SUZ domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QAQ5_LEIMA

TriTrypDb:

LmjF.24.0780 , LMJLV39_240013600 , LMJSD75_240013100

Length:

307

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QAQ5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QAQ5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	284	288	PF00656	0.612
CLV_NRD_NRD_1	143	145	PF00675	0.636
CLV_NRD_NRD_1	170	172	PF00675	0.592
CLV_NRD_NRD_1	191	193	PF00675	0.538
CLV_NRD_NRD_1	37	39	PF00675	0.584
CLV_PCSK_FUR_1	189	193	PF00082	0.501
CLV_PCSK_KEX2_1	143	145	PF00082	0.636
CLV_PCSK_KEX2_1	170	172	PF00082	0.592
CLV_PCSK_KEX2_1	191	193	PF00082	0.538
CLV_PCSK_KEX2_1	36	38	PF00082	0.590
CLV_PCSK_PC1ET2_1	36	38	PF00082	0.590
CLV_PCSK_PC7_1	139	145	PF00082	0.630
CLV_PCSK_SKI1_1	198	202	PF00082	0.541
CLV_PCSK_SKI1_1	83	87	PF00082	0.495
CLV_PCSK_SKI1_1	88	92	PF00082	0.534
CLV_PCSK_SKI1_1	96	100	PF00082	0.584
DEG_APCC_DBOX_1	114	122	PF00400	0.569
DEG_APCC_DBOX_1	197	205	PF00400	0.525
DEG_Nend_UBRbox_3	1	3	PF02207	0.558
DOC_ANK_TNKS_1	151	158	PF00023	0.686
DOC_MAPK_gen_1	186	196	PF00069	0.526
DOC_MAPK_MEF2A_6	96	103	PF00069	0.575
DOC_PP4_FxxP_1	108	111	PF00568	0.650
DOC_PP4_FxxP_1	230	233	PF00568	0.662
DOC_USP7_MATH_1	128	132	PF00917	0.611
DOC_USP7_MATH_1	13	17	PF00917	0.699
DOC_USP7_MATH_1	177	181	PF00917	0.609
DOC_USP7_MATH_1	40	44	PF00917	0.689
DOC_USP7_MATH_1	53	57	PF00917	0.666
DOC_USP7_MATH_1	61	65	PF00917	0.594
DOC_WW_Pin1_4	109	114	PF00397	0.530
DOC_WW_Pin1_4	124	129	PF00397	0.738
DOC_WW_Pin1_4	270	275	PF00397	0.677
DOC_WW_Pin1_4	301	306	PF00397	0.577
DOC_WW_Pin1_4	57	62	PF00397	0.671
LIG_14-3-3_CanoR_1	115	119	PF00244	0.607
LIG_14-3-3_CanoR_1	250	256	PF00244	0.692
LIG_ActinCP_TwfCPI_2	230	239	PF01115	0.619
LIG_BIR_III_4	245	249	PF00653	0.649
LIG_BRCT_BRCA1_1	299	303	PF00533	0.654
LIG_FHA_2	282	288	PF00498	0.611
LIG_FHA_2	75	81	PF00498	0.539
LIG_Integrin_isoDGR_2	4	6	PF01839	0.500
LIG_Integrin_RGD_1	285	287	PF01839	0.627
LIG_LIR_Apic_2	106	111	PF02991	0.650
LIG_LIR_Apic_2	228	233	PF02991	0.657
LIG_LIR_Gen_1	208	218	PF02991	0.565
LIG_LIR_Gen_1	7	15	PF02991	0.580
LIG_LIR_Nem_3	208	214	PF02991	0.555
LIG_LIR_Nem_3	300	306	PF02991	0.571
LIG_LIR_Nem_3	7	12	PF02991	0.574
LIG_PCNA_yPIPBox_3	83	91	PF02747	0.485
LIG_SH2_CRK	172	176	PF00017	0.641
LIG_SH2_CRK	211	215	PF00017	0.645
LIG_SH2_CRK	9	13	PF00017	0.581
LIG_SH2_NCK_1	116	120	PF00017	0.644
LIG_SH2_STAP1	9	13	PF00017	0.581
LIG_SH2_STAT5	116	119	PF00017	0.812
LIG_SH2_STAT5	187	190	PF00017	0.460
LIG_SH2_STAT5	234	237	PF00017	0.618
LIG_SH3_1	299	305	PF00018	0.548
LIG_SH3_3	299	305	PF00018	0.569
LIG_SH3_3	65	71	PF00018	0.563
LIG_TRAF2_1	16	19	PF00917	0.659
LIG_TRAF2_1	180	183	PF00917	0.525
LIG_TYR_ITIM	209	214	PF00017	0.561
MOD_CDC14_SPxK_1	112	115	PF00782	0.517
MOD_CDK_SPxK_1	109	115	PF00069	0.511
MOD_CK1_1	131	137	PF00069	0.611
MOD_CK1_1	251	257	PF00069	0.683
MOD_CK1_1	273	279	PF00069	0.658
MOD_CK2_1	13	19	PF00069	0.586
MOD_CK2_1	177	183	PF00069	0.529
MOD_CK2_1	74	80	PF00069	0.545
MOD_GlcNHglycan	133	136	PF01048	0.599
MOD_GlcNHglycan	179	182	PF01048	0.445
MOD_GlcNHglycan	299	302	PF01048	0.626
MOD_GlcNHglycan	6	9	PF01048	0.642
MOD_GlcNHglycan	63	66	PF01048	0.641
MOD_GSK3_1	124	131	PF00069	0.631
MOD_GSK3_1	297	304	PF00069	0.657
MOD_GSK3_1	53	60	PF00069	0.709
MOD_N-GLC_1	177	182	PF02516	0.532
MOD_NEK2_1	212	217	PF00069	0.573
MOD_NEK2_1	27	32	PF00069	0.571
MOD_PIKK_1	144	150	PF00454	0.646
MOD_PIKK_1	212	218	PF00454	0.575
MOD_PKA_2	114	120	PF00069	0.566
MOD_PKA_2	13	19	PF00069	0.586
MOD_PKA_2	249	255	PF00069	0.597
MOD_PKA_2	278	284	PF00069	0.610
MOD_Plk_1	27	33	PF00069	0.568
MOD_Plk_2-3	205	211	PF00069	0.539
MOD_Plk_4	27	33	PF00069	0.644
MOD_Plk_4	74	80	PF00069	0.513
MOD_ProDKin_1	109	115	PF00069	0.534
MOD_ProDKin_1	124	130	PF00069	0.738
MOD_ProDKin_1	270	276	PF00069	0.679
MOD_ProDKin_1	301	307	PF00069	0.560
MOD_ProDKin_1	57	63	PF00069	0.672
TRG_ENDOCYTIC_2	211	214	PF00928	0.564
TRG_ENDOCYTIC_2	9	12	PF00928	0.581
TRG_ER_diArg_1	149	152	PF00400	0.625
TRG_ER_diArg_1	169	171	PF00400	0.684
TRG_ER_diArg_1	188	191	PF00400	0.544
TRG_ER_diArg_1	255	258	PF00400	0.665

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5G1	Leptomonas seymouri	40%	100%
A0A3Q8IBA4	Leishmania donovani	85%	99%
A4HDD6	Leishmania braziliensis	69%	100%
A4I0R7	Leishmania infantum	85%	99%
E9AWR9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%