Hypothetical predicted transmembrane protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical predicted transmembrane protein

Species:

Leishmania major

UniProt:

Q4QAS5_LEIMA

TriTrypDb:

LmjF.24.0580 , LMJLV39_240011300 , LMJSD75_240010900

Length:

362

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

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Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	7
GO:0110165	cellular anatomical entity	1	7

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Expansion

Sequence features

Q4QAS5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QAS5

Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	219	223	PF00656	0.468
CLV_C14_Caspase3-7	66	70	PF00656	0.428
CLV_PCSK_SKI1_1	18	22	PF00082	0.329
CLV_PCSK_SKI1_1	42	46	PF00082	0.610
DEG_APCC_DBOX_1	84	92	PF00400	0.326
DEG_Nend_UBRbox_2	1	3	PF02207	0.690
DEG_SPOP_SBC_1	207	211	PF00917	0.408
DEG_SPOP_SBC_1	233	237	PF00917	0.398
DEG_SPOP_SBC_1	263	267	PF00917	0.385
DOC_CYCLIN_yCln2_LP_2	163	169	PF00134	0.452

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1P9U7	Leptomonas seymouri	41%	99%
A0A3S7WY91	Leishmania donovani	86%	100%
A4HDB6	Leishmania braziliensis	59%	100%
A4I0P6	Leishmania infantum	87%	100%
E9AWP8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	75%	100%

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