Non-specific serine/threonine protein kinase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QAQ4_LEIMA

TriTrypDb:

LmjF.24.0790 , LMJLV39_240013700 , LMJSD75_240013200

Length:

582

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005681	spliceosomal complex	3	2
GO:0032991	protein-containing complex	1	2
GO:0140513	nuclear protein-containing complex	2	2
GO:1990904	ribonucleoprotein complex	2	2

Expansion

Sequence features

Q4QAQ4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QAQ4

Function

Biological processes
Term	Name	Level	Count
GO:0000375	RNA splicing, via transesterification reactions	8	7
GO:0000377	RNA splicing, via transesterification reactions with bulged adenosine as nucleophile	9	7
GO:0000398	mRNA splicing, via spliceosome	8	7
GO:0006139	nucleobase-containing compound metabolic process	3	7
GO:0006396	RNA processing	6	7
GO:0006397	mRNA processing	7	7
GO:0006725	cellular aromatic compound metabolic process	3	7
GO:0006807	nitrogen compound metabolic process	2	7
GO:0008152	metabolic process	1	7
GO:0008380	RNA splicing	7	7
GO:0009987	cellular process	1	7
GO:0016070	RNA metabolic process	5	7
GO:0016071	mRNA metabolic process	6	7
GO:0034641	cellular nitrogen compound metabolic process	3	7
GO:0043170	macromolecule metabolic process	3	7
GO:0044237	cellular metabolic process	2	7
GO:0044238	primary metabolic process	2	7
GO:0046483	heterocycle metabolic process	3	7
GO:0071704	organic substance metabolic process	2	7
GO:0090304	nucleic acid metabolic process	4	7
GO:1901360	organic cyclic compound metabolic process	3	7

