Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QAT4_LEIMA

TriTrypDb:

LmjF.24.0470 , LMJLV39_240010200 , LMJSD75_240009800

Length:

420

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QAT4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QAT4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	175	179	PF00656	0.560
CLV_NRD_NRD_1	229	231	PF00675	0.647
CLV_NRD_NRD_1	264	266	PF00675	0.535
CLV_NRD_NRD_1	27	29	PF00675	0.572
CLV_NRD_NRD_1	327	329	PF00675	0.644
CLV_NRD_NRD_1	371	373	PF00675	0.644
CLV_PCSK_FUR_1	117	121	PF00082	0.538
CLV_PCSK_KEX2_1	119	121	PF00082	0.563
CLV_PCSK_KEX2_1	229	231	PF00082	0.647
CLV_PCSK_KEX2_1	264	266	PF00082	0.535
CLV_PCSK_KEX2_1	327	329	PF00082	0.644
CLV_PCSK_KEX2_1	371	373	PF00082	0.644
CLV_PCSK_PC1ET2_1	119	121	PF00082	0.504
CLV_PCSK_SKI1_1	120	124	PF00082	0.493
CLV_PCSK_SKI1_1	148	152	PF00082	0.415
CLV_PCSK_SKI1_1	233	237	PF00082	0.631
CLV_PCSK_SKI1_1	384	388	PF00082	0.641
CLV_PCSK_SKI1_1	66	70	PF00082	0.418
DEG_SPOP_SBC_1	315	319	PF00917	0.626
DOC_CKS1_1	283	288	PF01111	0.639
DOC_MAPK_gen_1	229	238	PF00069	0.656
DOC_MAPK_gen_1	64	71	PF00069	0.479
DOC_MAPK_MEF2A_6	64	71	PF00069	0.433
DOC_PP4_FxxP_1	245	248	PF00568	0.773
DOC_USP7_MATH_1	270	274	PF00917	0.632
DOC_USP7_MATH_1	278	282	PF00917	0.649
DOC_USP7_MATH_1	284	288	PF00917	0.615
DOC_USP7_MATH_1	309	313	PF00917	0.727
DOC_USP7_MATH_1	315	319	PF00917	0.654
DOC_USP7_MATH_1	399	403	PF00917	0.678
DOC_USP7_MATH_1	416	420	PF00917	0.641
DOC_WW_Pin1_4	105	110	PF00397	0.584
DOC_WW_Pin1_4	257	262	PF00397	0.695
DOC_WW_Pin1_4	268	273	PF00397	0.581
DOC_WW_Pin1_4	279	284	PF00397	0.604
DOC_WW_Pin1_4	293	298	PF00397	0.657
DOC_WW_Pin1_4	326	331	PF00397	0.709
DOC_WW_Pin1_4	359	364	PF00397	0.708
DOC_WW_Pin1_4	387	392	PF00397	0.634
DOC_WW_Pin1_4	7	12	PF00397	0.605
LIG_14-3-3_CanoR_1	120	128	PF00244	0.547
LIG_14-3-3_CanoR_1	230	238	PF00244	0.797
LIG_14-3-3_CanoR_1	311	320	PF00244	0.646
LIG_14-3-3_CanoR_1	322	327	PF00244	0.592
LIG_14-3-3_CanoR_1	384	393	PF00244	0.751
LIG_14-3-3_CanoR_1	400	404	PF00244	0.639
LIG_Actin_WH2_2	54	72	PF00022	0.402
LIG_APCC_ABBA_1	97	102	PF00400	0.429
LIG_BRCT_BRCA1_1	248	252	PF00533	0.669
LIG_BRCT_BRCA1_1	270	274	PF00533	0.575
LIG_Clathr_ClatBox_1	43	47	PF01394	0.352
LIG_DLG_GKlike_1	372	380	PF00625	0.616
LIG_FHA_1	122	128	PF00498	0.441
LIG_FHA_1	149	155	PF00498	0.533
LIG_FHA_1	258	264	PF00498	0.496
LIG_LIR_Apic_2	110	115	PF02991	0.542
LIG_LIR_Apic_2	198	204	PF02991	0.639
LIG_LIR_Apic_2	273	278	PF02991	0.597
LIG_LIR_Apic_2	293	298	PF02991	0.615
LIG_LIR_Gen_1	38	48	PF02991	0.400
LIG_LIR_Gen_1	74	82	PF02991	0.340
LIG_LIR_Nem_3	271	277	PF02991	0.586
LIG_LIR_Nem_3	38	43	PF02991	0.422
LIG_LIR_Nem_3	47	53	PF02991	0.457
LIG_LIR_Nem_3	74	79	PF02991	0.385
LIG_SH2_CRK	201	205	PF00017	0.658
LIG_SH2_NCK_1	112	116	PF00017	0.536
LIG_SH2_NCK_1	174	178	PF00017	0.521
LIG_SH2_PTP2	267	270	PF00017	0.649
