Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania major

UniProt:

Q4QAQ3_LEIMA

TriTrypDb:

LmjF.24.0800 , LMJLV39_240013800 , LMJSD75_240013300

Length:

602

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QAQ3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QAQ3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	168	172	PF00656	0.704
CLV_C14_Caspase3-7	327	331	PF00656	0.699
CLV_C14_Caspase3-7	376	380	PF00656	0.616
CLV_C14_Caspase3-7	422	426	PF00656	0.599
CLV_NRD_NRD_1	106	108	PF00675	0.652
CLV_NRD_NRD_1	219	221	PF00675	0.654
CLV_NRD_NRD_1	23	25	PF00675	0.729
CLV_NRD_NRD_1	26	28	PF00675	0.712
CLV_NRD_NRD_1	317	319	PF00675	0.694
CLV_NRD_NRD_1	325	327	PF00675	0.622
CLV_NRD_NRD_1	347	349	PF00675	0.476
CLV_NRD_NRD_1	414	416	PF00675	0.633
CLV_NRD_NRD_1	56	58	PF00675	0.689
CLV_NRD_NRD_1	82	84	PF00675	0.704
CLV_PCSK_FUR_1	24	28	PF00082	0.688
CLV_PCSK_KEX2_1	106	108	PF00082	0.652
CLV_PCSK_KEX2_1	130	132	PF00082	0.681
CLV_PCSK_KEX2_1	219	221	PF00082	0.654
CLV_PCSK_KEX2_1	23	25	PF00082	0.729
CLV_PCSK_KEX2_1	26	28	PF00082	0.712
CLV_PCSK_KEX2_1	316	318	PF00082	0.695
CLV_PCSK_KEX2_1	325	327	PF00082	0.613
CLV_PCSK_KEX2_1	413	415	PF00082	0.630
CLV_PCSK_KEX2_1	56	58	PF00082	0.689
CLV_PCSK_KEX2_1	82	84	PF00082	0.704
CLV_PCSK_PC1ET2_1	130	132	PF00082	0.681
CLV_PCSK_PC7_1	321	327	PF00082	0.686
CLV_PCSK_SKI1_1	414	418	PF00082	0.659
DOC_ANK_TNKS_1	325	332	PF00023	0.698
DOC_ANK_TNKS_1	82	89	PF00023	0.670
DOC_CKS1_1	356	361	PF01111	0.623
DOC_CYCLIN_yClb5_NLxxxL_5	144	150	PF00134	0.611
DOC_MAPK_gen_1	82	91	PF00069	0.590
DOC_MAPK_MEF2A_6	82	91	PF00069	0.669
DOC_PP2B_LxvP_1	548	551	PF13499	0.649
DOC_PP4_FxxP_1	149	152	PF00568	0.638
DOC_USP7_MATH_1	102	106	PF00917	0.659
DOC_USP7_MATH_1	263	267	PF00917	0.581
DOC_USP7_MATH_1	287	291	PF00917	0.629
DOC_USP7_MATH_1	319	323	PF00917	0.688
DOC_USP7_MATH_1	399	403	PF00917	0.658
DOC_USP7_MATH_1	4	8	PF00917	0.623
DOC_USP7_MATH_1	408	412	PF00917	0.533
DOC_USP7_MATH_1	481	485	PF00917	0.653
DOC_USP7_MATH_1	505	509	PF00917	0.716
DOC_USP7_MATH_1	527	531	PF00917	0.718
DOC_USP7_MATH_1	572	576	PF00917	0.606
DOC_USP7_MATH_1	59	63	PF00917	0.712
DOC_WW_Pin1_4	2	7	PF00397	0.516
DOC_WW_Pin1_4	200	205	PF00397	0.658
DOC_WW_Pin1_4	355	360	PF00397	0.759
DOC_WW_Pin1_4	43	48	PF00397	0.574
DOC_WW_Pin1_4	503	508	PF00397	0.815
DOC_WW_Pin1_4	523	528	PF00397	0.671
DOC_WW_Pin1_4	565	570	PF00397	0.681
LIG_14-3-3_CanoR_1	106	114	PF00244	0.672
LIG_14-3-3_CanoR_1	192	198	PF00244	0.673
LIG_14-3-3_CanoR_1	219	227	PF00244	0.544
LIG_14-3-3_CanoR_1	24	30	PF00244	0.684
LIG_14-3-3_CanoR_1	32	39	PF00244	0.690
LIG_14-3-3_CanoR_1	321	325	PF00244	0.649
