Putative DNAJ domain protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

DNAJ domain protein, putative

Species:

Leishmania major

UniProt:

Q4QAS9_LEIMA

TriTrypDb:

LmjF.24.0520 , LMJLV39_240010700 , LMJSD75_240010400

Length:

795

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 8, no: 2
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	4
GO:0110165	cellular anatomical entity	1	4

Expansion

Sequence features

Q4QAS9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QAS9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	453	457	PF00656	0.446
CLV_C14_Caspase3-7	776	780	PF00656	0.560
CLV_MEL_PAP_1	343	349	PF00089	0.643
CLV_NRD_NRD_1	101	103	PF00675	0.419
CLV_NRD_NRD_1	152	154	PF00675	0.589
CLV_NRD_NRD_1	220	222	PF00675	0.629
CLV_NRD_NRD_1	481	483	PF00675	0.609
CLV_NRD_NRD_1	584	586	PF00675	0.626
CLV_NRD_NRD_1	632	634	PF00675	0.560
CLV_NRD_NRD_1	660	662	PF00675	0.578
CLV_NRD_NRD_1	754	756	PF00675	0.359
CLV_NRD_NRD_1	8	10	PF00675	0.692
CLV_PCSK_FUR_1	633	637	PF00082	0.549
CLV_PCSK_KEX2_1	152	154	PF00082	0.589
CLV_PCSK_KEX2_1	481	483	PF00082	0.654
CLV_PCSK_KEX2_1	635	637	PF00082	0.571
CLV_PCSK_KEX2_1	659	661	PF00082	0.581
CLV_PCSK_KEX2_1	8	10	PF00082	0.634
CLV_PCSK_PC1ET2_1	635	637	PF00082	0.541
CLV_PCSK_SKI1_1	146	150	PF00082	0.592
CLV_PCSK_SKI1_1	161	165	PF00082	0.466
CLV_PCSK_SKI1_1	290	294	PF00082	0.586
CLV_PCSK_SKI1_1	297	301	PF00082	0.513
CLV_PCSK_SKI1_1	3	7	PF00082	0.706
CLV_PCSK_SKI1_1	326	330	PF00082	0.530
CLV_PCSK_SKI1_1	369	373	PF00082	0.774
CLV_PCSK_SKI1_1	482	486	PF00082	0.523
CLV_PCSK_SKI1_1	60	64	PF00082	0.491
CLV_PCSK_SKI1_1	618	622	PF00082	0.462
CLV_PCSK_SKI1_1	675	679	PF00082	0.395
CLV_PCSK_SKI1_1	684	688	PF00082	0.320
CLV_PCSK_SKI1_1	704	708	PF00082	0.234
DEG_APCC_DBOX_1	160	168	PF00400	0.310
DEG_APCC_DBOX_1	296	304	PF00400	0.358
DOC_CYCLIN_RxL_1	293	302	PF00134	0.382
DOC_CYCLIN_yCln2_LP_2	707	713	PF00134	0.665
DOC_MAPK_gen_1	158	167	PF00069	0.322
DOC_MAPK_gen_1	219	229	PF00069	0.407
DOC_MAPK_gen_1	585	591	PF00069	0.456
DOC_MAPK_gen_1	681	691	PF00069	0.547
DOC_MAPK_gen_1	8	15	PF00069	0.611
DOC_MAPK_MEF2A_6	158	167	PF00069	0.253
DOC_MAPK_MEF2A_6	684	691	PF00069	0.535
DOC_MAPK_MEF2A_6	8	15	PF00069	0.617
DOC_MAPK_NFAT4_5	684	692	PF00069	0.539
DOC_PP2B_LxvP_1	286	289	PF13499	0.393
DOC_PP2B_LxvP_1	364	367	PF13499	0.440
DOC_PP2B_LxvP_1	700	703	PF13499	0.639
DOC_PP4_FxxP_1	599	602	PF00568	0.408
DOC_USP7_MATH_1	35	39	PF00917	0.684
DOC_USP7_MATH_1	384	388	PF00917	0.577
