DUF523 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Protein of unknown function (DUF523), putative

Species:

Leishmania major

UniProt:

Q4QAR2_LEIMA

TriTrypDb:

LmjF.24.0710 , LMJLV39_240012700 , LMJSD75_240012300

Length:

439

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QAR2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QAR2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	210	214	PF00656	0.575
CLV_C14_Caspase3-7	337	341	PF00656	0.452
CLV_C14_Caspase3-7	417	421	PF00656	0.495
CLV_NRD_NRD_1	324	326	PF00675	0.744
CLV_NRD_NRD_1	334	336	PF00675	0.522
CLV_NRD_NRD_1	361	363	PF00675	0.478
CLV_NRD_NRD_1	392	394	PF00675	0.501
CLV_PCSK_FUR_1	390	394	PF00082	0.438
CLV_PCSK_KEX2_1	324	326	PF00082	0.744
CLV_PCSK_KEX2_1	334	336	PF00082	0.522
CLV_PCSK_KEX2_1	361	363	PF00082	0.478
CLV_PCSK_KEX2_1	392	394	PF00082	0.493
CLV_PCSK_KEX2_1	402	404	PF00082	0.619
CLV_PCSK_PC1ET2_1	402	404	PF00082	0.658
CLV_PCSK_SKI1_1	348	352	PF00082	0.494
CLV_PCSK_SKI1_1	380	384	PF00082	0.412
DEG_APCC_DBOX_1	170	178	PF00400	0.395
DEG_APCC_DBOX_1	347	355	PF00400	0.492
DEG_Nend_UBRbox_4	1	3	PF02207	0.541
DOC_CKS1_1	62	67	PF01111	0.557
DOC_CYCLIN_RxL_1	28	37	PF00134	0.480
DOC_CYCLIN_yCln2_LP_2	117	123	PF00134	0.357
DOC_MAPK_DCC_7	103	112	PF00069	0.420
DOC_MAPK_gen_1	31	40	PF00069	0.500
DOC_MAPK_MEF2A_6	103	112	PF00069	0.460
DOC_MAPK_MEF2A_6	135	142	PF00069	0.383
DOC_PP2B_LxvP_1	165	168	PF13499	0.392
DOC_USP7_MATH_1	196	200	PF00917	0.654
DOC_USP7_MATH_1	211	215	PF00917	0.518
DOC_USP7_MATH_1	3	7	PF00917	0.517
DOC_USP7_MATH_1	326	330	PF00917	0.535
DOC_USP7_MATH_1	89	93	PF00917	0.480
DOC_WW_Pin1_4	134	139	PF00397	0.412
DOC_WW_Pin1_4	247	252	PF00397	0.551
DOC_WW_Pin1_4	25	30	PF00397	0.532
DOC_WW_Pin1_4	276	281	PF00397	0.374
DOC_WW_Pin1_4	293	298	PF00397	0.506
DOC_WW_Pin1_4	391	396	PF00397	0.440
DOC_WW_Pin1_4	61	66	PF00397	0.547
LIG_14-3-3_CanoR_1	20	29	PF00244	0.507
LIG_14-3-3_CanoR_1	34	39	PF00244	0.487
LIG_14-3-3_CanoR_1	366	375	PF00244	0.615
LIG_BRCT_BRCA1_1	317	321	PF00533	0.555
LIG_CaM_NSCaTE_8	82	89	PF13499	0.471
LIG_FHA_1	135	141	PF00498	0.389
LIG_FHA_1	342	348	PF00498	0.444
LIG_FHA_1	92	98	PF00498	0.496
LIG_FHA_2	243	249	PF00498	0.598
LIG_FHA_2	415	421	PF00498	0.464
LIG_FHA_2	97	103	PF00498	0.586
LIG_LIR_LC3C_4	6	10	PF02991	0.473
LIG_LIR_Nem_3	144	150	PF02991	0.369
LIG_LIR_Nem_3	161	167	PF02991	0.374
LIG_LIR_Nem_3	79	85	PF02991	0.540
LIG_SH2_CRK	4	8	PF00017	0.543
LIG_SH2_SRC	290	293	PF00017	0.508
LIG_SH2_STAP1	290	294	PF00017	0.457
LIG_SH2_STAP1	4	8	PF00017	0.543
LIG_SH2_STAT5	225	228	PF00017	0.527
LIG_SH2_STAT5	386	389	PF00017	0.562
LIG_SH3_2	170	175	PF14604	0.396
LIG_SH3_3	102	108	PF00018	0.523
LIG_SH3_3	154	160	PF00018	0.338
LIG_SH3_3	167	173	PF00018	0.391
LIG_SH3_3	291	297	PF00018	0.552
LIG_SUMO_SIM_anti_2	6	11	PF11976	0.538
LIG_SUMO_SIM_par_1	106	113	PF11976	0.358
LIG_SUMO_SIM_par_1	6	11	PF11976	0.538
LIG_WRC_WIRS_1	419	424	PF05994	0.474
