Hypothetical predicted transmembrane protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical predicted transmembrane protein

Species:

Leishmania major

UniProt:

Q4QAR4_LEIMA

TriTrypDb:

LmjF.24.0690 , LMJLV39_240012500 , LMJSD75_240012100

Length:

174

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	7
GO:0110165	cellular anatomical entity	1	7

Expansion

Sequence features

Q4QAR4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QAR4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	3	5	PF00675	0.630
CLV_PCSK_KEX2_1	108	110	PF00082	0.560
CLV_PCSK_KEX2_1	116	118	PF00082	0.496
CLV_PCSK_KEX2_1	3	5	PF00082	0.630
CLV_PCSK_PC1ET2_1	108	110	PF00082	0.560
CLV_PCSK_PC1ET2_1	116	118	PF00082	0.496
CLV_PCSK_SKI1_1	103	107	PF00082	0.487
CLV_PCSK_SKI1_1	22	26	PF00082	0.777
CLV_PCSK_SKI1_1	29	33	PF00082	0.671
CLV_PCSK_SKI1_1	66	70	PF00082	0.761
CLV_Separin_Metazoa	19	23	PF03568	0.527
DEG_APCC_DBOX_1	131	139	PF00400	0.723
DEG_Nend_Nbox_1	1	3	PF02207	0.494
DEG_SPOP_SBC_1	12	16	PF00917	0.519
DOC_CYCLIN_RxL_1	60	72	PF00134	0.552
DOC_PP1_RVXF_1	101	108	PF00149	0.635
DOC_PP4_FxxP_1	10	13	PF00568	0.548
DOC_SPAK_OSR1_1	9	13	PF12202	0.521
DOC_USP7_MATH_1	13	17	PF00917	0.532
DOC_USP7_MATH_1	162	166	PF00917	0.707
DOC_USP7_MATH_1	58	62	PF00917	0.453
DOC_WW_Pin1_4	133	138	PF00397	0.802
DOC_WW_Pin1_4	14	19	PF00397	0.564
DOC_WW_Pin1_4	151	156	PF00397	0.600
DOC_WW_Pin1_4	69	74	PF00397	0.288
LIG_14-3-3_CanoR_1	22	31	PF00244	0.547
LIG_BRCT_BRCA1_1	60	64	PF00533	0.471
LIG_FHA_1	6	12	PF00498	0.515
LIG_FHA_2	23	29	PF00498	0.523
LIG_FHA_2	32	38	PF00498	0.446
LIG_LIR_Apic_2	8	13	PF02991	0.490
LIG_LIR_Gen_1	139	147	PF02991	0.793
LIG_LIR_Gen_1	37	45	PF02991	0.547
LIG_LIR_Nem_3	139	144	PF02991	0.791
LIG_LIR_Nem_3	37	42	PF02991	0.549
LIG_LIR_Nem_3	61	67	PF02991	0.528
LIG_MLH1_MIPbox_1	60	64	PF16413	0.471
LIG_Pex14_2	86	90	PF04695	0.329
LIG_REV1ctd_RIR_1	61	70	PF16727	0.531
LIG_SH2_CRK	39	43	PF00017	0.479
LIG_SH2_STAP1	39	43	PF00017	0.512
LIG_SH2_STAT5	67	70	PF00017	0.484
LIG_SH3_3	15	21	PF00018	0.492
LIG_SH3_3	91	97	PF00018	0.516
LIG_SxIP_EBH_1	48	57	PF03271	0.407
LIG_TRAF2_1	126	129	PF00917	0.791
LIG_TRAF2_1	137	140	PF00917	0.684
LIG_WRC_WIRS_1	87	92	PF05994	0.389
MOD_CK1_1	118	124	PF00069	0.755
MOD_CK1_1	14	20	PF00069	0.454
MOD_CK1_1	167	173	PF00069	0.696
MOD_CK1_1	5	11	PF00069	0.514
MOD_CK2_1	13	19	PF00069	0.520
MOD_CK2_1	133	139	PF00069	0.800
MOD_CK2_1	22	28	PF00069	0.444
MOD_GlcNHglycan	34	37	PF01048	0.760
MOD_GlcNHglycan	69	72	PF01048	0.601
MOD_GSK3_1	115	122	PF00069	0.744
MOD_GSK3_1	151	158	PF00069	0.764
MOD_GSK3_1	58	65	PF00069	0.526
MOD_NEK2_1	2	7	PF00069	0.485
MOD_NEK2_1	86	91	PF00069	0.367
MOD_PKA_2	118	124	PF00069	0.736
MOD_PKA_2	131	137	PF00069	0.666
MOD_PKA_2	2	8	PF00069	0.437
MOD_PKA_2	47	53	PF00069	0.489
MOD_PKB_1	117	125	PF00069	0.671
MOD_ProDKin_1	133	139	PF00069	0.800
MOD_ProDKin_1	14	20	PF00069	0.564
MOD_ProDKin_1	151	157	PF00069	0.603
MOD_ProDKin_1	69	75	PF00069	0.288
MOD_SUMO_for_1	147	150	PF00179	0.722
TRG_DiLeu_BaEn_1	140	145	PF01217	0.736
TRG_DiLeu_BaEn_2	18	24	PF01217	0.500
TRG_ENDOCYTIC_2	39	42	PF00928	0.481
TRG_ER_diArg_1	2	4	PF00400	0.433
TRG_Pf-PMV_PEXEL_1	169	174	PF00026	0.436
TRG_Pf-PMV_PEXEL_1	22	26	PF00026	0.732

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5G4	Leptomonas seymouri	41%	100%
A0A3S7WYC5	Leishmania donovani	92%	100%
A4HDC7	Leishmania braziliensis	66%	100%
A4I0Q7	Leishmania infantum	91%	100%
E9AWQ9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	77%	100%