Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QAT1_LEIMA

TriTrypDb:

LmjF.24.0500 , LMJLV39_240010500 , LMJSD75_240010200

Length:

234

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005654	nucleoplasm	2	2
GO:0005730	nucleolus	5	2
GO:0043226	organelle	2	2
GO:0043228	non-membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043232	intracellular non-membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4QAT1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QAT1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	121	127	PF00089	0.508
CLV_NRD_NRD_1	17	19	PF00675	0.441
CLV_NRD_NRD_1	174	176	PF00675	0.682
CLV_NRD_NRD_1	185	187	PF00675	0.668
CLV_NRD_NRD_1	212	214	PF00675	0.545
CLV_NRD_NRD_1	24	26	PF00675	0.440
CLV_NRD_NRD_1	90	92	PF00675	0.515
CLV_PCSK_FUR_1	183	187	PF00082	0.581
CLV_PCSK_KEX2_1	174	176	PF00082	0.682
CLV_PCSK_KEX2_1	180	182	PF00082	0.631
CLV_PCSK_KEX2_1	185	187	PF00082	0.473
CLV_PCSK_KEX2_1	212	214	PF00082	0.577
CLV_PCSK_KEX2_1	222	224	PF00082	0.502
CLV_PCSK_KEX2_1	23	25	PF00082	0.445
CLV_PCSK_KEX2_1	90	92	PF00082	0.515
CLV_PCSK_PC1ET2_1	180	182	PF00082	0.531
CLV_PCSK_PC1ET2_1	222	224	PF00082	0.549
CLV_PCSK_PC1ET2_1	23	25	PF00082	0.445
CLV_PCSK_PC7_1	181	187	PF00082	0.532
CLV_PCSK_SKI1_1	11	15	PF00082	0.514
CLV_PCSK_SKI1_1	25	29	PF00082	0.501
CLV_PCSK_SKI1_1	38	42	PF00082	0.556
CLV_PCSK_SKI1_1	91	95	PF00082	0.527
CLV_Separin_Metazoa	8	12	PF03568	0.513
DEG_APCC_DBOX_1	123	131	PF00400	0.606
DEG_Nend_UBRbox_2	1	3	PF02207	0.467
DOC_CYCLIN_RxL_1	33	45	PF00134	0.557
DOC_PP2B_LxvP_1	205	208	PF13499	0.568
DOC_SPAK_OSR1_1	198	202	PF12202	0.589
DOC_USP7_MATH_1	120	124	PF00917	0.665
DOC_USP7_MATH_1	133	137	PF00917	0.590
DOC_USP7_UBL2_3	19	23	PF12436	0.429
LIG_14-3-3_CanoR_1	124	128	PF00244	0.632
LIG_14-3-3_CanoR_1	72	76	PF00244	0.520
LIG_14-3-3_CanoR_1	90	94	PF00244	0.520
LIG_BIR_III_4	160	164	PF00653	0.562
LIG_FHA_1	4	10	PF00498	0.412
LIG_FHA_1	92	98	PF00498	0.591
LIG_FHA_2	215	221	PF00498	0.427
LIG_Integrin_RGD_1	186	188	PF01839	0.674
LIG_SH2_SRC	77	80	PF00017	0.567
LIG_SH2_STAP1	77	81	PF00017	0.563
LIG_SH3_2	208	213	PF14604	0.569
LIG_SH3_3	205	211	PF00018	0.511
LIG_SUMO_SIM_anti_2	6	11	PF11976	0.491
LIG_TRAF2_1	148	151	PF00917	0.606
LIG_TRAF2_1	226	229	PF00917	0.674
MOD_CK1_1	123	129	PF00069	0.604
MOD_CK1_1	48	54	PF00069	0.587
MOD_CK1_1	80	86	PF00069	0.587
MOD_CK1_1	89	95	PF00069	0.591
MOD_CK2_1	116	122	PF00069	0.687
MOD_CK2_1	145	151	PF00069	0.607
MOD_CK2_1	214	220	PF00069	0.572
MOD_CK2_1	89	95	PF00069	0.597
MOD_GlcNHglycan	117	121	PF01048	0.562
MOD_GlcNHglycan	135	138	PF01048	0.596
MOD_GlcNHglycan	47	50	PF01048	0.606
MOD_GlcNHglycan	59	62	PF01048	0.637
MOD_GSK3_1	116	123	PF00069	0.724
MOD_GSK3_1	141	148	PF00069	0.768
MOD_GSK3_1	44	51	PF00069	0.567
MOD_GSK3_1	52	59	PF00069	0.558
MOD_GSK3_1	80	87	PF00069	0.604
MOD_GSK3_1	89	96	PF00069	0.560
MOD_NEK2_1	116	121	PF00069	0.515
MOD_NEK2_1	214	219	PF00069	0.451
MOD_NEK2_1	93	98	PF00069	0.595
MOD_PKA_2	123	129	PF00069	0.630
MOD_PKA_2	71	77	PF00069	0.543
MOD_PKA_2	89	95	PF00069	0.643
MOD_Plk_1	77	83	PF00069	0.572
MOD_Plk_2-3	145	151	PF00069	0.601
MOD_Plk_4	71	77	PF00069	0.521
TRG_DiLeu_BaEn_4	150	156	PF01217	0.587
TRG_ER_diArg_1	211	213	PF00400	0.572
TRG_NLS_Bipartite_1	212	226	PF00514	0.566
TRG_NLS_MonoExtC_3	221	227	PF00514	0.545
TRG_Pf-PMV_PEXEL_1	212	216	PF00026	0.564

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZZ3	Leptomonas seymouri	49%	100%
A0A3S7WYA2	Leishmania donovani	86%	98%
A4HDA7	Leishmania braziliensis	71%	99%
A4I0P0	Leishmania infantum	86%	98%
E9AWP0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	98%
V5C0P2	Trypanosoma cruzi	32%	100%