LIG_SH2_STAT5	267	270	PF00017	0.573
LIG_SH3_1	327	333	PF00018	0.650
LIG_SH3_3	209	215	PF00018	0.551
LIG_SH3_3	266	272	PF00018	0.765
LIG_SH3_3	280	286	PF00018	0.572
LIG_SH3_3	327	333	PF00018	0.658
LIG_SH3_3	98	104	PF00018	0.426
LIG_SUMO_SIM_anti_2	42	47	PF11976	0.362
LIG_SUMO_SIM_par_1	42	47	PF11976	0.362
LIG_SUMO_SIM_par_1	57	63	PF11976	0.442
LIG_TRAF2_1	161	164	PF00917	0.553
LIG_TRAF2_1	305	308	PF00917	0.559
MOD_CDK_SPxxK_3	257	264	PF00069	0.508
MOD_CK1_1	105	111	PF00069	0.566
MOD_CK1_1	162	168	PF00069	0.673
MOD_CK1_1	181	187	PF00069	0.360
MOD_CK1_1	208	214	PF00069	0.575
MOD_CK1_1	234	240	PF00069	0.633
MOD_CK1_1	282	288	PF00069	0.713
MOD_CK1_1	31	37	PF00069	0.531
MOD_CK1_1	314	320	PF00069	0.652
MOD_CK1_1	332	338	PF00069	0.589
MOD_CK1_1	374	380	PF00069	0.573
MOD_CK1_1	395	401	PF00069	0.658
MOD_CK2_1	302	308	PF00069	0.558
MOD_GlcNHglycan	104	107	PF01048	0.466
MOD_GlcNHglycan	208	211	PF01048	0.791
MOD_GlcNHglycan	233	236	PF01048	0.597
MOD_GlcNHglycan	303	307	PF01048	0.673
MOD_GlcNHglycan	31	34	PF01048	0.548
MOD_GlcNHglycan	311	314	PF01048	0.650
MOD_GlcNHglycan	397	400	PF01048	0.758
MOD_GSK3_1	181	188	PF00069	0.582
MOD_GSK3_1	195	202	PF00069	0.597
MOD_GSK3_1	204	211	PF00069	0.616
MOD_GSK3_1	234	241	PF00069	0.792
MOD_GSK3_1	278	285	PF00069	0.587
MOD_GSK3_1	307	314	PF00069	0.750
MOD_GSK3_1	31	38	PF00069	0.528
MOD_GSK3_1	322	329	PF00069	0.732
MOD_GSK3_1	332	339	PF00069	0.664
MOD_GSK3_1	394	401	PF00069	0.670
MOD_GSK3_1	7	14	PF00069	0.652
MOD_LATS_1	27	33	PF00433	0.501
MOD_N-GLC_1	350	355	PF02516	0.606
MOD_N-GLC_2	141	143	PF02516	0.319
MOD_NEK2_1	149	154	PF00069	0.377
MOD_NEK2_1	206	211	PF00069	0.770
MOD_NEK2_1	238	243	PF00069	0.669
MOD_NEK2_1	336	341	PF00069	0.667
MOD_NEK2_1	393	398	PF00069	0.791
MOD_NEK2_1	60	65	PF00069	0.426
MOD_PKA_1	28	34	PF00069	0.493
MOD_PKA_1	371	377	PF00069	0.547
MOD_PKA_2	136	142	PF00069	0.522
MOD_PKA_2	371	377	PF00069	0.568
MOD_PKA_2	399	405	PF00069	0.633
MOD_PKB_1	135	143	PF00069	0.439
MOD_Plk_1	35	41	PF00069	0.487
MOD_Plk_1	372	378	PF00069	0.573
MOD_Plk_4	149	155	PF00069	0.395
MOD_Plk_4	178	184	PF00069	0.450
MOD_Plk_4	270	276	PF00069	0.611
MOD_Plk_4	332	338	PF00069	0.751
MOD_Plk_4	35	41	PF00069	0.435
MOD_ProDKin_1	105	111	PF00069	0.587
MOD_ProDKin_1	257	263	PF00069	0.687
MOD_ProDKin_1	268	274	PF00069	0.583
MOD_ProDKin_1	279	285	PF00069	0.605
MOD_ProDKin_1	293	299	PF00069	0.659
MOD_ProDKin_1	326	332	PF00069	0.707
MOD_ProDKin_1	359	365	PF00069	0.700
MOD_ProDKin_1	387	393	PF00069	0.637
MOD_ProDKin_1	7	13	PF00069	0.605
TRG_ENDOCYTIC_2	174	177	PF00928	0.517
TRG_ER_diArg_1	263	265	PF00400	0.532
TRG_ER_diArg_1	326	328	PF00400	0.649

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PEP2	Leptomonas seymouri	37%	100%
A0A3S7WY45	Leishmania donovani	88%	100%
A4HDU6	Leishmania braziliensis	61%	85%
A4I0N7	Leishmania infantum	88%	100%
E9AWN7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%