Hypothetical predicted transmembrane protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical predicted transmembrane protein

Species:

Leishmania major

UniProt:

Q4QAS5_LEIMA

TriTrypDb:

LmjF.24.0580 , LMJLV39_240011300 , LMJSD75_240010900

Length:

362

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	7
GO:0110165	cellular anatomical entity	1	7

Expansion

Sequence features

Q4QAS5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QAS5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	219	223	PF00656	0.468
CLV_C14_Caspase3-7	66	70	PF00656	0.428
CLV_PCSK_SKI1_1	18	22	PF00082	0.329
CLV_PCSK_SKI1_1	42	46	PF00082	0.610
DEG_APCC_DBOX_1	84	92	PF00400	0.326
DEG_Nend_UBRbox_2	1	3	PF02207	0.690
DEG_SPOP_SBC_1	207	211	PF00917	0.408
DEG_SPOP_SBC_1	233	237	PF00917	0.398
DEG_SPOP_SBC_1	263	267	PF00917	0.385
DOC_CYCLIN_yCln2_LP_2	163	169	PF00134	0.452
DOC_MAPK_FxFP_2	312	315	PF00069	0.453
DOC_MAPK_gen_1	15	25	PF00069	0.483
DOC_MAPK_gen_1	83	91	PF00069	0.330
DOC_MAPK_MEF2A_6	123	131	PF00069	0.322
DOC_MAPK_MEF2A_6	18	27	PF00069	0.478
DOC_PP1_RVXF_1	147	153	PF00149	0.346
DOC_PP2B_LxvP_1	163	166	PF13499	0.461
DOC_PP2B_LxvP_1	243	246	PF13499	0.461
DOC_PP2B_LxvP_1	313	316	PF13499	0.443
DOC_PP4_FxxP_1	258	261	PF00568	0.449
DOC_PP4_FxxP_1	312	315	PF00568	0.453
DOC_USP7_MATH_1	261	265	PF00917	0.406
DOC_USP7_MATH_1	332	336	PF00917	0.418
DOC_USP7_MATH_1	43	47	PF00917	0.421
DOC_USP7_MATH_1	7	11	PF00917	0.633
DOC_WW_Pin1_4	189	194	PF00397	0.416
DOC_WW_Pin1_4	229	234	PF00397	0.439
LIG_14-3-3_CanoR_1	110	116	PF00244	0.314
LIG_14-3-3_CanoR_1	42	52	PF00244	0.420
LIG_BRCT_BRCA1_1	255	259	PF00533	0.458
LIG_deltaCOP1_diTrp_1	171	179	PF00928	0.350
LIG_EH1_1	32	40	PF00400	0.279
LIG_FHA_1	107	113	PF00498	0.393
LIG_FHA_1	263	269	PF00498	0.371
LIG_FHA_2	207	213	PF00498	0.430
LIG_FHA_2	217	223	PF00498	0.417
LIG_FHA_2	43	49	PF00498	0.471
LIG_LIR_Apic_2	256	261	PF02991	0.454
LIG_LIR_Apic_2	285	291	PF02991	0.458
LIG_LIR_Apic_2	309	315	PF02991	0.449
LIG_LIR_Nem_3	318	323	PF02991	0.403
LIG_LYPXL_S_1	313	317	PF13949	0.645
LIG_LYPXL_yS_3	314	317	PF13949	0.440
LIG_MLH1_MIPbox_1	255	259	PF16413	0.458
LIG_NRBOX	180	186	PF00104	0.378
LIG_Pex14_2	269	273	PF04695	0.366
LIG_PTB_Apo_2	114	121	PF02174	0.326
LIG_PTB_Phospho_1	114	120	PF10480	0.333
LIG_Rb_LxCxE_1	318	340	PF01857	0.459
LIG_SH2_CRK	288	292	PF00017	0.395
LIG_SH2_GRB2like	158	161	PF00017	0.424
LIG_SH2_NCK_1	158	162	PF00017	0.425
LIG_SH2_NCK_1	288	292	PF00017	0.464
LIG_SH2_SRC	158	161	PF00017	0.463
