SET domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

TPR repeat, putative

Species:

Leishmania major

UniProt:

Q4QAU1_LEIMA

TriTrypDb:

LmjF.24.0400 , LMJLV39_240009300 , LMJSD75_240009000

Length:

661

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005576	extracellular region	2	3
GO:0110165	cellular anatomical entity	1	3

Expansion

Sequence features

Q4QAU1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QAU1

Function

Biological processes
Term	Name	Level	Count
GO:0009892	negative regulation of metabolic process	4	2
GO:0010468	regulation of gene expression	5	2
GO:0010605	negative regulation of macromolecule metabolic process	5	2
GO:0010629	negative regulation of gene expression	6	2
GO:0019222	regulation of metabolic process	3	2
GO:0040029	epigenetic regulation of gene expression	6	2
GO:0045814	negative regulation of gene expression, epigenetic	7	2
GO:0048519	negative regulation of biological process	3	2
GO:0050789	regulation of biological process	2	2
GO:0060255	regulation of macromolecule metabolic process	4	2
GO:0065007	biological regulation	1	2
GO:0006457	protein folding	2	1
GO:0009987	cellular process	1	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	2
GO:0008168	methyltransferase activity	4	2
GO:0008170	N-methyltransferase activity	5	2
GO:0008276	protein methyltransferase activity	3	2
GO:0008757	S-adenosylmethionine-dependent methyltransferase activity	5	2
GO:0016278	lysine N-methyltransferase activity	6	2
GO:0016279	protein-lysine N-methyltransferase activity	4	2
GO:0016740	transferase activity	2	2
GO:0016741	transferase activity, transferring one-carbon groups	3	2
GO:0018024	obsolete histone lysine N-methyltransferase activity	5	2
GO:0042054	histone methyltransferase activity	4	2
GO:0042799	histone H4K20 methyltransferase activity	6	2
GO:0140096	catalytic activity, acting on a protein	2	2
GO:0005102	signaling receptor binding	3	3
GO:0005179	hormone activity	5	3
GO:0005184	neuropeptide hormone activity	6	3
GO:0005488	binding	1	4
GO:0005515	protein binding	2	4
GO:0030545	signaling receptor regulator activity	2	3
GO:0030546	signaling receptor activator activity	3	3
GO:0048018	receptor ligand activity	4	3
GO:0098772	molecular function regulator activity	1	3
GO:0140677	molecular function activator activity	2	3
GO:0030544	Hsp70 protein binding	4	1
GO:0031072	heat shock protein binding	3	1
GO:0051879	Hsp90 protein binding	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	554	558	PF00656	0.471
CLV_C14_Caspase3-7	586	590	PF00656	0.374
CLV_NRD_NRD_1	113	115	PF00675	0.370
CLV_NRD_NRD_1	140	142	PF00675	0.497
CLV_NRD_NRD_1	185	187	PF00675	0.398
