Ubiquitin carboxyl-terminal hydrolase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ubiquitin carboxyl-terminal hydrolase, putative

Species:

Leishmania major

UniProt:

Q4QAS1_LEIMA

TriTrypDb:

LmjF.24.0620 , LMJLV39_240011800 , LMJSD75_240011400

Length:

809

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 13
NetGPI	no	yes: 0, no: 13

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	3
GO:0005730	nucleolus	5	2
GO:0005829	cytosol	2	3
GO:0043226	organelle	2	3
GO:0043227	membrane-bounded organelle	3	3
GO:0043228	non-membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	3
GO:0043231	intracellular membrane-bounded organelle	4	3
GO:0043232	intracellular non-membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	3

Expansion

Sequence features

Q4QAS1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QAS1

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	14
GO:0006511	ubiquitin-dependent protein catabolic process	7	14
GO:0006807	nitrogen compound metabolic process	2	14
GO:0008152	metabolic process	1	14
GO:0009056	catabolic process	2	14
GO:0009057	macromolecule catabolic process	4	14
GO:0009987	cellular process	1	14
GO:0016579	protein deubiquitination	6	14
GO:0019538	protein metabolic process	3	14
GO:0019941	modification-dependent protein catabolic process	6	14
GO:0036211	protein modification process	4	14
GO:0043170	macromolecule metabolic process	3	14
GO:0043412	macromolecule modification	4	14
GO:0043632	modification-dependent macromolecule catabolic process	5	14
GO:0044237	cellular metabolic process	2	14
GO:0044238	primary metabolic process	2	14
GO:0044248	cellular catabolic process	3	14
GO:0044260	obsolete cellular macromolecule metabolic process	3	14
GO:0044265	obsolete cellular macromolecule catabolic process	4	14
GO:0051603	proteolysis involved in protein catabolic process	5	14
GO:0070646	protein modification by small protein removal	5	14
GO:0070647	protein modification by small protein conjugation or removal	5	14
GO:0071704	organic substance metabolic process	2	14
GO:1901564	organonitrogen compound metabolic process	3	14
GO:1901575	organic substance catabolic process	3	14

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	14
GO:0004175	endopeptidase activity	4	3
GO:0004197	cysteine-type endopeptidase activity	5	3
GO:0004843	cysteine-type deubiquitinase activity	5	14
GO:0008233	peptidase activity	3	14
GO:0008234	cysteine-type peptidase activity	4	14
GO:0016787	hydrolase activity	2	14
GO:0019783	ubiquitin-like protein peptidase activity	4	14
GO:0101005	deubiquitinase activity	5	14
GO:0140096	catalytic activity, acting on a protein	2	14

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	342	346	PF00656	0.386
CLV_C14_Caspase3-7	468	472	PF00656	0.386
CLV_C14_Caspase3-7	591	595	PF00656	0.599
CLV_C14_Caspase3-7	624	628	PF00656	0.761
CLV_C14_Caspase3-7	63	67	PF00656	0.712
CLV_C14_Caspase3-7	703	707	PF00656	0.582
CLV_NRD_NRD_1	174	176	PF00675	0.327
CLV_NRD_NRD_1	18	20	PF00675	0.537
CLV_NRD_NRD_1	26	28	PF00675	0.503
CLV_NRD_NRD_1	493	495	PF00675	0.508
CLV_NRD_NRD_1	557	559	PF00675	0.588
CLV_NRD_NRD_1	641	643	PF00675	0.581
CLV_NRD_NRD_1	718	720	PF00675	0.798
CLV_NRD_NRD_1	736	738	PF00675	0.562
CLV_NRD_NRD_1	747	749	PF00675	0.611
CLV_NRD_NRD_1	807	809	PF00675	0.610
CLV_NRD_NRD_1	91	93	PF00675	0.585
CLV_PCSK_FUR_1	803	807	PF00082	0.573
CLV_PCSK_KEX2_1	296	298	PF00082	0.351
CLV_PCSK_KEX2_1	377	379	PF00082	0.382
CLV_PCSK_KEX2_1	431	433	PF00082	0.435
CLV_PCSK_KEX2_1	556	558	PF00082	0.560
CLV_PCSK_KEX2_1	616	618	PF00082	0.700
CLV_PCSK_KEX2_1	641	643	PF00082	0.581
CLV_PCSK_KEX2_1	747	749	PF00082	0.693
CLV_PCSK_KEX2_1	805	807	PF00082	0.577
CLV_PCSK_KEX2_1	91	93	PF00082	0.585
CLV_PCSK_PC1ET2_1	296	298	PF00082	0.351
CLV_PCSK_PC1ET2_1	377	379	PF00082	0.382
CLV_PCSK_PC1ET2_1	431	433	PF00082	0.351
CLV_PCSK_PC1ET2_1	556	558	PF00082	0.554
CLV_PCSK_PC1ET2_1	616	618	PF00082	0.747
CLV_PCSK_PC7_1	803	809	PF00082	0.724
CLV_PCSK_SKI1_1	14	18	PF00082	0.610
CLV_PCSK_SKI1_1	229	233	PF00082	0.308
CLV_PCSK_SKI1_1	377	381	PF00082	0.487
CLV_PCSK_SKI1_1	683	687	PF00082	0.711
CLV_PCSK_SKI1_1	695	699	PF00082	0.616
CLV_PCSK_SKI1_1	737	741	PF00082	0.717
CLV_PCSK_SKI1_1	774	778	PF00082	0.743
CLV_PCSK_SKI1_1	797	801	PF00082	0.647
DEG_Nend_UBRbox_2	1	3	PF02207	0.615
DEG_SPOP_SBC_1	604	608	PF00917	0.567
DOC_CKS1_1	740	745	PF01111	0.613
DOC_CYCLIN_RxL_1	4	15	PF00134	0.678
DOC_CYCLIN_yCln2_LP_2	160	166	PF00134	0.386
DOC_MAPK_DCC_7	112	121	PF00069	0.484
DOC_MAPK_DCC_7	388	396	PF00069	0.305
DOC_MAPK_gen_1	276	286	PF00069	0.419
DOC_MAPK_gen_1	358	367	PF00069	0.345
DOC_MAPK_HePTP_8	355	367	PF00069	0.417
DOC_MAPK_MEF2A_6	279	288	PF00069	0.433
DOC_MAPK_MEF2A_6	358	367	PF00069	0.303
DOC_MAPK_RevD_3	363	378	PF00069	0.349
DOC_PP1_RVXF_1	17	24	PF00149	0.457
DOC_PP1_RVXF_1	5	12	PF00149	0.616
DOC_PP2B_LxvP_1	160	163	PF13499	0.386
DOC_PP4_MxPP_1	503	506	PF00568	0.610
DOC_USP7_MATH_1	519	523	PF00917	0.792
DOC_USP7_MATH_1	586	590	PF00917	0.554
DOC_USP7_MATH_1	602	606	PF00917	0.522
DOC_USP7_MATH_1	623	627	PF00917	0.706
DOC_USP7_MATH_1	685	689	PF00917	0.729
DOC_USP7_UBL2_3	287	291	PF12436	0.433