LIG_SH2_STAP1	120	124	PF00017	0.427
LIG_SH2_STAP1	153	157	PF00017	0.365
LIG_SH2_STAT3	194	197	PF00017	0.359
LIG_SH3_3	169	175	PF00018	0.331
LIG_TRAF2_1	324	327	PF00917	0.479
MOD_CK1_1	138	144	PF00069	0.449
MOD_CK1_1	210	216	PF00069	0.557
MOD_CK1_1	232	238	PF00069	0.528
MOD_CK1_1	253	259	PF00069	0.495
MOD_CK1_1	264	270	PF00069	0.431
MOD_CK1_1	54	60	PF00069	0.555
MOD_CK2_1	174	180	PF00069	0.397
MOD_CK2_1	206	212	PF00069	0.521
MOD_CK2_1	42	48	PF00069	0.511
MOD_CMANNOS	195	198	PF00535	0.388
MOD_GlcNHglycan	137	140	PF01048	0.521
MOD_GlcNHglycan	187	190	PF01048	0.507
MOD_GlcNHglycan	200	203	PF01048	0.357
MOD_GlcNHglycan	222	225	PF01048	0.649
MOD_GlcNHglycan	238	241	PF01048	0.436
MOD_GlcNHglycan	252	255	PF01048	0.565
MOD_GlcNHglycan	347	350	PF01048	0.495
MOD_GlcNHglycan	45	48	PF01048	0.435
MOD_GlcNHglycan	53	56	PF01048	0.525
MOD_GSK3_1	185	192	PF00069	0.417
MOD_GSK3_1	206	213	PF00069	0.555
MOD_GSK3_1	216	223	PF00069	0.585
MOD_GSK3_1	229	236	PF00069	0.398
MOD_GSK3_1	263	270	PF00069	0.465
MOD_GSK3_1	332	339	PF00069	0.530
MOD_GSK3_1	50	57	PF00069	0.476
MOD_N-GLC_1	106	111	PF02516	0.479
MOD_N-GLC_1	118	123	PF02516	0.334
MOD_N-GLC_1	135	140	PF02516	0.516
MOD_N-GLC_1	159	164	PF02516	0.502
MOD_N-GLC_1	298	303	PF02516	0.510
MOD_N-GLC_1	345	350	PF02516	0.483
MOD_NEK2_1	106	111	PF00069	0.370
MOD_NEK2_1	183	188	PF00069	0.475
MOD_NEK2_1	234	239	PF00069	0.445
MOD_NEK2_1	269	274	PF00069	0.413
MOD_NEK2_1	297	302	PF00069	0.557
MOD_NEK2_1	51	56	PF00069	0.545
MOD_PIKK_1	118	124	PF00454	0.426
MOD_Plk_1	106	112	PF00069	0.469
MOD_Plk_1	135	141	PF00069	0.518
MOD_Plk_1	159	165	PF00069	0.428
MOD_Plk_1	211	217	PF00069	0.550
MOD_Plk_1	248	254	PF00069	0.495
MOD_Plk_1	345	351	PF00069	0.483
MOD_Plk_2-3	216	222	PF00069	0.561
MOD_Plk_4	138	144	PF00069	0.451
MOD_Plk_4	264	270	PF00069	0.508
MOD_ProDKin_1	189	195	PF00069	0.500
MOD_ProDKin_1	229	235	PF00069	0.538
TRG_DiLeu_BaEn_1	180	185	PF01217	0.451
TRG_DiLeu_BaEn_1	340	345	PF01217	0.564
TRG_DiLeu_BaEn_2	75	81	PF01217	0.442
TRG_DiLeu_BaLyEn_6	226	231	PF01217	0.544
TRG_ENDOCYTIC_2	314	317	PF00928	0.543
TRG_ER_diArg_1	227	230	PF00400	0.558
TRG_ER_diArg_1	82	85	PF00400	0.509
TRG_ER_diArg_1	92	95	PF00400	0.359
TRG_NES_CRM1_1	90	102	PF08389	0.357

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1P9U7	Leptomonas seymouri	41%	99%
A0A3S7WY91	Leishmania donovani	86%	100%
A4HDB6	Leishmania braziliensis	59%	100%
A4I0P6	Leishmania infantum	87%	100%
E9AWP8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	75%	100%