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	21	25	PF00656	0.666
CLV_NRD_NRD_1	188	190	PF00675	0.692
CLV_NRD_NRD_1	259	261	PF00675	0.521
CLV_NRD_NRD_1	337	339	PF00675	0.558
CLV_NRD_NRD_1	385	387	PF00675	0.495
CLV_NRD_NRD_1	538	540	PF00675	0.567
CLV_NRD_NRD_1	87	89	PF00675	0.661
CLV_PCSK_KEX2_1	188	190	PF00082	0.692
CLV_PCSK_KEX2_1	22	24	PF00082	0.697
CLV_PCSK_KEX2_1	538	540	PF00082	0.494
CLV_PCSK_KEX2_1	87	89	PF00082	0.661
CLV_PCSK_PC1ET2_1	22	24	PF00082	0.697
CLV_PCSK_SKI1_1	338	342	PF00082	0.552
CLV_PCSK_SKI1_1	346	350	PF00082	0.415
CLV_PCSK_SKI1_1	399	403	PF00082	0.418
CLV_PCSK_SKI1_1	88	92	PF00082	0.536
DEG_APCC_DBOX_1	169	177	PF00400	0.586
DEG_SCF_FBW7_1	213	218	PF00400	0.551
DEG_SPOP_SBC_1	106	110	PF00917	0.616
DEG_SPOP_SBC_1	181	185	PF00917	0.502
DEG_SPOP_SBC_1	282	286	PF00917	0.557
DEG_SPOP_SBC_1	3	7	PF00917	0.525
DEG_SPOP_SBC_1	411	415	PF00917	0.593
DOC_CDC14_PxL_1	35	43	PF14671	0.594
DOC_CYCLIN_RxL_1	343	352	PF00134	0.378
DOC_MAPK_gen_1	526	535	PF00069	0.460
DOC_MAPK_gen_1	565	572	PF00069	0.472
DOC_PP1_RVXF_1	344	350	PF00149	0.348
DOC_PP1_RVXF_1	370	376	PF00149	0.467
DOC_PP2B_LxvP_1	431	434	PF13499	0.639
DOC_USP7_MATH_1	100	104	PF00917	0.648
DOC_USP7_MATH_1	106	110	PF00917	0.644
DOC_USP7_MATH_1	166	170	PF00917	0.649
DOC_USP7_MATH_1	196	200	PF00917	0.636
DOC_USP7_MATH_1	215	219	PF00917	0.628
DOC_USP7_MATH_1	273	277	PF00917	0.641
DOC_USP7_MATH_1	282	286	PF00917	0.598
DOC_USP7_MATH_1	287	291	PF00917	0.525
DOC_USP7_MATH_1	3	7	PF00917	0.593
DOC_USP7_MATH_1	303	307	PF00917	0.552
DOC_USP7_MATH_1	371	375	PF00917	0.446
DOC_USP7_MATH_1	394	398	PF00917	0.626
DOC_USP7_MATH_1	411	415	PF00917	0.601
DOC_USP7_MATH_1	92	96	PF00917	0.727
DOC_USP7_UBL2_3	335	339	PF12436	0.541
DOC_USP7_UBL2_3	464	468	PF12436	0.443
DOC_WW_Pin1_4	209	214	PF00397	0.627
DOC_WW_Pin1_4	278	283	PF00397	0.814
DOC_WW_Pin1_4	285	290	PF00397	0.661
DOC_WW_Pin1_4	338	343	PF00397	0.542
DOC_WW_Pin1_4	407	412	PF00397	0.653
DOC_WW_Pin1_4	425	430	PF00397	0.649
LIG_14-3-3_CanoR_1	260	270	PF00244	0.608
LIG_14-3-3_CanoR_1	370	376	PF00244	0.443
LIG_14-3-3_CanoR_1	451	460	PF00244	0.429
LIG_14-3-3_CanoR_1	53	61	PF00244	0.592
LIG_14-3-3_CanoR_1	87	94	PF00244	0.660
LIG_BIR_II_1	1	5	PF00653	0.672
LIG_BIR_III_2	9	13	PF00653	0.686
LIG_BRCT_BRCA1_1	108	112	PF00533	0.682
LIG_BRCT_BRCA1_1	217	221	PF00533	0.646
LIG_BRCT_BRCA1_1	494	498	PF00533	0.604
LIG_Clathr_ClatBox_1	514	518	PF01394	0.459
LIG_EVH1_1	431	435	PF00568	0.591
LIG_FHA_1	154	160	PF00498	0.546
LIG_FHA_1	286	292	PF00498	0.718
LIG_FHA_1	306	312	PF00498	0.546
LIG_FHA_1	509	515	PF00498	0.494
LIG_FHA_1	564	570	PF00498	0.489
LIG_FHA_2	182	188	PF00498	0.665
LIG_FHA_2	328	334	PF00498	0.495
LIG_FHA_2	350	356	PF00498	0.443
LIG_FHA_2	555	561	PF00498	0.434
LIG_LIR_Gen_1	218	229	PF02991	0.628
LIG_LIR_Nem_3	218	224	PF02991	0.642
LIG_LIR_Nem_3	374	378	PF02991	0.448
LIG_LIR_Nem_3	89	94	PF02991	0.516
LIG_MLH1_MIPbox_1	109	113	PF16413	0.640
LIG_MYND_1	429	433	PF01753	0.650
LIG_PAM2_1	433	445	PF00658	0.556
LIG_PCNA_yPIPBox_3	250	261	PF02747	0.465
LIG_REV1ctd_RIR_1	373	379	PF16727	0.465
LIG_SH2_PTP2	227	230	PF00017	0.530
LIG_SH2_STAT5	227	230	PF00017	0.534
LIG_SH2_STAT5	383	386	PF00017	0.500
LIG_SH3_3	203	209	PF00018	0.619
LIG_SH3_3	423	429	PF00018	0.748
LIG_SUMO_SIM_par_1	531	537	PF11976	0.433
