LeishMANIAdb
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Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania major
UniProt:
Q4QAP7_LEIMA
TriTrypDb:
LmjF.24.0860 , LMJLV39_240014400 * , LMJSD75_240013900 *
Length:
344

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 1, no: 7
NetGPI no yes: 0, no: 8
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QAP7
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QAP7

PDB structure(s): 7am2_BN

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 181 185 PF00656 0.633
CLV_NRD_NRD_1 137 139 PF00675 0.544
CLV_NRD_NRD_1 188 190 PF00675 0.540
CLV_NRD_NRD_1 254 256 PF00675 0.752
CLV_NRD_NRD_1 266 268 PF00675 0.664
CLV_NRD_NRD_1 335 337 PF00675 0.601
CLV_NRD_NRD_1 40 42 PF00675 0.765
CLV_NRD_NRD_1 68 70 PF00675 0.529
CLV_PCSK_FUR_1 37 41 PF00082 0.773
CLV_PCSK_KEX2_1 133 135 PF00082 0.462
CLV_PCSK_KEX2_1 137 139 PF00082 0.447
CLV_PCSK_KEX2_1 188 190 PF00082 0.566
CLV_PCSK_KEX2_1 254 256 PF00082 0.591
CLV_PCSK_KEX2_1 335 337 PF00082 0.601
CLV_PCSK_KEX2_1 37 39 PF00082 0.756
CLV_PCSK_KEX2_1 40 42 PF00082 0.762
CLV_PCSK_KEX2_1 68 70 PF00082 0.530
CLV_PCSK_PC1ET2_1 133 135 PF00082 0.450
CLV_PCSK_SKI1_1 160 164 PF00082 0.638
CLV_PCSK_SKI1_1 188 192 PF00082 0.671
CLV_PCSK_SKI1_1 201 205 PF00082 0.467
CLV_PCSK_SKI1_1 239 243 PF00082 0.596
CLV_PCSK_SKI1_1 40 44 PF00082 0.700
DEG_APCC_DBOX_1 38 46 PF00400 0.698
DEG_Nend_UBRbox_1 1 4 PF02207 0.736
DOC_CDC14_PxL_1 300 308 PF14671 0.477
DOC_CYCLIN_RxL_1 195 205 PF00134 0.582
DOC_MAPK_gen_1 188 198 PF00069 0.584
DOC_MAPK_MEF2A_6 201 208 PF00069 0.432
DOC_USP7_MATH_1 55 59 PF00917 0.635
DOC_USP7_MATH_1 88 92 PF00917 0.497
DOC_USP7_MATH_1 93 97 PF00917 0.490
DOC_WW_Pin1_4 112 117 PF00397 0.476
DOC_WW_Pin1_4 169 174 PF00397 0.519
DOC_WW_Pin1_4 84 89 PF00397 0.518
LIG_14-3-3_CanoR_1 68 72 PF00244 0.554
LIG_BIR_III_4 29 33 PF00653 0.566
LIG_CtBP_PxDLS_1 76 80 PF00389 0.627
LIG_eIF4E_1 105 111 PF01652 0.452
LIG_FHA_1 324 330 PF00498 0.588
LIG_FHA_1 48 54 PF00498 0.706
LIG_FHA_2 123 129 PF00498 0.478
LIG_FHA_2 200 206 PF00498 0.427
LIG_LIR_Apic_2 70 76 PF02991 0.531
LIG_LIR_Gen_1 191 200 PF02991 0.517
LIG_LIR_Gen_1 310 321 PF02991 0.553
LIG_LIR_Nem_3 191 196 PF02991 0.570
LIG_LIR_Nem_3 310 316 PF02991 0.540
LIG_LIR_Nem_3 70 75 PF02991 0.558
LIG_PCNA_TLS_4 201 208 PF02747 0.466
LIG_RPA_C_Fungi 122 134 PF08784 0.463
LIG_SH2_CRK 193 197 PF00017 0.542
LIG_SH2_SRC 207 210 PF00017 0.615
