Putative dynein arm light chain

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

dynein arm light chain, putative

Species:

Leishmania major

UniProt:

Q4QAP9_LEIMA

TriTrypDb:

LmjF.24.0840 , LMJLV39_240014200 , LMJSD75_240013700

Length:

237

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0005930	axoneme	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4QAP9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QAP9

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	2
GO:0005515	protein binding	2	2
GO:0045504	dynein heavy chain binding	3	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	154	156	PF00675	0.249
CLV_PCSK_KEX2_1	30	32	PF00082	0.577
CLV_PCSK_PC1ET2_1	30	32	PF00082	0.569
CLV_PCSK_SKI1_1	115	119	PF00082	0.287
CLV_PCSK_SKI1_1	124	128	PF00082	0.268
CLV_PCSK_SKI1_1	155	159	PF00082	0.256
DOC_CKS1_1	12	17	PF01111	0.370
DOC_MAPK_gen_1	130	139	PF00069	0.250
DOC_MAPK_gen_1	208	216	PF00069	0.249
DOC_MAPK_MEF2A_6	124	131	PF00069	0.268
DOC_MAPK_NFAT4_5	124	132	PF00069	0.249
DOC_USP7_MATH_1	141	145	PF00917	0.269
DOC_USP7_MATH_1	4	8	PF00917	0.476
DOC_WW_Pin1_4	11	16	PF00397	0.365
DOC_WW_Pin1_4	67	72	PF00397	0.298
LIG_14-3-3_CanoR_1	136	140	PF00244	0.249
LIG_APCC_ABBAyCdc20_2	155	161	PF00400	0.341
LIG_BRCT_BRCA1_1	148	152	PF00533	0.309
LIG_eIF4E_1	12	18	PF01652	0.352
LIG_EVH1_2	52	56	PF00568	0.309
LIG_FHA_1	12	18	PF00498	0.378
LIG_FHA_1	223	229	PF00498	0.249
LIG_FHA_2	71	77	PF00498	0.249
LIG_LIR_Gen_1	220	228	PF02991	0.265
LIG_LIR_Gen_1	45	56	PF02991	0.265
LIG_LIR_Nem_3	103	109	PF02991	0.270
LIG_LIR_Nem_3	140	145	PF02991	0.267
LIG_LIR_Nem_3	220	224	PF02991	0.265
LIG_LIR_Nem_3	45	51	PF02991	0.283
LIG_NRBOX	83	89	PF00104	0.265
LIG_PCNA_yPIPBox_3	176	189	PF02747	0.367
LIG_PDZ_Class_1	232	237	PF00595	0.583
LIG_Rb_LxCxE_1	118	134	PF01857	0.385
LIG_REV1ctd_RIR_1	214	223	PF16727	0.249
LIG_SH2_CRK	106	110	PF00017	0.271
LIG_SH2_CRK	142	146	PF00017	0.249
LIG_SH2_STAP1	146	150	PF00017	0.249
LIG_SH3_3	228	234	PF00018	0.456
LIG_SH3_3	61	67	PF00018	0.385
LIG_SH3_4	38	45	PF00018	0.579
LIG_SUMO_SIM_anti_2	73	79	PF11976	0.265
LIG_SUMO_SIM_par_1	13	20	PF11976	0.366
LIG_WW_3	51	55	PF00397	0.249
MOD_CDK_SPxxK_3	67	74	PF00069	0.284
MOD_CK1_1	26	32	PF00069	0.637
MOD_CK2_1	117	123	PF00069	0.391
MOD_CK2_1	141	147	PF00069	0.244
MOD_GSK3_1	141	148	PF00069	0.257
MOD_GSK3_1	66	73	PF00069	0.263
MOD_NEK2_1	145	150	PF00069	0.249
MOD_NEK2_2	141	146	PF00069	0.239
MOD_PKA_2	135	141	PF00069	0.249
MOD_PKA_2	93	99	PF00069	0.249
MOD_Plk_1	146	152	PF00069	0.341
MOD_Plk_4	227	233	PF00069	0.521
MOD_Plk_4	5	11	PF00069	0.379
MOD_Plk_4	83	89	PF00069	0.309
MOD_ProDKin_1	11	17	PF00069	0.360
MOD_ProDKin_1	67	73	PF00069	0.298
MOD_SUMO_for_1	10	13	PF00179	0.354
TRG_DiLeu_BaEn_1	123	128	PF01217	0.249
TRG_DiLeu_BaEn_1	13	18	PF01217	0.356
TRG_ENDOCYTIC_2	106	109	PF00928	0.271
TRG_ENDOCYTIC_2	142	145	PF00928	0.268
TRG_ENDOCYTIC_2	221	224	PF00928	0.265
TRG_ER_diArg_1	129	132	PF00400	0.250
TRG_Pf-PMV_PEXEL_1	143	147	PF00026	0.249
TRG_Pf-PMV_PEXEL_1	172	177	PF00026	0.265

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBX9	Leptomonas seymouri	85%	99%
A0A0S4J6T9	Bodo saltans	46%	94%
A0A0S4J9S1	Bodo saltans	64%	100%
A0A0S4JQQ4	Bodo saltans	34%	99%
A0A0S4KG80	Bodo saltans	37%	87%
A0A0S4KGN7	Bodo saltans	33%	96%
A0A1X0NSA1	Trypanosomatidae	33%	70%
A0A1X0NVG2	Trypanosomatidae	70%	99%
A0A3Q8IC16	Leishmania donovani	98%	100%
A0A3Q8IM75	Leishmania donovani	36%	96%
A0A3R7KMX9	Trypanosoma rangeli	67%	99%
A0A3R7MN26	Trypanosoma rangeli	33%	69%
A0A3S7WWL7	Leishmania donovani	34%	81%
A0A422NWB3	Trypanosoma rangeli	28%	85%
A4HBW2	Leishmania braziliensis	35%	76%
A4I0S3	Leishmania infantum	98%	100%
A4I8Y3	Leishmania infantum	36%	96%
C9ZRW3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	77%
D0A1A2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	86%
D0A753	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	69%	100%
E9AGX0	Leishmania infantum	34%	81%
E9AIH0	Leishmania braziliensis	96%	100%
E9AV86	Leishmania mexicana (strain MHOM/GT/2001/U1103)	32%	75%
E9AWS5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	97%	100%
E9B3V2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	37%	96%
O14645	Homo sapiens	52%	92%
Q26630	Strongylocentrotus purpuratus	53%	91%
Q39604	Chlamydomonas reinhardtii	57%	94%
Q4FZV3	Rattus norvegicus	52%	92%
Q4Q472	Leishmania major	36%	100%
Q4QC94	Leishmania major	35%	81%
Q4R3K5	Macaca fascicularis	51%	92%
Q6GN86	Xenopus laevis	52%	93%
Q8BVN8	Mus musculus	51%	92%
Q9VGG6	Drosophila melanogaster	48%	95%
V5BR59	Trypanosoma cruzi	66%	99%
V5BZ65	Trypanosoma cruzi	31%	69%