009200 , LMJSD75_240008900

Length:

622

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	5
GO:0110165	cellular anatomical entity	1	5

Expansion

Sequence features

Q4QAU2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QAU2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	101	105	PF00656	0.624
CLV_C14_Caspase3-7	118	122	PF00656	0.421
CLV_C14_Caspase3-7	335	339	PF00656	0.572
CLV_MEL_PAP_1	566	572	PF00089	0.728
CLV_NRD_NRD_1	296	298	PF00675	0.713
CLV_NRD_NRD_1	478	480	PF00675	0.673
CLV_NRD_NRD_1	579	581	PF00675	0.662
CLV_PCSK_KEX2_1	296	298	PF00082	0.715
CLV_PCSK_KEX2_1	399	401	PF00082	0.692
CLV_PCSK_KEX2_1	579	581	PF00082	0.662
CLV_PCSK_PC1ET2_1	399	401	PF00082	0.682
CLV_PCSK_SKI1_1	155	159	PF00082	0.637
CLV_PCSK_SKI1_1	231	235	PF00082	0.739
CLV_PCSK_SKI1_1	419	423	PF00082	0.669
CLV_PCSK_SKI1_1	494	498	PF00082	0.730
CLV_PCSK_SKI1_1	562	566	PF00082	0.673
DEG_APCC_DBOX_1	198	206	PF00400	0.470
DEG_APCC_DBOX_1	457	465	PF00400	0.496
DEG_Nend_UBRbox_2	1	3	PF02207	0.732
DOC_ANK_TNKS_1	315	322	PF00023	0.572
DOC_CDC14_PxL_1	159	167	PF14671	0.542
DOC_CKS1_1	134	139	PF01111	0.574
DOC_CKS1_1	69	74	PF01111	0.565
DOC_CYCLIN_RxL_1	489	500	PF00134	0.433
DOC_CYCLIN_yCln2_LP_2	441	447	PF00134	0.473
DOC_MAPK_gen_1	562	572	PF00069	0.473
DOC_MAPK_JIP1_4	284	290	PF00069	0.613
DOC_MAPK_MEF2A_6	6	14	PF00069	0.563
DOC_PP1_RVXF_1	431	438	PF00149	0.571
DOC_PP1_RVXF_1	567	573	PF00149	0.554
DOC_PP1_RVXF_1	610	616	PF00149	0.472
DOC_PP2B_LxvP_1	529	532	PF13499	0.581
DOC_PP4_FxxP_1	492	495	PF00568	0.575
DOC_PP4_FxxP_1	527	530	PF00568	0.499
DOC_USP7_MATH_1	106	110	PF00917	0.583
DOC_USP7_MATH_1	141	145	PF00917	0.458
DOC_USP7_MATH_1	172	176	PF00917	0.442
DOC_USP7_MATH_1	232	236	PF00917	0.561
DOC_USP7_MATH_1	237	241	PF00917	0.560
DOC_USP7_MATH_1	251	255	PF00917	0.483
DOC_USP7_MATH_1	257	261	PF00917	0.430
DOC_USP7_MATH_1	421	425	PF00917	0.530
DOC_USP7_MATH_1	5	9	PF00917	0.452
DOC_USP7_MATH_1	521	525	PF00917	0.584
DOC_USP7_MATH_1	558	562	PF00917	0.488
DOC_USP7_MATH_1	590	594	PF00917	0.499
DOC_WW_Pin1_4	102	107	PF00397	0.489
DOC_WW_Pin1_4	133	138	PF00397	0.498
DOC_WW_Pin1_4	68	73	PF00397	0.520
LIG_14-3-3_CanoR_1	107	112	PF00244	0.586
LIG_14-3-3_CanoR_1	231	237	PF00244	0.625
LIG_14-3-3_CanoR_1	284	289	PF00244	0.527
LIG_14-3-3_CanoR_1	329	333	PF00244	0.664
LIG_14-3-3_CanoR_1	423	428	PF00244	0.543
LIG_14-3-3_CanoR_1	569	573	PF00244	0.481
LIG_14-3-3_CanoR_1	6	10	PF00244	0.527
LIG_14-3-3_CanoR_1	612	616	PF00244	0.469
LIG_Actin_WH2_2	464	481	PF00022	0.528
LIG_BIR_III_2	121	125	PF00653	0.527
LIG_BRCT_BRCA1_1	523	527	PF00533	0.576
LIG_deltaCOP1_diTrp_1	434	440	PF00928	0.517
