Crinkler (CRN) family protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QAU0_LEIMA

TriTrypDb:

LmjF.24.0410 , LMJLV39_240009400 , LMJSD75_240009100

Length:

760

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QAU0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QAU0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	488	492	PF00656	0.378
CLV_C14_Caspase3-7	80	84	PF00656	0.404
CLV_NRD_NRD_1	136	138	PF00675	0.763
CLV_NRD_NRD_1	369	371	PF00675	0.515
CLV_NRD_NRD_1	400	402	PF00675	0.548
CLV_NRD_NRD_1	704	706	PF00675	0.530
CLV_NRD_NRD_1	98	100	PF00675	0.547
CLV_PCSK_KEX2_1	136	138	PF00082	0.738
CLV_PCSK_KEX2_1	98	100	PF00082	0.547
CLV_PCSK_SKI1_1	332	336	PF00082	0.466
CLV_PCSK_SKI1_1	457	461	PF00082	0.422
CLV_PCSK_SKI1_1	497	501	PF00082	0.513
CLV_PCSK_SKI1_1	663	667	PF00082	0.672
DEG_APCC_DBOX_1	218	226	PF00400	0.601
DEG_APCC_DBOX_1	431	439	PF00400	0.422
DEG_APCC_DBOX_1	662	670	PF00400	0.416
DEG_SPOP_SBC_1	100	104	PF00917	0.668
DEG_SPOP_SBC_1	176	180	PF00917	0.738
DEG_SPOP_SBC_1	283	287	PF00917	0.628
DEG_SPOP_SBC_1	304	308	PF00917	0.694
DOC_CYCLIN_RxL_1	432	443	PF00134	0.444
DOC_CYCLIN_yClb3_PxF_3	521	527	PF00134	0.517
DOC_CYCLIN_yCln2_LP_2	11	17	PF00134	0.358
DOC_CYCLIN_yCln2_LP_2	295	301	PF00134	0.579
DOC_CYCLIN_yCln2_LP_2	708	714	PF00134	0.461
DOC_CYCLIN_yCln2_LP_2	738	744	PF00134	0.559
DOC_MAPK_gen_1	702	712	PF00069	0.527
DOC_MAPK_MEF2A_6	569	577	PF00069	0.360
DOC_MAPK_MEF2A_6	680	688	PF00069	0.465
DOC_MAPK_MEF2A_6	705	712	PF00069	0.464
DOC_PP1_RVXF_1	434	441	PF00149	0.460
DOC_PP1_RVXF_1	455	461	PF00149	0.404
DOC_PP2B_LxvP_1	11	14	PF13499	0.395
DOC_PP2B_LxvP_1	279	282	PF13499	0.658
DOC_PP2B_LxvP_1	708	711	PF13499	0.532
DOC_PP2B_LxvP_1	738	741	PF13499	0.517
DOC_PP2B_PxIxI_1	114	120	PF00149	0.538
DOC_USP7_MATH_1	100	104	PF00917	0.655
DOC_USP7_MATH_1	129	133	PF00917	0.691
DOC_USP7_MATH_1	177	181	PF00917	0.734
DOC_USP7_MATH_1	206	210	PF00917	0.585
DOC_USP7_MATH_1	261	265	PF00917	0.759
DOC_USP7_MATH_1	266	270	PF00917	0.706
DOC_USP7_MATH_1	283	287	PF00917	0.661
DOC_USP7_MATH_1	337	341	PF00917	0.569
DOC_USP7_MATH_1	636	640	PF00917	0.560
DOC_USP7_MATH_1	653	657	PF00917	0.328
DOC_USP7_MATH_2	581	587	PF00917	0.441
DOC_WW_Pin1_4	117	122	PF00397	0.586
DOC_WW_Pin1_4	136	141	PF00397	0.662
DOC_WW_Pin1_4	223	228	PF00397	0.690
DOC_WW_Pin1_4	262	267	PF00397	0.698
DOC_WW_Pin1_4	379	384	PF00397	0.566