LIG_TRAF2_1	330	333	PF00917	0.551
MOD_CK1_1	107	113	PF00069	0.667
MOD_CK1_1	136	142	PF00069	0.627
MOD_CK1_1	18	24	PF00069	0.581
MOD_CK1_1	199	205	PF00069	0.753
MOD_CK1_1	2	8	PF00069	0.613
MOD_CK1_1	280	286	PF00069	0.766
MOD_CK1_1	325	331	PF00069	0.633
MOD_CK1_1	406	412	PF00069	0.601
MOD_CK1_1	425	431	PF00069	0.779
MOD_CK2_1	117	123	PF00069	0.604
MOD_CK2_1	327	333	PF00069	0.497
MOD_CK2_1	371	377	PF00069	0.445
MOD_CK2_1	554	560	PF00069	0.370
MOD_Cter_Amidation	336	339	PF01082	0.539
MOD_Cter_Amidation	461	464	PF01082	0.411
MOD_GlcNHglycan	1	4	PF01048	0.575
MOD_GlcNHglycan	138	141	PF01048	0.659
MOD_GlcNHglycan	164	167	PF01048	0.623
MOD_GlcNHglycan	184	187	PF01048	0.787
MOD_GlcNHglycan	190	193	PF01048	0.693
MOD_GlcNHglycan	194	197	PF01048	0.694
MOD_GlcNHglycan	198	201	PF01048	0.706
MOD_GlcNHglycan	217	220	PF01048	0.623
MOD_GlcNHglycan	24	27	PF01048	0.599
MOD_GlcNHglycan	271	274	PF01048	0.679
MOD_GlcNHglycan	275	278	PF01048	0.701
MOD_GlcNHglycan	299	302	PF01048	0.691
MOD_GlcNHglycan	305	308	PF01048	0.619
MOD_GlcNHglycan	324	327	PF01048	0.526
MOD_GlcNHglycan	41	44	PF01048	0.529
MOD_GlcNHglycan	414	417	PF01048	0.669
MOD_GlcNHglycan	492	495	PF01048	0.695
MOD_GlcNHglycan	94	97	PF01048	0.755
MOD_GSK3_1	100	107	PF00069	0.663
MOD_GSK3_1	139	146	PF00069	0.673
MOD_GSK3_1	150	157	PF00069	0.727
MOD_GSK3_1	158	165	PF00069	0.517
MOD_GSK3_1	18	25	PF00069	0.833
MOD_GSK3_1	188	195	PF00069	0.637
MOD_GSK3_1	209	216	PF00069	0.582
MOD_GSK3_1	269	276	PF00069	0.668
MOD_GSK3_1	277	284	PF00069	0.793
MOD_GSK3_1	303	310	PF00069	0.669
MOD_GSK3_1	395	402	PF00069	0.496
MOD_GSK3_1	403	410	PF00069	0.564
MOD_GSK3_1	421	428	PF00069	0.753
MOD_GSK3_1	490	497	PF00069	0.678
MOD_LATS_1	13	19	PF00433	0.712
MOD_N-GLC_1	406	411	PF02516	0.606
MOD_NEK2_1	143	148	PF00069	0.676
MOD_NEK2_1	235	240	PF00069	0.562
MOD_NEK2_1	294	299	PF00069	0.546
MOD_NEK2_1	349	354	PF00069	0.429
MOD_NEK2_1	366	371	PF00069	0.457
MOD_NEK2_1	388	393	PF00069	0.419
MOD_NEK2_2	371	376	PF00069	0.450
MOD_NEK2_2	494	499	PF00069	0.679
MOD_PKA_1	188	194	PF00069	0.646
MOD_PKA_1	22	28	PF00069	0.656
MOD_PKA_2	187	193	PF00069	0.684
MOD_PKA_2	22	28	PF00069	0.656
MOD_PKA_2	450	456	PF00069	0.558
MOD_PKA_2	86	92	PF00069	0.623
MOD_Plk_1	349	355	PF00069	0.467
MOD_Plk_1	554	560	PF00069	0.391
MOD_Plk_4	307	313	PF00069	0.557
MOD_Plk_4	371	377	PF00069	0.464
MOD_Plk_4	399	405	PF00069	0.423
MOD_Plk_4	519	525	PF00069	0.412
MOD_ProDKin_1	209	215	PF00069	0.625
MOD_ProDKin_1	278	284	PF00069	0.812
MOD_ProDKin_1	285	291	PF00069	0.662
MOD_ProDKin_1	338	344	PF00069	0.533
MOD_ProDKin_1	407	413	PF00069	0.656
MOD_ProDKin_1	425	431	PF00069	0.646
TRG_DiLeu_BaEn_1	510	515	PF01217	0.425
TRG_DiLeu_BaLyEn_6	343	348	PF01217	0.420
TRG_DiLeu_BaLyEn_6	444	449	PF01217	0.347
TRG_ENDOCYTIC_2	227	230	PF00928	0.534
TRG_ER_diArg_1	44	47	PF00400	0.589
TRG_ER_diArg_1	476	479	PF00400	0.474
TRG_ER_diArg_1	545	548	PF00400	0.464
TRG_Pf-PMV_PEXEL_1	338	343	PF00026	0.579
TRG_Pf-PMV_PEXEL_1	346	350	PF00026	0.401
TRG_Pf-PMV_PEXEL_1	46	50	PF00026	0.591

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PD00	Leptomonas seymouri	48%	100%
A0A3R7R9R9	Trypanosoma rangeli	33%	100%
A0A3S7WYC4	Leishmania donovani	90%	100%
A4HDD7	Leishmania braziliensis	72%	100%
A4I0R8	Leishmania infantum	90%	100%
E9AWS0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	100%