CLV_NRD_NRD_1	358	360	PF00675	0.307
CLV_NRD_NRD_1	64	66	PF00675	0.395
CLV_PCSK_KEX2_1	112	114	PF00082	0.365
CLV_PCSK_KEX2_1	140	142	PF00082	0.475
CLV_PCSK_KEX2_1	185	187	PF00082	0.396
CLV_PCSK_KEX2_1	238	240	PF00082	0.466
CLV_PCSK_KEX2_1	357	359	PF00082	0.297
CLV_PCSK_KEX2_1	64	66	PF00082	0.395
CLV_PCSK_PC1ET2_1	238	240	PF00082	0.496
CLV_PCSK_PC1ET2_1	357	359	PF00082	0.312
CLV_PCSK_SKI1_1	130	134	PF00082	0.354
CLV_PCSK_SKI1_1	140	144	PF00082	0.433
CLV_PCSK_SKI1_1	245	249	PF00082	0.349
CLV_PCSK_SKI1_1	283	287	PF00082	0.482
CLV_PCSK_SKI1_1	359	363	PF00082	0.458
CLV_PCSK_SKI1_1	431	435	PF00082	0.455
CLV_PCSK_SKI1_1	440	444	PF00082	0.445
CLV_PCSK_SKI1_1	478	482	PF00082	0.300
CLV_PCSK_SKI1_1	513	517	PF00082	0.468
CLV_PCSK_SKI1_1	593	597	PF00082	0.348
CLV_PCSK_SKI1_1	655	659	PF00082	0.405
CLV_Separin_Metazoa	360	364	PF03568	0.483
CLV_Separin_Metazoa	437	441	PF03568	0.279
DEG_Nend_UBRbox_2	1	3	PF02207	0.527
DEG_SPOP_SBC_1	552	556	PF00917	0.378
DOC_CYCLIN_RxL_1	124	136	PF00134	0.384
DOC_CYCLIN_RxL_1	356	364	PF00134	0.414
DOC_CYCLIN_yCln2_LP_2	574	580	PF00134	0.337
DOC_CYCLIN_yCln2_LP_2	599	605	PF00134	0.354
DOC_MAPK_gen_1	64	70	PF00069	0.372
DOC_MAPK_MEF2A_6	166	173	PF00069	0.377
DOC_PP1_RVXF_1	189	196	PF00149	0.402
DOC_PP1_RVXF_1	200	206	PF00149	0.357
DOC_PP2B_LxvP_1	574	577	PF13499	0.420
DOC_USP7_MATH_1	308	312	PF00917	0.313
DOC_USP7_UBL2_3	655	659	PF12436	0.406
DOC_WW_Pin1_4	165	170	PF00397	0.439
DOC_WW_Pin1_4	424	429	PF00397	0.492
LIG_14-3-3_CanoR_1	202	206	PF00244	0.525
LIG_14-3-3_CanoR_1	440	449	PF00244	0.385
LIG_14-3-3_CanoR_1	503	509	PF00244	0.497
LIG_14-3-3_CanoR_1	640	644	PF00244	0.537
LIG_APCC_ABBA_1	468	473	PF00400	0.339
LIG_APCC_ABBAyCdc20_2	191	197	PF00400	0.513
LIG_APCC_ABBAyCdc20_2	467	473	PF00400	0.458
LIG_BIR_III_4	20	24	PF00653	0.289
LIG_BRCT_BRCA1_1	298	302	PF00533	0.357
LIG_BRCT_BRCA1_1	363	367	PF00533	0.347
LIG_CSL_BTD_1	425	428	PF09270	0.420
LIG_deltaCOP1_diTrp_1	473	481	PF00928	0.427
LIG_FHA_1	146	152	PF00498	0.530
LIG_FHA_1	215	221	PF00498	0.421
LIG_FHA_1	302	308	PF00498	0.436
LIG_FHA_1	463	469	PF00498	0.477
LIG_FHA_1	487	493	PF00498	0.323
LIG_FHA_1	521	527	PF00498	0.396
LIG_FHA_2	141	147	PF00498	0.451
LIG_FHA_2	210	216	PF00498	0.596
LIG_FHA_2	448	454	PF00498	0.441
LIG_FHA_2	458	464	PF00498	0.431
LIG_FHA_2	552	558	PF00498	0.461
LIG_FHA_2	56	62	PF00498	0.593
LIG_FHA_2	93	99	PF00498	0.364
LIG_HCF-1_HBM_1	197	200	PF13415	0.479
LIG_LIR_Apic_2	125	131	PF02991	0.450
LIG_LIR_Apic_2	523	527	PF02991	0.414
LIG_LIR_Gen_1	197	205	PF02991	0.442
LIG_LIR_Gen_1	75	84	PF02991	0.433
LIG_LIR_Nem_3	197	203	PF02991	0.452
LIG_LIR_Nem_3	272	277	PF02991	0.506
