2'-phosphotransferase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

phosphotransferase, putative

Species:

Leishmania major

UniProt:

Q4QAQ2_LEIMA

TriTrypDb:

LmjF.24.0810 , LMJLV39_240013900 , LMJSD75_240013400

Length:

582

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

Q4QAQ2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QAQ2

Function

Biological processes
Term	Name	Level	Count
GO:0000459	exonucleolytic trimming involved in rRNA processing	8	2
GO:0000467	exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	9	2
GO:0000469	cleavage involved in rRNA processing	7	2
GO:0006139	nucleobase-containing compound metabolic process	3	2
GO:0006364	rRNA processing	8	2
GO:0006396	RNA processing	6	2
GO:0006725	cellular aromatic compound metabolic process	3	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0008152	metabolic process	1	2
GO:0009987	cellular process	1	2
GO:0016070	RNA metabolic process	5	2
GO:0016072	rRNA metabolic process	7	2
GO:0031123	RNA 3'-end processing	7	2
GO:0031125	rRNA 3'-end processing	9	2
GO:0034470	ncRNA processing	7	2
GO:0034641	cellular nitrogen compound metabolic process	3	2
GO:0034660	ncRNA metabolic process	6	2
GO:0043170	macromolecule metabolic process	3	2
GO:0043628	regulatory ncRNA 3'-end processing	8	2
GO:0044237	cellular metabolic process	2	2
GO:0044238	primary metabolic process	2	2
GO:0046483	heterocycle metabolic process	3	2
GO:0071704	organic substance metabolic process	2	2
GO:0090304	nucleic acid metabolic process	4	2
GO:0090305	nucleic acid phosphodiester bond hydrolysis	5	2
GO:0090501	RNA phosphodiester bond hydrolysis	6	2
GO:0090503	RNA phosphodiester bond hydrolysis, exonucleolytic	7	2
GO:1901360	organic cyclic compound metabolic process	3	2