DOC_WW_Pin1_4	559	564	PF00397	0.453
DOC_WW_Pin1_4	639	644	PF00397	0.493
LIG_14-3-3_CanoR_1	284	290	PF00244	0.621
LIG_14-3-3_CanoR_1	30	34	PF00244	0.457
LIG_14-3-3_CanoR_1	377	383	PF00244	0.638
LIG_14-3-3_CanoR_1	394	400	PF00244	0.417
LIG_14-3-3_CanoR_1	420	430	PF00244	0.629
LIG_14-3-3_CanoR_1	705	709	PF00244	0.541
LIG_14-3-3_CanoR_1	98	107	PF00244	0.647
LIG_Actin_WH2_2	40	56	PF00022	0.543
LIG_Actin_WH2_2	486	503	PF00022	0.392
LIG_Actin_WH2_2	573	591	PF00022	0.446
LIG_APCC_ABBAyCdc20_2	317	323	PF00400	0.510
LIG_BIR_II_1	1	5	PF00653	0.596
LIG_BIR_III_3	1	5	PF00653	0.596
LIG_BRCT_BRCA1_1	392	396	PF00533	0.465
LIG_BRCT_BRCA1_1	586	590	PF00533	0.374
LIG_Clathr_ClatBox_1	451	455	PF01394	0.466
LIG_CSL_BTD_1	203	206	PF09270	0.655
LIG_FHA_1	276	282	PF00498	0.717
LIG_FHA_1	290	296	PF00498	0.507
LIG_FHA_1	317	323	PF00498	0.514
LIG_FHA_1	46	52	PF00498	0.440
LIG_FHA_1	560	566	PF00498	0.462
LIG_FHA_1	6	12	PF00498	0.547
LIG_FHA_1	650	656	PF00498	0.485
LIG_FHA_1	705	711	PF00498	0.658
LIG_FHA_1	84	90	PF00498	0.398
LIG_FHA_2	37	43	PF00498	0.426
LIG_LIR_Gen_1	268	279	PF02991	0.618
LIG_LIR_Gen_1	363	374	PF02991	0.573
LIG_LIR_Gen_1	393	404	PF02991	0.496
LIG_LIR_Gen_1	544	553	PF02991	0.463
LIG_LIR_Nem_3	268	274	PF02991	0.623
LIG_LIR_Nem_3	363	369	PF02991	0.484
LIG_LIR_Nem_3	393	399	PF02991	0.474
LIG_LIR_Nem_3	455	459	PF02991	0.420
LIG_LIR_Nem_3	544	548	PF02991	0.395
LIG_LIR_Nem_3	574	580	PF02991	0.347
LIG_LIR_Nem_3	587	593	PF02991	0.370
LIG_LIR_Nem_3	713	718	PF02991	0.684
LIG_LYPXL_S_1	552	556	PF13949	0.455
LIG_LYPXL_yS_3	553	556	PF13949	0.458
LIG_MYND_2	13	17	PF01753	0.350
LIG_NRBOX	363	369	PF00104	0.590
LIG_NRBOX	746	752	PF00104	0.460
LIG_PCNA_yPIPBox_3	483	497	PF02747	0.455
LIG_Pex14_2	456	460	PF04695	0.404
LIG_Pex14_2	590	594	PF04695	0.367
LIG_SH2_CRK	375	379	PF00017	0.530
LIG_SH2_CRK	447	451	PF00017	0.406
LIG_SH2_CRK	482	486	PF00017	0.375
LIG_SH2_CRK	578	582	PF00017	0.341
LIG_SH2_CRK	64	68	PF00017	0.422
LIG_SH2_GRB2like	18	21	PF00017	0.399
LIG_SH2_NCK_1	578	582	PF00017	0.341
LIG_SH2_SRC	18	21	PF00017	0.403
LIG_SH2_SRC	578	581	PF00017	0.341
LIG_SH2_SRC	647	650	PF00017	0.540
LIG_SH2_STAP1	607	611	PF00017	0.537
LIG_SH2_STAP1	734	738	PF00017	0.483
LIG_SH2_STAT3	718	721	PF00017	0.497
LIG_SH2_STAT5	18	21	PF00017	0.403
LIG_SH2_STAT5	366	369	PF00017	0.471
LIG_SH2_STAT5	434	437	PF00017	0.524
LIG_SH2_STAT5	46	49	PF00017	0.517
LIG_SH2_STAT5	647	650	PF00017	0.549