MOD_CDK_SPK_2	61	66	PF00069	0.502
MOD_CDK_SPxK_1	25	31	PF00069	0.544
MOD_CDK_SPxxK_3	61	68	PF00069	0.550
MOD_CK1_1	180	186	PF00069	0.557
MOD_CK1_1	200	206	PF00069	0.474
MOD_CK1_1	21	27	PF00069	0.490
MOD_CK1_1	296	302	PF00069	0.511
MOD_CK1_1	418	424	PF00069	0.474
MOD_CK1_1	92	98	PF00069	0.719
MOD_CK2_1	226	232	PF00069	0.600
MOD_CK2_1	242	248	PF00069	0.493
MOD_CK2_1	418	424	PF00069	0.431
MOD_Cter_Amidation	322	325	PF01082	0.631
MOD_GlcNHglycan	10	13	PF01048	0.537
MOD_GlcNHglycan	112	115	PF01048	0.531
MOD_GlcNHglycan	190	193	PF01048	0.622
MOD_GlcNHglycan	200	203	PF01048	0.536
MOD_GlcNHglycan	209	212	PF01048	0.474
MOD_GlcNHglycan	228	232	PF01048	0.490
MOD_GlcNHglycan	256	259	PF01048	0.603
MOD_GlcNHglycan	317	320	PF01048	0.554
MOD_GlcNHglycan	328	331	PF01048	0.580
MOD_GSK3_1	115	122	PF00069	0.462
MOD_GSK3_1	130	137	PF00069	0.392
MOD_GSK3_1	196	203	PF00069	0.620
MOD_GSK3_1	205	212	PF00069	0.570
MOD_GSK3_1	21	28	PF00069	0.476
MOD_GSK3_1	274	281	PF00069	0.334
MOD_GSK3_1	292	299	PF00069	0.498
MOD_GSK3_1	380	387	PF00069	0.565
MOD_GSK3_1	414	421	PF00069	0.537
MOD_GSK3_1	89	96	PF00069	0.564
MOD_N-GLC_1	242	247	PF02516	0.640
MOD_N-GLC_1	407	412	PF02516	0.635
MOD_N-GLC_2	308	310	PF02516	0.585
MOD_NEK2_1	207	212	PF00069	0.578
MOD_NEK2_1	226	231	PF00069	0.450
MOD_NEK2_1	33	38	PF00069	0.455
MOD_NEK2_1	350	355	PF00069	0.456
MOD_NEK2_1	422	427	PF00069	0.437
MOD_NEK2_1	8	13	PF00069	0.497
MOD_PIKK_1	21	27	PF00454	0.473
MOD_PIKK_1	341	347	PF00454	0.436
MOD_PIKK_1	432	438	PF00454	0.448
MOD_PK_1	93	99	PF00069	0.500
MOD_PKA_2	123	129	PF00069	0.493
MOD_PKA_2	177	183	PF00069	0.483
MOD_PKA_2	188	194	PF00069	0.562
MOD_PKA_2	33	39	PF00069	0.536
MOD_PKA_2	432	438	PF00069	0.492
MOD_PKA_2	92	98	PF00069	0.496
MOD_Plk_1	242	248	PF00069	0.597
MOD_Plk_2-3	384	390	PF00069	0.439
MOD_Plk_4	3	9	PF00069	0.539
MOD_Plk_4	317	323	PF00069	0.471
MOD_Plk_4	418	424	PF00069	0.437
MOD_ProDKin_1	134	140	PF00069	0.406
MOD_ProDKin_1	247	253	PF00069	0.547
MOD_ProDKin_1	25	31	PF00069	0.537
MOD_ProDKin_1	276	282	PF00069	0.370
MOD_ProDKin_1	293	299	PF00069	0.506
MOD_ProDKin_1	391	397	PF00069	0.446
MOD_ProDKin_1	61	67	PF00069	0.548
MOD_SUMO_for_1	217	220	PF00179	0.503
TRG_DiLeu_BaEn_1	222	227	PF01217	0.536
TRG_DiLeu_BaEn_1	232	237	PF01217	0.511
TRG_DiLeu_BaLyEn_6	135	140	PF01217	0.395
TRG_DiLeu_BaLyEn_6	377	382	PF01217	0.390
TRG_ENDOCYTIC_2	4	7	PF00928	0.541
TRG_ER_diArg_1	324	326	PF00400	0.677
TRG_ER_diArg_1	334	336	PF00400	0.495
TRG_ER_diArg_1	390	393	PF00400	0.461
TRG_ER_diArg_1	65	68	PF00400	0.546
TRG_NES_CRM1_1	149	161	PF08389	0.346
TRG_NLS_MonoExtN_4	399	405	PF00514	0.639
TRG_Pf-PMV_PEXEL_1	224	228	PF00026	0.527
TRG_Pf-PMV_PEXEL_1	380	384	PF00026	0.392

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I3F4	Leptomonas seymouri	43%	100%
A0A3S7WY61	Leishmania donovani	90%	100%
A4HDC8	Leishmania braziliensis	73%	100%
A4I0Q9	Leishmania infantum	90%	100%
E9AWR1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%