LIG_14-3-3_CanoR_1	360	366	PF00244	0.717
LIG_14-3-3_CanoR_1	482	488	PF00244	0.738
LIG_14-3-3_CanoR_1	500	509	PF00244	0.568
LIG_14-3-3_CanoR_1	532	538	PF00244	0.693
LIG_Actin_WH2_1	245	263	PF00022	0.487
LIG_BIR_II_1	1	5	PF00653	0.657
LIG_BIR_III_2	448	452	PF00653	0.755
LIG_BIR_III_3	1	5	PF00653	0.657
LIG_BRCT_BRCA1_1	201	205	PF00533	0.633
LIG_BRCT_BRCA1_1	456	460	PF00533	0.695
LIG_BRCT_BRCA1_1	567	571	PF00533	0.661
LIG_BRCT_BRCA1_1	9	13	PF00533	0.588
LIG_deltaCOP1_diTrp_1	342	346	PF00928	0.569
LIG_FHA_1	121	127	PF00498	0.666
LIG_FHA_1	293	299	PF00498	0.616
LIG_FHA_1	435	441	PF00498	0.737
LIG_FHA_1	534	540	PF00498	0.582
LIG_FHA_1	595	601	PF00498	0.481
LIG_FHA_2	16	22	PF00498	0.644
LIG_FHA_2	26	32	PF00498	0.605
LIG_FHA_2	536	542	PF00498	0.702
LIG_FHA_2	585	591	PF00498	0.646
LIG_HCF-1_HBM_1	250	253	PF13415	0.396
LIG_LIR_Apic_2	457	462	PF02991	0.693
LIG_LIR_Gen_1	417	425	PF02991	0.655
LIG_LIR_Nem_3	175	179	PF02991	0.701
LIG_LIR_Nem_3	417	423	PF02991	0.727
LIG_LIR_Nem_3	457	463	PF02991	0.758
LIG_PALB2_WD40_1	455	463	PF16756	0.697
LIG_Pex14_1	346	350	PF04695	0.558
LIG_SH2_NCK_1	225	229	PF00017	0.620
LIG_SH2_SRC	225	228	PF00017	0.695
LIG_SH2_STAP1	350	354	PF00017	0.590
LIG_SH2_STAT5	19	22	PF00017	0.722
LIG_SH2_STAT5	390	393	PF00017	0.573
LIG_SH3_3	221	227	PF00018	0.660
LIG_SH3_3	353	359	PF00018	0.612
LIG_SH3_3	448	454	PF00018	0.772
LIG_SH3_3	566	572	PF00018	0.563
LIG_SH3_3	81	87	PF00018	0.768
LIG_SUMO_SIM_par_1	535	541	PF11976	0.631
LIG_TRAF2_1	47	50	PF00917	0.610
LIG_TRAF2_2	337	342	PF00917	0.525
MOD_CDK_SPK_2	355	360	PF00069	0.621
MOD_CDK_SPxxK_3	355	362	PF00069	0.626
MOD_CK1_1	105	111	PF00069	0.650
MOD_CK1_1	203	209	PF00069	0.677
MOD_CK1_1	240	246	PF00069	0.535
MOD_CK1_1	424	430	PF00069	0.711
MOD_CK1_1	43	49	PF00069	0.694
MOD_CK1_1	503	509	PF00069	0.816
MOD_CK1_1	512	518	PF00069	0.706
MOD_CK1_1	530	536	PF00069	0.752
MOD_CK1_1	564	570	PF00069	0.723
MOD_CK1_1	7	13	PF00069	0.724
MOD_CK2_1	15	21	PF00069	0.646
MOD_CK2_1	25	31	PF00069	0.605
MOD_CK2_1	43	49	PF00069	0.684
MOD_CMANNOS	343	346	PF00535	0.565
MOD_Cter_Amidation	24	27	PF01082	0.671
MOD_GlcNHglycan	107	110	PF01048	0.650
MOD_GlcNHglycan	158	161	PF01048	0.629
MOD_GlcNHglycan	207	210	PF01048	0.747
MOD_GlcNHglycan	304	307	PF01048	0.619
MOD_GlcNHglycan	401	404	PF01048	0.609
MOD_GlcNHglycan	408	411	PF01048	0.662
MOD_GlcNHglycan	41	45	PF01048	0.663
MOD_GlcNHglycan	456	459	PF01048	0.732
MOD_GlcNHglycan	476	479	PF01048	0.542
MOD_GlcNHglycan	502	505	PF01048	0.623
MOD_GlcNHglycan	529	532	PF01048	0.798
MOD_GlcNHglycan	563	566	PF01048	0.761
MOD_GlcNHglycan	574	577	PF01048	0.712