LIG_SH2_STAT3 231 234 PF00017 0.588
LIG_SH2_STAT5 207 210 PF00017 0.533
LIG_SH2_STAT5 231 234 PF00017 0.504
LIG_SH2_STAT5 300 303 PF00017 0.434
LIG_SH3_2 262 267 PF14604 0.565
LIG_SH3_3 203 209 PF00018 0.475
LIG_SH3_3 259 265 PF00018 0.575
LIG_TRAF2_1 209 212 PF00917 0.593
LIG_TRFH_1 105 109 PF08558 0.445
LIG_TYR_ITIM 298 303 PF00017 0.435
MOD_CDK_SPK_2 169 174 PF00069 0.510
MOD_CK1_1 246 252 PF00069 0.742
MOD_CK1_1 46 52 PF00069 0.676
MOD_CK1_1 63 69 PF00069 0.498
MOD_CK2_1 199 205 PF00069 0.488
MOD_CK2_1 93 99 PF00069 0.523
MOD_Cter_Amidation 252 255 PF01082 0.584
MOD_GlcNHglycan 166 169 PF01048 0.603
MOD_GlcNHglycan 246 249 PF01048 0.783
MOD_GlcNHglycan 57 60 PF01048 0.674
MOD_GSK3_1 16 23 PF00069 0.690
MOD_GSK3_1 239 246 PF00069 0.630
MOD_GSK3_1 323 330 PF00069 0.601
MOD_GSK3_1 43 50 PF00069 0.681
MOD_GSK3_1 63 70 PF00069 0.361
MOD_GSK3_1 8 15 PF00069 0.637
MOD_GSK3_1 84 91 PF00069 0.495
MOD_NEK2_1 110 115 PF00069 0.497
MOD_NEK2_1 122 127 PF00069 0.474
MOD_NEK2_1 16 21 PF00069 0.701
MOD_NEK2_1 164 169 PF00069 0.603
MOD_NEK2_1 241 246 PF00069 0.606
MOD_NEK2_1 47 52 PF00069 0.610
MOD_NEK2_1 62 67 PF00069 0.536
MOD_PIKK_1 20 26 PF00454 0.525
MOD_PKA_1 188 194 PF00069 0.569
MOD_PKA_1 254 260 PF00069 0.587
MOD_PKA_1 40 46 PF00069 0.540
MOD_PKA_2 188 194 PF00069 0.602
MOD_PKA_2 254 260 PF00069 0.731
MOD_PKA_2 327 333 PF00069 0.592
MOD_PKA_2 40 46 PF00069 0.540
MOD_PKA_2 67 73 PF00069 0.544
MOD_PKB_1 38 46 PF00069 0.542
MOD_Plk_1 222 228 PF00069 0.403
MOD_Plk_4 222 228 PF00069 0.472
MOD_ProDKin_1 112 118 PF00069 0.469
MOD_ProDKin_1 169 175 PF00069 0.517
MOD_ProDKin_1 84 90 PF00069 0.513
MOD_SUMO_rev_2 278 288 PF00179 0.498
TRG_DiLeu_BaEn_1 152 157 PF01217 0.590
TRG_ENDOCYTIC_2 193 196 PF00928 0.543
TRG_ENDOCYTIC_2 300 303 PF00928 0.434
TRG_ER_diArg_1 136 138 PF00400 0.480
TRG_ER_diArg_1 188 190 PF00400 0.556
TRG_ER_diArg_1 36 39 PF00400 0.752
TRG_ER_diArg_1 40 42 PF00400 0.760
TRG_Pf-PMV_PEXEL_1 100 104 PF00026 0.448
TRG_Pf-PMV_PEXEL_1 201 205 PF00026 0.467

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PCF7 Leptomonas seymouri 57% 100%
A0A1X0NWV8 Trypanosomatidae 34% 100%
A0A3S7WYC1 Leishmania donovani 90% 100%
A4I0S5 Leishmania infantum 90% 100%
D0A755 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 36% 100%
E9AIG8 Leishmania braziliensis 74% 85%
E9AWS7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 89% 99%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS