Non-specific serine/threonine protein kinase

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QAR7_LEIMA

TriTrypDb:

LmjF.24.0660 , LMJLV39_240012200 , LMJSD75_240011800

Length:

763

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QAR7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QAR7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	154	158	PF00656	0.477
CLV_C14_Caspase3-7	189	193	PF00656	0.689
CLV_C14_Caspase3-7	649	653	PF00656	0.626
CLV_C14_Caspase3-7	723	727	PF00656	0.595
CLV_NRD_NRD_1	137	139	PF00675	0.456
CLV_NRD_NRD_1	379	381	PF00675	0.448
CLV_NRD_NRD_1	395	397	PF00675	0.340
CLV_NRD_NRD_1	712	714	PF00675	0.518
CLV_NRD_NRD_1	93	95	PF00675	0.344
CLV_PCSK_KEX2_1	142	144	PF00082	0.420
CLV_PCSK_KEX2_1	395	397	PF00082	0.357
CLV_PCSK_KEX2_1	405	407	PF00082	0.363
CLV_PCSK_KEX2_1	711	713	PF00082	0.485
CLV_PCSK_KEX2_1	93	95	PF00082	0.344
CLV_PCSK_PC1ET2_1	142	144	PF00082	0.398
CLV_PCSK_PC1ET2_1	405	407	PF00082	0.498
CLV_PCSK_PC1ET2_1	711	713	PF00082	0.575
CLV_PCSK_PC7_1	138	144	PF00082	0.404
CLV_PCSK_SKI1_1	132	136	PF00082	0.470
CLV_PCSK_SKI1_1	139	143	PF00082	0.528
CLV_PCSK_SKI1_1	15	19	PF00082	0.608
CLV_PCSK_SKI1_1	156	160	PF00082	0.374
CLV_PCSK_SKI1_1	180	184	PF00082	0.573
CLV_PCSK_SKI1_1	318	322	PF00082	0.565
CLV_PCSK_SKI1_1	354	358	PF00082	0.453
CLV_PCSK_SKI1_1	381	385	PF00082	0.387
CLV_PCSK_SKI1_1	388	392	PF00082	0.396
CLV_PCSK_SKI1_1	406	410	PF00082	0.407
DEG_Nend_Nbox_1	1	3	PF02207	0.616
DEG_SCF_FBW7_1	577	582	PF00400	0.395
DEG_SCF_FBW7_1	612	619	PF00400	0.500
DEG_SCF_FBW7_1	741	746	PF00400	0.564
DEG_SCF_SKP2-CKS1_1	574	581	PF00560	0.484
DOC_CKS1_1	613	618	PF01111	0.503
DOC_CKS1_1	740	745	PF01111	0.519
DOC_CYCLIN_RxL_1	138	150	PF00134	0.392
DOC_CYCLIN_RxL_1	313	325	PF00134	0.492
DOC_CYCLIN_RxL_1	617	627	PF00134	0.424
DOC_MAPK_gen_1	127	136	PF00069	0.622
DOC_MAPK_gen_1	380	386	PF00069	0.546
DOC_MAPK_gen_1	477	485	PF00069	0.437
DOC_MAPK_gen_1	673	681	PF00069	0.534
DOC_MAPK_JIP1_4	130	136	PF00069	0.497
DOC_MAPK_MEF2A_6	156	165	PF00069	0.271
DOC_MAPK_MEF2A_6	477	485	PF00069	0.437
DOC_MAPK_MEF2A_6	675	684	PF00069	0.521
DOC_MAPK_NFAT4_5	156	164	PF00069	0.274
DOC_PP1_RVXF_1	457	463	PF00149	0.328
DOC_PP2B_LxvP_1	202	205	PF13499	0.421
DOC_USP7_MATH_1	178	182	PF00917	0.556
DOC_USP7_MATH_1	205	209	PF00917	0.438
DOC_USP7_MATH_1	519	523	PF00917	0.431
DOC_USP7_MATH_1	616	620	PF00917	0.559
DOC_USP7_MATH_1	650	654	PF00917	0.540
DOC_USP7_MATH_1	692	696	PF00917	0.562
DOC_USP7_MATH_1	743	747	PF00917	0.642
DOC_USP7_MATH_1	85	89	PF00917	0.526
DOC_USP7_UBL2_3	135	139	PF12436	0.530
DOC_WW_Pin1_4	412	417	PF00397	0.383
DOC_WW_Pin1_4	575	580	PF00397	0.584
DOC_WW_Pin1_4	612	617	PF00397	0.548
DOC_WW_Pin1_4	739	744	PF00397	0.590