Molecular functions
Term	Name	Level	Count
GO:0000175	3'-5'-RNA exonuclease activity	7	2
GO:0000215	tRNA 2'-phosphotransferase activity	5	12
GO:0003676	nucleic acid binding	3	12
GO:0003824	catalytic activity	1	12
GO:0004518	nuclease activity	4	2
GO:0004527	exonuclease activity	5	2
GO:0004532	RNA exonuclease activity	5	2
GO:0004540	RNA nuclease activity	4	2
GO:0005488	binding	1	12
GO:0008408	3'-5' exonuclease activity	6	2
GO:0016740	transferase activity	2	12
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	12
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	12
GO:0016787	hydrolase activity	2	2
GO:0016788	hydrolase activity, acting on ester bonds	3	2
GO:0016796	exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	6	2
GO:0016896	RNA exonuclease activity, producing 5'-phosphomonoesters	6	2
GO:0097159	organic cyclic compound binding	2	12
GO:0140098	catalytic activity, acting on RNA	3	12
GO:0140101	catalytic activity, acting on a tRNA	4	12
GO:0140640	catalytic activity, acting on a nucleic acid	2	12
GO:1901363	heterocyclic compound binding	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	287	291	PF00656	0.637
CLV_C14_Caspase3-7	309	313	PF00656	0.729
CLV_C14_Caspase3-7	351	355	PF00656	0.543
CLV_C14_Caspase3-7	572	576	PF00656	0.322
CLV_NRD_NRD_1	253	255	PF00675	0.493
CLV_NRD_NRD_1	268	270	PF00675	0.587
CLV_NRD_NRD_1	33	35	PF00675	0.747
CLV_NRD_NRD_1	335	337	PF00675	0.643
CLV_NRD_NRD_1	417	419	PF00675	0.412
CLV_NRD_NRD_1	71	73	PF00675	0.319
CLV_PCSK_KEX2_1	193	195	PF00082	0.350
CLV_PCSK_KEX2_1	253	255	PF00082	0.464
CLV_PCSK_KEX2_1	268	270	PF00082	0.587
CLV_PCSK_KEX2_1	33	35	PF00082	0.738
CLV_PCSK_KEX2_1	335	337	PF00082	0.560
CLV_PCSK_KEX2_1	71	73	PF00082	0.319
CLV_PCSK_PC1ET2_1	193	195	PF00082	0.202
CLV_PCSK_PC7_1	331	337	PF00082	0.524
CLV_PCSK_SKI1_1	102	106	PF00082	0.218
CLV_PCSK_SKI1_1	166	170	PF00082	0.274
CLV_PCSK_SKI1_1	468	472	PF00082	0.433
CLV_PCSK_SKI1_1	89	93	PF00082	0.299
DEG_ODPH_VHL_1	50	63	PF01847	0.418
DOC_CKS1_1	179	184	PF01111	0.552
DOC_CKS1_1	18	23	PF01111	0.677
DOC_CKS1_1	551	556	PF01111	0.318
DOC_CYCLIN_yClb5_NLxxxL_5	242	248	PF00134	0.492
DOC_MAPK_gen_1	192	200	PF00069	0.556
DOC_MAPK_gen_1	253	260	PF00069	0.413
DOC_MAPK_gen_1	335	342	PF00069	0.594
DOC_MAPK_gen_1	418	424	PF00069	0.461
DOC_MAPK_MEF2A_6	253	262	PF00069	0.413
DOC_MAPK_MEF2A_6	522	531	PF00069	0.297
DOC_PP1_RVXF_1	390	397	PF00149	0.415
DOC_PP2B_LxvP_1	226	229	PF13499	0.546
DOC_PP4_FxxP_1	342	345	PF00568	0.482
DOC_USP7_MATH_1	151	155	PF00917	0.492
DOC_USP7_MATH_1	19	23	PF00917	0.765
DOC_USP7_MATH_1	283	287	PF00917	0.470
DOC_USP7_MATH_1	293	297	PF00917	0.729
DOC_USP7_MATH_1	38	42	PF00917	0.679
DOC_USP7_MATH_1	399	403	PF00917	0.368
