Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QAS8_LEIMA

TriTrypDb:

LmjF.24.0530 , LMJLV39_240010800 , LMJSD75_240010500

Length:

227

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4QAS8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QAS8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	114	118	PF00656	0.651
CLV_C14_Caspase3-7	150	154	PF00656	0.669
CLV_NRD_NRD_1	103	105	PF00675	0.600
CLV_NRD_NRD_1	111	113	PF00675	0.423
CLV_NRD_NRD_1	147	149	PF00675	0.611
CLV_NRD_NRD_1	171	173	PF00675	0.685
CLV_PCSK_KEX2_1	110	112	PF00082	0.502
CLV_PCSK_KEX2_1	147	149	PF00082	0.611
CLV_PCSK_KEX2_1	171	173	PF00082	0.685
CLV_PCSK_KEX2_1	213	215	PF00082	0.497
CLV_PCSK_PC1ET2_1	171	173	PF00082	0.692
CLV_PCSK_PC1ET2_1	213	215	PF00082	0.516
CLV_PCSK_SKI1_1	182	186	PF00082	0.650
CLV_PCSK_SKI1_1	192	196	PF00082	0.615
CLV_PCSK_SKI1_1	214	218	PF00082	0.517
CLV_PCSK_SKI1_1	55	59	PF00082	0.535
DEG_APCC_DBOX_1	213	221	PF00400	0.498
DEG_Nend_UBRbox_2	1	3	PF02207	0.723
DOC_CYCLIN_RxL_1	189	199	PF00134	0.611
DOC_MAPK_gen_1	213	220	PF00069	0.553
DOC_MAPK_MEF2A_6	213	220	PF00069	0.585
DOC_PP1_RVXF_1	53	59	PF00149	0.464
DOC_PP2B_LxvP_1	139	142	PF13499	0.604
DOC_USP7_MATH_1	178	182	PF00917	0.648
DOC_USP7_MATH_1	190	194	PF00917	0.557
DOC_WW_Pin1_4	3	8	PF00397	0.706
DOC_WW_Pin1_4	60	65	PF00397	0.593
LIG_14-3-3_CanoR_1	158	162	PF00244	0.632
LIG_FHA_1	114	120	PF00498	0.657
LIG_FHA_1	141	147	PF00498	0.567
LIG_FHA_2	121	127	PF00498	0.708
LIG_Integrin_RGD_1	112	114	PF01839	0.625
LIG_LIR_Apic_2	2	7	PF02991	0.648
LIG_MYND_1	28	32	PF01753	0.661
LIG_PDZ_Class_1	222	227	PF00595	0.667
LIG_SH2_CRK	17	21	PF00017	0.664
LIG_SH2_CRK	4	8	PF00017	0.646
LIG_SH2_CRK	50	54	PF00017	0.397
LIG_SH2_NCK_1	4	8	PF00017	0.646
LIG_SH2_STAP1	196	200	PF00017	0.580
LIG_SH2_STAT5	127	130	PF00017	0.693
LIG_SH3_3	7	13	PF00018	0.648
LIG_SUMO_SIM_par_1	215	223	PF11976	0.546
LIG_TRAF2_1	199	202	PF00917	0.562
LIG_TRAF2_1	42	45	PF00917	0.424
LIG_TYR_ITIM	15	20	PF00017	0.667
LIG_UBA3_1	206	213	PF00899	0.608
MOD_CDK_SPxxK_3	60	67	PF00069	0.600
MOD_CK1_1	154	160	PF00069	0.705
MOD_CK2_1	196	202	PF00069	0.669
MOD_GlcNHglycan	105	108	PF01048	0.491
MOD_GlcNHglycan	153	156	PF01048	0.653
MOD_GlcNHglycan	198	201	PF01048	0.627
MOD_GSK3_1	186	193	PF00069	0.651
MOD_NEK2_1	195	200	PF00069	0.600
MOD_PKA_2	103	109	PF00069	0.597
MOD_PKA_2	157	163	PF00069	0.702
MOD_Plk_1	120	126	PF00069	0.677
MOD_Plk_2-3	120	126	PF00069	0.638
MOD_Plk_4	157	163	PF00069	0.685
MOD_Plk_4	190	196	PF00069	0.668
MOD_ProDKin_1	3	9	PF00069	0.704
MOD_ProDKin_1	60	66	PF00069	0.594
TRG_DiLeu_BaEn_1	202	207	PF01217	0.624
TRG_ENDOCYTIC_2	17	20	PF00928	0.664
TRG_ENDOCYTIC_2	50	53	PF00928	0.404
TRG_ER_diArg_1	109	112	PF00400	0.509
TRG_ER_diArg_1	146	148	PF00400	0.608
TRG_Pf-PMV_PEXEL_1	71	75	PF00026	0.455

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDI0	Leptomonas seymouri	69%	98%
A0A1X0NIJ7	Trypanosomatidae	34%	88%
A0A3S7WY43	Leishmania donovani	96%	100%
A0A422P3Y6	Trypanosoma rangeli	36%	94%
A4HDB0	Leishmania braziliensis	85%	98%
A4I0P3	Leishmania infantum	96%	100%
D0A721	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	97%
E9AWP3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%