DOC_WW_Pin1_4	76	81	PF00397	0.520
LIG_14-3-3_CanoR_1	121	126	PF00244	0.525
LIG_14-3-3_CanoR_1	147	153	PF00244	0.374
LIG_14-3-3_CanoR_1	374	383	PF00244	0.477
LIG_14-3-3_CanoR_1	516	525	PF00244	0.483
LIG_14-3-3_CanoR_1	570	579	PF00244	0.528
LIG_14-3-3_CanoR_1	662	670	PF00244	0.684
LIG_Actin_WH2_2	376	393	PF00022	0.368
LIG_Actin_WH2_2	43	58	PF00022	0.451
LIG_APCC_ABBA_1	703	708	PF00400	0.381
LIG_BIR_III_2	192	196	PF00653	0.421
LIG_BRCT_BRCA1_1	551	555	PF00533	0.417
LIG_CaM_IQ_9	113	129	PF13499	0.555
LIG_Clathr_ClatBox_1	237	241	PF01394	0.490
LIG_deltaCOP1_diTrp_1	683	687	PF00928	0.605
LIG_eIF4E_1	258	264	PF01652	0.408
LIG_eIF4E_1	509	515	PF01652	0.451
LIG_FHA_1	158	164	PF00498	0.333
LIG_FHA_1	16	22	PF00498	0.489
LIG_FHA_1	209	215	PF00498	0.363
LIG_FHA_1	251	257	PF00498	0.474
LIG_FHA_1	276	282	PF00498	0.477
LIG_FHA_1	295	301	PF00498	0.464
LIG_FHA_1	417	423	PF00498	0.465
LIG_FHA_1	42	48	PF00498	0.567
LIG_FHA_1	440	446	PF00498	0.440
LIG_FHA_1	470	476	PF00498	0.413
LIG_FHA_1	656	662	PF00498	0.713
LIG_FHA_1	702	708	PF00498	0.450
LIG_FHA_1	740	746	PF00498	0.655
LIG_FHA_1	757	763	PF00498	0.566
LIG_FHA_1	77	83	PF00498	0.684
LIG_FHA_2	149	155	PF00498	0.508
LIG_FHA_2	187	193	PF00498	0.629
LIG_FHA_2	294	300	PF00498	0.412
LIG_FHA_2	580	586	PF00498	0.419
LIG_FHA_2	625	631	PF00498	0.582
LIG_FHA_2	647	653	PF00498	0.481
LIG_FHA_2	696	702	PF00498	0.490
LIG_IRF3_LxIS_1	29	36	PF10401	0.564
LIG_IRF3_LxIS_1	408	415	PF10401	0.473
LIG_LIR_Apic_2	526	532	PF02991	0.392
LIG_LIR_Apic_2	737	743	PF02991	0.562
LIG_LIR_Gen_1	105	113	PF02991	0.469
LIG_LIR_Gen_1	293	303	PF02991	0.412
LIG_LIR_Gen_1	332	342	PF02991	0.475
LIG_LIR_Gen_1	482	493	PF02991	0.358
LIG_LIR_Gen_1	69	80	PF02991	0.572
LIG_LIR_Gen_1	700	710	PF02991	0.474
LIG_LIR_Nem_3	105	110	PF02991	0.435
LIG_LIR_Nem_3	123	128	PF02991	0.512
LIG_LIR_Nem_3	144	149	PF02991	0.350
LIG_LIR_Nem_3	293	298	PF02991	0.479
LIG_LIR_Nem_3	482	488	PF02991	0.362
LIG_LIR_Nem_3	503	509	PF02991	0.396
LIG_LIR_Nem_3	69	75	PF02991	0.557
LIG_LIR_Nem_3	700	706	PF02991	0.452
LIG_LIR_Nem_3	748	753	PF02991	0.539
LIG_LIR_Nem_3	96	101	PF02991	0.520
LIG_MYND_1	283	287	PF01753	0.435
LIG_NRBOX	259	265	PF00104	0.414
LIG_PCNA_yPIPBox_3	634	648	PF02747	0.518
LIG_Rb_LxCxE_1	726	748	PF01857	0.555
LIG_SH2_CRK	128	132	PF00017	0.532
LIG_SH2_CRK	509	513	PF00017	0.456
LIG_SH2_CRK	529	533	PF00017	0.369
LIG_SH2_CRK	72	76	PF00017	0.565
LIG_SH2_NCK_1	454	458	PF00017	0.348
LIG_SH2_SRC	454	457	PF00017	0.354
LIG_SH2_STAP1	102	106	PF00017	0.470
LIG_SH2_STAP1	454	458	PF00017	0.348
LIG_SH2_STAP1	502	506	PF00017	0.397
LIG_SH2_STAT3	596	599	PF00017	0.532
LIG_SH2_STAT5	295	298	PF00017	0.512
LIG_SH2_STAT5	310	313	PF00017	0.324
LIG_SH2_STAT5	423	426	PF00017	0.522