DOC_USP7_MATH_1	469	473	PF00917	0.316
DOC_USP7_UBL2_3	379	383	PF12436	0.430
DOC_USP7_UBL2_3	565	569	PF12436	0.467
DOC_WW_Pin1_4	17	22	PF00397	0.738
DOC_WW_Pin1_4	178	183	PF00397	0.531
DOC_WW_Pin1_4	361	366	PF00397	0.564
DOC_WW_Pin1_4	550	555	PF00397	0.318
DOC_WW_Pin1_4	89	94	PF00397	0.501
LIG_14-3-3_CanoR_1	111	119	PF00244	0.574
LIG_14-3-3_CanoR_1	194	200	PF00244	0.431
LIG_14-3-3_CanoR_1	335	341	PF00244	0.699
LIG_14-3-3_CanoR_1	397	407	PF00244	0.433
LIG_14-3-3_CanoR_1	468	474	PF00244	0.391
LIG_14-3-3_CanoR_1	71	79	PF00244	0.447
LIG_AP2alpha_2	128	130	PF02296	0.538
LIG_APCC_ABBA_1	527	532	PF00400	0.313
LIG_BIR_III_2	148	152	PF00653	0.550
LIG_BIR_III_2	282	286	PF00653	0.512
LIG_BRCT_BRCA1_1	338	342	PF00533	0.564
LIG_BRCT_BRCA1_1	369	373	PF00533	0.616
LIG_BRCT_BRCA1_1	43	47	PF00533	0.673
LIG_FHA_1	344	350	PF00498	0.539
LIG_FHA_1	551	557	PF00498	0.301
LIG_FHA_2	157	163	PF00498	0.454
LIG_FHA_2	285	291	PF00498	0.599
LIG_FHA_2	307	313	PF00498	0.705
LIG_FHA_2	349	355	PF00498	0.477
LIG_FHA_2	469	475	PF00498	0.383
LIG_FHA_2	481	487	PF00498	0.403
LIG_GBD_Chelix_1	244	252	PF00786	0.273
LIG_LIR_Apic_2	16	21	PF02991	0.514
LIG_LIR_Apic_2	339	345	PF02991	0.523
LIG_LIR_Apic_2	46	52	PF02991	0.363
LIG_LIR_Gen_1	154	162	PF02991	0.479
LIG_LIR_Gen_1	402	412	PF02991	0.376
LIG_LIR_Gen_1	56	65	PF02991	0.306
LIG_LIR_Nem_3	128	133	PF02991	0.454
LIG_LIR_Nem_3	154	158	PF02991	0.480
LIG_LIR_Nem_3	402	408	PF02991	0.376
LIG_LIR_Nem_3	44	50	PF02991	0.520
LIG_LIR_Nem_3	486	491	PF02991	0.295
LIG_LIR_Nem_3	56	61	PF02991	0.295
LIG_LIR_Nem_3	80	84	PF02991	0.454
LIG_LIR_Nem_3	96	100	PF02991	0.454
LIG_LYPXL_SIV_4	442	450	PF13949	0.415
LIG_MYND_1	212	216	PF01753	0.470
LIG_NRBOX	247	253	PF00104	0.387
LIG_PDZ_Class_2	577	582	PF00595	0.565
LIG_RPA_C_Fungi	348	360	PF08784	0.565
LIG_SH2_CRK	155	159	PF00017	0.433
LIG_SH2_PTP2	100	103	PF00017	0.297
LIG_SH2_PTP2	405	408	PF00017	0.357
LIG_SH2_PTP2	49	52	PF00017	0.424
LIG_SH2_PTP2	58	61	PF00017	0.301
LIG_SH2_SRC	530	533	PF00017	0.313
LIG_SH2_STAT5	100	103	PF00017	0.297
LIG_SH2_STAT5	134	137	PF00017	0.449
LIG_SH2_STAT5	155	158	PF00017	0.333
LIG_SH2_STAT5	405	408	PF00017	0.351
LIG_SH2_STAT5	451	454	PF00017	0.297
LIG_SH2_STAT5	49	52	PF00017	0.424
LIG_SH2_STAT5	496	499	PF00017	0.326
LIG_SH2_STAT5	530	533	PF00017	0.313
LIG_SH2_STAT5	566	569	PF00017	0.374
LIG_SH2_STAT5	58	61	PF00017	0.301
LIG_SH3_1	297	303	PF00018	0.774
LIG_SH3_3	101	107	PF00018	0.332
LIG_SH3_3	210	216	PF00018	0.401
LIG_SH3_3	296	302	PF00018	0.753
LIG_SH3_3	320	326	PF00018	0.788
LIG_SUMO_SIM_par_1	256	261	PF11976	0.404
LIG_SUMO_SIM_par_1	345	351	PF11976	0.527
LIG_SUMO_SIM_par_1	82	87	PF11976	0.299
LIG_TRAF2_1	355	358	PF00917	0.562
LIG_TRAF2_1	472	475	PF00917	0.426
LIG_WW_3	301	305	PF00397	0.760
