HAD family hydrolase

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QAQ8_LEIMA

TriTrypDb:

LmjF.24.0750 , LMJLV39_240013100 , LMJSD75_240012700

Length:

325

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005815	microtubule organizing center	2	2
GO:0036064	ciliary basal body	3	2
GO:0110165	cellular anatomical entity	1	3
GO:0016020	membrane	2	1

Expansion

Sequence features

Q4QAQ8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QAQ8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	80	84	PF00656	0.404
CLV_NRD_NRD_1	290	292	PF00675	0.442
CLV_NRD_NRD_1	306	308	PF00675	0.292
CLV_PCSK_KEX2_1	270	272	PF00082	0.498
CLV_PCSK_KEX2_1	290	292	PF00082	0.427
CLV_PCSK_KEX2_1	43	45	PF00082	0.420
CLV_PCSK_PC1ET2_1	270	272	PF00082	0.498
CLV_PCSK_PC1ET2_1	43	45	PF00082	0.352
CLV_PCSK_SKI1_1	319	323	PF00082	0.576
DEG_SPOP_SBC_1	58	62	PF00917	0.404
DOC_MAPK_gen_1	52	59	PF00069	0.397
DOC_MAPK_MEF2A_6	10	17	PF00069	0.295
DOC_MAPK_MEF2A_6	298	305	PF00069	0.408
DOC_MAPK_MEF2A_6	52	59	PF00069	0.411
DOC_PP1_RVXF_1	8	15	PF00149	0.307
DOC_PP2B_LxvP_1	22	25	PF13499	0.271
DOC_USP7_MATH_1	86	90	PF00917	0.292
DOC_USP7_UBL2_3	243	247	PF12436	0.353
DOC_USP7_UBL2_3	308	312	PF12436	0.406
DOC_WW_Pin1_4	182	187	PF00397	0.448
DOC_WW_Pin1_4	89	94	PF00397	0.319
LIG_14-3-3_CanoR_1	124	134	PF00244	0.289
LIG_14-3-3_CanoR_1	298	304	PF00244	0.480
LIG_14-3-3_CanoR_1	37	43	PF00244	0.320
LIG_14-3-3_CanoR_1	72	77	PF00244	0.316
LIG_APCC_ABBAyCdc20_2	10	16	PF00400	0.289
LIG_BIR_II_1	1	5	PF00653	0.447
LIG_FHA_1	223	229	PF00498	0.489
LIG_FHA_1	54	60	PF00498	0.347
LIG_FHA_2	160	166	PF00498	0.315
LIG_FHA_2	167	173	PF00498	0.313
LIG_FHA_2	222	228	PF00498	0.525
LIG_FHA_2	275	281	PF00498	0.378
LIG_LIR_Gen_1	299	305	PF02991	0.488
LIG_LIR_Gen_1	9	17	PF02991	0.356
LIG_LIR_Nem_3	120	126	PF02991	0.335
LIG_LIR_Nem_3	269	275	PF02991	0.376
LIG_LIR_Nem_3	299	303	PF02991	0.496
LIG_LIR_Nem_3	9	14	PF02991	0.377
LIG_LYPXL_SIV_4	189	197	PF13949	0.491
LIG_LYPXL_yS_3	272	275	PF13949	0.485
LIG_RPA_C_Fungi	211	223	PF08784	0.585
LIG_SH2_STAP1	190	194	PF00017	0.501
LIG_SH2_STAT5	11	14	PF00017	0.404
LIG_SH3_3	17	23	PF00018	0.271
LIG_SUMO_SIM_anti_2	299	306	PF11976	0.490
LIG_SUMO_SIM_anti_2	53	62	PF11976	0.363
LIG_SUMO_SIM_par_1	55	62	PF11976	0.335
LIG_SUMO_SIM_par_1	66	71	PF11976	0.332
LIG_UBA3_1	245	252	PF00899	0.392
LIG_UBA3_1	45	54	PF00899	0.420
LIG_WRC_WIRS_1	297	302	PF05994	0.489
LIG_WRC_WIRS_1	73	78	PF05994	0.335
MOD_CK1_1	100	106	PF00069	0.362
MOD_CK1_1	182	188	PF00069	0.505
MOD_CK1_1	89	95	PF00069	0.442
MOD_CK2_1	182	188	PF00069	0.462
MOD_CK2_1	212	218	PF00069	0.465
MOD_CK2_1	221	227	PF00069	0.421
MOD_CK2_1	274	280	PF00069	0.389
MOD_CK2_1	283	289	PF00069	0.426
MOD_GlcNHglycan	238	241	PF01048	0.544
MOD_GlcNHglycan	285	288	PF01048	0.478
MOD_GlcNHglycan	34	37	PF01048	0.329
MOD_GSK3_1	222	229	PF00069	0.512
MOD_GSK3_1	53	60	PF00069	0.289
MOD_GSK3_1	89	96	PF00069	0.281
MOD_N-GLC_1	32	37	PF02516	0.204
MOD_N-GLC_1	93	98	PF02516	0.271
MOD_NEK2_1	159	164	PF00069	0.349
MOD_NEK2_1	179	184	PF00069	0.365
MOD_NEK2_1	221	226	PF00069	0.508
MOD_NEK2_1	281	286	PF00069	0.457
MOD_NEK2_1	57	62	PF00069	0.289
MOD_NEK2_1	98	103	PF00069	0.424
MOD_NEK2_2	38	43	PF00069	0.396
MOD_PIKK_1	159	165	PF00454	0.335
MOD_PK_1	252	258	PF00069	0.312
MOD_Plk_4	100	106	PF00069	0.249
MOD_Plk_4	299	305	PF00069	0.389
MOD_Plk_4	53	59	PF00069	0.301
MOD_Plk_4	72	78	PF00069	0.289
MOD_Plk_4	93	99	PF00069	0.291
MOD_ProDKin_1	182	188	PF00069	0.450
MOD_ProDKin_1	89	95	PF00069	0.319
MOD_SUMO_for_1	202	205	PF00179	0.361
MOD_SUMO_rev_2	239	245	PF00179	0.452
MOD_SUMO_rev_2	316	321	PF00179	0.561
TRG_DiLeu_BaEn_1	241	246	PF01217	0.461
TRG_DiLeu_BaLyEn_6	41	46	PF01217	0.378
TRG_ENDOCYTIC_2	11	14	PF00928	0.404
TRG_ENDOCYTIC_2	123	126	PF00928	0.292
TRG_ENDOCYTIC_2	272	275	PF00928	0.485
TRG_ER_diLys_1	320	325	PF00400	0.594
TRG_NLS_Bipartite_1	307	323	PF00514	0.440
TRG_NLS_MonoExtC_3	311	317	PF00514	0.475
TRG_Pf-PMV_PEXEL_1	247	251	PF00026	0.498
TRG_Pf-PMV_PEXEL_1	254	258	PF00026	0.443

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I6B2	Leptomonas seymouri	68%	100%
A0A1X0NJ52	Trypanosomatidae	50%	96%
A0A3Q8ICT7	Leishmania donovani	94%	100%
A0A3R7RGD3	Trypanosoma rangeli	52%	100%
A4HDD2	Leishmania braziliensis	81%	100%
A4I0R3	Leishmania infantum	95%	100%
D0A742	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	51%	98%
E9AWR5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
V5C0M0	Trypanosoma cruzi	51%	71%