LIG_SH2_STAT5	529	532	PF00017	0.377
LIG_SH2_STAT5	596	599	PF00017	0.613
LIG_SH2_STAT5	62	65	PF00017	0.672
LIG_SH2_STAT5	740	743	PF00017	0.518
LIG_SH3_2	283	288	PF14604	0.476
LIG_SH3_3	280	286	PF00018	0.595
LIG_SH3_3	361	367	PF00018	0.427
LIG_SUMO_SIM_anti_2	235	241	PF11976	0.502
LIG_SUMO_SIM_anti_2	296	302	PF11976	0.466
LIG_SUMO_SIM_anti_2	511	517	PF11976	0.314
LIG_SUMO_SIM_par_1	163	169	PF11976	0.397
LIG_SUMO_SIM_par_1	235	241	PF11976	0.374
LIG_SUMO_SIM_par_1	299	304	PF11976	0.418
LIG_SUMO_SIM_par_1	486	491	PF11976	0.469
LIG_SUMO_SIM_par_1	5	10	PF11976	0.491
LIG_TRAF2_1	151	154	PF00917	0.429
LIG_TRAF2_1	171	174	PF00917	0.209
LIG_UBA3_1	337	346	PF00899	0.447
LIG_UBA3_1	357	366	PF00899	0.475
LIG_UBA3_1	383	391	PF00899	0.362
LIG_UBA3_1	408	413	PF00899	0.372
LIG_WRC_WIRS_1	122	127	PF05994	0.498
LIG_WRC_WIRS_1	424	429	PF05994	0.385
MOD_CDK_SPxK_1	575	581	PF00069	0.590
MOD_CDK_SPxK_1	612	618	PF00069	0.576
MOD_CDK_SPxxK_3	76	83	PF00069	0.472
MOD_CK1_1	208	214	PF00069	0.560
MOD_CK1_1	249	255	PF00069	0.399
MOD_CK1_1	293	299	PF00069	0.419
MOD_CK1_1	332	338	PF00069	0.589
MOD_CK1_1	40	46	PF00069	0.643
MOD_CK1_1	415	421	PF00069	0.462
MOD_CK1_1	426	432	PF00069	0.415
MOD_CK1_1	592	598	PF00069	0.527
MOD_CK1_1	664	670	PF00069	0.637
MOD_CK1_1	695	701	PF00069	0.548
MOD_CK1_1	716	722	PF00069	0.697
MOD_CK1_1	73	79	PF00069	0.685
MOD_CK1_1	756	762	PF00069	0.695
MOD_CK2_1	147	153	PF00069	0.491
MOD_CK2_1	301	307	PF00069	0.478
MOD_CK2_1	570	576	PF00069	0.547
MOD_CK2_1	624	630	PF00069	0.557
MOD_CK2_1	650	656	PF00069	0.601
MOD_CK2_1	695	701	PF00069	0.588
MOD_Cter_Amidation	13	16	PF01082	0.570
MOD_GlcNHglycan	168	171	PF01048	0.493
MOD_GlcNHglycan	180	183	PF01048	0.627
MOD_GlcNHglycan	207	210	PF01048	0.312
MOD_GlcNHglycan	248	251	PF01048	0.630
MOD_GlcNHglycan	303	306	PF01048	0.357
MOD_GlcNHglycan	376	379	PF01048	0.522
MOD_GlcNHglycan	39	42	PF01048	0.629
MOD_GlcNHglycan	519	522	PF01048	0.418
MOD_GlcNHglycan	544	547	PF01048	0.387
MOD_GlcNHglycan	723	726	PF01048	0.585
MOD_GSK3_1	184	191	PF00069	0.534
MOD_GSK3_1	205	212	PF00069	0.532
MOD_GSK3_1	242	249	PF00069	0.469
MOD_GSK3_1	290	297	PF00069	0.451
MOD_GSK3_1	33	40	PF00069	0.651
MOD_GSK3_1	332	339	PF00069	0.579
MOD_GSK3_1	370	377	PF00069	0.572
MOD_GSK3_1	412	419	PF00069	0.469
MOD_GSK3_1	429	436	PF00069	0.490
MOD_GSK3_1	463	470	PF00069	0.466
MOD_GSK3_1	519	526	PF00069	0.416
MOD_GSK3_1	549	556	PF00069	0.418
MOD_GSK3_1	575	582	PF00069	0.529
MOD_GSK3_1	612	619	PF00069	0.568
MOD_GSK3_1	626	633	PF00069	0.620
MOD_GSK3_1	646	653	PF00069	0.495
MOD_GSK3_1	66	73	PF00069	0.548
MOD_GSK3_1	692	699	PF00069	0.471
MOD_GSK3_1	739	746	PF00069	0.651
MOD_GSK3_1	752	759	PF00069	0.545
MOD_N-GLC_1	67	72	PF02516	0.464
MOD_N-GLC_1	695	700	PF02516	0.452