LIG_SH2_STAT5	693	696	PF00017	0.470
LIG_SH3_1	325	331	PF00018	0.549
LIG_SH3_3	104	110	PF00018	0.630
LIG_SH3_3	118	124	PF00018	0.738
LIG_SH3_3	202	208	PF00018	0.664
LIG_SH3_3	260	266	PF00018	0.752
LIG_SH3_3	298	304	PF00018	0.600
LIG_SH3_3	325	331	PF00018	0.471
LIG_SH3_3	412	418	PF00018	0.434
LIG_SH3_3	439	445	PF00018	0.534
LIG_SH3_3	49	55	PF00018	0.475
LIG_SH3_3	511	517	PF00018	0.391
LIG_SH3_3	518	524	PF00018	0.515
LIG_SH3_3	560	566	PF00018	0.378
LIG_SH3_3	608	614	PF00018	0.520
LIG_SH3_3	632	638	PF00018	0.349
LIG_SH3_3	7	13	PF00018	0.516
LIG_SH3_4	516	523	PF00018	0.593
LIG_SUMO_SIM_par_1	115	120	PF11976	0.590
LIG_SUMO_SIM_par_1	449	455	PF11976	0.370
LIG_SUMO_SIM_par_1	85	90	PF11976	0.391
LIG_TRAF2_1	265	268	PF00917	0.574
LIG_TYR_ITIM	364	369	PF00017	0.464
LIG_UBA3_1	395	402	PF00899	0.594
LIG_WRC_WIRS_1	527	532	PF05994	0.463
LIG_WW_3	329	333	PF00397	0.423
LIG_WW_3	417	421	PF00397	0.490
LIG_WW_3	470	474	PF00397	0.601
MOD_CDK_SPxK_1	117	123	PF00069	0.595
MOD_CDK_SPxxK_3	140	147	PF00069	0.661
MOD_CK1_1	241	247	PF00069	0.682
MOD_CK1_1	269	275	PF00069	0.657
MOD_CK1_1	356	362	PF00069	0.526
MOD_CK1_1	36	42	PF00069	0.419
MOD_CK1_1	421	427	PF00069	0.417
MOD_CK1_1	639	645	PF00069	0.523
MOD_CK1_1	695	701	PF00069	0.561
MOD_CK2_1	189	195	PF00069	0.597
MOD_CK2_1	211	217	PF00069	0.783
MOD_CK2_1	261	267	PF00069	0.711
MOD_CK2_1	36	42	PF00069	0.446
MOD_Cter_Amidation	134	137	PF01082	0.706
MOD_Cter_Amidation	399	402	PF01082	0.533
MOD_GlcNHglycan	131	134	PF01048	0.833
MOD_GlcNHglycan	140	143	PF01048	0.628
MOD_GlcNHglycan	191	194	PF01048	0.697
MOD_GlcNHglycan	259	262	PF01048	0.763
MOD_GlcNHglycan	310	313	PF01048	0.622
MOD_GlcNHglycan	345	348	PF01048	0.538
MOD_GlcNHglycan	355	358	PF01048	0.548
MOD_GlcNHglycan	415	418	PF01048	0.439
MOD_GlcNHglycan	420	423	PF01048	0.460
MOD_GlcNHglycan	557	560	PF01048	0.351
MOD_GlcNHglycan	590	593	PF01048	0.384
MOD_GlcNHglycan	70	73	PF01048	0.479
MOD_GlcNHglycan	715	718	PF01048	0.628
MOD_GlcNHglycan	724	728	PF01048	0.538
MOD_GSK3_1	136	143	PF00069	0.668
MOD_GSK3_1	177	184	PF00069	0.756
MOD_GSK3_1	234	241	PF00069	0.711
MOD_GSK3_1	257	264	PF00069	0.638
MOD_GSK3_1	266	273	PF00069	0.642
MOD_GSK3_1	29	36	PF00069	0.423
MOD_GSK3_1	303	310	PF00069	0.652
MOD_GSK3_1	337	344	PF00069	0.692
MOD_GSK3_1	356	363	PF00069	0.436
MOD_GSK3_1	418	425	PF00069	0.574
MOD_GSK3_1	555	562	PF00069	0.370
