DNA helicase

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

DNA helicase

Gene product:

hypothetical protein, unknown function

Species:

Leishmania major

UniProt:

Q4QAS4_LEIMA

TriTrypDb:

LmjF.24.0590 , LMJLV39_240011400 , LMJSD75_240011000

Length:

688

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QAS4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QAS4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	332	338	PF00089	0.588
CLV_NRD_NRD_1	173	175	PF00675	0.771
CLV_NRD_NRD_1	381	383	PF00675	0.648
CLV_NRD_NRD_1	437	439	PF00675	0.553
CLV_NRD_NRD_1	442	444	PF00675	0.569
CLV_NRD_NRD_1	599	601	PF00675	0.586
CLV_NRD_NRD_1	680	682	PF00675	0.723
CLV_PCSK_KEX2_1	173	175	PF00082	0.765
CLV_PCSK_KEX2_1	201	203	PF00082	0.680
CLV_PCSK_KEX2_1	381	383	PF00082	0.750
CLV_PCSK_KEX2_1	437	439	PF00082	0.553
CLV_PCSK_KEX2_1	442	444	PF00082	0.569
CLV_PCSK_KEX2_1	599	601	PF00082	0.586
CLV_PCSK_KEX2_1	680	682	PF00082	0.687
CLV_PCSK_PC1ET2_1	201	203	PF00082	0.680
CLV_PCSK_PC7_1	377	383	PF00082	0.637
CLV_PCSK_PC7_1	438	444	PF00082	0.467
CLV_PCSK_SKI1_1	176	180	PF00082	0.675
CLV_PCSK_SKI1_1	225	229	PF00082	0.652
CLV_PCSK_SKI1_1	552	556	PF00082	0.488
CLV_Separin_Metazoa	386	390	PF03568	0.610
DEG_APCC_DBOX_1	334	342	PF00400	0.621
DEG_COP1_1	344	354	PF00400	0.512
DEG_SCF_FBW7_1	216	222	PF00400	0.643
DEG_SCF_FBW7_2	206	212	PF00400	0.658
DOC_CDC14_PxL_1	611	619	PF14671	0.523
DOC_CKS1_1	206	211	PF01111	0.620
DOC_CKS1_1	216	221	PF01111	0.575
DOC_CKS1_1	28	33	PF01111	0.679
DOC_CYCLIN_RxL_1	11	22	PF00134	0.606
DOC_MAPK_DCC_7	364	373	PF00069	0.550
DOC_MAPK_gen_1	229	238	PF00069	0.610
DOC_MAPK_gen_1	680	686	PF00069	0.688
DOC_MAPK_HePTP_8	361	373	PF00069	0.545
DOC_MAPK_MEF2A_6	304	313	PF00069	0.638
DOC_MAPK_MEF2A_6	335	342	PF00069	0.563
DOC_MAPK_MEF2A_6	364	373	PF00069	0.573
DOC_MAPK_MEF2A_6	429	436	PF00069	0.573
DOC_PP1_RVXF_1	260	266	PF00149	0.652
DOC_PP1_RVXF_1	623	629	PF00149	0.646
DOC_PP2B_LxvP_1	519	522	PF13499	0.598
DOC_PP2B_LxvP_1	565	568	PF13499	0.672
DOC_USP7_MATH_1	166	170	PF00917	0.649
DOC_USP7_MATH_1	284	288	PF00917	0.643
DOC_USP7_MATH_1	61	65	PF00917	0.476
DOC_USP7_MATH_1	651	655	PF00917	0.621
DOC_USP7_MATH_1	80	84	PF00917	0.748
DOC_USP7_MATH_1	97	101	PF00917	0.608
DOC_WW_Pin1_4	205	210	PF00397	0.770
DOC_WW_Pin1_4	215	220	PF00397	0.679
DOC_WW_Pin1_4	22	27	PF00397	0.666
DOC_WW_Pin1_4	396	401	PF00397	0.659
LIG_14-3-3_CanoR_1	176	185	PF00244	0.672
LIG_14-3-3_CanoR_1	202	207	PF00244	0.643
LIG_14-3-3_CanoR_1	232	238	PF00244	0.527
LIG_14-3-3_CanoR_1	262	268	PF00244	0.655