MOD_GlcNHglycan	61	64	PF01048	0.576
MOD_GlcNHglycan	96	100	PF01048	0.466
MOD_GSK3_1	121	128	PF00069	0.715
MOD_GSK3_1	15	22	PF00069	0.567
MOD_GSK3_1	174	181	PF00069	0.727
MOD_GSK3_1	199	206	PF00069	0.685
MOD_GSK3_1	2	9	PF00069	0.653
MOD_GSK3_1	214	221	PF00069	0.553
MOD_GSK3_1	361	368	PF00069	0.759
MOD_GSK3_1	371	378	PF00069	0.602
MOD_GSK3_1	388	395	PF00069	0.677
MOD_GSK3_1	435	442	PF00069	0.791
MOD_GSK3_1	505	512	PF00069	0.779
MOD_GSK3_1	523	530	PF00069	0.736
MOD_GSK3_1	533	540	PF00069	0.690
MOD_GSK3_1	561	568	PF00069	0.751
MOD_LATS_1	412	418	PF00433	0.658
MOD_N-GLC_1	32	37	PF02516	0.694
MOD_N-GLC_1	397	402	PF02516	0.566
MOD_NEK2_1	174	179	PF00069	0.799
MOD_NEK2_1	205	210	PF00069	0.632
MOD_NEK2_1	231	236	PF00069	0.515
MOD_NEK2_1	237	242	PF00069	0.465
MOD_NEK2_1	365	370	PF00069	0.745
MOD_NEK2_1	561	566	PF00069	0.737
MOD_NEK2_2	483	488	PF00069	0.594
MOD_NEK2_2	584	589	PF00069	0.587
MOD_PIKK_1	179	185	PF00454	0.652
MOD_PIKK_1	32	38	PF00454	0.690
MOD_PIKK_1	366	372	PF00454	0.580
MOD_PIKK_1	530	536	PF00454	0.589
MOD_PKA_1	414	420	PF00069	0.638
MOD_PKA_2	105	111	PF00069	0.759
MOD_PKA_2	191	197	PF00069	0.674
MOD_PKA_2	218	224	PF00069	0.554
MOD_PKA_2	25	31	PF00069	0.708
MOD_PKA_2	320	326	PF00069	0.695
MOD_PKA_2	361	367	PF00069	0.718
MOD_PKA_2	414	420	PF00069	0.638
MOD_PKA_2	481	487	PF00069	0.745
MOD_PKA_2	78	84	PF00069	0.693
MOD_PKB_1	259	267	PF00069	0.561
MOD_Plk_1	231	237	PF00069	0.496
MOD_Plk_1	255	261	PF00069	0.492
MOD_Plk_1	319	325	PF00069	0.711
MOD_Plk_1	32	38	PF00069	0.768
MOD_Plk_2-3	15	21	PF00069	0.598
MOD_Plk_4	15	21	PF00069	0.616
MOD_Plk_4	231	237	PF00069	0.547
MOD_Plk_4	293	299	PF00069	0.628
MOD_ProDKin_1	2	8	PF00069	0.516
MOD_ProDKin_1	200	206	PF00069	0.659
MOD_ProDKin_1	355	361	PF00069	0.761
MOD_ProDKin_1	43	49	PF00069	0.575
MOD_ProDKin_1	503	509	PF00069	0.818
MOD_ProDKin_1	523	529	PF00069	0.673
MOD_ProDKin_1	565	571	PF00069	0.683
MOD_SUMO_rev_2	342	351	PF00179	0.480
TRG_DiLeu_BaEn_1	50	55	PF01217	0.630
TRG_DiLeu_BaLyEn_6	244	249	PF01217	0.517
TRG_ENDOCYTIC_2	420	423	PF00928	0.747
TRG_ER_diArg_1	23	26	PF00400	0.736
TRG_ER_diArg_1	245	248	PF00400	0.609
TRG_ER_diArg_1	257	260	PF00400	0.451
TRG_ER_diArg_1	315	318	PF00400	0.690
TRG_ER_diArg_1	324	326	PF00400	0.612
TRG_ER_diArg_1	359	362	PF00400	0.711
TRG_ER_diArg_1	413	415	PF00400	0.634
TRG_ER_diArg_1	55	57	PF00400	0.687
TRG_ER_diArg_1	82	85	PF00400	0.698

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IG29	Leishmania donovani	84%	100%
A4HDD8	Leishmania braziliensis	57%	98%
A4I0R9	Leishmania infantum	84%	100%
E9AWS1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	94%