MOD_CDK_SPxK_1	17	23	PF00069	0.678
MOD_CK1_1	361	367	PF00069	0.607
MOD_CK1_1	41	47	PF00069	0.678
MOD_CK2_1	468	474	PF00069	0.353
MOD_CK2_1	480	486	PF00069	0.305
MOD_CK2_1	71	77	PF00069	0.288
MOD_CMANNOS	485	488	PF00535	0.433
MOD_GlcNHglycan	175	178	PF01048	0.433
MOD_GlcNHglycan	203	206	PF01048	0.450
MOD_GlcNHglycan	216	219	PF01048	0.255
MOD_GlcNHglycan	235	238	PF01048	0.312
MOD_GlcNHglycan	26	29	PF01048	0.742
MOD_GlcNHglycan	331	334	PF01048	0.750
MOD_GlcNHglycan	40	43	PF01048	0.705
MOD_GlcNHglycan	518	521	PF01048	0.302
MOD_GSK3_1	107	114	PF00069	0.297
MOD_GSK3_1	13	20	PF00069	0.721
MOD_GSK3_1	302	309	PF00069	0.790
MOD_GSK3_1	379	386	PF00069	0.361
MOD_GSK3_1	38	45	PF00069	0.727
MOD_GSK3_1	571	578	PF00069	0.445
MOD_N-GLC_1	201	206	PF02516	0.351
MOD_NEK2_1	13	18	PF00069	0.684
MOD_NEK2_1	173	178	PF00069	0.393
MOD_NEK2_1	360	365	PF00069	0.642
MOD_NEK2_1	384	389	PF00069	0.421
MOD_NEK2_1	543	548	PF00069	0.314
MOD_PIKK_1	117	123	PF00454	0.325
MOD_PIKK_1	193	199	PF00454	0.485
MOD_PIKK_1	4	10	PF00454	0.649
MOD_PK_1	336	342	PF00069	0.650
MOD_PKA_1	193	199	PF00069	0.246
MOD_PKA_1	335	341	PF00069	0.677
MOD_PKA_1	71	77	PF00069	0.288
MOD_PKA_2	173	179	PF00069	0.433
MOD_PKA_2	193	199	PF00069	0.224
MOD_PKA_2	335	341	PF00069	0.609
MOD_PKA_2	71	77	PF00069	0.288
MOD_Plk_1	258	264	PF00069	0.481
MOD_Plk_4	164	170	PF00069	0.313
MOD_Plk_4	247	253	PF00069	0.325
MOD_Plk_4	343	349	PF00069	0.517
MOD_Plk_4	384	390	PF00069	0.370
MOD_Plk_4	480	486	PF00069	0.301
MOD_ProDKin_1	17	23	PF00069	0.741
MOD_ProDKin_1	178	184	PF00069	0.405
MOD_ProDKin_1	361	367	PF00069	0.564
MOD_ProDKin_1	550	556	PF00069	0.318
MOD_ProDKin_1	89	95	PF00069	0.364
MOD_SUMO_rev_2	162	168	PF00179	0.313
MOD_SUMO_rev_2	374	381	PF00179	0.591
TRG_DiLeu_BaEn_2	135	141	PF01217	0.433
TRG_DiLeu_BaLyEn_6	462	467	PF01217	0.224
TRG_ENDOCYTIC_2	155	158	PF00928	0.333
TRG_ENDOCYTIC_2	405	408	PF00928	0.375
TRG_ENDOCYTIC_2	530	533	PF00928	0.326
TRG_ENDOCYTIC_2	58	61	PF00928	0.297
TRG_ER_diArg_1	252	254	PF00400	0.479
TRG_ER_diArg_1	267	269	PF00400	0.525
TRG_ER_diArg_1	334	336	PF00400	0.734
TRG_ER_diArg_1	71	73	PF00400	0.397
TRG_NES_CRM1_1	221	234	PF08389	0.439
TRG_Pf-PMV_PEXEL_1	254	259	PF00026	0.474
TRG_Pf-PMV_PEXEL_1	71	75	PF00026	0.389

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HWH5	Leptomonas seymouri	56%	94%
A0A0S4J7G0	Bodo saltans	40%	90%
A0A1X0NVN6	Trypanosomatidae	43%	100%
A0A3Q8IBU9	Leishmania donovani	90%	100%
A0A422MZ86	Trypanosoma rangeli	46%	100%
A4HDD9	Leishmania braziliensis	77%	100%
A4I0S0	Leishmania infantum	90%	100%
D0A750	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	100%
E9AWS2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
V5C0L6	Trypanosoma cruzi	46%	91%