LIG_LIR_Nem_3	279	285	PF02991	0.393
LIG_LIR_Nem_3	423	429	PF02991	0.498
LIG_LIR_Nem_3	75	81	PF02991	0.423
LIG_MLH1_MIPbox_1	298	302	PF16413	0.357
LIG_NRBOX	570	576	PF00104	0.431
LIG_NRBOX	65	71	PF00104	0.476
LIG_PCNA_PIPBox_1	218	227	PF02747	0.267
LIG_Pex14_1	632	636	PF04695	0.340
LIG_Pex14_2	243	247	PF04695	0.346
LIG_Pex14_2	297	301	PF04695	0.332
LIG_Pex14_2	84	88	PF04695	0.447
LIG_PTB_Apo_2	339	346	PF02174	0.332
LIG_PTB_Phospho_1	339	345	PF10480	0.333
LIG_REV1ctd_RIR_1	299	307	PF16727	0.299
LIG_SH2_CRK	200	204	PF00017	0.459
LIG_SH2_CRK	477	481	PF00017	0.317
LIG_SH2_GRB2like	71	74	PF00017	0.316
LIG_SH2_NCK_1	200	204	PF00017	0.459
LIG_SH2_NCK_1	320	324	PF00017	0.512
LIG_SH2_STAT5	128	131	PF00017	0.408
LIG_SH2_STAT5	200	203	PF00017	0.523
LIG_SH2_STAT5	224	227	PF00017	0.386
LIG_SH2_STAT5	345	348	PF00017	0.340
LIG_SH2_STAT5	449	452	PF00017	0.489
LIG_SH2_STAT5	482	485	PF00017	0.343
LIG_SH2_STAT5	525	528	PF00017	0.453
LIG_SH2_STAT5	623	626	PF00017	0.357
LIG_SH2_STAT5	78	81	PF00017	0.423
LIG_SH3_3	422	428	PF00018	0.517
LIG_SH3_3	574	580	PF00018	0.311
LIG_SUMO_SIM_anti_2	170	175	PF11976	0.462
LIG_SUMO_SIM_anti_2	567	573	PF11976	0.360
LIG_SUMO_SIM_par_1	328	333	PF11976	0.420
LIG_SUMO_SIM_par_1	544	550	PF11976	0.410
LIG_SUMO_SIM_par_1	567	573	PF11976	0.436
LIG_TRAF2_1	204	207	PF00917	0.358
LIG_TRAF2_1	322	325	PF00917	0.454
LIG_TRAF2_1	59	62	PF00917	0.495
LIG_WRC_WIRS_1	439	444	PF05994	0.392
LIG_WRPW_2	102	105	PF00400	0.474
MOD_CDK_SPxxK_3	424	431	PF00069	0.341
MOD_CK1_1	208	214	PF00069	0.548
MOD_CK1_1	378	384	PF00069	0.405
MOD_CK1_1	444	450	PF00069	0.453
MOD_CK1_1	53	59	PF00069	0.629
MOD_CK1_1	555	561	PF00069	0.527
MOD_CK1_1	72	78	PF00069	0.181
MOD_CK2_1	140	146	PF00069	0.514
MOD_CK2_1	201	207	PF00069	0.410
MOD_CK2_1	318	324	PF00069	0.462
MOD_CK2_1	447	453	PF00069	0.447
MOD_CK2_1	457	463	PF00069	0.460
MOD_CK2_1	55	61	PF00069	0.611
MOD_CK2_1	77	83	PF00069	0.362
MOD_CMANNOS	102	105	PF00535	0.474
MOD_CMANNOS	365	368	PF00535	0.339
MOD_Cter_Amidation	236	239	PF01082	0.307
MOD_Cter_Amidation	355	358	PF01082	0.295
MOD_GlcNHglycan	17	20	PF01048	0.487
MOD_GlcNHglycan	206	210	PF01048	0.575
MOD_GlcNHglycan	298	301	PF01048	0.365
MOD_GlcNHglycan	388	392	PF01048	0.494
MOD_GlcNHglycan	397	400	PF01048	0.419
MOD_GlcNHglycan	420	423	PF01048	0.501
MOD_GlcNHglycan	52	55	PF01048	0.689
MOD_GlcNHglycan	530	533	PF01048	0.513
MOD_GlcNHglycan	557	560	PF01048	0.524
MOD_GSK3_1	201	208	PF00069	0.544
MOD_GSK3_1	319	326	PF00069	0.406
MOD_GSK3_1	438	445	PF00069	0.456
MOD_GSK3_1	493	500	PF00069	0.493
MOD_GSK3_1	53	60	PF00069	0.571
MOD_GSK3_1	551	558	PF00069	0.517
MOD_GSK3_1	604	611	PF00069	0.506