DOC_USP7_MATH_1	389	393	PF00917	0.493
DOC_USP7_MATH_1	502	506	PF00917	0.453
DOC_USP7_MATH_1	52	56	PF00917	0.343
DOC_USP7_MATH_1	551	555	PF00917	0.546
DOC_USP7_MATH_1	563	567	PF00917	0.420
DOC_USP7_MATH_1	571	575	PF00917	0.398
DOC_USP7_MATH_1	602	606	PF00917	0.447
DOC_USP7_UBL2_3	485	489	PF12436	0.319
DOC_USP7_UBL2_3	56	60	PF12436	0.295
DOC_USP7_UBL2_3	756	760	PF12436	0.570
DOC_USP7_UBL2_3	81	85	PF12436	0.284
DOC_WW_Pin1_4	133	138	PF00397	0.447
DOC_WW_Pin1_4	139	144	PF00397	0.412
DOC_WW_Pin1_4	3	8	PF00397	0.463
DOC_WW_Pin1_4	385	390	PF00397	0.566
DOC_WW_Pin1_4	500	505	PF00397	0.480
LIG_14-3-3_CanoR_1	177	186	PF00244	0.381
LIG_14-3-3_CanoR_1	251	257	PF00244	0.363
LIG_14-3-3_CanoR_1	287	296	PF00244	0.394
LIG_14-3-3_CanoR_1	40	48	PF00244	0.331
LIG_14-3-3_CanoR_1	747	752	PF00244	0.638
LIG_AP2alpha_1	264	268	PF02296	0.423
LIG_APCC_ABBA_1	165	170	PF00400	0.314
LIG_BRCT_BRCA1_1	135	139	PF00533	0.477
LIG_BRCT_BRCA1_1	606	610	PF00533	0.342
LIG_BRCT_BRCA1_2	135	141	PF00533	0.477
LIG_Clathr_ClatBox_1	688	692	PF01394	0.622
LIG_CtBP_PxDLS_1	529	533	PF00389	0.487
LIG_deltaCOP1_diTrp_1	676	686	PF00928	0.636
LIG_EVH1_1	364	368	PF00568	0.481
LIG_FHA_1	23	29	PF00498	0.560
LIG_FHA_1	269	275	PF00498	0.431
LIG_FHA_1	359	365	PF00498	0.408
LIG_FHA_1	431	437	PF00498	0.407
LIG_FHA_1	516	522	PF00498	0.427
LIG_FHA_1	710	716	PF00498	0.596
LIG_FHA_2	122	128	PF00498	0.441
LIG_FHA_2	275	281	PF00498	0.438
LIG_FHA_2	531	537	PF00498	0.470
LIG_FHA_2	75	81	PF00498	0.344
LIG_GBD_Chelix_1	11	19	PF00786	0.661
LIG_GBD_Chelix_1	20	28	PF00786	0.581
LIG_LIR_Apic_2	598	602	PF02991	0.447
LIG_LIR_Gen_1	180	191	PF02991	0.371
LIG_LIR_Gen_1	334	343	PF02991	0.432
LIG_LIR_Gen_1	355	364	PF02991	0.354
LIG_LIR_Gen_1	433	441	PF02991	0.408
LIG_LIR_Gen_1	466	474	PF02991	0.391
LIG_LIR_Gen_1	516	526	PF02991	0.473
LIG_LIR_Gen_1	536	545	PF02991	0.442
LIG_LIR_Gen_1	683	691	PF02991	0.606
LIG_LIR_Nem_3	126	132	PF02991	0.464
LIG_LIR_Nem_3	180	186	PF02991	0.302
LIG_LIR_Nem_3	233	238	PF02991	0.409
LIG_LIR_Nem_3	262	268	PF02991	0.351
LIG_LIR_Nem_3	355	359	PF02991	0.337
LIG_LIR_Nem_3	42	48	PF02991	0.287
LIG_LIR_Nem_3	433	438	PF02991	0.342
LIG_LIR_Nem_3	466	470	PF02991	0.354
LIG_LIR_Nem_3	516	522	PF02991	0.420
LIG_LIR_Nem_3	536	541	PF02991	0.433
LIG_LIR_Nem_3	605	611	PF02991	0.370
LIG_LIR_Nem_3	683	689	PF02991	0.610
LIG_NRBOX	14	20	PF00104	0.531
LIG_NRBOX	773	779	PF00104	0.576
LIG_PCNA_yPIPBox_3	344	357	PF02747	0.387
LIG_Pex14_1	183	187	PF04695	0.394
LIG_Pex14_2	259	263	PF04695	0.307
