Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QAT0_LEIMA

TriTrypDb:

LmjF.24.0510 , LMJLV39_240010600 , LMJSD75_240010300

Length:

777

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QAT0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QAT0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	144	148	PF00656	0.660
CLV_C14_Caspase3-7	439	443	PF00656	0.660
CLV_C14_Caspase3-7	724	728	PF00656	0.597
CLV_NRD_NRD_1	335	337	PF00675	0.562
CLV_NRD_NRD_1	464	466	PF00675	0.730
CLV_NRD_NRD_1	588	590	PF00675	0.670
CLV_PCSK_KEX2_1	335	337	PF00082	0.579
CLV_PCSK_KEX2_1	588	590	PF00082	0.691
CLV_PCSK_SKI1_1	141	145	PF00082	0.650
CLV_PCSK_SKI1_1	164	168	PF00082	0.618
CLV_PCSK_SKI1_1	335	339	PF00082	0.577
CLV_PCSK_SKI1_1	51	55	PF00082	0.554
DEG_APCC_DBOX_1	186	194	PF00400	0.722
DEG_Nend_UBRbox_2	1	3	PF02207	0.738
DEG_SPOP_SBC_1	212	216	PF00917	0.688
DOC_CDC14_PxL_1	731	739	PF14671	0.607
DOC_CYCLIN_yCln2_LP_2	367	373	PF00134	0.635
DOC_MAPK_gen_1	335	341	PF00069	0.659
DOC_MAPK_MEF2A_6	716	725	PF00069	0.584
DOC_PP1_RVXF_1	407	414	PF00149	0.573
DOC_PP1_SILK_1	765	770	PF00149	0.614
DOC_PP2B_LxvP_1	367	370	PF13499	0.634
DOC_PP2B_LxvP_1	390	393	PF13499	0.657
DOC_PP2B_LxvP_1	590	593	PF13499	0.725
DOC_PP2B_LxvP_1	715	718	PF13499	0.578
DOC_PP4_FxxP_1	306	309	PF00568	0.681
DOC_USP7_MATH_1	162	166	PF00917	0.696
DOC_USP7_MATH_1	200	204	PF00917	0.661
DOC_USP7_MATH_1	213	217	PF00917	0.600
DOC_USP7_MATH_1	218	222	PF00917	0.511
DOC_USP7_MATH_1	34	38	PF00917	0.613
DOC_USP7_MATH_1	504	508	PF00917	0.690
DOC_USP7_UBL2_3	47	51	PF12436	0.532
DOC_WW_Pin1_4	305	310	PF00397	0.683
DOC_WW_Pin1_4	635	640	PF00397	0.730
LIG_14-3-3_CanoR_1	209	213	PF00244	0.661
LIG_14-3-3_CanoR_1	280	288	PF00244	0.748
LIG_14-3-3_CanoR_1	335	340	PF00244	0.722
LIG_14-3-3_CanoR_1	409	414	PF00244	0.534
LIG_14-3-3_CanoR_1	621	627	PF00244	0.606
LIG_14-3-3_CanoR_1	71	81	PF00244	0.598
LIG_14-3-3_CanoR_1	738	747	PF00244	0.660
LIG_APCC_ABBA_1	292	297	PF00400	0.722
LIG_BRCT_BRCA1_1	312	316	PF00533	0.718
LIG_BRCT_BRCA1_1	718	722	PF00533	0.699
LIG_Clathr_ClatBox_1	112	116	PF01394	0.574
LIG_CSL_BTD_1	288	291	PF09270	0.663
LIG_deltaCOP1_diTrp_1	235	242	PF00928	0.707
LIG_deltaCOP1_diTrp_1	284	289	PF00928	0.714
LIG_deltaCOP1_diTrp_1	415	420	PF00928	0.616
LIG_EVH1_1	287	291	PF00568	0.673
LIG_FHA_1	135	141	PF00498	0.567