LIG_14-3-3_CanoR_1	343	352	PF00244	0.562
LIG_14-3-3_CanoR_1	525	533	PF00244	0.476
LIG_14-3-3_CanoR_1	650	656	PF00244	0.622
LIG_Actin_WH2_2	455	473	PF00022	0.560
LIG_Actin_WH2_2	631	646	PF00022	0.636
LIG_APCC_ABBA_1	416	421	PF00400	0.554
LIG_APCC_ABBAyCdc20_2	415	421	PF00400	0.561
LIG_BIR_III_4	472	476	PF00653	0.589
LIG_BIR_III_4	586	590	PF00653	0.514
LIG_BRCT_BRCA1_1	223	227	PF00533	0.676
LIG_FHA_1	107	113	PF00498	0.780
LIG_FHA_1	118	124	PF00498	0.567
LIG_FHA_1	23	29	PF00498	0.671
LIG_FHA_1	345	351	PF00498	0.607
LIG_FHA_1	53	59	PF00498	0.645
LIG_FHA_2	273	279	PF00498	0.623
LIG_Integrin_RGD_1	665	667	PF01839	0.688
LIG_LIR_Gen_1	148	157	PF02991	0.558
LIG_LIR_Gen_1	266	274	PF02991	0.569
LIG_LIR_Gen_1	303	313	PF02991	0.583
LIG_LIR_Gen_1	444	453	PF02991	0.669
LIG_LIR_Gen_1	458	468	PF02991	0.437
LIG_LIR_Gen_1	492	503	PF02991	0.623
LIG_LIR_Gen_1	629	638	PF02991	0.516
LIG_LIR_LC3C_4	151	155	PF02991	0.602
LIG_LIR_Nem_3	139	144	PF02991	0.624
LIG_LIR_Nem_3	148	153	PF02991	0.526
LIG_LIR_Nem_3	266	270	PF02991	0.580
LIG_LIR_Nem_3	303	308	PF02991	0.590
LIG_LIR_Nem_3	444	448	PF02991	0.566
LIG_LIR_Nem_3	458	463	PF02991	0.400
LIG_LIR_Nem_3	480	486	PF02991	0.630
LIG_LIR_Nem_3	492	498	PF02991	0.621
LIG_LIR_Nem_3	505	509	PF02991	0.488
LIG_LYPXL_S_1	430	434	PF13949	0.578
LIG_LYPXL_yS_3	431	434	PF13949	0.575
LIG_PCNA_yPIPBox_3	644	656	PF02747	0.546
LIG_PDZ_Class_2	683	688	PF00595	0.655
LIG_RPA_C_Fungi	377	389	PF08784	0.625
LIG_SH2_CRK	305	309	PF00017	0.580
LIG_SH2_CRK	506	510	PF00017	0.546
LIG_SH2_GRB2like	539	542	PF00017	0.602
LIG_SH2_NCK_1	506	510	PF00017	0.546
LIG_SH2_STAP1	254	258	PF00017	0.665
LIG_SH2_STAP1	412	416	PF00017	0.462
LIG_SH2_STAP1	486	490	PF00017	0.590
LIG_SH2_STAP1	618	622	PF00017	0.537
LIG_SH2_STAT5	217	220	PF00017	0.691
LIG_SH2_STAT5	264	267	PF00017	0.658
LIG_SH2_STAT5	301	304	PF00017	0.504
LIG_SH2_STAT5	312	315	PF00017	0.710
LIG_SH2_STAT5	483	486	PF00017	0.624
LIG_SH2_STAT5	494	497	PF00017	0.510
LIG_SH2_STAT5	50	53	PF00017	0.621
LIG_SH2_STAT5	506	509	PF00017	0.490
LIG_SH2_STAT5	630	633	PF00017	0.609
LIG_SH3_3	203	209	PF00018	0.612
LIG_SH3_3	213	219	PF00018	0.566
LIG_SH3_3	240	246	PF00018	0.651
LIG_SH3_3	333	339	PF00018	0.656
LIG_SH3_3	346	352	PF00018	0.608
LIG_SH3_3	463	469	PF00018	0.565
LIG_SH3_3	609	615	PF00018	0.583
LIG_SH3_3	628	634	PF00018	0.459
LIG_SH3_3	71	77	PF00018	0.653
LIG_SH3_5	502	506	PF00018	0.626
LIG_WRC_WIRS_1	617	622	PF05994	0.567
MOD_CDK_SPK_2	215	220	PF00069	0.643
MOD_CK1_1	205	211	PF00069	0.679
MOD_CK1_1	344	350	PF00069	0.536