DOC_USP7_UBL2_3	698	702	PF12436	0.720
DOC_USP7_UBL2_3	775	779	PF12436	0.700
DOC_WW_Pin1_4	114	119	PF00397	0.457
DOC_WW_Pin1_4	139	144	PF00397	0.271
DOC_WW_Pin1_4	348	353	PF00397	0.292
DOC_WW_Pin1_4	377	382	PF00397	0.417
DOC_WW_Pin1_4	408	413	PF00397	0.469
DOC_WW_Pin1_4	423	428	PF00397	0.322
DOC_WW_Pin1_4	569	574	PF00397	0.719
DOC_WW_Pin1_4	578	583	PF00397	0.772
DOC_WW_Pin1_4	600	605	PF00397	0.663
DOC_WW_Pin1_4	711	716	PF00397	0.781
DOC_WW_Pin1_4	718	723	PF00397	0.611
DOC_WW_Pin1_4	739	744	PF00397	0.684
LIG_14-3-3_CanoR_1	106	110	PF00244	0.536
LIG_14-3-3_CanoR_1	212	219	PF00244	0.433
LIG_14-3-3_CanoR_1	244	254	PF00244	0.356
LIG_14-3-3_CanoR_1	400	405	PF00244	0.396
LIG_14-3-3_CanoR_1	476	482	PF00244	0.335
LIG_14-3-3_CanoR_1	611	616	PF00244	0.793
LIG_14-3-3_CanoR_1	747	755	PF00244	0.705
LIG_Actin_WH2_2	686	704	PF00022	0.590
LIG_AP2alpha_2	317	319	PF02296	0.292
LIG_AP2alpha_2	784	786	PF02296	0.649
LIG_APCC_ABBA_1	789	794	PF00400	0.643
LIG_BRCT_BRCA1_1	204	208	PF00533	0.327
LIG_BRCT_BRCA1_1	7	11	PF00533	0.656
LIG_BRCT_BRCA1_1	720	724	PF00533	0.607
LIG_EH_1	789	793	PF12763	0.723
LIG_FHA_1	140	146	PF00498	0.300
LIG_FHA_1	246	252	PF00498	0.292
LIG_FHA_1	44	50	PF00498	0.599
LIG_FHA_1	579	585	PF00498	0.555
LIG_FHA_2	531	537	PF00498	0.741
LIG_FHA_2	575	581	PF00498	0.792
LIG_FHA_2	622	628	PF00498	0.722
LIG_LIR_Apic_2	24	29	PF02991	0.546
LIG_LIR_Apic_2	348	352	PF02991	0.445
LIG_LIR_Gen_1	317	327	PF02991	0.334
LIG_LIR_Gen_1	336	344	PF02991	0.153
LIG_LIR_Gen_1	399	405	PF02991	0.351
LIG_LIR_Nem_3	15	21	PF02991	0.546
LIG_LIR_Nem_3	22	26	PF02991	0.537
LIG_LIR_Nem_3	313	319	PF02991	0.330
LIG_LIR_Nem_3	336	341	PF02991	0.433
LIG_LIR_Nem_3	399	404	PF02991	0.394
LIG_LIR_Nem_3	449	455	PF02991	0.352
LIG_LIR_Nem_3	688	693	PF02991	0.627
LIG_LIR_Nem_3	784	789	PF02991	0.755
LIG_PCNA_yPIPBox_3	267	275	PF02747	0.360
LIG_Pex14_2	149	153	PF04695	0.327
LIG_Pex14_2	164	168	PF04695	0.327
LIG_PTB_Apo_2	125	132	PF02174	0.336
LIG_SH2_CRK	26	30	PF00017	0.532
LIG_SH2_CRK	401	405	PF00017	0.351
LIG_SH2_CRK	690	694	PF00017	0.582
LIG_SH2_GRB2like	312	315	PF00017	0.342
LIG_SH2_STAP1	312	316	PF00017	0.342
LIG_SH2_STAP1	437	441	PF00017	0.292
LIG_SH2_STAT5	148	151	PF00017	0.323
LIG_SH2_STAT5	258	261	PF00017	0.301
LIG_SH2_STAT5	349	352	PF00017	0.344
LIG_SH2_STAT5	401	404	PF00017	0.409
LIG_SH2_STAT5	456	459	PF00017	0.421
LIG_SH2_STAT5	639	642	PF00017	0.608
LIG_SH3_3	29	35	PF00018	0.595
LIG_SH3_3	364	370	PF00018	0.433
LIG_SH3_3	37	43	PF00018	0.583