MOD_GSK3_1	584	591	PF00069	0.371
MOD_GSK3_1	649	656	PF00069	0.550
MOD_GSK3_1	706	713	PF00069	0.548
MOD_GSK3_1	83	90	PF00069	0.406
MOD_N-GLC_1	525	530	PF02516	0.425
MOD_NEK2_1	270	275	PF00069	0.735
MOD_NEK2_1	341	346	PF00069	0.627
MOD_NEK2_1	378	383	PF00069	0.551
MOD_NEK2_1	395	400	PF00069	0.527
MOD_NEK2_1	446	451	PF00069	0.451
MOD_NEK2_1	584	589	PF00069	0.366
MOD_NEK2_1	704	709	PF00069	0.664
MOD_NEK2_2	266	271	PF00069	0.581
MOD_NEK2_2	316	321	PF00069	0.524
MOD_PIKK_1	211	217	PF00454	0.601
MOD_PIKK_1	241	247	PF00454	0.668
MOD_PIKK_1	528	534	PF00454	0.395
MOD_PK_1	221	227	PF00069	0.644
MOD_PK_1	706	712	PF00069	0.573
MOD_PKA_1	98	104	PF00069	0.574
MOD_PKA_2	196	202	PF00069	0.663
MOD_PKA_2	283	289	PF00069	0.723
MOD_PKA_2	29	35	PF00069	0.454
MOD_PKA_2	316	322	PF00069	0.516
MOD_PKA_2	609	615	PF00069	0.606
MOD_PKA_2	704	710	PF00069	0.681
MOD_PKA_2	98	104	PF00069	0.584
MOD_PKB_1	219	227	PF00069	0.640
MOD_Plk_1	266	272	PF00069	0.565
MOD_Plk_1	525	531	PF00069	0.403
MOD_Plk_4	226	232	PF00069	0.583
MOD_Plk_4	266	272	PF00069	0.566
MOD_Plk_4	316	322	PF00069	0.516
MOD_Plk_4	425	431	PF00069	0.516
MOD_Plk_4	446	452	PF00069	0.370
MOD_Plk_4	642	648	PF00069	0.525
MOD_Plk_4	692	698	PF00069	0.558
MOD_Plk_4	83	89	PF00069	0.386
MOD_ProDKin_1	117	123	PF00069	0.595
MOD_ProDKin_1	136	142	PF00069	0.662
MOD_ProDKin_1	223	229	PF00069	0.689
MOD_ProDKin_1	262	268	PF00069	0.701
MOD_ProDKin_1	379	385	PF00069	0.567
MOD_ProDKin_1	559	565	PF00069	0.453
MOD_ProDKin_1	639	645	PF00069	0.497
TRG_DiLeu_BaEn_1	502	507	PF01217	0.481
TRG_DiLeu_BaEn_1	746	751	PF01217	0.490
TRG_DiLeu_BaLyEn_6	11	16	PF01217	0.464
TRG_DiLeu_BaLyEn_6	454	459	PF01217	0.412
TRG_DiLeu_BaLyEn_6	470	475	PF01217	0.453
TRG_DiLeu_BaLyEn_6	617	622	PF01217	0.491
TRG_ENDOCYTIC_2	366	369	PF00928	0.490
TRG_ENDOCYTIC_2	375	378	PF00928	0.550
TRG_ENDOCYTIC_2	447	450	PF00928	0.408
TRG_ENDOCYTIC_2	482	485	PF00928	0.380
TRG_ENDOCYTIC_2	553	556	PF00928	0.458
TRG_ENDOCYTIC_2	64	67	PF00928	0.430
TRG_ENDOCYTIC_2	693	696	PF00928	0.495
TRG_ER_diArg_1	98	100	PF00400	0.544
TRG_Pf-PMV_PEXEL_1	436	441	PF00026	0.440
TRG_Pf-PMV_PEXEL_1	473	477	PF00026	0.577

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I868	Leptomonas seymouri	52%	96%
A0A3S7WY82	Leishmania donovani	91%	100%
A4HD97	Leishmania braziliensis	76%	100%
E9AH52	Leishmania infantum	92%	100%
E9AWN1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%