LIG_FHA_1	21	27	PF00498	0.693
LIG_FHA_1	215	221	PF00498	0.737
LIG_FHA_1	273	279	PF00498	0.618
LIG_FHA_1	336	342	PF00498	0.804
LIG_FHA_1	48	54	PF00498	0.588
LIG_FHA_1	514	520	PF00498	0.504
LIG_FHA_1	585	591	PF00498	0.701
LIG_FHA_1	643	649	PF00498	0.732
LIG_FHA_1	760	766	PF00498	0.686
LIG_FHA_2	142	148	PF00498	0.560
LIG_FHA_2	28	34	PF00498	0.625
LIG_FHA_2	437	443	PF00498	0.615
LIG_FHA_2	55	61	PF00498	0.623
LIG_LIR_Apic_2	282	288	PF02991	0.783
LIG_LIR_Gen_1	32	43	PF02991	0.613
LIG_LIR_Gen_1	496	506	PF02991	0.584
LIG_LIR_Gen_1	719	730	PF02991	0.577
LIG_LIR_Nem_3	205	210	PF02991	0.544
LIG_LIR_Nem_3	32	38	PF02991	0.619
LIG_LIR_Nem_3	719	725	PF02991	0.586
LIG_MYND_1	290	294	PF01753	0.716
LIG_NRBOX	149	155	PF00104	0.581
LIG_NRBOX	168	174	PF00104	0.680
LIG_PCNA_PIPBox_1	360	369	PF02747	0.530
LIG_PCNA_yPIPBox_3	71	81	PF02747	0.598
LIG_Pex14_2	139	143	PF04695	0.549
LIG_Pex14_2	413	417	PF04695	0.569
LIG_SH2_CRK	210	214	PF00017	0.658
LIG_SH2_NCK_1	210	214	PF00017	0.658
LIG_SH2_STAP1	480	484	PF00017	0.605
LIG_SH2_STAT5	207	210	PF00017	0.648
LIG_SH2_STAT5	736	739	PF00017	0.578
LIG_SH3_3	285	291	PF00018	0.650
LIG_SH3_3	306	312	PF00018	0.599
LIG_SUMO_SIM_anti_2	247	253	PF11976	0.469
LIG_SUMO_SIM_anti_2	764	771	PF11976	0.691
LIG_SUMO_SIM_par_1	502	509	PF11976	0.587
LIG_SUMO_SIM_par_1	645	654	PF11976	0.734
LIG_TRAF2_1	267	270	PF00917	0.769
LIG_TRAF2_1	30	33	PF00917	0.603
LIG_TRAF2_1	340	343	PF00917	0.683
LIG_TRAF2_1	774	777	PF00917	0.692
LIG_WRC_WIRS_1	140	145	PF05994	0.587
LIG_WRC_WIRS_1	193	198	PF05994	0.736
LIG_WW_2	290	293	PF00397	0.669
MOD_CK1_1	158	164	PF00069	0.608
MOD_CK1_1	20	26	PF00069	0.695
MOD_CK1_1	214	220	PF00069	0.541
MOD_CK1_1	310	316	PF00069	0.796
MOD_CK1_1	513	519	PF00069	0.674
MOD_CK1_1	584	590	PF00069	0.729
MOD_CK2_1	162	168	PF00069	0.668
MOD_CK2_1	26	32	PF00069	0.632
MOD_CK2_1	264	270	PF00069	0.734
MOD_CK2_1	409	415	PF00069	0.458
MOD_CK2_1	54	60	PF00069	0.532
MOD_CK2_1	690	696	PF00069	0.712
MOD_CK2_1	771	777	PF00069	0.678
MOD_CMANNOS	417	420	PF00535	0.648
MOD_Cter_Amidation	333	336	PF01082	0.565
MOD_GlcNHglycan	109	112	PF01048	0.598
MOD_GlcNHglycan	121	124	PF01048	0.509
MOD_GlcNHglycan	127	130	PF01048	0.430
MOD_GlcNHglycan	157	160	PF01048	0.659
MOD_GlcNHglycan	164	167	PF01048	0.609
MOD_GlcNHglycan	201	205	PF01048	0.667
MOD_GlcNHglycan	220	223	PF01048	0.462
