Putative inositol polyphosphate phosphatase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

inositol polyphosphate phosphatase, putative

Species:

Leishmania major

UniProt:

Q4QAQ1_LEIMA

TriTrypDb:

LmjF.24.0820 , LMJLV39_240014000 , LMJSD75_240013500

Length:

2737

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

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Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	5
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	5

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Expansion

Sequence features

Q4QAQ1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

No structure information available for this entry

Related structures:

Function

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Biological processes
Term	Name	Level	Count
GO:0006629	lipid metabolic process	3	6
GO:0006644	phospholipid metabolic process	4	6
GO:0006650	glycerophospholipid metabolic process	5	6
GO:0006793	phosphorus metabolic process	3	6
GO:0006796	phosphate-containing compound metabolic process	4	6
GO:0008152	metabolic process	1	6
GO:0009987	cellular process	1	6
GO:0016311	dephosphorylation	5	6
GO:0019637	organophosphate metabolic process	3	6
GO:0030258	lipid modification	4	6

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Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	6
GO:0004439	phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity	8	6
GO:0016787	hydrolase activity	2	6
GO:0016788	hydrolase activity, acting on ester bonds	3	6
GO:0016791	phosphatase activity	5	6
GO:0034593	phosphatidylinositol bisphosphate phosphatase activity	7	6
GO:0034595	phosphatidylinositol phosphate 5-phosphatase activity	7	6
GO:0042578	phosphoric ester hydrolase activity	4	6
GO:0043813	phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity	8	6
GO:0052866	phosphatidylinositol phosphate phosphatase activity	6	6

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	1668	1672	PF00656	0.358
CLV_C14_Caspase3-7	2332	2336	PF00656	0.558
CLV_C14_Caspase3-7	75	79	PF00656	0.637
CLV_MEL_PAP_1	459	465	PF00089	0.532
CLV_NRD_NRD_1	1085	1087	PF00675	0.643
CLV_NRD_NRD_1	1097	1099	PF00675	0.599
CLV_NRD_NRD_1	1286	1288	PF00675	0.601
CLV_NRD_NRD_1	136	138	PF00675	0.381
CLV_NRD_NRD_1	1499	1501	PF00675	0.672
CLV_NRD_NRD_1	1504	1506	PF00675	0.691

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A3S7WY77	Leishmania donovani	89%	100%
A4HDE0	Leishmania braziliensis	70%	99%
A4I0S1	Leishmania infantum	89%	100%
E9AWS3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%

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