LIG_SH3_3	387	393	PF00018	0.393
LIG_SH3_3	409	415	PF00018	0.327
LIG_SH3_3	421	427	PF00018	0.211
LIG_SH3_3	598	604	PF00018	0.637
LIG_SH3_3	658	664	PF00018	0.650
LIG_SH3_3	743	749	PF00018	0.565
LIG_SH3_3	779	785	PF00018	0.557
LIG_SUMO_SIM_par_1	320	325	PF11976	0.308
LIG_SUMO_SIM_par_1	392	397	PF11976	0.390
LIG_TRAF2_1	266	269	PF00917	0.352
LIG_TRAF2_1	340	343	PF00917	0.305
LIG_TRAF2_1	534	537	PF00917	0.662
LIG_TRAF2_1	791	794	PF00917	0.686
LIG_TRAF2_2	665	670	PF00917	0.533
LIG_UBA3_1	197	206	PF00899	0.352
LIG_UBA3_1	231	240	PF00899	0.388
LIG_WRC_WIRS_1	150	155	PF05994	0.433
LIG_WW_3	504	508	PF00397	0.543
MOD_CDK_SPK_2	348	353	PF00069	0.292
MOD_CDK_SPxxK_3	718	725	PF00069	0.632
MOD_CK1_1	155	161	PF00069	0.364
MOD_CK1_1	348	354	PF00069	0.433
MOD_CK1_1	406	412	PF00069	0.431
MOD_CK1_1	426	432	PF00069	0.442
MOD_CK1_1	472	478	PF00069	0.392
MOD_CK1_1	520	526	PF00069	0.687
MOD_CK1_1	589	595	PF00069	0.692
MOD_CK1_1	603	609	PF00069	0.604
MOD_CK1_1	710	716	PF00069	0.680
MOD_CK2_1	263	269	PF00069	0.329
MOD_CK2_1	530	536	PF00069	0.648
MOD_CK2_1	543	549	PF00069	0.488
MOD_CK2_1	574	580	PF00069	0.709
MOD_CK2_1	652	658	PF00069	0.694
MOD_Cter_Amidation	294	297	PF01082	0.305
MOD_Cter_Amidation	803	806	PF01082	0.569
MOD_GlcNHglycan	154	157	PF01048	0.410
MOD_GlcNHglycan	36	39	PF01048	0.655
MOD_GlcNHglycan	515	518	PF01048	0.735
MOD_GlcNHglycan	588	591	PF01048	0.669
MOD_GlcNHglycan	750	753	PF01048	0.786
MOD_GSK3_1	202	209	PF00069	0.332
MOD_GSK3_1	223	230	PF00069	0.412
MOD_GSK3_1	396	403	PF00069	0.348
MOD_GSK3_1	404	411	PF00069	0.344
MOD_GSK3_1	422	429	PF00069	0.390
MOD_GSK3_1	490	497	PF00069	0.503
MOD_GSK3_1	513	520	PF00069	0.736
MOD_GSK3_1	574	581	PF00069	0.768
MOD_GSK3_1	600	607	PF00069	0.679
MOD_GSK3_1	621	628	PF00069	0.698
MOD_GSK3_1	707	714	PF00069	0.741
MOD_GSK3_1	94	101	PF00069	0.513
MOD_N-GLC_1	469	474	PF02516	0.375
MOD_N-GLC_1	5	10	PF02516	0.657
MOD_N-GLC_1	586	591	PF02516	0.611
MOD_N-GLC_2	128	130	PF02516	0.342
MOD_N-GLC_2	648	650	PF02516	0.643
MOD_NEK2_1	105	110	PF00069	0.537
MOD_NEK2_1	126	131	PF00069	0.295
MOD_NEK2_1	149	154	PF00069	0.325
MOD_NEK2_1	170	175	PF00069	0.320
MOD_NEK2_1	223	228	PF00069	0.412
MOD_NEK2_1	235	240	PF00069	0.308
MOD_NEK2_1	396	401	PF00069	0.390
MOD_NEK2_1	404	409	PF00069	0.347
MOD_NEK2_1	469	474	PF00069	0.433
MOD_NEK2_1	490	495	PF00069	0.358
MOD_NEK2_2	685	690	PF00069	0.631
MOD_PIKK_1	155	161	PF00454	0.462
MOD_PIKK_1	258	264	PF00454	0.386
MOD_PIKK_1	52	58	PF00454	0.754