MOD_NEK2_1	120	125	PF00069	0.422
MOD_NEK2_1	145	150	PF00069	0.384
MOD_NEK2_1	301	306	PF00069	0.481
MOD_NEK2_1	33	38	PF00069	0.745
MOD_NEK2_1	342	347	PF00069	0.536
MOD_NEK2_1	514	519	PF00069	0.300
MOD_NEK2_1	55	60	PF00069	0.602
MOD_NEK2_1	624	629	PF00069	0.551
MOD_NEK2_1	646	651	PF00069	0.563
MOD_NEK2_1	66	71	PF00069	0.524
MOD_NEK2_1	661	666	PF00069	0.512
MOD_NEK2_2	423	428	PF00069	0.411
MOD_OFUCOSY	331	336	PF10250	0.470
MOD_PIKK_1	661	667	PF00454	0.692
MOD_PK_1	242	248	PF00069	0.413
MOD_PKA_1	15	21	PF00069	0.441
MOD_PKA_1	500	506	PF00069	0.501
MOD_PKA_1	713	719	PF00069	0.638
MOD_PKA_2	120	126	PF00069	0.486
MOD_PKA_2	379	385	PF00069	0.472
MOD_PKA_2	55	61	PF00069	0.587
MOD_PKA_2	650	656	PF00069	0.623
MOD_PKA_2	661	667	PF00069	0.664
MOD_Plk_1	31	37	PF00069	0.573
MOD_Plk_1	467	473	PF00069	0.539
MOD_Plk_1	589	595	PF00069	0.522
MOD_Plk_1	655	661	PF00069	0.580
MOD_Plk_1	67	73	PF00069	0.458
MOD_Plk_1	699	705	PF00069	0.535
MOD_Plk_4	121	127	PF00069	0.518
MOD_Plk_4	379	385	PF00069	0.531
MOD_Plk_4	43	49	PF00069	0.638
MOD_Plk_4	523	529	PF00069	0.493
MOD_Plk_4	592	598	PF00069	0.550
MOD_Plk_4	650	656	PF00069	0.556
MOD_Plk_4	67	73	PF00069	0.631
MOD_Plk_4	87	93	PF00069	0.580
MOD_ProDKin_1	412	418	PF00069	0.384
MOD_ProDKin_1	575	581	PF00069	0.590
MOD_ProDKin_1	612	618	PF00069	0.551
MOD_ProDKin_1	739	745	PF00069	0.590
MOD_ProDKin_1	76	82	PF00069	0.517
MOD_SUMO_for_1	141	144	PF00179	0.388
MOD_SUMO_rev_2	150	158	PF00179	0.496
MOD_SUMO_rev_2	265	273	PF00179	0.463
TRG_DiLeu_BaEn_1	352	357	PF01217	0.425
TRG_DiLeu_BaEn_1	87	92	PF01217	0.521
TRG_DiLeu_BaEn_2	655	661	PF01217	0.508
TRG_DiLeu_BaEn_2	95	101	PF01217	0.436
TRG_DiLeu_BaLyEn_6	259	264	PF01217	0.411
TRG_DiLeu_BaLyEn_6	337	342	PF01217	0.505
TRG_DiLeu_BaLyEn_6	677	682	PF01217	0.513
TRG_ENDOCYTIC_2	200	203	PF00928	0.415
TRG_ENDOCYTIC_2	261	264	PF00928	0.494
TRG_ENDOCYTIC_2	295	298	PF00928	0.465
TRG_ENDOCYTIC_2	509	512	PF00928	0.457
TRG_ENDOCYTIC_2	72	75	PF00928	0.559
TRG_ENDOCYTIC_2	750	753	PF00928	0.617
TRG_ER_diArg_1	394	396	PF00400	0.367
TRG_ER_diArg_1	92	94	PF00400	0.356
TRG_NES_CRM1_1	229	241	PF08389	0.446
TRG_NLS_MonoCore_2	710	715	PF00514	0.615
TRG_NLS_MonoExtC_3	137	142	PF00514	0.399
TRG_NLS_MonoExtC_3	710	715	PF00514	0.512
TRG_NLS_MonoExtN_4	135	142	PF00514	0.435

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5G6	Leptomonas seymouri	46%	100%
A0A1X0NK62	Trypanosomatidae	27%	92%
A0A3S5IQT2	Trypanosoma rangeli	28%	100%
A0A3S7WY64	Leishmania donovani	90%	100%
A4HDC4	Leishmania braziliensis	71%	100%
A4I0Q4	Leishmania infantum	90%	100%
D0A732	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	99%
E9AWQ6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
V5C0M8	Trypanosoma cruzi	27%	100%