MOD_GSK3_1	634	641	PF00069	0.424
MOD_N-GLC_1	308	313	PF02516	0.304
MOD_N-GLC_1	72	77	PF02516	0.313
MOD_NEK2_1	122	127	PF00069	0.418
MOD_NEK2_1	205	210	PF00069	0.481
MOD_NEK2_1	285	290	PF00069	0.411
MOD_NEK2_1	301	306	PF00069	0.402
MOD_NEK2_1	318	323	PF00069	0.391
MOD_NEK2_1	361	366	PF00069	0.436
MOD_NEK2_1	395	400	PF00069	0.442
MOD_NEK2_1	438	443	PF00069	0.393
MOD_NEK2_1	50	55	PF00069	0.674
MOD_NEK2_1	564	569	PF00069	0.414
MOD_NEK2_1	638	643	PF00069	0.459
MOD_NEK2_1	69	74	PF00069	0.384
MOD_NEK2_2	308	313	PF00069	0.398
MOD_NEK2_2	77	82	PF00069	0.263
MOD_OFUCOSY	305	312	PF10250	0.302
MOD_PIKK_1	209	215	PF00454	0.526
MOD_PIKK_1	375	381	PF00454	0.462
MOD_PIKK_1	457	463	PF00454	0.465
MOD_PIKK_1	502	508	PF00454	0.492
MOD_PK_1	319	325	PF00069	0.479
MOD_PKA_1	140	146	PF00069	0.526
MOD_PKA_2	140	146	PF00069	0.456
MOD_PKA_2	201	207	PF00069	0.395
MOD_PKA_2	262	268	PF00069	0.515
MOD_PKA_2	375	381	PF00069	0.419
MOD_PKA_2	502	508	PF00069	0.513
MOD_PKA_2	639	645	PF00069	0.538
MOD_PKA_2	84	90	PF00069	0.463
MOD_Plk_1	214	220	PF00069	0.401
MOD_Plk_1	323	329	PF00069	0.404
MOD_Plk_2-3	583	589	PF00069	0.454
MOD_Plk_4	444	450	PF00069	0.424
MOD_Plk_4	520	526	PF00069	0.437
MOD_Plk_4	564	570	PF00069	0.493
MOD_Plk_4	619	625	PF00069	0.384
MOD_ProDKin_1	165	171	PF00069	0.432
MOD_ProDKin_1	424	430	PF00069	0.488
MOD_SUMO_for_1	8	11	PF00179	0.406
MOD_SUMO_rev_2	192	201	PF00179	0.469
MOD_SUMO_rev_2	505	515	PF00179	0.405
TRG_DiLeu_BaEn_3	324	330	PF01217	0.407
TRG_DiLeu_BaEn_4	61	67	PF01217	0.443
TRG_DiLeu_BaLyEn_6	128	133	PF01217	0.329
TRG_DiLeu_BaLyEn_6	30	35	PF01217	0.316
TRG_DiLeu_BaLyEn_6	406	411	PF01217	0.475
TRG_DiLeu_BaLyEn_6	612	617	PF01217	0.316
TRG_ENDOCYTIC_2	200	203	PF00928	0.443
TRG_ENDOCYTIC_2	320	323	PF00928	0.444
TRG_ENDOCYTIC_2	477	480	PF00928	0.307
TRG_ENDOCYTIC_2	71	74	PF00928	0.316
TRG_ENDOCYTIC_2	78	81	PF00928	0.344
TRG_ER_diArg_1	112	114	PF00400	0.384
TRG_ER_diArg_1	140	142	PF00400	0.505
TRG_ER_diArg_1	228	231	PF00400	0.486
TRG_ER_diArg_1	270	273	PF00400	0.505
TRG_ER_diArg_1	64	66	PF00400	0.395
TRG_ER_FFAT_2	444	453	PF00635	0.361
TRG_NES_CRM1_1	453	466	PF08389	0.358
TRG_Pf-PMV_PEXEL_1	431	435	PF00026	0.467

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I9W0	Leptomonas seymouri	66%	100%
A0A0S4J867	Bodo saltans	31%	100%
A0A1X0NIX9	Trypanosomatidae	38%	98%
A0A3S5H7C8	Leishmania donovani	94%	100%
A0A422P403	Trypanosoma rangeli	38%	100%
A4HD96	Leishmania braziliensis	84%	100%
D0A710	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	100%
E9AH51	Leishmania infantum	93%	100%
E9AWN0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
V5BRA0	Trypanosoma cruzi	39%	99%