MOD_CK1_1	356	362	PF00069	0.475
MOD_CK2_1	145	151	PF00069	0.575
MOD_CK2_1	272	278	PF00069	0.626
MOD_CK2_1	438	444	PF00069	0.653
MOD_CK2_1	80	86	PF00069	0.650
MOD_Cter_Amidation	597	600	PF01082	0.597
MOD_GlcNHglycan	147	150	PF01048	0.582
MOD_GlcNHglycan	528	531	PF01048	0.481
MOD_GlcNHglycan	559	562	PF01048	0.645
MOD_GSK3_1	201	208	PF00069	0.647
MOD_GSK3_1	215	222	PF00069	0.668
MOD_N-GLC_1	22	27	PF02516	0.572
MOD_N-GLC_2	231	233	PF02516	0.522
MOD_NEK2_1	341	346	PF00069	0.611
MOD_NEK2_1	373	378	PF00069	0.637
MOD_NEK2_1	448	453	PF00069	0.647
MOD_NEK2_1	626	631	PF00069	0.747
MOD_OFUCOSY	93	99	PF10250	0.629
MOD_PIKK_1	176	182	PF00454	0.643
MOD_PIKK_1	320	326	PF00454	0.621
MOD_PIKK_1	356	362	PF00454	0.579
MOD_PIKK_1	666	672	PF00454	0.669
MOD_PK_1	202	208	PF00069	0.604
MOD_PKA_1	201	207	PF00069	0.628
MOD_PKA_1	437	443	PF00069	0.540
MOD_PKA_2	201	207	PF00069	0.644
MOD_PKA_2	231	237	PF00069	0.569
MOD_PKA_2	437	443	PF00069	0.607
MOD_PKB_1	174	182	PF00069	0.669
MOD_Plk_1	117	123	PF00069	0.633
MOD_Plk_1	504	510	PF00069	0.551
MOD_Plk_1	80	86	PF00069	0.646
MOD_Plk_4	108	114	PF00069	0.613
MOD_Plk_4	210	216	PF00069	0.691
MOD_Plk_4	237	243	PF00069	0.646
MOD_Plk_4	24	30	PF00069	0.716
MOD_Plk_4	616	622	PF00069	0.560
MOD_Plk_4	651	657	PF00069	0.623
MOD_ProDKin_1	205	211	PF00069	0.769
MOD_ProDKin_1	215	221	PF00069	0.678
MOD_ProDKin_1	22	28	PF00069	0.666
MOD_ProDKin_1	396	402	PF00069	0.659
MOD_SUMO_for_1	546	549	PF00179	0.609
MOD_SUMO_rev_2	619	626	PF00179	0.551
TRG_DiLeu_BaLyEn_6	13	18	PF01217	0.606
TRG_DiLeu_BaLyEn_6	363	368	PF01217	0.598
TRG_ENDOCYTIC_2	194	197	PF00928	0.728
TRG_ENDOCYTIC_2	267	270	PF00928	0.578
TRG_ENDOCYTIC_2	305	308	PF00928	0.587
TRG_ENDOCYTIC_2	431	434	PF00928	0.575
TRG_ENDOCYTIC_2	494	497	PF00928	0.622
TRG_ENDOCYTIC_2	506	509	PF00928	0.495
TRG_ENDOCYTIC_2	630	633	PF00928	0.507
TRG_ER_diArg_1	173	176	PF00400	0.774
TRG_ER_diArg_1	363	366	PF00400	0.490
TRG_ER_diArg_1	380	382	PF00400	0.587
TRG_ER_diArg_1	388	391	PF00400	0.505
TRG_ER_diArg_1	436	438	PF00400	0.511
TRG_ER_diArg_1	599	601	PF00400	0.586
TRG_NES_CRM1_1	545	557	PF08389	0.478
TRG_Pf-PMV_PEXEL_1	366	370	PF00026	0.484
TRG_Pf-PMV_PEXEL_1	450	454	PF00026	0.562
TRG_Pf-PMV_PEXEL_1	501	505	PF00026	0.631
TRG_Pf-PMV_PEXEL_1	513	517	PF00026	0.498
TRG_Pf-PMV_PEXEL_1	63	68	PF00026	0.544

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IBT9	Leishmania donovani	92%	100%
A4HDB7	Leishmania braziliensis	71%	80%
A4I0P7	Leishmania infantum	92%	100%
E9AWP9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%