LIG_FHA_1	14	20	PF00498	0.429
LIG_FHA_1	204	210	PF00498	0.489
LIG_FHA_1	228	234	PF00498	0.609
LIG_FHA_1	36	42	PF00498	0.569
LIG_FHA_1	47	53	PF00498	0.482
LIG_FHA_1	547	553	PF00498	0.502
LIG_FHA_1	69	75	PF00498	0.520
LIG_FHA_2	116	122	PF00498	0.560
LIG_FHA_2	32	38	PF00498	0.572
LIG_FHA_2	333	339	PF00498	0.604
LIG_FHA_2	429	435	PF00498	0.523
LIG_LIR_Apic_2	131	137	PF02991	0.487
LIG_LIR_Apic_2	198	203	PF02991	0.503
LIG_LIR_Apic_2	362	368	PF02991	0.522
LIG_LIR_Apic_2	524	530	PF02991	0.571
LIG_LIR_Gen_1	571	578	PF02991	0.474
LIG_LIR_Gen_1	596	605	PF02991	0.528
LIG_LIR_Gen_1	614	621	PF02991	0.311
LIG_LIR_Nem_3	544	548	PF02991	0.510
LIG_LIR_Nem_3	571	576	PF02991	0.479
LIG_LIR_Nem_3	596	601	PF02991	0.538
LIG_LIR_Nem_3	614	618	PF02991	0.318
LIG_MYND_1	507	511	PF01753	0.607
LIG_NBox_RRM_1	119	129	PF00076	0.571
LIG_NRBOX	265	271	PF00104	0.526
LIG_PCNA_TLS_4	579	586	PF02747	0.463
LIG_PCNA_yPIPBox_3	139	149	PF02747	0.483
LIG_Pex14_1	581	585	PF04695	0.458
LIG_Pex14_2	572	576	PF04695	0.468
LIG_SH2_CRK	156	160	PF00017	0.444
LIG_SH2_GRB2like	575	578	PF00017	0.470
LIG_SH2_SRC	594	597	PF00017	0.464
LIG_SH2_STAP1	146	150	PF00017	0.435
LIG_SH2_STAP1	273	277	PF00017	0.529
LIG_SH2_STAP1	62	66	PF00017	0.594
LIG_SH2_STAP1	77	81	PF00017	0.400
LIG_SH2_STAP1	88	92	PF00017	0.427
LIG_SH2_STAT5	22	25	PF00017	0.411
LIG_SH2_STAT5	548	551	PF00017	0.504
LIG_SH2_STAT5	575	578	PF00017	0.479
LIG_SH2_STAT5	88	91	PF00017	0.463
LIG_SH3_3	322	328	PF00018	0.592
LIG_SH3_3	381	387	PF00018	0.505
LIG_SH3_3	492	498	PF00018	0.521
LIG_SH3_3	501	507	PF00018	0.522
LIG_SH3_3	525	531	PF00018	0.532
LIG_SH3_3	66	72	PF00018	0.518
LIG_SUMO_SIM_anti_2	16	22	PF11976	0.371
LIG_SUMO_SIM_anti_2	413	418	PF11976	0.574
LIG_SUMO_SIM_par_1	388	394	PF11976	0.505
LIG_SUMO_SIM_par_1	410	415	PF11976	0.541
LIG_TRFH_1	527	531	PF08558	0.629
LIG_UBA3_1	461	465	PF00899	0.621
LIG_WW_1	530	533	PF00397	0.664
MOD_CDK_SPK_2	102	107	PF00069	0.580
MOD_CK1_1	110	116	PF00069	0.774
MOD_CK1_1	239	245	PF00069	0.785
MOD_CK1_1	261	267	PF00069	0.708
MOD_CK1_1	271	277	PF00069	0.577
MOD_CK1_1	304	310	PF00069	0.774
MOD_CK2_1	167	173	PF00069	0.566
MOD_CK2_1	192	198	PF00069	0.618
MOD_CK2_1	428	434	PF00069	0.667
MOD_CMANNOS	437	440	PF00535	0.635
MOD_CMANNOS	581	584	PF00535	0.572
MOD_GlcNHglycan	109	112	PF01048	0.777
MOD_GlcNHglycan	159	162	PF01048	0.667
MOD_GlcNHglycan	167	170	PF01048	0.530
MOD_GlcNHglycan	242	245	PF01048	0.687
MOD_GlcNHglycan	270	273	PF01048	0.778
MOD_GlcNHglycan	361	364	PF01048	0.657
MOD_GlcNHglycan	425	428	PF01048	0.736
MOD_GlcNHglycan	511	514	PF01048	0.790
MOD_GSK3_1	106	113	PF00069	0.749
MOD_GSK3_1	129	136	PF00069	0.704