MOD_PIKK_1	663	669	PF00454	0.567
MOD_PK_1	206	212	PF00069	0.417
MOD_PK_1	361	367	PF00069	0.351
MOD_PKA_1	361	367	PF00069	0.351
MOD_PKA_1	494	500	PF00069	0.607
MOD_PKA_2	105	111	PF00069	0.428
MOD_PKA_2	211	217	PF00069	0.433
MOD_PKA_2	299	305	PF00069	0.378
MOD_PKA_2	475	481	PF00069	0.362
MOD_PKA_2	513	519	PF00069	0.673
MOD_Plk_1	396	402	PF00069	0.428
MOD_Plk_1	469	475	PF00069	0.402
MOD_Plk_1	5	11	PF00069	0.619
MOD_Plk_2-3	446	452	PF00069	0.478
MOD_Plk_4	131	137	PF00069	0.342
MOD_Plk_4	227	233	PF00069	0.386
MOD_Plk_4	307	313	PF00069	0.342
MOD_Plk_4	400	406	PF00069	0.305
MOD_Plk_4	685	691	PF00069	0.629
MOD_ProDKin_1	114	120	PF00069	0.449
MOD_ProDKin_1	139	145	PF00069	0.271
MOD_ProDKin_1	348	354	PF00069	0.292
MOD_ProDKin_1	377	383	PF00069	0.417
MOD_ProDKin_1	408	414	PF00069	0.469
MOD_ProDKin_1	423	429	PF00069	0.322
MOD_ProDKin_1	569	575	PF00069	0.717
MOD_ProDKin_1	578	584	PF00069	0.773
MOD_ProDKin_1	600	606	PF00069	0.663
MOD_ProDKin_1	711	717	PF00069	0.783
MOD_ProDKin_1	718	724	PF00069	0.610
MOD_ProDKin_1	739	745	PF00069	0.689
MOD_SUMO_for_1	286	289	PF00179	0.433
MOD_SUMO_rev_2	282	288	PF00179	0.364
MOD_SUMO_rev_2	289	298	PF00179	0.360
TRG_DiLeu_BaEn_1	270	275	PF01217	0.352
TRG_DiLeu_BaEn_1	549	554	PF01217	0.585
TRG_DiLeu_BaEn_1	580	585	PF01217	0.642
TRG_DiLeu_BaLyEn_6	199	204	PF01217	0.433
TRG_ENDOCYTIC_2	316	319	PF00928	0.292
TRG_ENDOCYTIC_2	401	404	PF00928	0.378
TRG_ENDOCYTIC_2	455	458	PF00928	0.292
TRG_ENDOCYTIC_2	488	491	PF00928	0.322
TRG_ENDOCYTIC_2	690	693	PF00928	0.583
TRG_ER_diArg_1	640	642	PF00400	0.580
TRG_ER_diArg_1	746	748	PF00400	0.661
TRG_ER_diArg_1	802	805	PF00400	0.578
TRG_ER_diArg_1	806	808	PF00400	0.585
TRG_ER_diArg_1	90	92	PF00400	0.579
TRG_NES_CRM1_1	159	172	PF08389	0.351
TRG_NES_CRM1_1	757	769	PF08389	0.735
TRG_NLS_MonoExtN_4	358	364	PF00514	0.433
TRG_NLS_MonoExtN_4	772	778	PF00514	0.603
TRG_Pf-PMV_PEXEL_1	47	51	PF00026	0.659
TRG_Pf-PMV_PEXEL_1	543	547	PF00026	0.495

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2Z2	Leptomonas seymouri	62%	100%
A0A0S4JHR5	Bodo saltans	36%	99%
A0A1X0NIL8	Trypanosomatidae	38%	100%
A0A3S7WY54	Leishmania donovani	92%	100%
A0A422P3Z4	Trypanosoma rangeli	39%	100%
A4HDC0	Leishmania braziliensis	75%	100%
A4HZ39	Leishmania infantum	22%	100%
A4I0Q0	Leishmania infantum	92%	100%
D0A726	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	100%
E9AWQ2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
Q4QCH5	Leishmania major	22%	100%
V5BR83	Trypanosoma cruzi	43%	100%