MOD_GlcNHglycan	265	269	PF01048	0.708
MOD_GlcNHglycan	324	327	PF01048	0.744
MOD_GlcNHglycan	374	377	PF01048	0.481
MOD_GlcNHglycan	511	515	PF01048	0.628
MOD_GlcNHglycan	593	596	PF01048	0.670
MOD_GlcNHglycan	632	635	PF01048	0.556
MOD_GSK3_1	158	165	PF00069	0.587
MOD_GSK3_1	17	24	PF00069	0.735
MOD_GSK3_1	192	199	PF00069	0.679
MOD_GSK3_1	208	215	PF00069	0.605
MOD_GSK3_1	218	225	PF00069	0.574
MOD_GSK3_1	260	267	PF00069	0.684
MOD_GSK3_1	307	314	PF00069	0.792
MOD_GSK3_1	395	402	PF00069	0.546
MOD_GSK3_1	47	54	PF00069	0.540
MOD_GSK3_1	506	513	PF00069	0.686
MOD_GSK3_1	663	670	PF00069	0.738
MOD_GSK3_1	736	743	PF00069	0.482
MOD_GSK3_1	759	766	PF00069	0.672
MOD_GSK3_1	767	774	PF00069	0.564
MOD_N-GLC_1	606	611	PF02516	0.634
MOD_N-GLC_1	663	668	PF02516	0.645
MOD_NEK2_1	139	144	PF00069	0.591
MOD_NEK2_1	208	213	PF00069	0.729
MOD_NEK2_1	399	404	PF00069	0.591
MOD_NEK2_1	544	549	PF00069	0.689
MOD_NEK2_1	630	635	PF00069	0.685
MOD_NEK2_1	667	672	PF00069	0.699
MOD_NEK2_2	34	39	PF00069	0.610
MOD_PIKK_1	403	409	PF00454	0.498
MOD_PIKK_1	424	430	PF00454	0.686
MOD_PIKK_1	488	494	PF00454	0.622
MOD_PIKK_1	54	60	PF00454	0.595
MOD_PIKK_1	75	81	PF00454	0.643
MOD_PKA_1	335	341	PF00069	0.554
MOD_PKA_2	18	24	PF00069	0.609
MOD_PKA_2	208	214	PF00069	0.698
MOD_PKA_2	27	33	PF00069	0.587
MOD_PKA_2	279	285	PF00069	0.751
MOD_PKA_2	335	341	PF00069	0.709
MOD_PKA_2	494	500	PF00069	0.600
MOD_PKA_2	54	60	PF00069	0.610
MOD_PKA_2	740	746	PF00069	0.606
MOD_PKA_2	747	753	PF00069	0.592
MOD_Plk_1	222	228	PF00069	0.506
MOD_Plk_1	394	400	PF00069	0.614
MOD_Plk_1	475	481	PF00069	0.622
MOD_Plk_1	51	57	PF00069	0.587
MOD_Plk_1	510	516	PF00069	0.707
MOD_Plk_1	763	769	PF00069	0.688
MOD_Plk_4	663	669	PF00069	0.702
MOD_ProDKin_1	305	311	PF00069	0.683
MOD_ProDKin_1	635	641	PF00069	0.730
TRG_DiLeu_BaEn_1	168	173	PF01217	0.629
TRG_DiLeu_BaEn_1	357	362	PF01217	0.584
TRG_DiLeu_LyEn_5	168	173	PF01217	0.683
TRG_ER_diArg_1	588	590	PF00400	0.670
TRG_Pf-PMV_PEXEL_1	171	175	PF00026	0.676
TRG_Pf-PMV_PEXEL_1	246	250	PF00026	0.608
TRG_Pf-PMV_PEXEL_1	612	616	PF00026	0.741

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7L7	Leptomonas seymouri	36%	100%
A0A3Q8ICS5	Leishmania donovani	89%	100%
A4HDA8	Leishmania braziliensis	69%	99%
A4I0P1	Leishmania infantum	90%	100%
E9AWP1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%