LIG_Pex14_2	264	268	PF04695	0.320
LIG_Pex14_2	328	332	PF04695	0.365
LIG_SH2_CRK	519	523	PF00017	0.471
LIG_SH2_CRK	538	542	PF00017	0.436
LIG_SH2_NCK_1	238	242	PF00017	0.452
LIG_SH2_NCK_1	316	320	PF00017	0.416
LIG_SH2_SRC	107	110	PF00017	0.489
LIG_SH2_SRC	614	617	PF00017	0.474
LIG_SH2_STAP1	179	183	PF00017	0.399
LIG_SH2_STAP1	597	601	PF00017	0.447
LIG_SH2_STAT3	131	134	PF00017	0.429
LIG_SH2_STAT5	225	228	PF00017	0.402
LIG_SH2_STAT5	336	339	PF00017	0.350
LIG_SH2_STAT5	467	470	PF00017	0.360
LIG_SH2_STAT5	538	541	PF00017	0.373
LIG_SH2_STAT5	590	593	PF00017	0.376
LIG_SH2_STAT5	597	600	PF00017	0.381
LIG_SH2_STAT5	614	617	PF00017	0.260
LIG_SH3_1	668	674	PF00018	0.680
LIG_SH3_3	362	368	PF00018	0.442
LIG_SH3_3	523	529	PF00018	0.478
LIG_SH3_3	557	563	PF00018	0.552
LIG_SH3_3	668	674	PF00018	0.680
LIG_SH3_3	729	735	PF00018	0.657
LIG_SUMO_SIM_par_1	225	231	PF11976	0.410
LIG_SUMO_SIM_par_1	686	693	PF11976	0.628
LIG_TRAF2_1	528	531	PF00917	0.506
LIG_TRAF2_1	55	58	PF00917	0.321
LIG_TRAF2_1	628	631	PF00917	0.746
LIG_TRAF2_1	680	683	PF00917	0.633
LIG_TRAF2_1	77	80	PF00917	0.344
LIG_TRAF2_1	784	787	PF00917	0.589
LIG_TYR_ITIM	517	522	PF00017	0.445
LIG_UBA3_1	751	756	PF00899	0.618
LIG_WRC_WIRS_1	260	265	PF05994	0.364
LIG_WRC_WIRS_1	282	287	PF05994	0.430
LIG_WRC_WIRS_1	467	472	PF05994	0.415
LIG_WRC_WIRS_1	596	601	PF05994	0.456
MOD_CDK_SPK_2	3	8	PF00069	0.463
MOD_CDK_SPxK_1	3	9	PF00069	0.461
MOD_CDK_SPxK_1	385	391	PF00069	0.558
MOD_CDK_SPxxK_3	139	146	PF00069	0.413
MOD_CK1_1	469	475	PF00069	0.357
MOD_CK1_1	654	660	PF00069	0.769
MOD_CK2_1	121	127	PF00069	0.416
MOD_CK2_1	187	193	PF00069	0.361
MOD_CK2_1	236	242	PF00069	0.454
MOD_CK2_1	252	258	PF00069	0.320
MOD_CK2_1	274	280	PF00069	0.415
MOD_CK2_1	377	383	PF00069	0.526
MOD_CK2_1	52	58	PF00069	0.323
MOD_CK2_1	646	652	PF00069	0.789
MOD_CK2_1	74	80	PF00069	0.344
MOD_CMANNOS	723	726	PF00535	0.370
MOD_DYRK1A_RPxSP_1	3	7	PF00069	0.464
MOD_GlcNHglycan	108	112	PF01048	0.686
MOD_GlcNHglycan	179	182	PF01048	0.625
MOD_GlcNHglycan	290	293	PF01048	0.613
MOD_GlcNHglycan	37	40	PF01048	0.719
MOD_GlcNHglycan	504	507	PF01048	0.598
MOD_GlcNHglycan	637	641	PF01048	0.546
MOD_GlcNHglycan	648	651	PF01048	0.529
MOD_GlcNHglycan	652	656	PF01048	0.522
MOD_GSK3_1	133	140	PF00069	0.472
MOD_GSK3_1	236	243	PF00069	0.346
MOD_GSK3_1	270	277	PF00069	0.425
MOD_GSK3_1	35	42	PF00069	0.602
MOD_GSK3_1	372	379	PF00069	0.478
MOD_GSK3_1	385	392	PF00069	0.467
MOD_GSK3_1	536	543	PF00069	0.374