MOD_GSK3_1	232	239	PF00069	0.803
MOD_GSK3_1	257	264	PF00069	0.700
MOD_GSK3_1	271	278	PF00069	0.522
MOD_GSK3_1	302	309	PF00069	0.753
MOD_GSK3_1	31	38	PF00069	0.613
MOD_GSK3_1	328	335	PF00069	0.717
MOD_GSK3_1	419	426	PF00069	0.651
MOD_GSK3_1	599	606	PF00069	0.562
MOD_GSK3_1	98	105	PF00069	0.653
MOD_LATS_1	282	288	PF00433	0.749
MOD_N-GLC_1	10	15	PF02516	0.513
MOD_N-GLC_1	102	107	PF02516	0.591
MOD_N-GLC_1	375	380	PF02516	0.669
MOD_N-GLC_1	546	551	PF02516	0.613
MOD_N-GLC_1	86	91	PF02516	0.659
MOD_NEK2_1	10	15	PF00069	0.367
MOD_NEK2_1	165	170	PF00069	0.671
MOD_NEK2_1	211	216	PF00069	0.638
MOD_NEK2_1	262	267	PF00069	0.642
MOD_NEK2_1	275	280	PF00069	0.702
MOD_NEK2_1	31	36	PF00069	0.604
MOD_NEK2_1	404	409	PF00069	0.493
MOD_NEK2_1	485	490	PF00069	0.693
MOD_NEK2_1	585	590	PF00069	0.584
MOD_NEK2_2	141	146	PF00069	0.600
MOD_NEK2_2	328	333	PF00069	0.759
MOD_NEK2_2	568	573	PF00069	0.702
MOD_PIKK_1	243	249	PF00454	0.827
MOD_PIKK_1	264	270	PF00454	0.728
MOD_PIKK_1	471	477	PF00454	0.721
MOD_PIKK_1	98	104	PF00454	0.728
MOD_PKA_2	106	112	PF00069	0.745
MOD_PKA_2	211	217	PF00069	0.564
MOD_PKA_2	302	308	PF00069	0.711
MOD_PKA_2	328	334	PF00069	0.804
MOD_PKA_2	422	428	PF00069	0.790
MOD_PKA_2	5	11	PF00069	0.397
MOD_PKA_2	568	574	PF00069	0.600
MOD_PKA_2	611	617	PF00069	0.583
MOD_Plk_1	10	16	PF00069	0.513
MOD_Plk_1	115	121	PF00069	0.764
MOD_Plk_1	130	136	PF00069	0.523
MOD_Plk_1	172	178	PF00069	0.565
MOD_Plk_1	344	350	PF00069	0.700
MOD_Plk_1	412	418	PF00069	0.689
MOD_Plk_1	558	564	PF00069	0.608
MOD_Plk_2-3	344	350	PF00069	0.730
MOD_Plk_4	130	136	PF00069	0.595
MOD_Plk_4	141	147	PF00069	0.569
MOD_Plk_4	192	198	PF00069	0.570
MOD_Plk_4	251	257	PF00069	0.636
MOD_Plk_4	284	290	PF00069	0.701
MOD_Plk_4	328	334	PF00069	0.734
MOD_Plk_4	412	418	PF00069	0.616
MOD_Plk_4	445	451	PF00069	0.594
MOD_Plk_4	5	11	PF00069	0.422
MOD_Plk_4	568	574	PF00069	0.702
MOD_ProDKin_1	102	108	PF00069	0.612
MOD_ProDKin_1	133	139	PF00069	0.622
MOD_ProDKin_1	68	74	PF00069	0.655
MOD_SUMO_for_1	541	544	PF00179	0.747
TRG_DiLeu_BaLyEn_6	146	151	PF01217	0.532
TRG_DiLeu_BaLyEn_6	179	184	PF01217	0.584
TRG_DiLeu_BaLyEn_6	492	497	PF01217	0.684
TRG_ENDOCYTIC_2	156	159	PF00928	0.544
TRG_ENDOCYTIC_2	218	221	PF00928	0.567
TRG_ENDOCYTIC_2	533	536	PF00928	0.668
TRG_ER_diArg_1	295	297	PF00400	0.645
TRG_ER_diArg_1	523	526	PF00400	0.746
TRG_ER_diArg_1	578	580	PF00400	0.588

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7L4	Leptomonas seymouri	46%	97%
A0A3Q8IMJ3	Leishmania donovani	94%	100%
A4HD95	Leishmania braziliensis	77%	100%
E9AH50	Leishmania infantum	94%	100%
E9AWM9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	81%