MOD_GSK3_1	571	578	PF00069	0.364
MOD_GSK3_1	762	769	PF00069	0.574
MOD_GSK3_1	778	785	PF00069	0.499
MOD_N-GLC_1	513	518	PF02516	0.594
MOD_NEK2_1	1	6	PF00069	0.668
MOD_NEK2_1	186	191	PF00069	0.334
MOD_NEK2_1	259	264	PF00069	0.352
MOD_NEK2_1	268	273	PF00069	0.376
MOD_NEK2_1	274	279	PF00069	0.347
MOD_NEK2_1	34	39	PF00069	0.683
MOD_NEK2_1	74	79	PF00069	0.330
MOD_NEK2_1	778	783	PF00069	0.649
MOD_NEK2_2	389	394	PF00069	0.507
MOD_PIKK_1	146	152	PF00454	0.436
MOD_PIKK_1	168	174	PF00454	0.451
MOD_PIKK_1	274	280	PF00454	0.441
MOD_PKA_1	407	413	PF00069	0.365
MOD_PKA_2	39	45	PF00069	0.448
MOD_PKA_2	754	760	PF00069	0.612
MOD_Plk_1	274	280	PF00069	0.461
MOD_Plk_1	513	519	PF00069	0.397
MOD_Plk_2-3	203	209	PF00069	0.353
MOD_Plk_2-3	96	102	PF00069	0.353
MOD_Plk_4	187	193	PF00069	0.341
MOD_Plk_4	252	258	PF00069	0.402
MOD_Plk_4	259	265	PF00069	0.382
MOD_Plk_4	281	287	PF00069	0.413
MOD_Plk_4	540	546	PF00069	0.430
MOD_Plk_4	571	577	PF00069	0.381
MOD_Plk_4	592	598	PF00069	0.308
MOD_ProDKin_1	133	139	PF00069	0.449
MOD_ProDKin_1	3	9	PF00069	0.461
MOD_ProDKin_1	385	391	PF00069	0.558
MOD_ProDKin_1	500	506	PF00069	0.470
MOD_SUMO_for_1	680	683	PF00179	0.635
MOD_SUMO_rev_2	55	62	PF00179	0.303
MOD_SUMO_rev_2	676	686	PF00179	0.598
MOD_SUMO_rev_2	96	105	PF00179	0.287
TRG_DiLeu_BaEn_1	683	688	PF01217	0.614
TRG_DiLeu_BaEn_2	681	687	PF01217	0.630
TRG_DiLeu_BaEn_4	478	484	PF01217	0.391
TRG_DiLeu_LyEn_5	208	213	PF01217	0.378
TRG_ENDOCYTIC_2	265	268	PF00928	0.355
TRG_ENDOCYTIC_2	316	319	PF00928	0.353
TRG_ENDOCYTIC_2	336	339	PF00928	0.416
TRG_ENDOCYTIC_2	45	48	PF00928	0.284
TRG_ENDOCYTIC_2	467	470	PF00928	0.340
TRG_ENDOCYTIC_2	474	477	PF00928	0.308
TRG_ENDOCYTIC_2	519	522	PF00928	0.435
TRG_ENDOCYTIC_2	538	541	PF00928	0.432
TRG_ENDOCYTIC_2	95	98	PF00928	0.282
TRG_ER_diArg_1	151	153	PF00400	0.390
TRG_ER_diArg_1	481	483	PF00400	0.453
TRG_ER_diArg_1	658	661	PF00400	0.780
TRG_ER_diArg_1	7	9	PF00400	0.589
TRG_NLS_MonoExtN_4	582	589	PF00514	0.408
TRG_Pf-PMV_PEXEL_1	152	156	PF00026	0.634
TRG_Pf-PMV_PEXEL_1	411	415	PF00026	0.516

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ILW3	Leptomonas seymouri	67%	99%
A0A1X0NIM6	Trypanosomatidae	36%	100%
A0A3Q8IB91	Leishmania donovani	94%	100%
A0A422P3X6	Trypanosoma rangeli	38%	100%
A4HDA9	Leishmania braziliensis	82%	100%
A4I0P2	Leishmania infantum	95%	100%
D0A720	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	100%
E9AWP2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
V5DSK9	Trypanosoma cruzi	37%	100%